Publications 2021

Here you will find publications of the DZHK in chronological order. First authors in grey are members of the Young DZHK. For more publications, please also check out the websites of the individual research institutions that participate in the DZHK.

DZHK Papers of the Month

January

Clonal Hematopoiesis-Driver Dnmt3a Mutations Alter Immune Cells in Heart Failure. Abplanalp, W. T., Cremer, S., John, D., Hoffmann, J., Schuhmacher, B., Merten, M., Rieger, M. A., Vasa-Nicotera, M., Zeiher, A. M. & Dimmeler, S. Circ Res. 128, 216-28, (2021) www.ncbi.nlm.nih.gov/pubmed/33155517

Single-Cell Rna-Sequencing Reveals Profound Changes in Circulating Immune Cells in Patients with Heart Failure. Abplanalp, W. T., John, D., Cremer, S., Assmus, B., Dorsheimer, L., Hoffmann, J., Becker-Pergola, G., Rieger, M. A., Zeiher, A. M., Vasa-Nicotera, M. & Dimmeler, S. Cardiovasc Res. 117, 484-94, (2021) www.ncbi.nlm.nih.gov/pubmed/32311026

Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci. Ahluwalia, T. S., Prins, B. P., Abdollahi, M., Armstrong, N. J., Aslibekyan, S., Bain, L., Jefferis, B., Baumert, J., Beekman, M., Ben-Shlomo, Y., Bis, J. C., Mitchell, B. D., de Geus, E., Delgado, G. E., Marek, D., Eriksson, J., Kajantie, E., Kanoni, S., Kemp, J. P., Lu, C., Marioni, R. E., McLachlan, S., Milaneschi, Y., Nolte, I. M., Petrelis, A. M., Porcu, E., Sabater-Lleal, M., Naderi, E., Seppälä, I., Shah, T., Singhal, G., Standl, M., Teumer, A., Thalamuthu, A., Thiering, E., Trompet, S., Ballantyne, C. M., Benjamin, E. J., Casas, J. P., Toben, C., Dedoussis, G., Deelen, J., Durda, P., Engmann, J., Feitosa, M. F., Grallert, H., Hammarstedt, A., Harris, S. E., Homuth, G., Hottenga, J. J., Jalkanen, S., Jamshidi, Y., Jawahar, M. C., Jess, T., Kivimaki, M., Kleber, M. E., Lahti, J., Liu, Y., Marques-Vidal, P., Mellström, D., Mooijaart, S. P., Müller-Nurasyid, M., Penninx, B., Revez, J. A., Rossing, P., Räikkönen, K., Sattar, N., Scharnagl, H., Sennblad, B., Silveira, A., Pourcain, B. S., Timpson, N. J., Trollor, J., van Dongen, J., Van Heemst, D., Visvikis-Siest, S., Vollenweider, P., Völker, U., Waldenberger, M., Willemsen, G., Zabaneh, D., Morris, R. W., Arnett, D. K., Baune, B. T., Boomsma, D. I., Chang, Y. C., Deary, I. J., Deloukas, P., Eriksson, J. G., Evans, D. M., Ferreira, M. A., Gaunt, T., Gudnason, V., Hamsten, A., Heinrich, J., Hingorani, A., Humphries, S. E., Jukema, J. W., Koeing, W., Kumari, M., Kutalik, Z., Lawlor, D. A., Lehtimäki, T., März, W., Mather, K., Naitza, S., Nauck, M., Ohlsson, C., Price, J. F., Raitakari, O., Rice, K., Sachdev, P. S., Slagboom, E., Sørensen, T. I. A., Spector, T., Stacey, D., Stathopoulou, M. G., Tanaka, T., Wannamethee, S. G., Whincup, P., Rotter, J. I., Dehghan, A., Boerwinkle, E., Psaty, B. M., Snieder, H. & Alizadeh, B. Z. Hum Mol Genet. (2021)

Measuring Myocardial Extracellular Volume of the Right Ventricle in Patients with Congenital Heart Disease. Al-Wakeel-Marquard, N., Ferreira da Silva, T., Jeuthe, S., Rastin, S., Muench, F., D, O. H. I., Yilmaz, S., Berger, F., Kuehne, T. & Messroghli, D. R. Sci Rep. 11, 2679, (2021) www.ncbi.nlm.nih.gov/pubmed/33514806

Feasibility of a Culturally Adapted Dietary Weight-Loss Intervention among Ghanaian Migrants in Berlin, Germany: The Adapt Study. Amoah, S., Ennin, R., Sagoe, K., Steinbrecher, A., Pischon, T., Mockenhaupt, F. P. & Danquah, I. Int J Environ Res Public Health. 18, (2021)

Exercise-Stress Real-Time Cardiac Magnetic Resonance Imaging for Non-Invasive Characterisation of Heart Failure with Preserved Ejection Fraction: The Hfpef Stress Trial. Backhaus, S. J., Lange, T., George, E. F., Hellenkamp, K., Gertz, R. J., Billing, M., Wachter, R., Steinmetz, M., Kutty, S., Raaz, U., Lotz, J., Friede, T., Uecker, M., Hasenfuß, G., Seidler, T. & Schuster, A. Circulation. (2021) www.ncbi.nlm.nih.gov/pubmed/33472397

Effects of a Brief Alcohol Intervention Addressing the Full Spectrum of Drinking in an Adult General Population Sample: A Randomized Controlled Trial. Baumann, S., Staudt, A., Freyer-Adam, J., Bischof, G., Meyer, C. & John, U. Addiction. (2021)

Plasminogen Activator Inhibitor-1 Reduces Cardiac Fibrosis and Promotes M2 Macrophage Polarization in Inflammatory Cardiomyopathy. Baumeier, C., Escher, F., Aleshcheva, G., Pietsch, H. & Schultheiss, H. P. Basic Res Cardiol. 116, 1, (2021)

