Publications 2021

Here you will find publications of the DZHK in chronological order. First authors in grey are members of the Young DZHK. For more publications, please also check out the websites of the individual research institutions that participate in the DZHK.

DZHK Papers of the Month

September

The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner. Luck, R., Karakatsani, A., Shah, B., Schermann, G., Adler, H., Kupke, J., Tisch, N., Jeong, H. W., Back, M. K., Hetsch, F., D'Errico, A., De Palma, M., Wiedtke, E., Grimm, D., Acker-Palmer, A., von Engelhardt, J., Adams, R. H., Augustin, H. G. & Ruiz de Almodovar, C. Cell reports 36, 109522 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34407407  

Study design and rationale of the pAtients pResenTing with cOngenital heaRt dIseAse Register (ARTORIA-R). Sinning, C., Zengin, E., Diller, G. P., Onorati, F., Castel, M. A., Petit, T., Chen, Y. S., Lo Rito, M., Chiarello, C., Guillemain, R., Coniat, K. N., Magnussen, C., Knappe, D., Becher, P. M., Schrage, B., Smits, J. M., Metzner, A., Knosalla, C., Schoenrath, F., Miera, O., Cho, M. Y., Bernhardt, A., Weimann, J., Gossling, A., Terzi, A., Amodeo, A., Alfieri, S., Angeli, E., Ragni, L., Napoleone, C. P., Gerosa, G., Pradegan, N., Rodrigus, I., Dumfarth, J., de Pauw, M., Francois, K., Van Caenegem, O., Ancion, A., Van Cleemput, J., Milicic, D., Moza, A., Schenker, P., Thul, J., Steinmetz, M., Warnecke, G., Ius, F., Freyt, S., Avsar, M., Sandhaus, T., Haneya, A., Eifert, S., Saeed, D., Borger, M., Welp, H., Ablonczy, L., Schmack, B., Ruhparwar, A., Naito, S., Hua, X., Fluschnik, N., Nies, M., Keil, L., Senftinger, J., Ismaili, D., Kany, S., Csengeri, D., Cardillo, M., Oliveti, A., Faggian, G., Dorent, R., Jasseron, C., Blanco, A. P., Marquez, J. M. S., Lopez-Vilella, R., Garcia-Alvarez, A., Lopez, M. L. P., Rocafort, A. G., Fernandez, O. G., Prieto-Arevalo, R., Zatarain-Nicolas, E., Blanchart, K., Boignard, A., Battistella, P., Guendouz, S., Houyel, L., Para, M., Flecher, E., Gay, A., Epailly, E., Dambrin, C., Lam, K., Ka-Lai, C. H., Cho, Y. H., Choi, J. O., Kim, J. J., Coats, L., Crossland, D. S., Mumford, L., Hakmi, S., Sivathasan, C., Fabritz, L., Schubert, S., Gummert, J., Hubler, M., Jacksch, P., Zuckermann, A., Laufer, G., Baumgartner, H., Giamberti, A., Reichenspurner, H. & Kirchhof, P. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34510806  

Integrative analysis of epigenetics data identifies gene-specific regulatory elements. Schmidt, F., Marx, A., Baumgarten, N., Hebel, M., Wegner, M., Kaulich, M., Leisegang, M. S., Brandes, R. P., Goke, J., Vreeken, J. & Schulz, M. H. Nucleic acids research (2021). https://www.ncbi.nlm.nih.gov/pubmed/34508352  

miR-181c level predicts response to exercise training in patients with heart failure and preserved ejection fraction: an analysis of the OptimEx-Clin trial. Gevaert, A. B., Witvrouwen, I., Van Craenenbroeck, A. H., Van Laere, S. J., Boen, J. R. A., Van de Heyning, C. M., Belyavskiy, E., Mueller, S., Winzer, E., Duvinage, A., Edelmann, F., Beckers, P. J., Heidbuchel, H., Wisloff, U., Pieske, B., Adams, V., Halle, M., Van Craenenbroeck, E. M. & OptimEx-Clin Study, G. European journal of preventive cardiology (2021). www.ncbi.nlm.nih.gov/pubmed/34508569

Disturbed Glucose Metabolism and Left Ventricular Geometry in the General Population. Schmitt, V. H., Billaudelle, A. M., Schulz, A., Keller, K., Hahad, O., Trobs, S. O., Koeck, T., Michal, M., Schuster, A. K., Toenges, G., Lackner, K. J., Prochaska, J. H., Munzel, T. & Wild, P. S. Journal of clinical medicine 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34501302

Safety and efficacy of minimalist transcatheter aortic valve implantation using a new-generation balloon-expandable transcatheter heart valve in bicuspid and tricuspid aortic valves. Michel, J. M., Frangieh, A. H., Giacoppo, D., Alvarez-Covarrubias, H. A., Pellegrini, C., Rheude, T., Deutsch, O., Mayr, N. P., Rumpf, P. M., Stahli, B. E., Kastrati, A., Schunkert, H., Xhepa, E., Joner, M. & Kasel, A. M. Clinical research in cardiology : official journal of the German Cardiac Society (2021). https://www.ncbi.nlm.nih.gov/pubmed/34505192  

Key Chemokine Pathways in Atherosclerosis and Their Therapeutic Potential. Marquez, A. B., van der Vorst, E. P. C. & Maas, S. L. Journal of clinical medicine 10 (2021). www.ncbi.nlm.nih.gov/pubmed/34501271

Circadian rhythms in ischaemic heart disease. Key aspects for preclinical and translational research: Position paper of the ESC Working Group on Cellular Biology of the Heart. Lecour, S., Du Pre, B. C., Botker, H. E., Brundel, B., Daiber, A., Davidson, S. M., Ferdinandy, P., Girao, H., Gollmann-Tepekoylu, C., Gyongyosi, M., Hausenloy, D. J., Madonna, R., Marber, M., Perrino, C., Pesce, M., Schulz, R., Sluijter, J. P. G., Steffens, S., Van Linthout, S., Young, M. E. & Van Laake, L. W. Cardiovascular research (2021). https://www.ncbi.nlm.nih.gov/pubmed/34505881  

Secundum Type Atrial Septal Defect in Patients with Trisomy 21-Therapeutic Strategies, Outcome, and Survival: A Nationwide Study of the German National Registry for Congenital Heart Defects. Lammers, A. E., Stegger, J., Koerten, M. A., Helm, P. C., Bauer, U. M., Baumgartner, H. & Uebing, A. S. Journal of clinical medicine 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34501254

Head-to-Head Comparison of Different Software Solutions for AVC Quantification Using Contrast-Enhanced MDCT. Evertz, R., Hub, S., Backhaus, S. J., Lange, T., Toischer, K., Kowallick, J. T., Hasenfuss, G. & Schuster, A. Journal of clinical medicine 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34501418  

Glucosamine protects against neuronal but not vascular damage in experimental diabetic retinopathy. Eshwaran, R., Kolibabka, M., Poschet, G., Jainta, G., Zhao, D., Teuma, L., Murillo, K., Hammes, H. P., Schmidt, M., Wieland, T. & Feng, Y. Molecular metabolism, 101333 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34506973  

A challenging recanalization of long iliacal stent malposition. Bongiovanni, D., Sanz Sanchez, J., Reimers, B. & Pagnotta, P. J Cardiovasc Med (Hagerstown) (2021). https://www.ncbi.nlm.nih.gov/pubmed/34506347  

Treatment-Relevant Findings in Transesophageal Echocardiography After Stroke: A Prospective Multicenter Cohort Study. Thomalla, G., Upneja, M., Camen, S., Jensen, M., Schroder, J., Barow, E., Boskamp, S., Ostermeier, B., Kissling, S., Leinisch, E., Tiburtius, C., Clausen, H., Cheng, B., Blankenberg, S., Nedelmann, M., Steinbrecher, A., Andres, F., Rosenkranz, M., Sinning, C., Schnabel, R. B. & Gerloff, C. Stroke, STROKEAHA121034868 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34496617  

Serum Sphingosine-1-Phosphate Levels Are Associated With Severity and Outcome in Patients With Cerebral Ischemia. Schwedhelm, E., Schwieren, L., Tiedt, S., von Lucadou, M., Gloyer, N. O., Boger, R., Magnus, T., Daum, G., Thomalla, G., Gerloff, C. & Choe, C. U. Stroke, STROKEAHA120033414 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34496616  

Re-do MitraClip in patients with functional mitral valve regurgitation and advanced heart failure. Kreusser, M. M., Weber, A., Geis, N. A., Grossekettler, L., Volz, M. J., Hamed, S., Katus, H. A., Pleger, S. T., Frey, N. & Raake, P. W. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34498422  

Associations of circulating dimethylarginines with the metabolic syndrome in the Framingham Offspring study. Yola, I. M., Moser, C., Duncan, M. S., Schwedhelm, E., Atzler, D., Maas, R., Hannemann, J., Boger, R. H., Vasan, R. S. & Xanthakis, V. PloS one 16, e0254577 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34492019  

Association of Thyroid Dysfunction With Cognitive Function: An Individual Participant Data Analysis. van Vliet, N. A., van Heemst, D., Almeida, O. P., Asvold, B. O., Aubert, C. E., Bae, J. B., Barnes, L. E., Bauer, D. C., Blauw, G. J., Brayne, C., Cappola, A. R., Ceresini, G., Comijs, H. C., Dartigues, J. F., Degryse, J. M., Dullaart, R. P. F., van Eersel, M. E. A., den Elzen, W. P. J., Ferrucci, L., Fink, H. A., Flicker, L., Grabe, H. J., Han, J. W., Helmer, C., Huisman, M., Ikram, M. A., Imaizumi, M., de Jongh, R. T., Jukema, J. W., Kim, K. W., Kuller, L. H., Lopez, O. L., Mooijaart, S. P., Moon, J. H., Moutzouri, E., Nauck, M., Parle, J., Peeters, R. P., Samuels, M. H., Schmidt, C. O., Schminke, U., Slagboom, P. E., Stordal, E., Vaes, B., Volzke, H., Westendorp, R. G. J., Yamada, M., Yeap, B. B., Rodondi, N., Gussekloo, J., Trompet, S. & Thyroid Studies, C. JAMA Intern Med (2021). https://www.ncbi.nlm.nih.gov/pubmed/34491268  

Host-pathogen interactions of clinical S. aureus isolates to induce infective endocarditis. Schwarz, C., Tore, Y., Hoesker, V., Ameling, S., Grun, K., Volker, U., Schulze, P. C., Franz, M., Faber, C., Schaumburg, F., Niemann, S. & Hoerr, V. Virulence 12, 2073-2087 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34490828  

Substrate Stiffness Influences Structural and Functional Remodeling in Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Korner, A., Mosqueira, M., Hecker, M. & Ullrich, N. D. Frontiers in physiology 12, 710619 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34489730  

Histone deacetylase 4 deletion broadly affects cardiac epigenetic repression and regulates transcriptional susceptibility via H3K9 methylation. Finke, D., Schanze, L. M., Schreiter, F., Kreusser, M. M., Katus, H. A., Backs, J. & Lehmann, L. H. Journal of molecular and cellular cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34492228  

Timely Identification of Hospitalized Patients at Risk for COVID-19 Associated Right Heart Failure should be a Major Goal of Echocardiographic Surveillance. Dandel, M. J Am Soc Echocardiogr (2021). https://www.ncbi.nlm.nih.gov/pubmed/34492343  

Seasonal trends of incidence and outcomes of cardiogenic shock : findings from a large, nationwide inpatients sample with 441,696 cases. Becher, P. M., Schrage, B., Gossling, A., Fluschnik, N., Seiffert, M., Bernhardt, A. M., Reichenspurner, H., Kirchhof, P., Blankenberg, S., Westermann, D. & Collaboration Study, G. Crit Care 25, 325 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34488844   

Glutamate 73 Promotes Anti-arrhythmic Effects of Voltage-Dependent Anion Channel Through Regulation of Mitochondrial Ca(2+) Uptake. Shimizu, H., Huber, S., Langenbacher, A. D., Crisman, L., Huang, J., Wang, K., Wilting, F., Gudermann, T., Schredelseker, J. & Chen, J. N. Frontiers in physiology 12, 724828 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34483974  

Dataset for: Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC)-derived sensory neurons. Schinke, C., Fernandez Vallone, V., Ivanov, A., Peng, Y., Kortvelyessy, P., Nolte, L., Huehnchen, P., Beule, D., Stachelscheid, H., Boehmerle, W. & Endres, M. Data in brief 38, 107320 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34485650  

Fibroblast Derived Human Engineered Connective Tissue for Screening Applications. Santos, G. L., Meyer, T., Tiburcy, M., DeGrave, A., Zimmermann, W. H. & Lutz, S. Journal of visualized experiments : JoVE (2021). https://www.ncbi.nlm.nih.gov/pubmed/34487119  

Ventricular assist devices in paediatric cardiomyopathy and congenital heart disease: An analysis of the German National Register for Congenital Heart Defects. Lammers, A. E., Sprenger, K. S., Diller, G. P., Miera, O., Lebherz, C., Helm, P. C., Abdul-Khaliq, H., Asfour, B., Ewert, P., Bauer, U. M. M., Kehl, H. G., Humpl, T., Warnecke, G., Baumgartner, H., Berger, F., Tutarel, O. & German Competence Network for Congenital Heart Defects, I. International journal of cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34487787  

Arginine:Glycine Amidinotransferase Is Essential for Creatine Supply in Mice During Chronic Hypoxia. Hannemann, J., Cordts, K., Seniuk, A., Choe, C. U., Schmidt-Hutten, L., Duque Escobar, J., Weinberger, F., Boger, R. & Schwedhelm, E. Frontiers in physiology 12, 703069 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34483959  

Gender differences in characteristics and outcomes in heart failure patients referred for end-stage treatment. Fluschnik, N., Strangl, F., Kondziella, C., Gossling, A., Becher, P. M., Schrage, B., Schnabel, R. B., Bernadyn, J., Bremer, W., Grahn, H., Bernhardt, A. M., Reichenspurner, H., Rybczynski, M., Blankenberg, S., Kirchhof, P., Magnussen, C. & Knappe, D. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34486813  

Long-term clinical outcomes after drug eluting stent implantation with and without stent overlap. Coughlan, J. J., Aytekin, A., Koch, T., Wiebe, J., Lenz, T., Cassese, S., Joner, M., Koppara, T., Xhepa, E., Ibrahim, T., Fusaro, M., Laugwitz, K. L., Schunkert, H., Kastrati, A. & Kufner, S. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions (2021). https://www.ncbi.nlm.nih.gov/pubmed/34487415  

Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Collaborators, G. B. D. S. Lancet Neurol (2021). https://www.ncbi.nlm.nih.gov/pubmed/34487721  

Non-negative blind deconvolution for signal processing in a CRISPR-edited iPSC-cardiomyocyte model of dilated cardiomyopathy. Xu, H., Wali, R., Cheruiyot, C., Bodenschatz, J., Hasenfuss, G., Janshoff, A., Habeck, M. & Ebert, A. FEBS letters (2021). https://www.ncbi.nlm.nih.gov/pubmed/34482543  

Adipose tissue-heart crosstalk as a novel target for treatment of cardiometabolic diseases. Smeir, E., Kintscher, U. & Foryst-Ludwig, A. Current opinion in pharmacology 60, 249-254 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34482212  

Nascent Ribo-Seq measures ribosomal loading time and reveals kinetic impact on ribosome density. Schott, J., Reitter, S., Lindner, D., Grosser, J., Bruer, M., Shenoy, A., Geiger, T., Mathes, A., Dobreva, G. & Stoecklin, G. Nat Methods (2021). https://www.ncbi.nlm.nih.gov/pubmed/34480152  

Establishment of a second generation homozygous CRISPRa human induced pluripotent stem cell (hiPSC) line for enhanced levels of endogenous gene activation. Schoger, E., Zimmermann, W. H., Cyganek, L. & Zelarayan, L. C. Stem Cell Res 56, 102518 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34481190

The genomics of heart failure: design and rationale of the HERMES consortium. Lumbers, R. T., Shah, S., Lin, H., Czuba, T., Henry, A., Swerdlow, D. I., Malarstig, A., Andersson, C., Verweij, N., Holmes, M. V., Arnlov, J., Svensson, P., Hemingway, H., Sallah, N., Almgren, P., Aragam, K. G., Asselin, G., Backman, J. D., Biggs, M. L., Bloom, H. L., Boersma, E., Brandimarto, J., Brown, M. R., Brunner-La Rocca, H. P., Carey, D. J., Chaffin, M. D., Chasman, D. I., Chazara, O., Chen, X., Chen, X., Chung, J. H., Chutkow, W., Cleland, J. G. F., Cook, J. P., de Denus, S., Dehghan, A., Delgado, G. E., Denaxas, S., Doney, A. S., Dorr, M., Dudley, S. C., Engstrom, G., Esko, T., Fatemifar, G., Felix, S. B., Finan, C., Ford, I., Fougerousse, F., Fouodjio, R., Ghanbari, M., Ghasemi, S., Giedraitis, V., Giulianini, F., Gottdiener, J. S., Gross, S., Guethbjartsson, D. F., Gui, H., Gutmann, R., Haggerty, C. M., van der Harst, P., Hedman, A. K., Helgadottir, A., Hillege, H., Hyde, C. L., Jacob, J., Jukema, J. W., Kamanu, F., Kardys, I., Kavousi, M., Khaw, K. T., Kleber, M. E., Kober, L., Koekemoer, A., Kraus, B., Kuchenbaecker, K., Langenberg, C., Lind, L., Lindgren, C. M., London, B., Lotta, L. A., Lovering, R. C., Luan, J., Magnusson, P., Mahajan, A., Mann, D., Margulies, K. B., Marston, N. A., Marz, W., McMurray, J. J. V., Melander, O., Melloni, G., Mordi, I. R., Morley, M. P., Morris, A. D., Morris, A. P., Morrison, A. C., Nagle, M. W., Nelson, C. P., Newton-Cheh, C., Niessner, A., Niiranen, T., Nowak, C., O'Donoghue, M. L., Owens, A. T., Palmer, C. N. A., Pare, G., Perola, M., Perreault, L. L., Portilla-Fernandez, E., Psaty, B. M., Rice, K. M., Ridker, P. M., Romaine, S. P. R., Roselli, C., Rotter, J. I., Ruff, C. T., Sabatine, M. S., Salo, P., Salomaa, V., van Setten, J., Shalaby, A. A., Smelser, D. T., Smith, N. L., Stefansson, K., Stender, S., Stott, D. J., Sveinbjornsson, G., Tammesoo, M. L., Tardif, J. C., Taylor, K. D., Teder-Laving, M., Teumer, A., Thorgeirsson, G., Thorsteinsdottir, U., Torp-Pedersen, C., Trompet, S., Tuckwell, D., Tyl, B., Uitterlinden, A. G., Vaura, F., Veluchamy, A., Visscher, P. M., Volker, U., Voors, A. A., Wang, X., Wareham, N. J., Weeke, P. E., Weiss, R., White, H. D., Wiggins, K. L., Xing, H., Yang, J., Yang, Y., Yerges-Armstrong, L. M., Yu, B., Zannad, F., Zhao, F., Regeneron Genetics, C., Wilk, J. B., Holm, H., Sattar, N., Lubitz, S. A., Lanfear, D. E., Shah, S., Dunn, M. E., Wells, Q. S., Asselbergs, F. W., Hingorani, A. D., Dube, M. P., Samani, N. J., Lang, C. C., Cappola, T. P., Ellinor, P. T., Vasan, R. S. & Smith, J. G. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34480422  

Psoriasis and its impact on the clinical outcome of patients with pulmonary embolism. Keller, K., Hobohm, L., Ostad, M. A., Karbach, S., Espinola-Klein, C., Munzel, T., Gelfand, J. M., Konstantinides, S. V., Steinbrink, K. & Gori, T. International journal of cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34480990  

Influence of baseline parameters on one-year physical, mental, and health-related quality of life in patients with heart failure and preserved ejection fraction. Fitz, J., Edelmann, F., Hasenfuss, G., Sandek, A., Nolte, K., Hashemi, D., Trippel, T. D., Wachter, R. & Herrmann-Lingen, C. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34480783  

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Vosa, U., Claringbould, A., Westra, H. J., Bonder, M. J., Deelen, P., Zeng, B., Kirsten, H., Saha, A., Kreuzhuber, R., Yazar, S., Brugge, H., Oelen, R., de Vries, D. H., van der Wijst, M. G. P., Kasela, S., Pervjakova, N., Alves, I., Fave, M. J., Agbessi, M., Christiansen, M. W., Jansen, R., Seppala, I., Tong, L., Teumer, A., Schramm, K., Hemani, G., Verlouw, J., Yaghootkar, H., Sonmez Flitman, R., Brown, A., Kukushkina, V., Kalnapenkis, A., Rueger, S., Porcu, E., Kronberg, J., Kettunen, J., Lee, B., Zhang, F., Qi, T., Hernandez, J. A., Arindrarto, W., Beutner, F., Consortium, B., i, Q. T. L. C., Dmitrieva, J., Elansary, M., Fairfax, B. P., Georges, M., Heijmans, B. T., Hewitt, A. W., Kahonen, M., Kim, Y., Knight, J. C., Kovacs, P., Krohn, K., Li, S., Loeffler, M., Marigorta, U. M., Mei, H., Momozawa, Y., Muller-Nurasyid, M., Nauck, M., Nivard, M. G., Penninx, B., Pritchard, J. K., Raitakari, O. T., Rotzschke, O., Slagboom, E. P., Stehouwer, C. D. A., Stumvoll, M., Sullivan, P., t Hoen, P. A. C., Thiery, J., Tonjes, A., van Dongen, J., van Iterson, M., Veldink, J. H., Volker, U., Warmerdam, R., Wijmenga, C., Swertz, M., Andiappan, A., Montgomery, G. W., Ripatti, S., Perola, M., Kutalik, Z., Dermitzakis, E., Bergmann, S., Frayling, T., van Meurs, J., Prokisch, H., Ahsan, H., Pierce, B. L., Lehtimaki, T., Boomsma, D. I., Psaty, B. M., Gharib, S. A., Awadalla, P., Milani, L., Ouwehand, W. H., Downes, K., Stegle, O., Battle, A., Visscher, P. M., Yang, J., Scholz, M., Powell, J., Gibson, G., Esko, T. & Franke, L. Nature genetics 53, 1300-1310 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34475573  

Impact of implantation depth on outcomes of new-generation balloon-expandable transcatheter heart valves. Kim, W. K., Renker, M., Doerr, O., Hofmann, S., Nef, H., Choi, Y. H. & Hamm, C. W. Clinical research in cardiology : official journal of the German Cardiac Society (2021). https://www.ncbi.nlm.nih.gov/pubmed/34476559  

Myeloid cell-specific deletion of inducible nitric oxide synthase protects against smoke-induced pulmonary hypertension in mice. Gredic, M., Wu, C. Y., Hadzic, S., Pak, O., Savai, R., Kojonazarov, B., Doswada, S., Weiss, A., Weigert, A., Guenther, A., Brandes, R. P., Schermuly, R. T., Grimminger, F., Seeger, W., Sommer, N., Kraut, S. & Weissmann, N. The European respiratory journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/34475225  

Phenotyping Heart Failure Patients for Iron Deficiency and Use of Intravenous Iron Therapy: Data from the Swedish Heart Failure Registry. Becher, P. M., Schrage, B., Benson, L., Fudim, M., Corovic Cabrera, C., Dahlstrom, U., Rosano, G. M., Jankowska, E. A., Anker, S. D., Lund, L. H. & Savarese, G. European journal of heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34476878  

Persistent inflammatory residual risk despite aggressive cholesterol-lowering therapy: what is next? Arnold, N. & Koenig, W. Current opinion in cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34475328  

Anticoagulation, therapy of concomitant conditions, and early rhythm control therapy: a detailed analysis of treatment patterns in the EAST - AFNET 4 trial. Metzner, A., Suling, A., Brandes, A., Breithardt, G., Camm, A. J., Crijns, H., Eckardt, L., Elvan, A., Goette, A., Haegeli, L. M., Heidbuchel, H., Kautzner, J., Kuck, K. H., Mont, L., Ng, A. A., Szumowski, L., Themistoclakis, S., van Gelder, I. C., Vardas, P., Wegscheider, K., Willems, S. & Kirchhof, P. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34473249  

Coronary collateralization of a tumor located in the aorto-pulmonary window. Lanmueller, P., Heck, R., Leschber, G., Knosalla, C. & Hennig, F. The Annals of thoracic surgery (2021). https://www.ncbi.nlm.nih.gov/pubmed/34474020  

Inhibition of the NLRP3/IL-1beta axis protects against sepsis-induced cardiomyopathy. Busch, K., Kny, M., Huang, N., Klassert, T. E., Stock, M., Hahn, A., Graeger, S., Todiras, M., Schmidt, S., Chamling, B., Willenbrock, M., Gross, S., Biedenweg, D., Heuser, A., Scheidereit, C., Butter, C., Felix, S. B., Otto, O., Luft, F. C., Slevogt, H. & Fielitz, J. J Cachexia Sarcopenia Muscle (2021). https://www.ncbi.nlm.nih.gov/pubmed/34472725  

[Practical limitations of medical clarification and informed consent in the context of drug therapy]. Meyer, T. & Steuer, M. Med Klin Intensivmed Notfmed (2021). https://www.ncbi.nlm.nih.gov/pubmed/34468769  

Cardiac Hypertrophy Is Associated With Advanced Brain Aging in the General Population. Frenzel, S., Wittfeld, K., Bulow, R., Volzke, H., Friedrich, N., Habes, M., Felix, S. B., Dorr, M., Grabe, H. J. & Bahls, M. Journal of the American Heart Association 10, e020994 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34465186  

Twelve-month clinical outcomes in patients with acute coronary syndrome undergoing complex percutaneous coronary intervention: insights from the ISAR-REACT 5 trial. Coughlan, J. J., Aytekin, A., Ndrepepa, G., Schupke, S., Bernlochner, I., Mayer, K., Neumann, F. J., Menichelli, M., Richardt, G., Wohrle, J., Xhepa, E., Kufner, S., Sager, H. B., Joner, M., Ibrahim, T., Fusaro, M., Laugwitz, K. L., Schunkert, H., Kastrati, A. & Cassese, S. Eur Heart J Acute Cardiovasc Care (2021). https://www.ncbi.nlm.nih.gov/pubmed/34468709  

A backward-mode optical-resolution photoacoustic microscope for 3D imaging using a planar Fabry-Perot sensor. Baumann, E., Pohle, U., Zhang, E., Allen, T., Villringer, C., Pulwer, S., Gerhardt, H. & Laufer, J. Photoacoustics 24, 100293 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34466380   

[Left atrial appendage closure : Current data and future developments]. Skurk, C., Seppelt, C., Meteeva, D., Rheinthaler, M. & Landmesser, U. Herz (2021). https://www.ncbi.nlm.nih.gov/pubmed/34463787  

Identification of disease-relevant modulators of the SHH pathway in the developing brain. Mecklenburg, N., Kowalczyk, I., Witte, F., Gorne, J., Laier, A., Mamo, T. M., Gonschior, H., Lehmann, M., Richter, M., Sporbert, A., Purfurst, B., Hubner, N. & Hammes, A. Development 148 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34463328  

Target Populations and Treatment Cost for Bempedoic Acid and PCSK9 Inhibitors: A Simulation Study in a Contemporary CAD Cohort. Blaum, C., Brunner, F. J., Gossling, A., Kroger, F., Bay, B., Lorenz, T., Graef, A., Zeller, T., Schnabel, R., Clemmensen, P., Westermann, D., Blankenberg, S., Seiffert, M. & Waldeyer, C. Clin Ther (2021). https://www.ncbi.nlm.nih.gov/pubmed/34462126


August

Propensity score-based analysis of 30-day survival in cardiogenic shock patients supported with different microaxial left ventricular assist devices. Nersesian, G., Potapov, E. V., Nelki, V., Stein, J., Starck, C., Falk, V., Schoenrath, F., Krackhardt, F., Tschope, C. & Spillmann, F. J Card Surg (2021). https://www.ncbi.nlm.nih.gov/pubmed/34460968  

Nonsteroidal mineralocorticoid receptor antagonism for cardiovascular and renal disorders - New perspectives for combination therapy. Kolkhof, P., Joseph, A. & Kintscher, U. Pharmacol Res 172, 105859 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34461222  

Anti-inflammatory HDL effects are impaired in atrial fibrillation. Holzwirth, E., Fischer-Schaepmann, T., Obradovic, D., von Lucadou, M., Schwedhelm, E., Daum, G., Hindricks, G., Marsche, G., Trieb, M., Thiele, H., Kornej, J. & Buttner, P. Heart and vessels (2021). https://www.ncbi.nlm.nih.gov/pubmed/34459957  

