DZHK Paper of the month

A Minimal-Invasive Approach for Standardized Induction of Myocardial Infarction in Mice. Circulation Research, DZHK authors: Florian Sicklinger, Yunhang Zhang, Lorenz Lehmann, Mathias H. Konstandin, Hugo A. Katus, Florian Leuschner

Immunothrombotic Dysregulation in COVID-19 Pneumonia is Associated with Respiratory Failure and Coagulopathy. CIRCULATION 28 Jul 2020, DZHK authors: Leo Nicolai, Alexander Leunig, Rainer Kaiser, Tobias Weinberger, Clemens Scherer, Stefan Kääb, Steffen Massberg. Kami Pekayvaz,...

Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis. Science Translational Medicine (2020), DZHK authors: D. Santovito, L. Natarelli, M. Aslani, E. Lutgens, P. von Hundelshausen, S. Steffens, J. Duchene, R.T.A....

Phosphodiesterase 3A and arterial hypertension. Circulation (2020) DZHK authors: M. Ercu*, L. Markó*, C. Schächterle, D. Tsvetkov, T. U. P. Bartolomaeus, N. Hübner, S. K. Forslund, D. N. Müller, M. Gollasch, M. Bader, Friedrich C. Luft** and E. Klussmann**

Somatic gene editing ameliorates skeletal and cardiac muscle failure in pig and human models of Duchenne muscular dystrophy. Nature Medicine, DZHK authors: A. Moretti, P. Hoppmann, A. B. Meier, T. Bozoglu, A. Baehr, C. M. Schneider, D. Sinnecker, K. Klett, F. Abdel Rahman, T....

AntimiR-21 Prevents Myocardial Dysfunction in a Pig Model of Ischemia/Reperfusion Injury. JACC (2020), DZHK authors: Rabea Hinkel, Deepak Ramanujam, Katharina Klett, Christina Beck, Anne Dueck, Karl-Ludwig Laugwitz, Lars Maegdefessel, Christian Weber, Christian Kupatt, Stefan...

The histone demethylase JMJD2B regulates endothelial-to-mesenchymal transition. PNAS (2020), DZHK authors: Simone F. Glaser, Andreas W. Heumüller, Lukas Tombor, Patrick Hofmann, Stefan Günther, David Hassel, Reinier A. Boon, Wesley Abplanalp, David John, Stefanie Dimmeler

Loss of ADAMTS19 causes progressive non-syndromic heart valve disease. Nat Genet (2019), DZHK authors: Philipp Hofmann, Kirstin Hoff, Enrique Audain, Hans-Heiner Kramer, Marc-Phillip Hitz

CRISPR-Mediated Activation of Endogenous Gene Expression in the Postnatal Heart. Circulation Research. DZHK authors: Eric Schoger, Lavanya M. Iyer, Claudia Noack, Shirin Doroudgar, Wolfram-H. Zimmermann, Laura C. Zelarayan,

Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium. The Lancet. DZHK authors: Fabian J. Brunner, Christoph Waldeyer, David M. Leistner, Ulf Landmesser, Stefan Blankenberg