Brown Adipose Tissue Is Associated with Cardiometabolic Health. Becher, T., Palanisamy, S., Kramer, D. J., Eljalby, M., Marx, S. J., Wibmer, A. G., Butler, S. D., Jiang, C. S., Vaughan, R., Schöder, H., Mark, A. & Cohen, P. Nat Med. 27, 58-65, (2021)

Research Priorities in Atrial Fibrillation Screening: A Report from a National Heart, Lung, and Blood Institute Virtual Workshop. Benjamin, E. J., Go, A. S., Desvigne-Nickens, P., Anderson, C. D., Casadei, B., Chen, L. Y., Crijns, H., Freedman, B., Hills, M. T., Healey, J. S., Kamel, H., Kim, D. Y., Link, M. S., Lopes, R. D., Lubitz, S. A., McManus, D. D., Noseworthy, P. A., Perez, M. V., Piccini, J. P., Schnabel, R. B., Singer, D. E., Tieleman, R. G., Turakhia, M. P., Van Gelder, I. C., Cooper, L. S. & Al-Khatib, S. M. Circulation. 143, 372-88, (2021) www.ncbi.nlm.nih.gov/pubmed/33493033

Left and Right Ventricular Dysfunction in Patients with Covid-19-Associated Myocardial Injury. Bieber, S., Kraechan, A., Hellmuth, J. C., Muenchhoff, M., Scherer, C., Schroeder, I., Irlbeck, M., Kaeaeb, S., Massberg, S., Hausleiter, J., Grabmaier, U., Orban, M. & Weckbach, L. T. Infection. (2021) www.ncbi.nlm.nih.gov/pubmed/33515390

Interdisciplinary Clinical Target Volume Generation for Cardiac Radioablation: Multi-Center Benchmarking for the Radiosurgery for Ventricular Tachycardia (Raventa) Trial. Boda-Heggemann, J., Blanck, O., Mehrhof, F., Ernst, F., Buergy, D., Fleckenstein, J., Tülümen, E., Krug, D., Siebert, F. A., Zaman, A., Kluge, A. K., Parwani, A. S., Andratschke, N., Mayinger, M. C., Ehrbar, S., Saguner, A. M., Celik, E., Baus, W. W., Stauber, A., Vogel, L., Schweikard, A., Budach, V., Dunst, J., Boldt, L. H., Bonnemeier, H. & Rudic, B. Int J Radiat Oncol Biol Phys. (2021) www.ncbi.nlm.nih.gov/pubmed/33508373

Dual Sglt-1 and Sglt-2 Inhibition Improves Left Atrial Dysfunction in Hfpef. Bode, D., Semmler, L., Wakula, P., Hegemann, N., Primessnig, U., Beindorff, N., Powell, D., Dahmen, R., Ruetten, H., Oeing, C., Alogna, A., Messroghli, D., Pieske, B. M., Heinzel, F. R. & Hohendanner, F. Cardiovasc Diabetol. 20, 7, (2021)

Coxsackievirus B3 Infection of Human Ipsc Lines and Derived Primary Germ-Layer Cells Regarding Receptor Expression. Böhnke, J., Pinkert, S., Schmidt, M., Binder, H., Bilz, N. C., Jung, M., Reibetanz, U., Beling, A., Rujescu, D. & Claus, C. Int J Mol Sci. 22, (2021) www.ncbi.nlm.nih.gov/pubmed/33513663

Sars-Cov-2 Infection Is Associated with a Pro-Thrombotic Platelet Phenotype. Bongiovanni, D., Klug, M., Lazareva, O., Weidlich, S., Biasi, M., Ursu, S., Warth, S., Buske, C., Lukas, M., Spinner, C. D., Scheidt, M. V., Condorelli, G., Baumbach, J., Laugwitz, K. L., List, M. & Bernlochner, I. Cell Death Dis. 12, 50, (2021)

Risk Prediction of Atrial Fibrillation in the Community Combining Biomarkers and Genetics. Börschel, C. S., Ohlrogge, A. H., Geelhoed, B., Niiranen, T., Havulinna, A. S., Palosaari, T., Jousilahti, P., Rienstra, M., van der Harst, P., Blankenberg, S., Zeller, T., Salomaa, V. & Schnabel, R. B. Europace. (2021)

Dgk and Dzhk Position Paper on Genome Editing: Basic Science Applications and Future Perspective. Brandes, R. P., Dueck, A., Engelhardt, S., Kaulich, M., Kupatt, C., De Angelis, M. T., Leisegang, M. S., le Noble, F., Moretti, A., Müller, O. J., Skryabin, B. V., Thum, T. & Wurst, W. Basic Res Cardiol. 116, 2, (2021)

Empagliflozin and Health-Related Quality of Life Outcomes in Patients with Heart Failure with Reduced Ejection Fraction: The Emperor-Reduced Trial. Butler, J., Anker, S. D., Filippatos, G., Khan, M. S., Ferreira, J. P., Pocock, S. J., Giannetti, N., Januzzi, J. L., Piña, I. L., Lam, C. S. P., Ponikowski, P., Sattar, N., Verma, S., Brueckmann, M., Jamal, W., Vedin, O., Peil, B., Zeller, C., Zannad, F. & Packer, M. Eur Heart J. (2021)

Adult with Congenital Heart Disease We Need More Europe for a Better Care. Chessa, M. & Tutarel, O. Eur J Heart Fail. (2021) www.ncbi.nlm.nih.gov/pubmed/33496353

Variation in the Serpina6/Serpina1 Locus Alters Morning Plasma Cortisol, Hepatic Corticosteroid Binding Globulin Expression, Gene Expression in Peripheral Tissues, and Risk of Cardiovascular Disease. Crawford, A. A., Bankier, S., Altmaier, E., Barnes, C. L. K., Clark, D. W., Ermel, R., Friedrich, N., van der Harst, P., Joshi, P. K., Karhunen, V., Lahti, J., Mahajan, A., Mangino, M., Nethander, M., Neumann, A., Pietzner, M., Sukhavasi, K., Wang, C. A., Bakker, S. J. L., Bjorkegren, J. L. M., Campbell, H., Eriksson, J., Gieger, C., Hayward, C., Jarvelin, M. R., McLachlan, S., Morris, A. P., Ohlsson, C., Pennell, C. E., Price, J., Rudan, I., Ruusalepp, A., Spector, T., Tiemeier, H., Völzke, H., Wilson, J. F., Michoel, T., Timpson, N. J., Smith, G. D. & Walker, B. R. J Hum Genet. (2021) www.ncbi.nlm.nih.gov/pubmed/33469137