Circulating Cellular Communication Network Factor 1 Protein as a Sensitive Liquid Biopsy Marker for Early Detection of Breast Cancer. Bartkowiak, K., Heidrich, I., Kwiatkowski, M., Banys-Paluchowski, M., Andreas, A., Wurlitzer, M., Geffken, M., Voss, H., Zeller, T., Blankenberg, S., Peine, S., Joosse, S. A., Muller, V., Schluter, H., Oliveira-Ferrer, L. & Pantel, K. Clinical chemistry (2021). https://www.ncbi.nlm.nih.gov/pubmed/34458901  

Rendezvous of CoreValve Skirt With Tendyne Crown. Puehler, T., Saad, M., Haneya, A., Frank, D. & Lutter, G. JACC. Cardiovascular interventions (2021). https://www.ncbi.nlm.nih.gov/pubmed/34454854  

Decreased proteasomal cleavage at nitrotyrosine sites in proteins and peptides. Ott, C., Tomasina, F., Campolo, N., Bartesaghi, S., Mastrogiovanni, M., Leyva, A., Batthyany, C., Meinl, W., Grune, T. & Radi, R. Redox biology 46, 102106 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34455147

Omega-3 fatty acid blood levels are inversely associated with cardiometabolic risk factors in HFpEF patients: the Aldo-DHF randomized controlled trial. Lechner, K., Scherr, J., Lorenz, E., Lechner, B., Haller, B., Krannich, A., Halle, M., Wachter, R., Duvinage, A. & Edelmann, F. Clinical research in cardiology : official journal of the German Cardiac Society (2021). https://www.ncbi.nlm.nih.gov/pubmed/34453204  

Atrial fibrillation before heart transplantation is a risk factor for post-transplant atrial fibrillation and mortality. Darche, F. F., Helmschrott, M., Rahm, A. K., Thomas, D., Schweizer, P. A., Bruckner, T., Ehlermann, P., Kreusser, M. M., Warnecke, G., Frey, N. & Rivinius, R. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34453484  

Adenine Nucleotide Translocase 1 Expression Modulates the Immune Response in Ischemic Hearts. Yergoz, F., Friebel, J., Krankel, N., Rauch-Kroehnert, U., Schultheiss, H. P., Landmesser, U. & Dorner, A. Cells 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34440901  

Systematic, early rhythm control strategy for atrial fibrillation in patients with or without symptoms: the EAST-AFNET 4 trial. Willems, S., Borof, K., Brandes, A., Breithardt, G., Camm, A. J., Crijns, H., Eckardt, L., Gessler, N., Goette, A., Haegeli, L. M., Heidbuchel, H., Kautzner, J., Ng, G. A., Schnabel, R. B., Suling, A., Szumowski, L., Themistoclakis, S., Vardas, P., van Gelder, I. C., Wegscheider, K. & Kirchhof, P. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/34447995  

PASCAL-based mitral valve repair in an all-comer population: acute and mid-term clinical results. Schlegel, P., Crespo Lopez, P., Kreusser, M. M., Katus, H. A., Frey, N., Geis, N. A. & Raake, P. W. J. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34448541   

A Novel Missense Mutation in TNNI3K Causes Recessively Inherited Cardiac Conduction Disease in a Consanguineous Pakistani Family. Ramzan, S., Tennstedt, S., Tariq, M., Khan, S., Noor Ul Ayan, H., Ali, A., Munz, M., Thiele, H., Korejo, A. A., Mughal, A. R., Jamal, S. Z., Nurnberg, P., Baig, S. M., Erdmann, J. & Ahmad, I. Genes (Basel) 12 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34440456  

Complete Atrioventricular Septal Defects after the Age of 40 Years. Maurer, S. J., Moosholzer, L., Pujol, C., Nagdyman, N., Ewert, P. & Tutarel, O. Journal of clinical medicine 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34441962  

Empagliflozin in Heart Failure with a Preserved Ejection Fraction. Anker, S. D., Butler, J., Filippatos, G., Ferreira, J. P., Bocchi, E., Bohm, M., Brunner-La Rocca, H. P., Choi, D. J., Chopra, V., Chuquiure-Valenzuela, E., Giannetti, N., Gomez-Mesa, J. E., Janssens, S., Januzzi, J. L., Gonzalez-Juanatey, J. R., Merkely, B., Nicholls, S. J., Perrone, S. V., Pina, I. L., Ponikowski, P., Senni, M., Sim, D., Spinar, J., Squire, I., Taddei, S., Tsutsui, H., Verma, S., Vinereanu, D., Zhang, J., Carson, P., Lam, C. S. P., Marx, N., Zeller, C., Sattar, N., Jamal, W., Schnaidt, S., Schnee, J. M., Brueckmann, M., Pocock, S. J., Zannad, F., Packer, M. & Investigators, E. M.-P. T. The New England journal of medicine (2021). https://www.ncbi.nlm.nih.gov/pubmed/34449189   

Reduced nitric oxide bioavailability impairs myocardial oxygen balance during exercise in swine with multiple risk factors. van de Wouw, J., Sorop, O., van Drie, R. W. A., Joles, J. A., Danser, A. H. J., Verhaar, M. C., Merkus, D. & Duncker, D. J. Basic research in cardiology 116, 50 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34435256  

Effects of single bouts of different endurance exercises with different intensities on microRNA biomarkers with and without blood flow restriction: a three-arm, randomized crossover trial. Sieland, J., Niederer, D., Engeroff, T., Vogt, L., Troidl, C., Schmitz-Rixen, T., Banzer, W. & Troidl, K. Eur J Appl Physiol (2021). https://www.ncbi.nlm.nih.gov/pubmed/34435273  

Pulmonary valve prostheses: patient's lifetime procedure load and durability. Evaluation of the German National Register for Congenital Heart Defects. Boethig, D., Avsar, M., Bauer, U. M. M., Sarikouch, S., Beerbaum, P., Berger, F., Cesnjevar, R., Dahnert, I., Dittrich, S., Ewert, P., Haverich, A., Horer, J., Kostelka, M., Photiadis, J., Sandica, E., Schubert, S., Urban, A., Bobylev, D., Horke, A. & National Register For Congenital Heart Defects, I. Interactive cardiovascular and thoracic surgery (2021). https://www.ncbi.nlm.nih.gov/pubmed/34436589  

Initial Experience With the PASCAL Ace Implant System for Treatment of Severe Tricuspid Regurgitation. Aurich, M., Volz, M. J., Mereles, D., Geis, N. A., Frey, N., Konstandin, M. H. & Raake, P. W. Circulation. Cardiovascular interventions, CIRCINTERVENTIONS121010770 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34433291  

TNF-alpha blockade may lead to improvement of vascular function in psoriasis patients. Wegner, J., Karbach, S., Drosos, I., Schnorbus, B., Muxel, S., Schmidt, F., Wenzel, P., Waisman, A., Munzel, T., Gori, T. & von Stebut, E. Exp Dermatol (2021). https://www.ncbi.nlm.nih.gov/pubmed/34432926  

Mortality risk among 5-year survivors of childhood cancer in Germany-Results from the CVSS study (Cardiac and Vascular late Sequelae in long-term Survivors of childhood cancer study). Merzenich, H., Baaken, D., Schneider, A., Neu, M. A., Wingerter, A., Faber, J., Wild, P. S. & Spix, C. Int J Cancer (2021). https://www.ncbi.nlm.nih.gov/pubmed/34431525  

Interleukin 6 and Cardiovascular Outcomes in Patients With Chronic Kidney Disease and Chronic Coronary Syndrome. Batra, G., Ghukasyan Lakic, T., Lindback, J., Held, C., White, H. D., Stewart, R. A. H., Koenig, W., Cannon, C. P., Budaj, A., Hagstrom, E., Siegbahn, A., Wallentin, L. & Investigators, S. JAMA cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34431970  

Pushing the limits for interventional treatment of aortic valve stenosis. Xhepa, E., Alvarez-Covarrubias, H. A. & Joner, M. Herz (2021). https://www.ncbi.nlm.nih.gov/pubmed/34427692  

(Intermediate) size matters. Kim, W. K. & Choi, Y. H. International journal of cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34428531  

Short regulatory DNA sequences to target brain endothelial cells for gene therapy. Grasshoff, H., Muller-Fielitz, H., Dogbevia, G. K., Korbelin, J., Bannach, J., Vahldieck, C. M., Kusche-Vihrog, K., Johren, O., Muller, O. J., Nogueiras, R., Prevot, V. & Schwaninger, M. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 271678X211039617 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34427142  

Benefits of Transvenous Mitral Annuloplasty in Heart Failure with Lower Degrees of Functional Mitral Regurgitation. Letter regarding the article ' Treating symptoms and reversing remodeling: clinical and echocardiographic 1-year outcomes with percutaneous mitral annuloplasty for mild to moderate secondary mitral regurgitation '. Dandel, M. & Hetzer, R. European journal of heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34427022  

Cardiac Magnetic Resonance Reveals Incipient Cardiomyopathy Traits in Adult Patients With Phenylketonuria. Tanacli, R., Hassel, J. H., Gebker, R., Berger, A., Grafe, M., Schneeweis, C., Doeblin, P., Fleck, E., Stehning, C., Tacke, F., Pieske, B., Spranger, J., Plockinger, U., Ziagaki, A. & Kelle, S. Journal of the American Heart Association 10, e020351 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34423658  

Novel biomarker-driven prognostic models to predict morbidity and mortality in chronic heart failure: the EMPEROR-Reduced trial. Pocock, S. J., Ferreira, J. P., Gregson, J., Anker, S. D., Butler, J., Filippatos, G., Gollop, N. D., Iwata, T., Brueckmann, M., Januzzi, J. L., Voors, A. A., Zannad, F. & Packer, M. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/34423361  

Five-year cumulative incidence and progression of age-related macular degeneration: results from the German population-based Gutenberg Health Study (GHS). Korb, C. A., Elbaz, H., Schuster, A. K., Nickels, S., Ponto, K. A., Schulz, A., Wild, P. S., Munzel, T., Beutel, M. E., Schmidtmann, I., Lackner, K. J., Peto, T. & Pfeiffer, N. Graefes Arch Clin Exp Ophthalmol (2021). https://www.ncbi.nlm.nih.gov/pubmed/34424371  

Coronary venous therapy to improve microvascular dysfunction. Gori, T. Clinical hemorheology and microcirculation (2021). www.ncbi.nlm.nih.gov/pubmed/34420944

Identification of a Functional PDE5A Variant at the Chromosome 4q27 Coronary Artery Disease Locus in an Extended Myocardial Infarction Family. Dang, T. A., Kessler, T., Wobst, J., Wierer, M., Braenne, I., Strom, T. M., Tennstedt, S., Sager, H. B., Meitinger, T., Erdmann, J. & Schunkert, H. Circulation 144, 662-665 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34424768  

Optical coherence tomography tissue coverage and characterization at six months after implantation of bioresorbable scaffolds versus conventional everolimus eluting stents in the ISAR-Absorb MI trial. Rai, H., Alfonso, F., Maeng, M., Bradaric, C., Wiebe, J., Cuesta, J., Christiansen, E. H., Cassese, S., Hoppmann, P., Colleran, R., Harzer, F., Bresha, J., Nano, N., Schneider, S., Laugwitz, K. L., Joner, M., Kastrati, A. & Byrne, R. A. The international journal of cardiovascular imaging (2021). https://www.ncbi.nlm.nih.gov/pubmed/34420177  

Mitral Regurgitation Following Acute Myocardial Infarction Treated by Percutaneous Coronary Intervention-Prevalence, Risk factors, and Predictors of Outcome. Sharma, H., Radhakrishnan, A., Nightingale, P., Brown, S., May, J., O'Connor, K., Shakeel, I., Zia, N., Doshi, S. N., Townend, J. N., Myerson, S. G., Kirchhof, P., Ludman, P. F., Adnan Nadir, M. & Steeds, R. P. The American journal of cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34417016  

Heart failure with preserved ejection fraction in humans and mice: embracing clinical complexity in mouse models. Withaar, C., Lam, C. S. P., Schiattarella, G. G., de Boer, R. A. & Meems, L. M. G. European heart journal (2021). www.ncbi.nlm.nih.gov/pubmed/34414416

Forced expiratory volume in one second predicts cardiac status and outcome in chronic heart failure. Heidorn, M. W., Steck, S., Muller, F., Trobs, S. O., Buch, G., Schulz, A., Schwuchow-Thonke, S., Schuch, A., Strauch, K., Schmidtmann, I., Lackner, K. J., Gori, T., Munzel, T., Wild, P. S. & Prochaska, J. H. Chest (2021). https://www.ncbi.nlm.nih.gov/pubmed/34416218  

Post-translational modifications talk and crosstalk to class IIa histone deacetylases. Guttzeit, S. & Backs, J. Journal of molecular and cellular cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34416247  

Association of sex-specific differences in lipoprotein(a) concentrations with cardiovascular mortality in individuals with type 2 diabetes mellitus. Markus, M. R. P., Ittermann, T., Schipf, S., Bahls, M., Nauck, M., Volzke, H., Santos, R. D., Peters, A., Zeller, T., Felix, S. B., Vasan, R. S., Thorand, B., Steinhagen-Thiessen, E. & Dorr, M. Cardiovascular diabetology 20, 168 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34407812  

Neurological symptoms and complications in predominantly hospitalized COVID-19 patients: Results of the European multinational Lean European Open Survey on SARS-Infected Patients (LEOSS). Kleineberg, N. N., Knauss, S., Gulke, E., Pinnschmidt, H. O., Jakob, C. E. M., Lingor, P., Hellwig, K., Berthele, A., Hoglinger, G., Fink, G. R., Endres, M., Gerloff, C., Klein, C., Stecher, M., Classen, A. Y., Rieg, S., Borgmann, S., Hanses, F., Ruthrich, M. M., Hower, M., Tometten, L., Haselberger, M., Piepel, C., Merle, U., Dolff, S., Degenhardt, C., Jensen, B. O., Vehreschild, M., Erber, J., Franke, C., Warnke, C. & Group, L. S. European journal of neurology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34411383  

COVID19-associated cardiomyocyte dysfunction, arrhythmias and the effect of Canakinumab. Dimai, S., Semmler, L., Prabhu, A., Stachelscheid, H., Huettemeister, J., Klaucke, S. C., Lacour, P., Blaschke, F., Kruse, J., Parwani, A., Boldt, L. H., Bullinger, L., Pieske, B. M., Heinzel, F. R. & Hohendanner, F. PloS one 16, e0255976 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34411149  

