Registry for primary electrical disease


Funding ID

81Z2500204

Project number

467

Institution
Ruprecht-Karls-Universität Heidelberg
Project leader
Martin Borggrefe
Site
Heidelberg/Mannheim
Short description

Registry for primary electrical disease of the heart: Channelopathies are a heterogeneous group of disorders resulting from the dysfunction of ion channels located in the membranes of all … 

Registry for primary electrical disease of the heart: Channelopathies are a heterogeneous group of disorders resulting from the dysfunction of ion channels located in the membranes of all cells. Channelopathies are diseases that develop because of defects in ion channels caused by either genetic or acquired factors . In patients with inherited channelopathies phenotype, individual disease course and mechanisms of arrhythmogenesis are quite different among individual patients. While in some patients causes and genetic background of ventricular fibrillation are better understood, others will develop ventricular fibrillation of unknown cause. The clinical phenotype might be influenced by unknown genetic mutations, epigenetic modifiers, gender or other still unkown risk factors. Therefore, the aim of our registry for primary electrical disease of the heart, is to identify genetic and epigenetic factors which may cause lethal arrhythmias as a result of dysfunctioning cardiac ion channels.

Project type
Partner Site Projects
Keywords
primary electrical disease of the heart, channelopathies, risk stratification
Topic
other arrhythmias
Funding
€ 243.188,46
Begin
01.01.2015
End
31.12.2018