Alcohol Consumption, Cardiac Biomarkers, and Risk of Atrial Fibrillation and Adverse Outcomes. Csengeri, D., Sprünker, N. A., Di Castelnuovo, A., Niiranen, T., Vishram-Nielsen, J. K., Costanzo, S., Söderberg, S., Jensen, S. M., Vartiainen, E., Donati, M. B., Magnussen, C., Camen, S., Gianfagna, F., Løchen, M. L., Kee, F., Kontto, J., Mathiesen, E. B., Koenig, W., Stefan, B., de Gaetano, G., Jørgensen, T., Kuulasmaa, K., Zeller, T., Salomaa, V., Iacoviello, L. & Schnabel, R. B. Eur Heart J. (2021)

Phosphoproteomics Identify Arachidonic-Acid-Regulated Signal Transduction Pathways Modulating Macrophage Functions with Implications for Ovarian Cancer. Dietze, R., Hammoud, M. K., Gómez-Serrano, M., Unger, A., Bieringer, T., Finkernagel, F., Sokol, A. M., Nist, A., Stiewe, T., Reinartz, S., Ponath, V., Preußer, C., von Strandmann, E. P., Müller-Brüsselbach, S., Graumann, J. & Müller, R. Theranostics. 11, 1377-95, (2021)

Ablation of Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy: Treatment Strategy, Characteristics of Consecutive Atrial Tachycardia and Long-Term Outcome. Dinshaw, L., Münkler, P., Schäffer, B., Klatt, N., Jungen, C., Dickow, J., Tamenang, A., Schleberger, R., Pecha, S., Pinnschmidt, H., Patten, M., Reichenspurner, H., Willems, S. & Meyer, C. J Am Heart Assoc. e017451, (2021)

Cost Saving Analysis of Specialized, Ehealth-Based Management of Patients Receiving Oral Anticoagulation Therapy: Results from the Thrombeval Study. Eggebrecht, L., Ludolph, P., Göbel, S., Panova-Noeva, M., Arnold, N., Nagler, M., Bickel, C., Lauterbach, M., Hardt, R., Cate, H. T., Lackner, K. J., Espinola-Klein, C., Münzel, T., Prochaska, J. H. & Wild, P. S. Sci Rep. 11, 2577, (2021) www.ncbi.nlm.nih.gov/pubmed/33510343

Rationale and Design of the Cardiovascular Status in Patients with Endogenous Cortisol Excess Study (Cv-Cort-Ex): A Prospective Non-Interventional Follow-up Study. Ehrlich, K., Morbach, C., Reiter, T., Heuschmann, P. U., Hannemann, A., Fassnacht, M., Störk, S., Hahner, S. & Deutschbein, T. BMC Endocr Disord. 21, 11, (2021)

Inflammation Predicts New Onset of Depression in Men, but Not in Women within a Prospective, Representative Community Cohort. Ernst, M., Brähler, E., Otten, D., Werner, A. M., Tibubos, A. N., Reiner, I., Wicke, F., Wiltink, J., Michal, M., Nagler, M., Münzel, T., Wild, P. S., König, J., Pfeiffer, N., Borta, A., Lackner, K. J. & Beutel, M. E. Sci Rep. 11, 2271, (2021) www.ncbi.nlm.nih.gov/pubmed/33500534

Uncertainty Resolved? Falk, V. Innovations (Phila). 1556984520988796, (2021) www.ncbi.nlm.nih.gov/pubmed/33491537

An Overview of Anamorelin as a Treatment Option for Cancer-Associated Anorexia and Cachexia. Fonseca, G. & von Haehling, S. Expert Opin Pharmacother. 1-8, (2021) www.ncbi.nlm.nih.gov/pubmed/33491505

Impact of Oral Anticoagulation on Clinical Outcomes of Covid-19: A Nationwide Cohort Study of Hospitalized Patients in Germany. Fröhlich, G. M., Jeschke, E., Eichler, U., Thiele, H., Alhariri, L., Reinthaler, M., Kastrati, A., Leistner, D. M., Skurk, C., Landmesser, U. & Günster, C. Clin Res Cardiol. 1-10, (2021)

Corrigendum to "Interaction between Cieds and Modern Radiotherapy Techniques: Flattening Filter Free-Vmat, Dose-Rate Effects, Scatter Radiation, and Neutron-Generating Energies" [Radiother Oncol 152 (2020) 196-202]. Gauter-Fleckenstein, B., Nguyen, J., Jahnke, L., Gaiser, T., Rudic, B., Büttner, S., Wenz, F., Borggrefe, M. & Tülümen, E. Radiother Oncol. 154, 291, (2021)

Inflammatory Chemokines in Atherosclerosis. Gencer, S., Evans, B. R., van der Vorst, E. P. C., Döring, Y. & Weber, C. Cells. 10, (2021) www.ncbi.nlm.nih.gov/pubmed/33503867

Concomitant Tricuspid Regurgitation Severity and Its Secondary Reduction Determine Long-Term Prognosis after Transcatheter Mitral Valve Edge-to-Edge Repair. Geyer, M., Keller, K., Bachmann, K., Born, S., Tamm, A. R., Ruf, T. F., Kreidel, F., Hahad, O., Petrescu, A., Hell, M., Beiras-Fernandez, A., Kornberger, A., Schulz, E., Münzel, T. & von Bardeleben, R. S. Clin Res Cardiol. (2021)