Long-term experience using CNI-free immunosuppression in selected paediatric heart transplant recipients. Rosenthal, L. M., Nordmeyer, J., Kramer, P., Danne, F., Pfitzer, C., Berger, F., Schmitt, K. R. L. & Schubert, S. Pediatric transplantation, e14111 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34405495

Minimally invasive surgery versus sternotomy in native mitral valve endocarditis: a matched comparison. Kofler, M., Van Praet, K. M., Schambach, J., Akansel, S., Sundermann, S., Schonrath, F., Jacobs, S., Falk, V. & Kempfert, J. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021). https://www.ncbi.nlm.nih.gov/pubmed/34406371  

Catheter ablation vs. antiarrhythmic drugs as 'first-line' initial therapy for atrial fibrillation: a pooled analysis of randomized data. Chen, S., Purerfellner, H., Ouyang, F., Kiuchi, M. G., Meyer, C., Martinek, M., Futyma, P., Zhu, L., Schratter, A., Wang, J., Acou, W. J., Ling, Z., Yin, Y., Liu, S., Sommer, P., Schmidt, B. & Chun, J. K. R. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34405878  

Guidance on the management of left ventricular assist device (LVAD) supported patients for the non-LVAD specialist healthcare provider: executive summary. Ben Gal, T., Ben Avraham, B., Milicic, D., Crespo-Leiro, M. G., Coats, A. J. S., Rosano, G., Seferovic, P., Ruschitzka, F., Metra, M., Anker, S., Filippatos, G., Altenberger, J., Adamopoulos, S., Barak, Y., Chioncel, O., de Jonge, N., Elliston, J., Frigerio, M., Goncalvesova, E., Gotsman, I., Grupper, A., Hamdan, R., Hammer, Y., Hasin, T., Hill, L., Itzhaki Ben Zadok, O., Abuhazira, M., Lavee, J., Mullens, W., Nalbantgil, S., Piepoli, M. F., Ponikowski, P., Potena, L., Ristic, A., Ruhparwar, A., Shaul, A., Tops, L. F., Tsui, S., Winnik, S., Jaarsma, T. & Gustafsson, F. European journal of heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34409711  

Alamandine but not angiotensin-(1-7) produces cardiovascular effects at the rostral insular cortex. Marins, F. R., Oliveira, A. C., Qadri, F., Motta-Santos, D., Alenina, N., Bader, M., Fontes, M. A. P. & Santos, R. A. S. Am J Physiol Regul Integr Comp Physiol 321, R513-R521 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34346721  

Decreased Serum Brain-Derived Neurotrophic Factor Concentrations 72 Hours Following Marathon Running. Roeh, A., Holdenrieder, S., Schoenfeld, J., Haeckert, J., Halle, M., Falkai, P., Scherr, J. & Hasan, A. Frontiers in physiology 12, 668454 (2021).

 

Temporal trends and predictors of inhospital death in patients hospitalised for heart failure in Germany. Keller, K., Hobohm, L., Ostad, M. A., Gobel, S., Lankeit, M., Konstantinides, S., Munzel, T. & Wenzel, P. European journal of preventive cardiology 28, 990-997 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34402877  

Rationale, design and baseline characteristics of the MyoVasc study: A prospective cohort study investigating development and progression of heart failure. Gobel, S., Prochaska, J. H., Trobs, S. O., Panova-Noeva, M., Espinola-Klein, C., Michal, M., Lackner, K. J., Gori, T., Munzel, T. & Wild, P. S. European journal of preventive cardiology 28, 1009-1018 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34402876

Techniques for Robotic-Assisted Surgical Myocardial Revascularization. Amabile, A., Komlo, C., Van Praet, K. M., Nazari-Shafti, T. Z., Torregrossa, G., Kofler, M., Kempfert, J., Geirsson, A., Falk, V., Jacobs, S. & Balkhy, H. H. Surgical technology international 39 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34403487  

Breaking the silence on bias: the expectations of being a physician. Sinning, C. & Arzanauskaite, M. European heart journal. Case reports 5, ytab256 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34396035

The site of waist measurement impacts the estimation of visceral fat: Results from three-dimensional photonic body scanning. Repp, K. D., Radke, D., Ittermann, T., Albers, M., Markus, M. R. P., de Santa Helena, E. T., Friedrich, N., Bulow, R. & Volzke, H. Br J Nutr, 1-32 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34392851  

Current devices and interventions in mitral regurgitation. Koell, B., Kalbacher, D. & Lubos, E. Herz (2021). https://www.ncbi.nlm.nih.gov/pubmed/34398248  

High-sensitivity cardiac troponin T determines all-cause mortality in cancer patients: a single-centre cohort study. Finke, D., Romann, S. W., Heckmann, M. B., Hund, H., Bougatf, N., Kantharajah, A., Katus, H. A., Muller, O. J., Frey, N., Giannitsis, E. & Lehmann, L. H. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34396713  

The endothelial niche in heart failure: from development to regeneration. Wagner, J. U. G. & Dimmeler, S. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/34392349  

A universal peptide matrix interactomics approach to disclose motif dependent protein binding. Ramberger, E., Suarez-Artiles, L., Perez-Hernandez, D., Haji, M., Popp, O., Reimer, U., Leutz, A., Dittmar, G. & Mertins, P. Molecular & cellular proteomics : MCP, 100135 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34391889   

Doxorubicin induces wide-spread transcriptional changes in the myocardium of hearts distinguishing between mice with preserved and impaired cardiac function. Stamm, P., Kirmes, I., Palmer, A., Molitor, M., Kvandova, M., Kalinovic, S., Mihalikova, D., Reid, G., Wenzel, P., Munzel, T., Daiber, A. & Jansen, T. Life sciences, 119879 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34390723  

Cardiovascular Effects of Non-Insulin Glucose-Lowering Agents: A Comprehensive Review of Trial Evidence and Potential Cardioprotective Mechanisms. Savarese, G., Butler, J., Lund, L. H., Bhatt, D. L. & Anker, S. D. Cardiovascular research (2021). https://www.ncbi.nlm.nih.gov/pubmed/34390570  

The anti-parallel dimer binding interface in STAT3 transcription factor is required for the inactivation of cytokine-mediated signal transduction. Menon, P. R., Doudin, A., Gregus, A., Wirths, O., Staab, J. & Meyer, T. Biochimica et biophysica acta. Molecular cell research, 119118 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34390807  

Transcatheter aortic valve implantation in patients with a small aortic annulus: performance of supra-, intra- and infra-annular transcatheter heart valves. Voigtlander, L., Kim, W. K., Mauri, V., Gossling, A., Renker, M., Sugiura, A., Linder, M., Schmidt, T., Schofer, N., Westermann, D., Reichenspurner, H., Nickenig, G., Blankenberg, S., Hamm, C., Conradi, L., Adam, M., Sinning, J. M. & Seiffert, M. Clinical research in cardiology : official journal of the German Cardiac Society (2021). https://www.ncbi.nlm.nih.gov/pubmed/34387736  

KATP channels and NO dilate redundantly intramuscular arterioles during electrical stimulation of the skeletal muscle in mice. Schemke, S. & de Wit, C. Pflugers Archiv : European journal of physiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34386847  

Chronic venous insufficiency, cardiovascular disease, and mortality: a population study. Prochaska, J. H., Arnold, N., Falcke, A., Kopp, S., Schulz, A., Buch, G., Moll, S., Panova-Noeva, M., Junger, C., Eggebrecht, L., Pfeiffer, N., Beutel, M., Binder, H., Grabbe, S., Lackner, K. J., Ten Cate-Hoek, A., Espinola-Klein, C., Munzel, T. & Wild, P. S. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/34387673  

Platelet Surface Protein Expression and Reactivity upon TRAP Stimulation after BNT162b2 Vaccination. Klug, M., Lazareva, O., Kirmes, K., Rosenbaum, M., Lukas, M., Weidlich, S., Spinner, C. D., von Scheidt, M., Gosetti, R., Baumbach, J., Ruland, J., Condorelli, G., Laugwitz, K. L., List, M., Bernlochner, I. & Bongiovanni, D. Thrombosis and haemostasis (2021). https://www.ncbi.nlm.nih.gov/pubmed/34388849  

[Noise annoyance in the German general population : Prevalence and determinants in the Gutenberg Health Study]. Hahad, O., Beutel, M., Michal, M., Schulz, A., Pfeiffer, N., Gianicolo, E., Lackner, K., Wild, P., Daiber, A. & Munzel, T. Herz (2021). https://www.ncbi.nlm.nih.gov/pubmed/34387703  

Multispectral optoacoustic tomography of lipid and hemoglobin contrast in human carotid atherosclerosis. Karlas, A., Kallmayer, M., Bariotakis, M., Fasoula, N. A., Liapis, E., Hyafil, F., Pelisek, J., Wildgruber, M., Eckstein, H. H. & Ntziachristos, V. Photoacoustics 23, 100283 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34381689  

In-depth profiling of COVID-19 risk factors and preventive measures in healthcare workers. Wratil, P. R., Schmacke, N. A., Osterman, A., Weinberger, T., Rech, J., Karakoc, B., Zeilberger, M., Steffen, J., Mueller, T. T., Spaeth, P. M., Stern, M., Albanese, M., Thun, H., Reinbold, J., Sandmeyer, B., Kressirer, P., Grabein, B., Falkai, P., Adorjan, K., Hornung, V. et al. Infection, 1-14 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34379308  

Exercise Hemodynamic Profiling Is Associated With Outcome in Patients Undergoing Percutaneous Mitral Valve Repair. Rieth, A. J., Kriechbaum, S. D., Richter, M. J., Wenninger, E., Fischer-Rasokat, U., Tello, K., Gall, H., Ghofrani, H. A., Guth, S., Wiedenroth, C. B., Mitrovic, V., Hamm, C. W., Liebetrau, C. & Walther, C. Circulation. Cardiovascular interventions, CIRCINTERVENTIONS120010453 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34376055   

Distribution of HOMA-IR in a population-based cohort and proposal for reference intervals. Matli, B., Schulz, A., Koeck, T., Falter, T., Lotz, J., Rossmann, H., Pfeiffer, N., Beutel, M., Munzel, T., Strauch, K., Wild, P. S. & Lackner, K. J. Clin Chem Lab Med (2021). https://www.ncbi.nlm.nih.gov/pubmed/34380182  

Is It in the EPIgenome?: Epigenetics Marks at Birth Are Associated With Arterial Stiffness in Children. Brandes, R. P. & Gilsbach, R. Hypertension 78, 801-803 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34379434  

Proteomic mechanistic profile of patients with diabetes at risk of developing heart failure: insights from the HOMAGE trial. Verdonschot, J. A. J., Ferreira, J. P., Pellicori, P., Brunner-La Rocca, H. P., Clark, A. L., Cosmi, F., Cuthbert, J., Girerd, N., Mariottoni, B., Petutschnigg, J., Rossignol, P., Cleland, J. G. F., Zannad, F., Heymans, S. R. B. & consortium, H. H. O. i. A. Cardiovascular diabetology 20, 163 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34372849   

Right/Left Ventricular Blood Pool T2 Ratio as an Innovative Cardiac MRI Screening Tool for the Identification of Left-to-Right Shunts in Patients With Right Ventricular Disease. Emrich, T., Bordonaro, V., Schoepf, U. J., Petrescu, A., Young, G., Halfmann, M., Schoeler, T., Decker, J., Abidoye, I., Emrich, A. L., Kreitner, K. F., Schmidt, K. H., Varga-Szemes, A. & Secinaro, A. J Magn Reson Imaging (2021). https://www.ncbi.nlm.nih.gov/pubmed/34374157  

Canagliflozin and myocardial oxidative stress: SGLT1 inhibition takes centre stage. Schiattarella, G. G. & Bode, D. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/34370850

Empagliflozin in Heart Failure With Predicted Preserved Versus Reduced Ejection Fraction: Data From the EMPA-REG OUTCOME Trial. Savarese, G., Uijl, A., Lund, L. H., Anker, S. D., Asselbergs, F., Fitchett, D., Inzucchi, S. E., Koudstaal, S., Ofstad, A. P., Schrage, B., Vedin, O., Wanner, C., Zannad, F., Zwiener, I. & Butler, J. Journal of cardiac failure 27, 888-895 (2021). https://pubmed.ncbi.nlm.nih.gov/34364665/ 

Heteromeric TRP Channels in Lung Inflammation. Zergane, M., Kuebler, W. M. & Michalick, L. Cells 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34359824  

Neutrophil Extracellular Traps Affecting Cardiovascular Health in Infectious and Inflammatory Diseases. Thakur, M., Evans, B., Schindewolf, M., Baumgartner, I. & Doring, Y. Cells 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34359859  

Five-year change in refractive error and its risk factors: results from the Gutenberg Health Study. Stingl, J. V., Ban, S. A., Nagler, M., Schmidtmann, I., Wild, P. S., Lackner, K. J., Munzel, T., Beutel, M. E., Pfeiffer, N. & Schuster, A. K. Br J Ophthalmol (2021). https://www.ncbi.nlm.nih.gov/pubmed/34362774  

Calculated Plasma Volume Status Is Associated with Adverse Outcomes in Patients Undergoing Transcatheter Aortic Valve Implantation. Seoudy, H., Saad, M., Salem, M., Allouch, K., Frank, J., Puehler, T., Salem, M., Lutter, G., Kuhn, C. & Frank, D. Journal of clinical medicine 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34362114   

Estimation of anaerobic threshold by cardiac repolarization instability: a prospective validation study. Schuttler, D., Krammer, S., von Stulpnagel, L., Sams, L., Bauer, A., Hamm, W. & Brunner, S. BMC Sports Sci Med Rehabil 13, 85 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34362449  

LncRNA AERRIE Is Required for Sulfatase 1 Expression, but Not for Endothelial-to-Mesenchymal Transition. Pham, T. P., van Bergen, A. S., Kremer, V., Glaser, S. F., Dimmeler, S. & Boon, R. A. International journal of molecular sciences 22 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34360851  

RhoA Signaling in Immune Cell Response and Cardiac Disease. Kilian, L. S., Frank, D. & Rangrez, A. Y. Cells 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34359851  

PCSK9: A Multi-Faceted Protein That Is Involved in Cardiovascular Biology. Sundararaman, S. S., Doring, Y. & van der Vorst, E. P. C. Biomedicines 9 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34356856  

Inflammation in Metabolic and Cardiovascular Disorders-Role of Oxidative Stress. Sun, Y., Rawish, E., Nording, H. M. & Langer, H. F. Life (Basel) 11 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34357044  

