Translationale Studien zur Rolle der non-coding RNA (miR und long ncRNA) für die kardievaskuläre Repair- und Immunmodulationsprozesse beim akuten Koronarsyndrom


Funding ID

81Z2100202

Project number

452

Institution
Charité - Universitätsmedizin Berlin
Project leader
Ulf Landmesser
Site
Berlin
Short description

The project aims to better define mechanisms regulating vascular and cardiac immune and repair responses in cardiovascular diseases. We combine flow cytometric sorting of human monocyte … 

The project aims to better define mechanisms regulating vascular and cardiac immune and repair responses in cardiovascular diseases. We combine flow cytometric sorting of human monocyte populations and the characterization of their coding and non-coding RNA profiles in relation to monocyte functions. Furthermore, we assess the functional impact of each of the known 2000+ miR species for monocyte-endothelial cell interaction and for cardiomyocyte proliferation. Another sub-project investigates microvesicles and their miR cargo for the interaction between blood leukocyte populations and the endothelium in patients with acute and stable cardiovascular diseases. Finally, we assess the role of lipoproteins for the interaction between cells of the innate immunity and cells of the vascular wall.

Project type
Partner Site Projects
Keywords
non-coding RNA, inflammation, vascular, endothelium, repair, monocytes, mircoRNA
Topic
inflammation/vascular inflammation
Funding
€ 755.604,00
Begin
01.01.2015
End
31.12.2018