Cardiomyocytes Stimulate Angiogenesis after Ischemic Injury in a Zeb2-Dependent Manner. Gladka, M. M., Kohela, A., Molenaar, B., Versteeg, D., Kooijman, L., Monshouwer-Kloots, J., Kremer, V., Vos, H. R., Huibers, M. M. H., Haigh, J. J., Huylebroeck, D., Boon, R. A., Giacca, M. & van Rooij, E. Nat Commun. 12, 84, (2021)

DNA Methylation and Lipid Metabolism: An Ewas of 226 Metabolic Measures. Gomez-Alonso, M. D. C., Kretschmer, A., Wilson, R., Pfeiffer, L., Karhunen, V., Seppälä, I., Zhang, W., Mittelstraß, K., Wahl, S., Matias-Garcia, P. R., Prokisch, H., Horn, S., Meitinger, T., Serrano-Garcia, L. R., Sebert, S., Raitakari, O., Loh, M., Rathmann, W., Müller-Nurasyid, M., Herder, C., Roden, M., Hurme, M., Jarvelin, M. R., Ala-Korpela, M., Kooner, J. S., Peters, A., Lehtimäki, T., Chambers, J. C., Gieger, C., Kettunen, J. & Waldenberger, M. Clin Epigenetics. 13, 7, (2021)

Associated Factors of White Matter Hyperintensity Volume: A Machine-Learning Approach. Grosu, S., Rospleszcz, S., Hartmann, F., Habes, M., Bamberg, F., Schlett, C. L., Galie, F., Lorbeer, R., Auweter, S., Selder, S., Buelow, R., Heier, M., Rathmann, W., Mueller-Peltzer, K., Ladwig, K. H., Grabe, H. J., Peters, A., Ertl-Wagner, B. B. & Stoecklein, S. Sci Rep. 11, 2325, (2021) www.ncbi.nlm.nih.gov/pubmed/33504924

Role of Cardiac Biomarkers in Epidemiology and Risk Outcomes. Haller, P. M., Beer, B. N., Tonkin, A. M., Blankenberg, S. & Neumann, J. T. Clin Chem. 67, 96-106, (2021)

Mir-375- and Mir-1-Regulated Coxsackievirus B3 Has No Pancreas and Heart Toxicity but Strong Antitumor Efficiency in Colorectal Carcinomas. Hazini, A., Dieringer, B., Pryshliak, M., Knoch, K. P., Heimann, L., Tolksdorf, B., Pappritz, K., El-Shafeey, M., Solimena, M., Beling, A., Kurreck, J., Klingel, K. & Fechner, H. Hum Gene Ther. (2021) www.ncbi.nlm.nih.gov/pubmed/33481658

Impaired in Vitro Growth Response of Plasma-Treated Cardiomyocytes Predicts Poor Outcome in Patients with Transthyretin Amyloidosis. Hein, S., Furkel, J., Knoll, M., Aus dem Siepen, F., Schönland, S., Hegenbart, U., Katus, H. A., Kristen, A. V. & Konstandin, M. H. Clin Res Cardiol. (2021) www.ncbi.nlm.nih.gov/pubmed/33481097

Apixaban or Vitamin K Antagonists and Aspirin or Placebo According to Kidney Function in Patients with Atrial Fibrillation after Acute Coronary Syndrome or Pci: Insights from the Augustus Trial. Hijazi, Z., Alexander, J. H., Li, Z., Wojdyla, D. M., Mehran, R., Granger, C. B., Parkhomenko, A., Bahit, M. C., Windecker, S., Aronson, R., Berwanger, O., Halvorsen, S., de Waha-Thiele, S., Sinnaeve, P., Darius, H., Storey, R. F. & Lopes, R. D. Circulation. (2021)

Randomized Study Defining the Optimum Target Interlesion Distance in Ablation Index-Guided Atrial Fibrillation Ablation: Authors' Reply. Hoffmann, P. & Althoff, T. F. Europace. (2021)

Prognostic Impact of Pretherapeutic Hemoglobin Levels on All-Cause Mortality in Cardiooncology. Hohneck, A., Rosenkaimer, S., Sieburg, T., Holzwarth, J., Hofheinz, R. D., Akin, I., Borggrefe, M. & Gerhards, S. Anticancer Res. 41, 369-78, (2021)

Epigenetic Gene Expression Links Heart Failure to Memory Impairment. Islam, M. R., Lbik, D., Sakib, M. S., Maximilian Hofmann, R., Berulava, T., Jiménez Mausbach, M., Cha, J., Goldberg, M., Vakhtang, E., Schiffmann, C., Zieseniss, A., Katschinski, D. M., Sananbenesi, F., Toischer, K. & Fischer, A. EMBO Mol Med. e11900, (2021) www.ncbi.nlm.nih.gov/pubmed/33471428

Prognostic Impact of Percutaneous Coronary Intervention of Chronic Total Occlusion in Acute and Periprocedural Myocardial Infarction. Kim, S. H., Behnes, M., Mashayekhi, K., Bufe, A., Meyer-Gessner, M., El-Battrawy, I. & Akin, I. J Clin Med. 10, (2021)

Proteomics in Kidney and Cardiovascular Clinical Research. Klein, O. Proteomics Clin Appl. 15, e1900132, (2021)

Empagliflozin Improves Endothelial and Cardiomyocyte Function in Human Heart Failure with Preserved Ejection Fraction Via Reduced Pro-Inflammatory-Oxidative Pathways and Protein Kinase Gα Oxidation. Kolijn, D., Pabel, S., Tian, Y., Lódi, M., Herwig, M., Carrizzo, A., Zhazykbayeva, S., Kovács, Á., Fülöp, G., Falcão-Pires, I., Reusch, P. H., Linthout, S. V., Papp, Z., van Heerebeek, L., Vecchione, C., Maier, L. S., Ciccarelli, M., Tschöpe, C., Mügge, A., Bagi, Z., Sossalla, S. & Hamdani, N. Cardiovasc Res. 117, 495-507, (2021) www.ncbi.nlm.nih.gov/pubmed/32396609