Nox4 Maintains Blood Pressure during Low Sodium Diet. Rezende, F., Malacarne, P. F., Muller, N., Rathkolb, B., Hrabe de Angelis, M., Schroder, K. & R, P. B. Antioxidants 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34356336  

Markers of Myocardial Damage Predict Mortality in Patients With Aortic Stenosis. Kwak, S., Everett, R. J., Treibel, T. A., Yang, S., Hwang, D., Ko, T., Williams, M. C., Bing, R., Singh, T., Joshi, S., Lee, H., Lee, W., Kim, Y. J., Chin, C. W. L., Fukui, M., Al Musa, T., Rigolli, M., Singh, A., Tastet, L., Dobson, L. E. et al. Journal of the American College of Cardiology 78, 545-558 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34353531  

Genetics, atrial cardiomyopathy, and stroke: enough components for a sufficient cause? Camen, S. & Schnabel, R. B. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/34355772   

The Interplay between S-Glutathionylation and Phosphorylation of Cardiac Troponin I and Myosin Binding Protein C in End-Stage Human Failing Hearts. Budde, H., Hassoun, R., Tangos, M., Zhazykbayeva, S., Herwig, M., Varatnitskaya, M., Sieme, M., Delalat, S., Sultana, I., Kolijn, D., Gomori, K., Jarkas, M., Lodi, M., Jaquet, K., Kovacs, A., Mannherz, H. G., Sequeira, V., Mugge, A., Leichert, L. I., Sossalla, S. et al. Antioxidants 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34356367  

Safety and efficacy of currently utilized treatment modalities in the management of patients with PIK3CA-related overgrowth syndrome - a systematic review. Bernhard, S. M., Adam, L., Atef, H., Haberli, D., Bramer, W. M., Minder, B., Doring, Y., Laine, J. E., Muka, T., Rossler, J. & Baumgartner, I. J Vasc Surg Venous Lymphat Disord (2021). https://www.ncbi.nlm.nih.gov/pubmed/34358672  

Serum neurofilament is associated with motor function, cognitive decline and subclinical cardiac damage in advanced Parkinson's disease (MARK-PD). Niemann, L., Lezius, S., Maceski, A., Leppert, D., Englisch, C., Schwedhelm, E., Zeller, T., Gerloff, C., Kuhle, J. & Choe, C. U. Parkinsonism Relat Disord 90, 44-48 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34352610  

Longitudinal measurement invariance of the patient health questionnaire in a German sample. Moehring, A., Guertler, D., Krause, K., Bischof, G., Rumpf, H. J., Batra, A., Wurm, S., John, U. & Meyer, C. BMC Psychiatry 21, 386 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34348669  

The association of anaemia and high-sensitivity cardiac troponin and its effect on diagnosing myocardial infarction. Haller, P. M., Neumann, J. T., Sorensen, N. A., Hartikainen, T. S., Gossling, A., Lehmacher, J., Keller, T., Zeller, T., Blankenberg, S. & Westermann, D. Eur Heart J Acute Cardiovasc Care (2021). https://www.ncbi.nlm.nih.gov/pubmed/34350455  

Domains of Physical Activity in Relation to Stiffness Index in the General Population. Arnold, N., Deiseroth, A., Hahad, O., Diestelmeier, S., Schulz, A., Daubenbuchel, A., Gori, T., Binder, H., Pfeiffer, N., Prochaska, J., Beutel, M., Lackner, K. J., Munzel, T. & Wild, P. S. Journal of the American Heart Association, e020930 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34348471  

Organs-on-chip models for cardiovascular drug development. Zimmermann, W. H. Cardiovascular research (2021). https://www.ncbi.nlm.nih.gov/pubmed/34347045  

Correction to: Prevention of coronary obstruction in patients at risk undergoing transcatheter aortic valve implantation: the Hamburg BASILICA experience. Westermann, D., Ludwig, S., Kalbacher, D., Spink, C., Linder, M., Bhadra, O. D., Nikorowitsch, J., Waldschmidt, L., Demal, T., Voigtlander, L., Schaefer, A., Seiffert, M., Pecha, S., Schofer, N., Greenbaum, A. B., Reichenspurner, H., Blankenberg, S., Conradi, L. & Schirmer, J. Clinical research in cardiology : official journal of the German Cardiac Society (2021). https://www.ncbi.nlm.nih.gov/pubmed/34347163  

Alamandine but not angiotensin-(1-7) produces cardiovascular effects at the rostral insular cortex. Marins, F. R., Oliveira, A. C., Qadri, F., Motta-Santos, D., Alenina, N., Bader, M., Fontes, M. A. P. & Souza Santos, R. Am J Physiol Regul Integr Comp Physiol (2021). https://www.ncbi.nlm.nih.gov/pubmed/34346721  

Establishment of two homozygous CRISPR interference (CRISPRi) knock-in human induced pluripotent stem cell (hiPSC) lines for titratable endogenous gene repression. Schoger, E., Zimmermann, W. H., Cyganek, L. & Zelarayan, L. C. Stem Cell Res 55, 102473 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34343828  

[Update Atrial Fibrillation - Current Management strategies]. Schaffer, B., Gunawardene, M. A. & Willems, S. Deutsche medizinische Wochenschrift 146, 982-987 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34344034  

Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality: results from the MORGAM Consortium. Morseth, B., Geelhoed, B., Linneberg, A., Johansson, L., Kuulasmaa, K., Salomaa, V., Iacoviello, L., Costanzo, S., Soderberg, S., Niiranen, T. J., Vishram-Nielsen, J. K. K., Njolstad, I., Wilsgaard, T., Mathiesen, E. B., Lochen, M. L., Zeller, T., Blankenberg, S., Ojeda, F. M., Schnabel, R. B. & consortium, M. Open heart 8 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34341095

Brown adipose tissue is associated with healthier body fat distribution and metabolic benefits independent of regional adiposity. Wibmer, A. G., Becher, T., Eljalby, M., Crane, A., Andrieu, P. C., Jiang, C. S., Vaughan, R., Schoder, H. & Cohen, P. Cell Rep Med 2, 100332 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34337558  

Flow-dependent regulation of endothelial Tie2 by GATA3 in vivo. Idowu, T. O., Etzrodt, V., Pape, T., Heineke, J., Stahl, K., Haller, H. & David, S. Intensive care medicine experimental 9, 38 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34337671  

Large LAA-Too Big for Closure?: LAA Closure With the World's Biggest Percutaneous Closure Device. Skurk, C., Reinthaler, M., Kasner, M. & Landmesser, U. JACC. Cardiovascular interventions (2021). https://www.ncbi.nlm.nih.gov/pubmed/34332941  

An optimized imaging protocol for [(99m)Tc]Tc-DPD scintigraphy and SPECT/CT quantification in cardiac transthyretin (ATTR) amyloidosis. Schatka, I., Bingel, A., Schau, F., Bluemel, S., Messroghli, D. R., Frumkin, D., Knebel, F., Diekmann, S. M., Elsanhoury, A., Tschope, C., Hahn, K., Amthauer, H., Rogasch, J. M. M. & Wetz, C. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34331215  

Peroxisomes contribute to intracellular calcium dynamics in cardiomyocytes and non-excitable cells. Sargsyan, Y., Bickmeyer, U., Gibhardt, C. S., Streckfuss-Bomeke, K., Bogeski, I. & Thoms, S. Life science alliance 4 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34330788


July

Frequency of Bioprosthetic Valve Fracturing Utilization in an All-Comers Valve-in-Valve TAVR Cohort. Ruge, H., Erlebach, M. & Lange, R. Frontiers in cardiovascular medicine 8, 653871 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34277723  

A novel algorithm for 3-D visualization of electrogram duration for substrate-mapping in patients with ischemic heart disease and ventricular tachycardia. Masjedi, M., Jungen, C., Kuklik, P., Alken, F. A., Kahle, A. K., Klatt, N., Scherschel, K., Lorenz, J. & Meyer, C. PloS one 16, e0254683 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34260658  

Increased Sphingosine-1-Phosphate Serum Concentrations in Subjects with Periodontitis: A Matter of Inflammation. Moritz, E., Jedlitschky, G., Negnal, J., Tzvetkov, M. V., Daum, G., Dorr, M., Felix, S. B., Volzke, H., Nauck, M., Schwedhelm, E., Meisel, P., Kocher, T., Rauch, B. H. & Holtfreter, B. J Inflamm Res 14, 2883-2896 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34234513  

Soluble Platelet Release Factors as Biomarkers for Cardiovascular Disease. Baidildinova, G., Nagy, M., Jurk, K., Wild, P. S., Ten Cate, H. & van der Meijden, P. E. J. Frontiers in cardiovascular medicine 8, 684920 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34235190  

Procedural outcomes in patients with dual versus single antiplatelet therapy prior to transcatheter aortic valve replacement. Seoudy, H., Thomann, M., Frank, J., Lutz, M., Puehler, T., Lutter, G., Muller, O. J., Frey, N., Saad, M. & Frank, D. Scientific reports 11, 15415 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34326368  

A piggyBac-based platform for genome editing and clonal rhesus macaque iPSC line derivation. Rodriguez-Polo, I., Missbach, S., Petkov, S., Mattern, F., Maierhofer, A., Grzadzielewska, I., Tereshchenko, Y., Urrutia-Cabrera, D., Haaf, T., Dressel, R., Bartels, I. & Behr, R. Scientific reports 11, 15439 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34326359  

A BMP4-p38 MAPK signaling axis controls ISL1 protein stability and activity during cardiogenesis. Jing, Y., Ren, Y., Witzel, H. R. & Dobreva, G. Stem cell reports (2021). https://www.ncbi.nlm.nih.gov/pubmed/34329593  

Cardiac contractility modulation in patients with ischemic versus non-ischemic cardiomyopathy: Results from the mainined observational study. Fastner, C., Yuecel, G., Rudic, B., Schmiel, G., Toepel, M., Burkhoff, D., Liebe, V., Kruska, M., Hetjens, S., Borggrefe, M., Akin, I. & Kuschyk, J. International journal of cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34329680  

Transthoracic echocardiographic reference values of the aortic root: results from the Hamburg City Health Study. Wenzel, J. P., Petersen, E., Nikorowitsch, J., Senftinger, J., Sinning, C., Theissen, M., Petersen, J., Reichenspurner, H. & Girdauskas, E. The international journal of cardiovascular imaging (2021). https://www.ncbi.nlm.nih.gov/pubmed/34324091  

Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis. Shankar, T. S., Ramadurai, D. K. A., Steinhorst, K., Sommakia, S., Badolia, R., Thodou Krokidi, A., Calder, D., Navankasattusas, S., Sander, P., Kwon, O. S., Aravamudhan, A., Ling, J., Dendorfer, A., Xie, C., Kwon, O., Cheng, E. H. Y., Whitehead, K. J., Gudermann, T., Richardson, R. S., Sachse, F. B. et al. Nature communications 12, 4583 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34321484  

Effects of statins after transcatheter aortic valve implantation in key patient populations. Fischer-Rasokat, U., Renker, M., Bansch, C., Weferling, M., Liebetrau, C., Herrmann, E., Liakopoulos, O., Choi, Y. H., Hamm, C. W. & Kim, W. K. Journal of cardiovascular pharmacology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34321397  

Quiescent-Interval Slice-Selective MRA Accurately Estimates Intravascular Stent Dimensions Prior to Intervention in Patients With Peripheral Artery Disease. Decker, J. A., Fischer, A. M., Schoepf, U. J., Xiong, F., Todoran, T. M., Aldinger, J., Ellis, L., Edelman, R. R., Koktzoglou, I., Emrich, T. & Varga-Szemes, A. J Magn Reson Imaging (2021). https://www.ncbi.nlm.nih.gov/pubmed/34323329  

Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease. Audain, E., Wilsdon, A., Breckpot, J., Izarzugaza, J. M., Fitzgerald, T. W., Kahlert, A. K., Sifrim, A., Wunnemann, F., Perez-Riverol, Y., Abdul-Khaliq, H., Bak, M., Bassett, A. S., Benson, W. D., Berger, F., Daehnert, I., Devriendt, K., Dittrich, S., Daubeney, P. E., Garg, V., Hackmann, K. et al. PLoS genetics 17, e1009679 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34324492  

Percutaneous dilatational tracheotomy in high-risk ICU patients. Lusebrink, E., Krogmann, A., Tietz, F., Riebisch, M., Okrojek, R., Peltz, F., Skurk, C., Hullermann, C., Sackarnd, J., Wassilowsky, D., Toischer, K., Scherer, C., Preusch, M., Testori, C., Flierl, U., Peterss, S., Hoffmann, S., Kneidinger, N., Hagl, C., Massberg, S. et al. Ann Intensive Care 11, 116 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34319491  

Role of CMR Imaging in Diagnostics and Evaluation of Cardiac Involvement in Muscle Dystrophies. Blaszczyk, E., Groschel, J. & Schulz-Menger, J. Current heart failure reports 18, 211-224 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34319529  

ESC working group on cardiac cellular electrophysiology position paper: relevance, opportunities, and limitations of experimental models for cardiac electrophysiology research. Odening, K. E., Gomez, A. M., Dobrev, D., Fabritz, L., Heinzel, F. R., Mangoni, M. E., Molina, C. E., Sacconi, L., Smith, G., Stengl, M., Thomas, D., Zaza, A., Remme, C. A. & Heijman, J. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34313298  

A genetic variant alters the secondary structure of the lncRNA H19 and is associated with dilated cardiomyopathy. Martens, L., Ruhle, F., Witten, A., Meder, B., Katus, H. A., Arbustini, E., Hasenfuss, G., Sinner, M. F., Kaab, S., Pankuweit, S., Angermann, C., Bornberg-Bauer, E. & Stoll, M. RNA Biol, 1-7 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34313541  

Lack of Significant Association between Sex Hormone Concentrations and Atopic Dermatitis in Adolescents and Adults in Two Population-Based Studies. Kische, H., Hannemann, A., Voss, C., Nauck, M., Volzke, H., Pieper, L., Beesdo-Baum, K. & Arnold, A. J Invest Dermatol (2021). https://www.ncbi.nlm.nih.gov/pubmed/34314741  

Genotype-Phenotype Relationships in the Context of Transcriptional Adaptation and Genetic Robustness. Jakutis, G. & Stainier, D. Y. R. Annu Rev Genet (2021). https://www.ncbi.nlm.nih.gov/pubmed/34314597  

Extracellular NLRP3 inflammasome particles are internalized by human coronary artery smooth muscle cells and induce pro-atherogenic effects. Gaul, S., Schaeffer, K. M., Opitz, L., Maeder, C., Kogel, A., Uhlmann, L., Kalwa, H., Wagner, U., Haas, J., Behzadi, A., Pelegrin, P., Boeckel, J. N. & Laufs, U. Scientific reports 11, 15156 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34312415  

