Integration of transcriptional and posttranscriptional regulation in dilated cardiomyopathy


Funding ID

81Z2100101

Project number

449

Institution
Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft
Project leader
Norbert Hübner
Site
Berlin
Short description

We investigate the molecular basis of cardiovascular diseases with a main focus on dilated cardiomyopathy (DCM), a major cause of congestive heart failure. Genetic factors are known to … 

We investigate the molecular basis of cardiovascular diseases with a main focus on dilated cardiomyopathy (DCM), a major cause of congestive heart failure. Genetic factors are known to play an important role in disease etiology but the molecular mechanisms are largely unknown. In order to elucidate the impact of pathogenic variation, we perform RNA-seq and ribosome profiling of cardiac disease tissue. Ribosome profiling is a powerful and novel methodology to obtain qualitative and quantitative information about translation on a genome-wide scale. This technology provides a way to thoroughly investigate translational regulation and to significantly improve the estimate of protein levels compared to traditional gene expression approaches.

Project type
Partner Site Projects
Keywords
Genetic variation, transcriptional and translational regulation
Topic
genetics of cardiovascular diseases
Funding
€ 193.415,05
Begin
01.01.2015
End
31.12.2018