Fast Strain-Encoded Cardiac Magnetic Resonance for Diagnostic Classification and Risk Stratification of Heart Failure Patients. Korosoglou, G., Giusca, S., Montenbruck, M., Patel, A. R., Lapinskas, T., Götze, C., Zieschang, V., Al-Tabatabaee, S., Pieske, B., Florian, A., Erley, J., Katus, H. A., Kelle, S. & Steen, H. JACC Cardiovasc Imaging. (2021)

A Guide to Understanding Endoplasmic Reticulum Stress in Metabolic Disorders. Lemmer, I. L., Willemsen, N., Hilal, N. & Bartelt, A. Mol Metab. 101169, (2021) www.ncbi.nlm.nih.gov/pubmed/33484951

Human Induced Pluripotent Stem Cell Derived Cardiomyocytes: The New Working Horse in Cardiovascular Pharmacology? Lemoine, M. D. & Christ, T. J Cardiovasc Pharmacol. Publish Ahead of Print, (2021)

Vascular Biotransformation of Organic Nitrates Is Independent of Cytochrome P450 Monooxygenases. Lopez, M., Malacarne, P. F., Gajos-Draus, A., Ding, X., Daiber, A., Lundberg, J. O., Offermanns, S., Brandes, R. P. & Rezende, F. Br J Pharmacol. (2021)

Association of Antecedent Cardiovascular Risk Factor Levels and Trajectories with Cardiovascular Magnetic Resonance-Derived Cardiac Function and Structure. Lorbeer, R., Rospleszcz, S., Schlett, C. L., Rado, S. D., Thorand, B., Meisinger, C., Rathmann, W., Heier, M., Vasan, R. S., Bamberg, F., Peters, A. & Lieb, W. J Cardiovasc Magn Reson. 23, 2, (2021)

The Multiple Options of Left Atrial and Ventricular Venting During Veno-Arterial Extra-Corporeal Membrane Oxygenation: Practical Considerations. Lüsebrink, E., Massberg, S. & Orban, M. Eur Heart J. (2021)

Cognitive Impairment in Patients with Atrial Fibrillation: Implications for Outcome in a Cohort Study. Malavasi, V. L., Zoccali, C., Brandi, M. C., Micali, G., Vitolo, M., Imberti, J. F., Mussi, C., Schnabel, R. B., Freedman, B. & Boriani, G. Int J Cardiol. 323, 83-89, (2021)

Low Serum Vitamin D Level Associated with Incident Advanced Liver Disease in the General Population - a Prospective Study. Männistö, V., Jääskeläinen, T., Färkkilä, M., Jula, A., Männistö, S., Lundqvist, A., Zeller, T., Blankenberg, S., Salomaa, V., Perola, M. & Åberg, F. Scand J Gastroenterol. 1-5, (2021) www.ncbi.nlm.nih.gov/pubmed/33478287

Trend-Db-a Transcriptome-Wide Atlas of the Dynamic Landscape of Alternative Polyadenylation. Marini, F., Scherzinger, D. & Danckwardt, S. Nucleic Acids Res. 49, D243-d53, (2021)

Impact of Chronic Kidney Disease in 29 893 Patients Undergoing Transcatheter or Surgical Aortic Valve Replacement from the German Aortic Valve Registry. Mas-Peiro, S., Faerber, G., Bon, D., Herrmann, E., Bauer, T., Bleiziffer, S., Bekeredjian, R., Böning, A., Frerker, C., Beckmann, A., Möllmann, H., Vasa-Nicotera, M., Ensminger, S., Hamm, C. W., Beyersdorf, F., Fichtlscherer, S. & Walther, T. Eur J Cardiothorac Surg. (2021)

Mental Disorders and Cardiovascular Disease: What Should We Be Looking out For? Michal, M. & Beutel, M. Heart. (2021) www.ncbi.nlm.nih.gov/pubmed/33509980

Current Use of Cardiac Magnetic Resonance in Tertiary Referral Centres for the Diagnosis of Cardiomyopathy: The Esc Eorp Cardiomyopathy/Myocarditis Registry. Mizia-Stec, K., Charron, P., Gimeno Blanes, J. R., Elliott, P., Kaski, J. P., Maggioni, A. P., Tavazzi, L., Tendera, M., Felix, S. B., Dominguez, F., Ojrzynska, N., Losi, M. A., Limongelli, G., Barriales-Villa, R., Seferovic, P. M., Biagini, E., Wybraniec, M., Laroche, C. & Caforio, A. L. P. Eur Heart J Cardiovasc Imaging. (2021)

Effects of Statins on Mitochondrial Pathways. Mollazadeh, H., Tavana, E., Fanni, G., Bo, S., Banach, M., Pirro, M., von Haehling, S., Jamialahmadi, T. & Sahebkar, A. J Cachexia Sarcopenia Muscle. (2021) www.ncbi.nlm.nih.gov/pubmed/33511728

Hybrid Arch Repair for Acute Type a Aortic Dissection: A New Concept and Step-by-Step Procedure. Montagner, M., Kofler, M., Buz, S. & Kempfert, J. Interact Cardiovasc Thorac Surg. (2021) www.ncbi.nlm.nih.gov/pubmed/33479734

Interdisciplinary Management of Acute Ischaemic Stroke: Current Evidence Training Requirements for Endovascular Stroke Treatment: Position Paper from the Esc Council on Stroke and the European Association for Percutaneous Cardiovascular Interventions with the Support of the European Board of Neurointervention. Nardai, S., Lanzer, P., Abelson, M., Baumbach, A., Doehner, W., Hopkins, L. N., Kovac, J., Meuwissen, M., Roffi, M., Sievert, H., Skrypnik, D., Sulzenko, J., van Zwam, W., Gruber, A., Ribo, M., Cognard, C., Szikora, I., Flodmark, O. & Widimsky, P. Eur Heart J. 42, 298-307, (2021) www.ncbi.nlm.nih.gov/pubmed/33160282