Heightened amygdalar activity mediates the cardiometabolic effects of transportation noise stress. Hahad, O., Daiber, A. & Munzel, T. Psychoneuroendocrinology, 105347 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34304945  

Long-Term Outcome with New Generation Prostheses in Patients Undergoing Transcatheter Aortic Valve Replacement. Tamm, A. R., Geyer, M., Kreidel, F., Dausmann, L., Jablonski, C., Hahad, O., Schulz, E., Munzel, T. & Von Bardeleben, R. S. Journal of clinical medicine 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34300268  

Cardiac Rehabilitation in German Speaking Countries of Europe-Evidence-Based Guidelines from Germany, Austria and Switzerland LLKardReha-DACH-Part 2. Schwaab, B., Bjarnason-Wehrens, B., Meng, K., Albus, C., Salzwedel, A., Schmid, J. P., Benzer, W., Metz, M., Jensen, K., Rauch, B., Bonner, G., Brzoska, P., Buhr-Schinner, H., Charrier, A., Cordes, C., Dorr, G., Eichler, S., Exner, A. K., Fromm, B., Gielen, S. et al. Journal of clinical medicine 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34300237  

Immunomodulatory Nanomedicine for the Treatment of Atherosclerosis. Peters, L. J. F., Jans, A., Bartneck, M. & van der Vorst, E. P. C. Journal of clinical medicine 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34300351  

Expression of Connexin43 Stimulates Endothelial Angiogenesis Independently of Gap Junctional Communication In Vitro. Koepple, C., Zhou, Z., Huber, L., Schulte, M., Schmidt, K., Gloe, T., Kneser, U., Schmidt, V. J. & de Wit, C. International journal of molecular sciences 22 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34299018  

Smoking and Neuropsychiatric Disease-Associations and Underlying Mechanisms. Hahad, O., Daiber, A., Michal, M., Kuntic, M., Lieb, K., Beutel, M. & Munzel, T. International journal of molecular sciences 22 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34298890  

Inconsistent Findings of Cardiac Troponin T and I in Clinical Routine Diagnostics: Factors of Influence. Eidizadeh, A., Fraune, L., Leha, A., Wachter, R., Asif, A. R. & Binder, L. Journal of clinical medicine 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34300313  

Methylation status of nc886 epiallele reflects periconceptional conditions and is associated with glucose metabolism through nc886 RNAs. Marttila, S., Viiri, L. E., Mishra, P. P., Kuhnel, B., Matias-Garcia, P. R., Lyytikainen, L. P., Ceder, T., Mononen, N., Rathmann, W., Winkelmann, J., Peters, A., Kahonen, M., Hutri-Kahonen, N., Juonala, M., Aalto-Setala, K., Raitakari, O., Lehtimaki, T., Waldenberger, M. & Raitoharju, E. Clinical epigenetics 13, 143 (2021). https://www.ncbi.nlm.nih.gov/pubmed/3429413

Feasibility of Coronary Access in Patients With Acute Coronary Syndrome and Previous TAVR. Kim, W. K., Pellegrini, C., Ludwig, S., Mollmann, H., Leuschner, F., Makkar, R., Leick, J., Amat-Santos, I. J., Dorr, O., Breitbart, P., Jimenez Diaz, V. A., Dabrowski, M., Rudolph, T., Avanzas, P., Kaur, J., Toggweiler, S., Kerber, S., Ranosch, P., Regazzoli, D., Frank, D. et al. JACC. Cardiovascular interventions 14, 1578-1590 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34294400  

How Many Dimensions Do We Need to Assess RV Function Before Tricuspid Interventions? Karam, N. & Hausleiter, J. JACC. Cardiovascular interventions 14, 1562-1564 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34294397  

Impact of Acute and Chronic Psychosocial Stress on Vascular Inflammation. Hinterdobler, J., Schunkert, H., Kessler, T. & Sager, H. B. Antioxidants & redox signaling (2021). https://www.ncbi.nlm.nih.gov/pubmed/34293932  

Osteopontin and galectin-3 as biomarkers of maladaptive right ventricular remodeling in pulmonary hypertension. Keranov, S., Dorr, O., Jafari, L., Liebetrau, C., Keller, T., Troidl, C., Riehm, J., Rutsatz, W., Bauer, P., Kriechbaum, S., Voss, S., Richter, M. J., Tello, K., Gall, H., Ghofrani, H. A., Guth, S., Seeger, W., Hamm, C. W. & Nef, H. Biomarkers in medicine 15, 1021-1034 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34289706  

Immunotherapy and cardiovascular diseases (CVD): novel avenues for immunotherapeutic approaches. Bonfiglio, C. A., Weber, C., Atzler, D. & Lutgens, E. QJM : monthly journal of the Association of Physicians (2021). https://www.ncbi.nlm.nih.gov/pubmed/34293177  

Fuse your mitochondria, lose appetite: an anorexic, anti-obesity sphingolipid. Muley, C. & Bartelt, A. EMBO molecular medicine, e14618 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34288516  

Altered Adiponectin Response in Older Women Following Dextrose and High-Fat Dietary Challenges. Herpich, C., Kochlik, B., Hass, U., Weber, D., Grune, T. & Norman, K. Molecular nutrition & food research, e2100487 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34288404  

Move more - be happier? Physical Activity and Health-Related Quality of Life in Children with Congenital Heart Disease. Brudy, L., Meyer, M., Oberhoffer, R., Ewert, P. & Muller, J. American heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/34289343  

TRPV1 activation and internalization is part of the LPS-induced inflammation in human iPSC-derived cardiomyocytes. Sattler, K., El-Battrawy, I., Cyganek, L., Lang, S., Lan, H., Li, X., Zhao, Z., Utikal, J., Wieland, T., Borggrefe, M., Zhou, X. & Akin, I. Scientific reports 11, 14689 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34282193  

The Consequences of Soluble Epoxide Hydrolase Deletion on Tumorigenesis and Metastasis in a Mouse Model of Breast Cancer. Kesavan, R., Fromel, T., Zukunft, S., Brune, B., Weigert, A., Wittig, I., Popp, R. & Fleming, I. International journal of molecular sciences 22 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34281173   

A deeper understanding of the causal relationships between thyroid function and atrial fibrillation. Kus, A., Teumer, A. & Medici, M. The Journal of clinical endocrinology and metabolism (2021). https://www.ncbi.nlm.nih.gov/pubmed/34279034  

Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis. Hinterdobler, J., Schott, S., Jin, H., Meesmann, A., Steinsiek, A. L., Zimmermann, A. S., Wobst, J., Muller, P., Mauersberger, C., Vilne, B., Baecklund, A., Chen, C. S., Moggio, A., Braster, Q., Molitor, M., Krane, M., Kempf, W. E., Ladwig, K. H., Hristov, M., Hulsmans, M. et al. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/34279021  

Interventional Snare Procedure to Lift a Balloon-Expandable TAVR Impeding a Mechanical Bi-Leaflet Mitral Valve. Nicolai, L., Nabauer, M., Sadoni, S., Theiss, H., Orban, M., Hagl, C., Massberg, S., Hausleiter, J. & Braun, D. JACC. Cardiovascular interventions 14, e189-e190 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34274302  

Frequency of silent brain infarction in transient global amnesia. Ganeshan, R., Betz, M., Scheitz, J. F., Erdur, H., Audebert, H. J., Fiebach, J. B. & Villringer, K. Journal of neurology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34275010  

Aircraft noise exposure drives the activation of white blood cells and induces microvascular dysfunction in mice. Eckrich, J., Frenis, K., Rodriguez-Blanco, G., Ruan, Y., Jiang, S., Bayo Jimenez, M. T., Kuntic, M., Oelze, M., Hahad, O., Li, H., Gericke, A., Steven, S., Strieth, S., von Kriegsheim, A., Munzel, T., Ernst, B. P. & Daiber, A. Redox biology 46, 102063 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34274810  

Thiol-based redox-active proteins as cardioprotective therapeutic agents in cardiovascular diseases. Andreadou, I., Efentakis, P., Frenis, K., Daiber, A. & Schulz, R. Basic research in cardiology 116, 44 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34275052  

Cardiac output states in patients with severe functional tricuspid regurgitation: impact on treatment success and prognosis. Unterhuber, M., Kresoja, K. P., Besler, C., Rommel, K. P., Orban, M., von Roeder, M., Braun, D., Stolz, L., Massberg, S., Trebicka, J., Zachaus, M., Hausleiter, J., Thiele, H. & Lurz, P. European journal of heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34272792  

SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy. Boeckel, J. N., Mobius-Winkler, M., Muller, M., Rebs, S., Eger, N., Schoppe, L., Tappu, R., Kokot, K. E., Kneuer, J. M., Gaul, S., Bordalo, D. M., Lai, A., Haas, J., Ghanbari, M., Drewe-Boss, P., Liss, M., Katus, H. A., Ohler, U., Gotthardt, M., Laufs, U. et al. Genomics Proteomics Bioinformatics (2021). https://www.ncbi.nlm.nih.gov/pubmed/34273561  

Dietary habits and the presence and degree of asymptomatic diverticular disease by magnetic resonance imaging in a Western population: a population-based cohort study. Askani, E., Rospleszcz, S., Rothenbacher, T., Wawro, N., Messmann, H., De Cecco, C. N., von Kruchten, R., Kulka, C., Kiefer, L. S., Rathmann, W., Peters, A., Schlett, C. L., Bamberg, F., Linseisen, J. & Storz, C. Nutr Metab (Lond) 18, 73 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34271946  

Diastolic dysfunction in individuals with and without heart failure with preserved ejection fraction. Wenzel, J. P., Kellen, R. B., Magnussen, C., Blankenberg, S., Schrage, B., Schnabel, R. & Nikorowitsch, J. Clinical research in cardiology : official journal of the German Cardiac Society (2021). https://www.ncbi.nlm.nih.gov/pubmed/34269862  

CaMKII inhibition has dual effects on spontaneous Ca(2+) release and Ca(2+) alternans in ventricular cardiomyocytes from mice with a gain-of-function RyR2 mutation. Sadredini, M., Haugsten Hansen, M., Frisk, M., Louch, W. E., Lehnart, S. E., Sjaastad, I. & Stokke, M. K. American journal of physiology. Heart and circulatory physiology 321, H446-H460 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34270372  

Luteolin alleviates cognitive impairment in Alzheimer's disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation. Kou, J. J., Shi, J. Z., He, Y. Y., Hao, J. J., Zhang, H. Y., Luo, D. M., Song, J. K., Yan, Y., Xie, X. M., Du, G. H. & Pang, X. B. Acta Pharmacol Sin (2021). https://www.ncbi.nlm.nih.gov/pubmed/34267346    

First experiences of local pulse wave velocity measurements in 4D-MRI in focally stented femoropopliteal arteries. Hermann, I., Shchetynska-Marinova, T., Amendt, K., Hohneck, A. L., Schonberg, S. O., Zollner, F. G. & Sigl, M. VASA. Zeitschrift fur Gefasskrankheiten (2021). https://www.ncbi.nlm.nih.gov/pubmed/34269078  

Lack of specialist care is associated with increased morbidity and mortality in adult congenital heart disease: a population-based study. Diller, G. P., Orwat, S., Lammers, A. E., Radke, R. M., De-Torres-Alba, F., Schmidt, R., Marschall, U., Bauer, U. M., Enders, D., Bronstein, L., Kaleschke, G. & Baumgartner, H. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/34269382

Multimarker profiling identifies protective and harmful immune processes in heart failure: findings from BIOSTAT-CHF. Markousis-Mavrogenis, G., Tromp, J., Ouwerkerk, W., Fereirra, J. P., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., Lang, C. C., Metra, M., Samani, N. J., Consortium, B.-C., de Boer, R. A., van Veldhuisen, D. J., Voors, A. A. & van der Meer, P. Cardiovascular research (2021). https://www.ncbi.nlm.nih.gov/pubmed/34264317  

Combined extracorporeal membrane oxygenation and microaxial pump-when left ventricular preload is too low to unload in cardiogenic shock. Lusebrink, E., Massberg, S. & Orban, M. Health Sci Rep 4, e321 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34263084  

Reply to 'Heart failure with preserved ejection fraction and COVID-19: which comes first, the chicken or the egg?'. Anker, M. S. & Tschope, C. European journal of heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34263996   

[Influence of deep implantation on conduction disturbances after transcatheter aortic valve implantation]. Saad, M., Klaus, Y., Buhse, P., Puehler, T., Lutter, G., Seoudy, H. & Frank, D. Herzschrittmachertherapie & Elektrophysiologie (2021). https://www.ncbi.nlm.nih.gov/pubmed/34259933

Apixaban versus PhenpRocoumon: Oral AntiCoagulation plus antiplatelet tHerapy in patients with Acute Coronary Syndrome and Atrial Fibrillation (APPROACH-ACS-AF): Rationale and design of the prospective randomized parallel-group, open-label, blinded-endpoint, superiority, multicenter-trial of a triple therapy versus a dual therapy in patients with Atrial Fibrillation and Acute Coronary Syndrome undergoing coronary stenting. Riesinger, L., Strobl, C., Leistner, D. M., Gori, T., Akin, I., Mehr, M., Kellnar, A., Mahabadi, A. A., Bogossian, H., Block, M., Edelmann, F., Sarafoff, N., Sibbing, D., Ince, H., Rassaf, T., Mansmann, U., Mehilli, J., Kaab, S., Hausleiter, J., Massberg, S. et al. International journal of cardiology. Heart & vasculature 35, 100810 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34258380  

Haematopoietic and cardiac GPR55 synchronize post-myocardial infarction remodelling. Puhl, S. L., Hilby, M., Kohlhaas, M., Keidel, L. M., Jansen, Y., Hristov, M., Schindler, J., Maack, C. & Steffens, S. Scientific reports 11, 14385 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34257332   

Salivary metabolites associated with a 5-year tooth loss identified in a population-based setting. Andorfer, L., Holtfreter, B., Weiss, S., Matthes, R., Pitchika, V., Schmidt, C. O., Samietz, S., Kastenmuller, G., Nauck, M., Volker, U., Volzke, H., Csonka, L. N., Suhre, K., Pietzner, M. & Kocher, T. BMC Med 19, 161 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34256740  