Gender Score Development in the Berlin Aging Study Ii: A Retrospective Approach. Nauman, A. T., Behlouli, H., Alexander, N., Kendel, F., Drewelies, J., Mantantzis, K., Berger, N., Wagner, G. G., Gerstorf, D., Demuth, I., Pilote, L. & Regitz-Zagrosek, V. Biol Sex Differ. 12, 15, (2021)

Surgical Implantation Techniques of Modern Continuous Flow Ventricular Assist Devices. Nersesian, G., Potapov, E., Starck, C. T., Nazari-Shafti, T. Z., Kofler, M., Kempfert, J., Falk, V. & Van Praet, K. M. Surg Technol Int. 38, (2021)

Endothelial Barrier Function after Stenting: Science-Fiction or Relevant Endpoint? Nicol, P. & Joner, M. Cardiovasc Revasc Med. (2021)

Association of Proton Pump Inhibitor Use with Endothelial Function and Metabolites of the Nitric Oxide Pathway: A Cross-Sectional Study. Nolde, M., Bahls, M., Friedrich, N., Dörr, M., Dreischulte, T., Felix, S. B., Rückert-Eheberg, I. M., Ahn, N., Amann, U., Schwedhelm, E., Völzke, H., Lerch, M. M., Linseisen, J., Meisinger, C. & Baumeister, S. E. Pharmacotherapy. (2021)

Molecular Mechanism of Autosomal Recessive Long Qt-Syndrome 1 without Deafness. Oertli, A., Rinné, S., Moss, R., Kääb, S., Seemann, G., Beckmann, B. M. & Decher, N. Int J Mol Sci. 22, (2021) www.ncbi.nlm.nih.gov/pubmed/33498651

Improving Translational Research in Sex-Specific Effects of Comorbidities and Risk Factors in Ischaemic Heart Disease and Cardioprotection: Position Paper and Recommendations of the Esc Working Group on Cellular Biology of the Heart. Perrino, C., Ferdinandy, P., Bøtker, H. E., Brundel, B., Collins, P., Davidson, S. M., den Ruijter, H. M., Engel, F. B., Gerdts, E., Girao, H., Gyöngyösi, M., Hausenloy, D. J., Lecour, S., Madonna, R., Marber, M., Murphy, E., Pesce, M., Regitz-Zagrosek, V., Sluijter, J. P. G., Steffens, S., Gollmann-Tepeköylü, C., Van Laake, L. W., Van Linthout, S., Schulz, R. & Ytrehus, K. Cardiovasc Res. 117, 367-85, (2021) www.ncbi.nlm.nih.gov/pubmed/32484892

History of Acute Coronary Syndrome: A Common, Maybe Underestimated, Risk Factor for Heart Failure with Preserved Ejection Fraction. Pieske, B. & Morris, D. A. Rev Esp Cardiol (Engl Ed). (2021)

Sex-Related Differences in D-Dimer Levels for Venous Thromboembolism Screening. Reagh, J. J., Zheng, H., Stolz, U., Parry, B. A., Chang, A. M., House, S. L., Giordano, N. J., Cohen, J., Singer, A. J., Francis, S., Prochaska, J. H., Zeserson, E., Wild, P. S., Limkakeng, A. T., Jr., Walters, E. L., LoVecchio, F., Theodoro, D., Hollander, J. E., Kabrhel, C. & Fermann, G. J. Acad Emerg Med. (2021) www.ncbi.nlm.nih.gov/pubmed/33497508

Age- and Gender-Related Reference Values of Cardiac Morphology and Function in Cardiovascular Magnetic Resonance. Riffel, J. H., Mayo, R., Mueller-Hennessen, M., Giannitsis, E., Katus, H. A. & Andre, F. Int J Cardiovasc Imaging. (2021) www.ncbi.nlm.nih.gov/pubmed/33483891

Health-Related Quality of Life, Anxiety and Depression up to 12 months Post-Stroke: Influence of Sex, Age, Stroke Severity and Atrial Fibrillation - a Longitudinal Subanalysis of the Find-Af(Randomised) Trial. Sadlonova, M., Wasser, K., Nagel, J., Weber-Krüger, M., Gröschel, S., Uphaus, T., Liman, J., Hamann, G. F., Kermer, P., Gröschel, K., Herrmann-Lingen, C. & Wachter, R. J Psychosom Res. 142, 110353, (2021)

Immune Cell-Based Cardiovascular Risk Assessment: Spotlight on the Neutrophil-Lymphocyte Ratio. Sager, H. B. & Koenig, W. Eur Heart J. (2021)

When Big Eaters Stop Feasting: Loss of Metabolic Control in Macrophages Exacerbates Hypertension in Obesity. Schäfer, K. & Wenzel, P. Cardiovasc Res. 117, 351-53, (2021) www.ncbi.nlm.nih.gov/pubmed/32298411

Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution. Schlein, C., Fischer, A. W., Sass, F., Worthmann, A., Tödter, K., Jaeckstein, M. Y., Behrens, J., Lynes, M. D., Kiebish, M. A., Narain, N. R., Bussberg, V., Darkwah, A., Jespersen, N. Z., Nielsen, S., Scheele, C., Schweizer, M., Braren, I., Bartelt, A., Tseng, Y. H., Heeren, J. & Scheja, L. Cell Rep. 34, 108624, (2021)

Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy. Schuldt, M., Pei, J., Harakalova, M., Dorsch, L. M., Schlossarek, S., Mokry, M., Knol, J. C., Pham, T. V., Schelfhorst, T., Piersma, S. R., Dos Remedios, C., Dalinghaus, M., Michels, M., Asselbergs, F. W., Moutin, M. J., Carrier, L., Jimenez, C. R., van der Velden, J. & Kuster, D. W. D. Circ Heart Fail. 14, e007022, (2021)

Relation of Body Fat Mass and Fat-Free Mass to Total Mortality: Results from 7 Prospective Cohort Studies. Sedlmeier, A. M., Baumeister, S. E., Weber, A., Fischer, B., Thorand, B., Ittermann, T., Dörr, M., Felix, S. B., Völzke, H., Peters, A. & Leitzmann, M. F. Am J Clin Nutr. (2021)