Diagnostic Validation of a High-Sensitivity Cardiac Troponin I Assay. Sorensen, N. A., Gossling, A., Neumann, J. T., Hartikainen, T. S., Haller, P. M., Scharlemann, L., Lehmacher, J., Ziegler, A., Blankenberg, S., Zeller, T., Nordholt, G., Renne, T. & Westermann, D. Clinical chemistry (2021). https://www.ncbi.nlm.nih.gov/pubmed/34254126  

Effects of fatty acids on T cell function: role in atherosclerosis. Reilly, N. A., Lutgens, E., Kuiper, J., Heijmans, B. T. & Wouter Jukema, J. Nature reviews. Cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34253911  

Targeting the chemokine network in atherosclerosis. Yan, Y., Thakur, M., van der Vorst, E. P. C., Weber, C. & Doring, Y. Atherosclerosis 330, 95-106 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34247863  

Optimized bioresorbable scaffold implantation: From PSP to CIAO and back to facts. Seguchi, M. & Joner, M. Cardiovascular revascularization medicine : including molecular interventions (2021). https://www.ncbi.nlm.nih.gov/pubmed/34247984  

Occupational exposure to metal-rich particulate matter modifies the expression of repair genes in foundry workers. Panjali, Z., Hahad, O., Rajabi, F., Maddah, S. & Zendehdel, R. Toxicol Ind Health, 7482337211021202 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34247554  

Percutaneous mitral valve repair assisted by a catheter-based circulatory support device in a heart transplant patient. Nersesian, G., Lewin, D., Schoenrath, F., Solowjowa, N., Kukucka, M., Falk, V., Klein, C., Potapov, E. & Unbehaun, A. J Card Surg (2021). https://www.ncbi.nlm.nih.gov/pubmed/34250624  

Meta-Analysis of Short vs. Prolonged Dual Antiplatelet Therapy after Drug-Eluting Stent Implantation and Role of Continuation with either Aspirin or a P2Y12 Inhibitor Thereafter. Lahu, S., Bristot, P., Gewalt, S., Goedel, A., Giacoppo, D., Schupke, S., Schunkert, H., Kastrati, A. & Sarafoff, N. J Atheroscler Thromb (2021). https://www.ncbi.nlm.nih.gov/pubmed/34248087  

Multi-parametric assessment of left ventricular hypertrophy using late gadolinium enhancement, T1 mapping and strain-encoded cardiovascular magnetic resonance. Giusca, S., Steen, H., Montenbruck, M., Patel, A. R., Pieske, B., Erley, J., Kelle, S. & Korosoglou, G. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 23, 92 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34247623  

Rationale and design of a digital trial using smartphones to detect subclinical atrial fibrillation in a population at risk: The eHealth-based bavarian alternative detection of Atrial Fibrillation (eBRAVE-AF) trial. Freyer, L., von Stulpnagel, L., Spielbichler, P., Sappler, N., Wenner, F., Schreinlechner, M., Krasniqi, A., Behroz, A., Eiffener, E., Zens, M., Dolejsi, T., Massberg, S., Rizas, K. D. & Bauer, A. American heart journal 241, 26-34 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34252387  

Single-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms in cardiomyocytes. Zhu, C., Wu, J., Sun, H., Briganti, F., Meder, B., Wei, W. & Steinmetz, L. M. Nature communications 12, 4203 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34244519  

A novel risk model for predicting potentially life-threatening arrhythmias in non-ischemic dilated cardiomyopathy (DCM-SVA risk). Kayvanpour, E., Sammani, A., Sedaghat-Hamedani, F., Lehmann, D. H., Broezel, A., Koelemenoglu, J., Chmielewski, P., Curjol, A., Socie, P., Miersch, T., Haas, J., Gi, W. T., Richard, P., Ploski, R., Truszkowska, G., Baas, A. F., Foss-Nieradko, B., Michalak, E., Stepien-Wojno, M., Zakrzewska-Koperska, J. et al. International journal of cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34245791  

Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice. Deuse, T., Tediashvili, G., Hu, X., Gravina, A., Tamenang, A., Wang, D., Connolly, A., Mueller, C., Mallavia, B., Looney, M. R., Alawi, M., Lanier, L. L. & Schrepfer, S. Proceedings of the National Academy of Sciences of the United States of America 118 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34244428  

Optimising clinical trials in acute myocardial infarction complicated by cardiogenic shock: a statement from the 2020 Critical Care Clinical Trialists Workshop. Arrigo, M., Price, S., Baran, D. A., Poss, J., Aissaoui, N., Bayes-Genis, A., Bonello, L., Francois, B., Gayat, E., Gilard, M., Kapur, N. K., Karakas, M., Kostrubiec, M., Leprince, P., Levy, B., Rosenberg, Y., Thiele, H., Zeymer, U., Harhay, M. O. & Mebazaa, A. The Lancet. Respiratory medicine (2021). https://www.ncbi.nlm.nih.gov/pubmed/34245691  

Multiethnic Genome-wide Association Study of Subclinical Atherosclerosis in Individuals with Type 2 Diabetes. Lu, Y., Dimitrov, L., Chen, S. H., Bielak, L. F., Bis, J. C., Feitosa, M. F., Lu, L., Kavousi, M., Raffield, L. M., Smith, A. V., Wang, L., Weiss, S., Yao, J., Zhu, J., Gudmundsson, E. F., Gudmundsdottir, V., Bos, D., Ghanbari, M., Ikram, M. A., Hwang, S. J. et al. Circulation. Genomic and precision medicine (2021). https://www.ncbi.nlm.nih.gov/pubmed/34241534  

Low-Flow, Low-Gradient Severe Aortic Stenosis: Are We Aware of the Perfect Treatment Option? Lange, R. & Vitanova, K. JACC. Cardiovascular interventions 14, 1493-1494 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34238559  

24-Months Cluster-Randomized Intervention Trial of a Targeted Fall Prevention Program in a Primary Care Setting. Hentschke, C., Halle, M., Geilhof, B., Landendoerfer, P., Blank, W., Sieber, C. C., Siegrist, M. & Freiberger, E. J Gen Intern Med (2021). https://www.ncbi.nlm.nih.gov/pubmed/34240282  

A case report of cryoballoon-based pulmonary vein isolation in a patient with situs inversus abdominalis and levocardia. Anwar, O., Espersen, T., Willems, S. & Eickholt, C. European heart journal. Case reports 5, ytab245 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34240004  

MicroRNA-21 Controls Circadian Regulation of Apoptosis in Atherosclerotic Lesions. Schober, A., Blay, R. M., Saboor Maleki, S., Zahedi, F., Winklmaier, A. E., Kakar, M. Y., Baatsch, I. M., Zhu, M., Geissler, C., Fusco, A. E., Eberlein, A., Li, N., Megens, R. T. A., Banafsche, R., Kumbrink, J., Weber, C. & Nazari-Jahantigh, M. Circulation (2021). https://www.ncbi.nlm.nih.gov/pubmed/34233454  

Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity. Maifeld, A., Wild, J., Karlsen, T. V., Rakova, N., Wistorf, E., Linz, P., Jung, R., Birukov, A., Gimenez-Rivera, V. A., Wilck, N., Bartolomaeus, T., Dechend, R., Kleinewietfeld, M., Forslund, S. K., Krause, A., Kokolakis, G., Philipp, S., Clausen, B. E., Brand, A., Waisman, A. et al. J Invest Dermatol (2021). https://www.ncbi.nlm.nih.gov/pubmed/34237339

Genetics of coronary artery disease in the post GWAS era. Chen, Z. & Schunkert, H. Journal of internal medicine (2021). https://www.ncbi.nlm.nih.gov/pubmed/34237186  

Understanding Arteriosclerosis 2.0: Making Sense of Genetic Variants with scATAC. Brandes, R. P. & Gilsbach, R. Circulation research 129, 259-261 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34236882

A pathophysiological compass to personalize antianginal drug treatment. Bertero, E., Heusch, G., Munzel, T. & Maack, C. Nature reviews. Cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34234310  

Transvenous lead extraction: The influence of age on patient outcomes in the PROMET study cohort. Akhtar, Z., Elbatran, A. I., Starck, C. T., Gonzalez, E., Al-Razzo, O., Mazzone, P., Delnoy, P. P., Breitenstein, A., Steffel, J., Eulert-Grehn, J., Lanmuller, P., Melillo, F., Marzi, A., Leung, L. W. M., Domenichini, G., Sohal, M. & Gallagher, M. M. Pacing and clinical electrophysiology : PACE (2021). https://www.ncbi.nlm.nih.gov/pubmed/34235772  

Evaluation of Patients for Percutaneous Edge-to-edge Mitral Valve Repair: Comparison of Cardiac Computed Tomography Angiography With Transesophageal Echocardiography. Renker, M., Fischer-Rasokat, U., Walther, C., Kim, W. K., Rixe, J., Dorr, O., Nef, H., Rolf, A., Mollmann, H. & Hamm, C. W. Journal of thoracic imaging (2021). https://www.ncbi.nlm.nih.gov/pubmed/34232143  

Volume Balance in Chronic Kidney Disease: Evaluation Methodologies and Innovation Opportunities. La Porta, E., Lanino, L., Calatroni, M., Caramella, E., Avella, A., Quinn, C., Faragli, A., Estienne, L., Alogna, A. & Esposito, P. Kidney Blood Press Res, 1-15 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34233334  

Aortic root dimensions as a correlate for aortic regurgitation's severity. Wenzel, J. P., Petersen, E., Nikorowitsch, J., Muller, J., Kolbel, T., Reichenspurner, H., Blankenberg, S. & Girdauskas, E. The international journal of cardiovascular imaging (2021). https://www.ncbi.nlm.nih.gov/pubmed/34232460  

DNA damage and extranuclear DNA sensors: a dangerous duo in atherosclerosis. Santovito, D. & Steffens, S. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/34226940  

Liver X Receptor Agonist AZ876 Induces Beneficial Endogenous Cardiac Lipid Reprogramming and Protects Against Isoproterenol-Induced Cardiac Damage. Ritter, D., Goeritzer, M., Thiele, A., Blumrich, A., Beyhoff, N., Luettges, K., Smeir, E., Kasch, J., Grune, J., Muller, O. J., Klopfleisch, R., Jaeger, C., Foryst-Ludwig, A. & Kintscher, U. Journal of the American Heart Association 10, e019473 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34227403  

The (pro)renin receptor (ATP6ap2) facilitates receptor-mediated endocytosis and lysosomal function in the renal proximal tubule. Figueiredo, M., Daryadel, A., Sihn, G., Muller, D. N., Popova, E., Rouselle, A., Nguyen, G., Bader, M. & Wagner, C. A. Pflugers Archiv : European journal of physiology 473, 1229-1246 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34228176  

A comparison of metabolic labeling and statistical methods to infer genome-wide dynamics of RNA turnover. Boileau, E., Altmuller, J., Naarmann-de Vries, I. S. & Dieterich, C. Brief Bioinform (2021). https://www.ncbi.nlm.nih.gov/pubmed/34228787  

Increased susceptibility of human endothelial cells to infections by SARS-CoV-2 variants. Wagner, J. U. G., Bojkova, D., Shumliakivska, M., Luxan, G., Nicin, L., Aslan, G. S., Milting, H., Kandler, J. D., Dendorfer, A., Heumueller, A. W., Fleming, I., Bibli, S. I., Jakobi, T., Dieterich, C., Zeiher, A. M., Ciesek, S., Cinatl, J. & Dimmeler, S. Basic research in cardiology 116, 42 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34224022  

Machine learning based disease prediction from genotype data. Katsaouni, N., Tashkandi, A., Wiese, L. & Schulz, M. H. Biological chemistry 402, 871-885 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34218544  

Coagulopathy and sepsis: Pathophysiology, clinical manifestations and treatment. Giustozzi, M., Ehrlinder, H., Bongiovanni, D., Borovac, J. A., Guerreiro, R. A., Gasecka, A., Papakonstantinou, P. E. & Parker, W. A. E. Blood Rev, 100864 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34217531  

The hydrogen-peroxide producing NADPH oxidase 4 does not limit neointima development after vascular injury in mice. Buchmann, G. K., Schurmann, C., Spaeth, M., Abplanalp, W., Tombor, L., John, D., Warwick, T., Rezende, F., Weigert, A., Shah, A. M., Hansmann, M. L., Weissmann, N., Dimmeler, S., Schroder, K. & Brandes, R. P. Redox biology 45, 102050 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34218201  

Pathogenic Variants Associated with Dilated Cardiomyopathy Predict Outcome in Pediatric Myocarditis. Seidel, F., Holtgrewe, M., Al-Wakeel-Marquard, N., Opgen-Rhein, B., Dartsch, J., Herbst, C., Beule, D., Pickardt, T., Klingel, K., Messroghli, D., Berger, F., Schubert, S., Kuhnisch, J. & Klaassen, S. Circulation. Genomic and precision medicine (2021). https://www.ncbi.nlm.nih.gov/pubmed/34213952  

Newly acquired complete right bundle branch block early after heart transplantation is associated with lower survival. Rahm, A. K., Helmschrott, M., Darche, F. F., Thomas, D., Bruckner, T., Ehlermann, P., Kreusser, M. M., Warnecke, G., Frey, N. & Rivinius, R. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34213089  

Exploration of Analgesia with Tramadol in the Coxsackievirus B3 Myocarditis Mouse Model. Pinkert, S., Kespohl, M., Kelm, N., Kaya, Z., Heuser, A., Klingel, K. & Beling, A. Viruses 13 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34202636  

Age-related decline in murine heart and skeletal muscle performance is attenuated by reduced Ahnak1 expression. Mahmoodzadeh, S., Koch, K., Schriever, C., Xu, J., Steinecker, M., Leber, J., Dworatzek, E., Purfurst, B., Kunz, S., Recchia, D., Canepari, M., Heuser, A., Di Francescantonio, S. & Morano, I. J Cachexia Sarcopenia Muscle (2021). https://www.ncbi.nlm.nih.gov/pubmed/34212535  

Chronic Inflammation Mediates the Association between Cortisol and Hyperglycemia: Findings from the Cross-Sectional Population-Based KORA Age Study. Johar, H., Spieler, D., Bidlingmaier, M., Herder, C., Rathmann, W., Koenig, W., Peters, A., Kruse, J. & Ladwig, K. H. Journal of clinical medicine 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34206644  

Reconstitution of Functional Integrin alphaIIbbeta3 and Its Activation in Plasma Membrane-Mimetic Lipid Environments. Janke, U., Mitlehner, A., Weide, A., Gutmann, T. & Delcea, M. Membranes (Basel) 11 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34209233  