Arterial Delivery of Vegf-C Stabilizes Atherosclerotic Lesions. Silvestre-Roig, C., Lemnitzer, P., Gall, J., Schwager, S., Toska, A., Yvan-Charvet, L., Detmar, M. & Soehnlein, O. Circ Res. 128, 284-86, (2021) www.ncbi.nlm.nih.gov/pubmed/33210556

Valvular Atrial Fibrillation and a Cha2ds2-Vasc Score of 1-a Statement of the Esc Working Group on Cardiovascular Pharmacotherapy and Esc Council on Stroke. Sulzgruber, P., Doehner, W. & Niessner, A. Eur Heart J. (2021) www.ncbi.nlm.nih.gov/pubmed/33496325

Shared Genetic Pathways Contribute to Risk of Hypertrophic and Dilated Cardiomyopathies with Opposite Directions of Effect. Tadros, R., Francis, C., Xu, X., Vermeer, A. M. C., Harper, A. R., Huurman, R., Kelu Bisabu, K., Walsh, R., Hoorntje, E. T., Te Rijdt, W. P., Buchan, R. J., van Velzen, H. G., van Slegtenhorst, M. A., Vermeulen, J. M., Offerhaus, J. A., Bai, W., de Marvao, A., Lahrouchi, N., Beekman, L., Karper, J. C., Veldink, J. H., Kayvanpour, E., Pantazis, A., Baksi, A. J., Whiffin, N., Mazzarotto, F., Sloane, G., Suzuki, H., Schneider-Luftman, D., Elliott, P., Richard, P., Ader, F., Villard, E., Lichtner, P., Meitinger, T., Tanck, M. W. T., van Tintelen, J. P., Thain, A., McCarty, D., Hegele, R. A., Roberts, J. D., Amyot, J., Dubé, M. P., Cadrin-Tourigny, J., Giraldeau, G., L'Allier, P. L., Garceau, P., Tardif, J. C., Boekholdt, S. M., Lumbers, R. T., Asselbergs, F. W., Barton, P. J. R., Cook, S. A., Prasad, S. K., O'Regan, D. P., van der Velden, J., Verweij, K. J. H., Talajic, M., Lettre, G., Pinto, Y. M., Meder, B., Charron, P., de Boer, R. A., Christiaans, I., Michels, M., Wilde, A. A. M., Watkins, H., Matthews, P. M., Ware, J. S. & Bezzina, C. R. Nat Genet. (2021) www.ncbi.nlm.nih.gov/pubmed/33495596

Connecting the Dots? Rate Control, Heart Failure, and Atrial Fibrillation. Toennis, T. & Kirchhof, P. Cardiovasc Res. 117, 336-37, (2021) www.ncbi.nlm.nih.gov/pubmed/33458743

Risk Markers of Incident Atrial Fibrillation in Patients with Coronary Heart Disease. Tomasdottir, M. M., Held C Md, P., Hadziosmanovic, N., Westerbergh, J., Lindbäck, J., Aylward, P. E., Budaj, A., Cannon, C. P., Engdahl, J., Granger, C. B., Koenig, W., Manolis, A. J., Oldgren, J., Stewart, R. A. H., Svennberg, E., Vinereanu, D., White, H. D., Siegbahn, A., Wallentin, L. & Hijazi, Z. Am Heart J. 233, 92-101, (2021)

Single Cell Sequencing Reveals Endothelial Plasticity with Transient Mesenchymal Activation after Myocardial Infarction. Tombor, L. S., John, D., Glaser, S. F., Luxán, G., Forte, E., Furtado, M., Rosenthal, N., Baumgarten, N., Schulz, M. H., Wittig, J., Rogg, E. M., Manavski, Y., Fischer, A., Muhly-Reinholz, M., Klee, K., Looso, M., Selignow, C., Acker, T., Bibli, S. I., Fleming, I., Patrick, R., Harvey, R. P., Abplanalp, W. T. & Dimmeler, S. Nat Commun. 12, 681, (2021) www.ncbi.nlm.nih.gov/pubmed/33514719

Kv1.1 Potassium Channel Subunit Deficiency Alters Ventricular Arrhythmia Susceptibility, Contractility, and Repolarization. Trosclair, K., Si, M., Watts, M., Gautier, N. M., Voigt, N., Traylor, J., Bitay, M., Baczko, I., Dobrev, D., Hamilton, K. A., Bhuiyan, M. S., Dominic, P. & Glasscock, E. Physiol Rep. 9, e14702, (2021)

Chitinase 3 Like 1 (Chi3l1) Is a Regulator of Smooth Muscle Cell Physiology and Atherosclerotic Lesion Stability. Tsantilas, P., Lao, S., Wu, Z., Eberhard, A., Winski, G., Vaerst, M., Nanda, V., Wang, Y., Kojima, Y., Ye, J., Flores, A., Jarr, K. U., Pelisek, J., Eckstein, H. H., Matic, L., Hedin, U., Tsao, P. S., Paloschi, V., Maegdefessel, L. & Leeper, N. J. Cardiovasc Res. (2021) www.ncbi.nlm.nih.gov/pubmed/33471078

Covid-19-Convalescence Phase Unmasks a Silent Myocardial Infarction Due to Coronary Plaque Rupture. Tschöpe, C., Sherif, M., Anker, M. S., Geisel, D., Kuehne, T. & Kelle, S. ESC Heart Fail. (2021)

Extent of Peri-Infarct Scar on Late Gadolinium Enhancement Cardiac Magnetic Resonance Imaging and Outcome in Patients with Ischemic Cardiomyopathy. Tülümen, E., Rudic, B., Ringlage, H., Hohneck, A., Röger, S., Liebe, V., Kuschyk, J., Overhoff, D., Budjan, J., Akin, I., Borggrefe, M. & Papavassiliu, T. Heart Rhythm. (2021) www.ncbi.nlm.nih.gov/pubmed/33515714

The Effect of a Video-Supported Assessment to Increase the Accuracy of Self-Reported Physical Activity. Ullrich, A., Voigt, L., Siewert-Markus, U., Meyer, C., Dörr, M. & Ulbricht, S. Scand J Med Sci Sports. (2021)

Imaging Atherosclerotic Plaques by Targeting Galectin-3 and Activated Macrophages Using ((89)Zr)-Dfo- Galectin3-F(Ab')(2) Mab. Varasteh, Z., De Rose, F., Mohanta, S., Li, Y., Zhang, X., Miritsch, B., Scafetta, G., Yin, C., Sager, H. B., Glasl, S., Gorpas, D., Habenicht, A. J. R., Ntziachristos, V., Weber, W. A., Bartolazzi, A., Schwaiger, M. & D'Alessandria, C. Theranostics. 11, 1864-76, (2021)

Clinical Impact and 'Natural' Course of Uncorrected Tricuspid Regurgitation after Implantation of a Left Ventricular Assist Device: An Analysis of the European Registry for Patients with Mechanical Circulatory Support (Euromacs). Veen, K. M., Mokhles, M. M., Soliman, O., de By, T., Mohacsi, P., Schoenrath, F., Paluszkiewicz, L., Netuka, I., Bogers, A., Takkenberg, J. J. M. & Caliskan, K. Eur J Cardiothorac Surg. 59, 207-16, (2021)

Complexity of the Eukaryotic Dolichol-Linked Oligosaccharide Scramblase Suggested by Activity Correlation Profiling Mass Spectrometry. Verchère, A., Cowton, A., Jenni, A., Rauch, M., Häner, R., Graumann, J., Bütikofer, P. & Menon, A. K. Sci Rep. 11, 1411, (2021)

Inflammation: A Putative Link between Phosphate Metabolism and Cardiovascular Disease. Voelkl, J., Egli-Spichtig, D., Alesutan, I. & Wagner, C. A. Clin Sci (Lond). 135, 201-27, (2021)

Plasma Proteins Associated with Cardiovascular Death in Patients with Chronic Coronary Heart Disease: A Retrospective Study. Wallentin, L., Eriksson, N., Olszowka, M., Grammer, T. B., Hagström, E., Held, C., Kleber, M. E., Koenig, W., März, W., Stewart, R. A. H., White, H. D., Åberg, M. & Siegbahn, A. PLoS Med. 18, e1003513, (2021)

Prospective Longitudinal Serosurvey of Health Care Workers in the First Wave of the Sars-Cov-2 Pandemic in a Quaternary Care Hospital in Munich, Germany. Weinberger, T., Steffen, J., Osterman, A., Mueller, T. T., Muenchhoff, M., Wratil, P. R., Graf, A., Krebs, S., Quartucci, C., Spaeth, P. M., Grabein, B., Adorjan, K., Blum, H., Keppler, O. T. & Klein, M. Clin Infect Dis. (2021)

Early Aspirin Discontinuation after Coronary Stenting: A Systematic Review and Meta-Analysis. Wiebe, J., Ndrepepa, G., Kufner, S., Lahmann, A. L., Xhepa, E., Kuna, C., Voll, F., Gosetti, R., Laugwitz, K. L., Joner, M., Kastrati, A. & Cassese, S. J Am Heart Assoc. 10, e018304, (2021)

Myeloid Cells, Tissue Homeostasis, and Anatomical Barriers as Innate Immune Effectors in Arterial Hypertension. Wild, J. & Wenzel, P. J Mol Med (Berl). (2021)

Ythdf Is a N6-Methyladenosine Reader That Modulates Fmr1 Target Mrna Selection and Restricts Axonal Growth in Drosophila. Worpenberg, L., Paolantoni, C., Longhi, S., Mulorz, M. M., Lence, T., Wessels, H. H., Dassi, E., Aiello, G., Sutandy, F. X. R., Scheibe, M., Edupuganti, R. R., Busch, A., Möckel, M. M., Vermeulen, M., Butter, F., König, J., Notarangelo, M., Ohler, U., Dieterich, C., Quattrone, A., Soldano, A. & Roignant, J. Y. Embo j. e104975, (2021)

Detection of Aberrant Gene Expression Events in Rna Sequencing Data. Yépez, V. A., Mertes, C., Müller, M. F., Klaproth-Andrade, D., Wachutka, L., Frésard, L., Gusic, M., Scheller, I. F., Goldberg, P. F., Prokisch, H. & Gagneur, J. Nat Protoc. (2021)

Longitudinal Associations between Ambient Air Pollution and Insulin Sensitivity: Results from the Kora Cohort Study. Zhang, S., Mwiberi, S., Pickford, R., Breitner, S., Huth, C., Koenig, W., Rathmann, W., Herder, C., Roden, M., Cyrys, J., Peters, A., Wolf, K. & Schneider, A. Lancet Planet Health. 5, e39-e49, (2021)

Multiscale Strategy to Resolve Stroma-Cardiac Fibroblast Interactions. Zimmermann, W. H. Circ Res. 128, 39-41, (2021)

Evl Regulates Vegf Receptor-2 Internalization and Signaling in Developmental Angiogenesis. Zink, J., Frye, M., Frömel, T., Carlantoni, C., John, D., Schreier, D., Weigert, A., Laban, H., Salinas, G., Stingl, H., Günther, L., Popp, R., Hu, J., Vanhollebeke, B., Schmidt, H., Acker-Palmer, A., Renné, T., Fleming, I. & Benz, P. M. EMBO Rep. e48961, (2021) www.ncbi.nlm.nih.gov/pubmed/33512764

Predictors and Prognostic Implications of Cardiac Arrhythmias in Patients Hospitalized for Covid-19. Zylla, M. M., Merle, U., Vey, J. A., Korosoglou, G., Hofmann, E., Müller, M., Herth, F., Schmidt, W., Blessing, E., Göggelmann, C., Weidner, N., Fiedler, M. O., Weigand, M. A., Kälble, F., Morath, C., Leiner, J., Kieser, M., Katus, H. A. & Thomas, D. J Clin Med. 10, (2021)