Long-Term Survival in Patients with or without Implantable Cardioverter Defibrillator after Transcatheter Aortic Valve Implantation. Fischer-Rasokat, U., Renker, M., Liebetrau, C., Weferling, M., Rolf, A., Hain, A., Sperzel, J., Choi, Y. H., Hamm, C. W. & Kim, W. K. Journal of clinical medicine 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34208816  

Effects of Thyroid Function on Hemostasis, Coagulation, and Fibrinolysis: A Mendelian Randomization Study. Ellervik, C., Mora, S., Kus, A., Asvold, B., Marouli, E., Deloukas, P., Sterenborg, R., Teumer, A., Burgess, S., Sabater-Lleal, M., Huffman, J., Johnson, A. D., Tregouet, D. A., Smith, N. L., Medici, M., DeVries, P. S., Chasman, D. I. & Kjaergaard, A. D. Thyroid : official journal of the American Thyroid Association (2021). https://www.ncbi.nlm.nih.gov/pubmed/34210154  

Multiphoton Imaging of Ca(2+) Instability in Acute Myocardial Slices from a RyR2(R2474S) Murine Model of Catecholaminergic Polymorphic Ventricular Tachycardia. Borile, G., Zaglia, T., Lehnart, S. E. & Mongillo, M. Journal of clinical medicine 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34206855  

The Interplay between Nutrition, Innate Immunity, and the Commensal Microbiota in Adaptive Intestinal Morphogenesis. Bayer, F., Dremova, O., Khuu, M. P., Mammadova, K., Pontarollo, G., Kiouptsi, K., Soshnikova, N., May-Simera, H. L., Endres, K. & Reinhardt, C. Nutrients 13 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34206809  

Transcriptome signature of miRNA-26b KO mouse model suggests novel targets. van der Vorst, E. P. C., Pepe, M. A. A., Peters, L. J. F., Haberbosch, M., Jansen, Y., Nauman, R., Stathopoulos, G. T., Weber, C. & Bidzhekov, K. BMC Genom Data 22, 23 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34193044  

Basophils balance healing after myocardial infarction via IL-4/IL-13. Sicklinger, F., Meyer, I. S., Li, X., Radtke, D., Dicks, S., Kornadt, M. P., Mertens, C., Meier, J. K., Lavine, K. J., Zhang, Y., Kuhn, T. C., Terzer, T., Patel, J., Boerries, M., Schramm, G., Frey, N., Katus, H. A., Voehringer, D. & Leuschner, F. The Journal of clinical investigation 131 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34196299   

Persisting and reoccurring cyanosis after Fontan operation is associated with increased late mortality. Schafstedde, M., Nordmeyer, S., Schleiger, A., Nordmeyer, J., Berger, F., Kramer, P. & Ovroutski, S. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021). https://www.ncbi.nlm.nih.gov/pubmed/34195822  

Current Status of Catheter-based Mitral Valve Replacement. Rawish, E., Schmidt, T., Eitel, I. & Frerker, C. Current cardiology reports 23, 95 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34196796  

Transition to adulthood and transfer to adult care of adolescents with congenital heart disease: a global consensus statement of the ESC Association of Cardiovascular Nursing and Allied Professions (ACNAP), the ESC Working Group on Adult Congenital Heart Disease (WG ACHD), the Association for European Paediatric and Congenital Cardiology (AEPC), the Pan-African Society of Cardiology (PASCAR), the Asia-Pacific Pediatric Cardiac Society (APPCS), the Inter-American Society of Cardiology (IASC), the Cardiac Society of Australia and New Zealand (CSANZ), the International Society for Adult Congenital Heart Disease (ISACHD), the World Heart Federation (WHF), the European Congenital Heart Disease Organisation (ECHDO), and the Global Alliance for Rheumatic and Congenital Hearts (Global ARCH). Moons, P., Bratt, E. L., De Backer, J., Goossens, E., Hornung, T., Tutarel, O., Zuhlke, L., Araujo, J. J., Callus, E., Gabriel, H., Shahid, N., Sliwa, K., Verstappen, A., Yang, H. L. & Thomet, C. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/34198319  

Identification of a critical lipid ratio in raft-like phases exposed to nitric oxide: An AFM study. Karanth, S., Azinfar, A., Helm, C. A. & Delcea, M. Biophys J 120, 3103-3111 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34197799  

Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging. McCartney, D. L., Min, J. L., Richmond, R. C., Lu, A. T., Sobczyk, M. K., Davies, G., Broer, L., Guo, X., Jeong, A., Jung, J., Kasela, S., Katrinli, S., Kuo, P. L., Matias-Garcia, P. R., Mishra, P. P., Nygaard, M., Palviainen, T., Patki, A., Raffield, L. M., Ratliff, S. M. et al. Genome biology 22, 194 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34187551  

alpha1-adrenoceptors and takotsubo syndrome: pathophysiologic connotations-Authors' reply. Huang, M., El-Battrawy, I., Zhou, X. & Akin, I. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 23, 1152 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34189578  

Ticagrelor or Prasugrel for Patients With Acute Coronary Syndrome Treated With Percutaneous Coronary Intervention: A Prespecified Subgroup Analysis of a Randomized Clinical Trial. Coughlan, J. J., Aytekin, A., Lahu, S., Ndrepepa, G., Menichelli, M., Mayer, K., Wohrle, J., Bernlochner, I., Gewalt, S., Witzenbichler, B., Hochholzer, W., Sibbing, D., Cassese, S., Angiolillo, D. J., Hemetsberger, R., Valina, C., Muller, A., Kufner, S., Liebetrau, C., Xhepa, E. et al. JAMA cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34190967


June

Discontinuation versus continuation of renin-angiotensin-system inhibitors in COVID-19 (ACEI-COVID): a prospective, parallel group, randomised, controlled, open-label trial. Bauer, A., Schreinlechner, M., Sappler, N., Dolejsi, T., Tilg, H., Aulinger, B. A., Weiss, G., Bellmann-Weiler, R., Adolf, C., Wolf, D., Pirklbauer, M., Graziadei, I., Ganzer, H., von Bary, C., May, A. E., Woll, E., von Scheidt, W., Rassaf, T., Duerschmied, D., Brenner, C., Kaab, S., Metzler, B., Joannidis, M., Kain, H. U., Kaiser, N., Schwinger, R., Witzenbichler, B., Alber, H., Straube, F., Hartmann, N., Achenbach, S., von Bergwelt-Baildon, M., von Stulpnagel, L., Schoenherr, S., Forer, L., Embacher-Aichhorn, S., Mansmann, U., Rizas, K. D., Massberg, S. & investigators, A.-C. The Lancet. Respiratory medicine 9, 863-872 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34126053  

Long-chain acylcarnitine 18:1 acutely increases human atrial myocardial contractility and arrhythmia susceptibility. Aitken-Buck, H. M., Krause, J., van Hout, I., Davis, P. J., Bunton, R. W., Parry, D. J., Williams, M. J. A., Coffey, S., Zeller, T., Jones, P. P. & Lamberts, R. R. American journal of physiology. Heart and circulatory physiology 321, H162-H174 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34085842Lenvatinib halts aortic aneurysm growth by restoring smooth muscle cell contractility.

Busch, A., Pauli, J., Winski, G., Bleichert, S., Chernogubova, E., Metschl, S., Winter, H., Trenner, M., Wiegering, A., Otto, C., Fischer, J., Reiser, J., Werner, J., Roy, J., Brostjan, C., Knappich, C., Eckstein, H. H., Paloschi, V. & Maegdefessel, L. JCI insight 6 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34185710  

Adaptive versus maladaptive cardiac remodelling in response to sustained β-adrenergic stimulation in a new 'ISO on/off model'. Werhahn, S. M., Kreusser, J. S., Hagenmüller, M., Beckendorf, J., Diemert, N., Hoffmann, S., Schultz, J. H., Backs, J. & Dewenter, M. PloS one 16, e0248933 (2021).

Right bundle branch block is not associated with worse short- and mid-term outcome after transcatheter aortic valve implantation. Weferling, M., Liebetrau, C., Renker, M., Fischer-Rasokat, U., Choi, Y. H., Hamm, C. W. & Kim, W. K. PloS one 16, e0253332 (2021).

Speeding Up the Heart? Traditional and New Perspectives on HCN4 Function. Hennis, K., Rötzer, R. D., Piantoni, C., Biel, M., Wahl-Schott, C. & Fenske, S. Frontiers in physiology 12, 669029 (2021).

Identification and Tissue-Specific Characterization of Novel SHOX-Regulated Genes in Zebrafish Highlights SOX Family Members Among Other Genes. Hoffmann, S., Roeth, R., Diebold, S., Gogel, J., Hassel, D., Just, S. & Rappold, G. A. Frontiers in genetics 12, 688808 (2021).

Discontinuation versus continuation of renin-angiotensin-system inhibitors in COVID-19 (ACEI-COVID): a prospective, parallel group, randomised, controlled, open-label trial. Bauer, A., Schreinlechner, M., Sappler, N., Dolejsi, T., Tilg, H., Aulinger, B. A., Weiss, G., Bellmann-Weiler, R., Adolf, C., Wolf, D., Pirklbauer, M., Graziadei, I., Ganzer, H., von Bary, C., May, A. E., Woll, E., von Scheidt, W., Rassaf, T., Duerschmied, D., Brenner, C., Kaab, S., Metzler, B., Joannidis, M., Kain, H. U., Kaiser, N., Schwinger, R., Witzenbichler, B., Alber, H., Straube, F., Hartmann, N., Achenbach, S., von Bergwelt-Baildon, M., von Stulpnagel, L., Schoenherr, S., Forer, L., Embacher-Aichhorn, S., Mansmann, U., Rizas, K. D., Massberg, S. & investigators, A.-C. The Lancet. Respiratory medicine 9, 863-872 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34126053  

Sex-Specific Differences of the Inflammatory State in Experimental Autoimmune Myocarditis. Barcena, M. L., Jeuthe, S., Niehues, M. H., Pozdniakova, S., Haritonow, N., Kühl, A. A., Messroghli, D. R. & Regitz-Zagrosek, V. Frontiers in immunology 12, 686384 (2021).

Cardiac 18F-FDG Positron Emission Tomography: An Accurate Tool to Monitor In vivo Metabolic and Functional Alterations in Murine Myocardial Infarction. Fischer, M., Zacherl, M. J., Weckbach, L., Paintmayer, L., Weinberger, T., Stark, K., Massberg, S., Bartenstein, P., Lehner, S., Schulz, C. & Todica, A. Frontiers in cardiovascular medicine 8, 656742 (2021).

Impact of Syndecan-2-Selected Mesenchymal Stromal Cells on the Early Onset of Diabetic Cardiomyopathy in Diabetic db/db Mice. Pappritz, K., Dong, F., Miteva, K., Kovacs, A., El-Shafeey, M., Kerim, B., O'Flynn, L., Elliman, S. J., O'Brien, T., Hamdani, N., Tschöpe, C. & Van Linthout, S. Frontiers in cardiovascular medicine 8, 632728 (2021).

Cigarette Smoking Is Related to Endothelial Dysfunction of Resistance, but Not Conduit Arteries in the General Population-Results From the Gutenberg Health Study. Hahad, O., Arnold, N., Prochaska, J. H., Panova-Noeva, M., Schulz, A., Lackner, K. J., Pfeiffer, N., Schmidtmann, I., Michal, M., Beutel, M., Wild, P. S., Keaney, J. F., Jr., Daiber, A. & Münzel, T. Frontiers in cardiovascular medicine 8, 674622 (2021).

Long-chain acylcarnitine 18:1 acutely increases human atrial myocardial contractility and arrhythmia susceptibility. Aitken-Buck, H. M., Krause, J., van Hout, I., Davis, P. J., Bunton, R. W., Parry, D. J., Williams, M. J. A., Coffey, S., Zeller, T., Jones, P. P. & Lamberts, R. R. American journal of physiology. Heart and circulatory physiology 321, H162-H174 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34085842  

A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion. Witte, F., Ruiz-Orera, J., Mattioli, C. C., Blachut, S., Adami, E., Schulz, J. F., Schneider-Lunitz, V., Hummel, O., Patone, G., Mucke, M. B., Silhavy, J., Heinig, M., Bottolo, L., Sanchis, D., Vingron, M., Chekulaeva, M., Pravenec, M., Hubner, N. & van Heesch, S. Genome biology 22, 191 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34183069  

Histone deacetylase 2-dependent ventricular electrical remodeling in a porcine model of early heart failure. Syren, P., Rahm, A. K., Schweizer, P. A., Bruehl, C., Katus, H. A., Frey, N., Thomas, D. & Lugenbiel, P. Life sciences 281, 119769 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34186046  

Regional and ethnic influences on the response to empagliflozin in patients with heart failure and a reduced ejection fraction: the EMPEROR-Reduced trial. Lam, C. S. P., Ferreira, J. P., Pfarr, E., Sim, D., Tsutsui, H., Anker, S. D., Butler, J., Filippatos, G., Pocock, S. J., Sattar, N., Verma, S., Brueckmann, M., Schnee, J., Cotton, D., Zannad, F. & Packer, M. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/34184057  

Prediction of stroke risk based on left atrial appendage morphology: from pareidolia to artificial intelligence. Althoff, T. F. & Mont, L. The international journal of cardiovascular imaging 37, 2529-2531 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34185210  

The Heidelberg cardio-oncology unit (COUNT)-a possible blueprint for improved care of cardio-oncological patients. Lehmann, L. H., Stein, F., Jager, D. & Frey, N. Clinical research in cardiology : official journal of the German Cardiac Society (2021). https://www.ncbi.nlm.nih.gov/pubmed/34181066  

Spontaneous Iliopsoas Muscle Hemorrhage-Predictors of Associated Mortality. Decker, J. A., Brill, L. M., Orlowski, U., Varga-Szemes, A., Emrich, T., Schoepf, U. J., Schwarz, F., Kroncke, T. J. & Scheurig-Munkler, C. Acad Radiol (2021). https://www.ncbi.nlm.nih.gov/pubmed/34176729  

Dietary interventions and nutritional supplements for heart failure: a systematic appraisal and evidence map. Khan, M. S., Khan, F., Fonarow, G. C., Sreenivasan, J., Greene, S. J., Khan, S. U., Usman, M. S., Vaduganathan, M., Fudim, M., Anker, S. D. & Butler, J. European journal of heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34173307  

Post-myocardial infarction heart failure dysregulates the bone vascular niche. Hoffmann, J., Luxan, G., Abplanalp, W. T., Glaser, S. F., Rasper, T., Fischer, A., Muhly-Reinholz, M., Potente, M., Assmus, B., John, D., Zeiher, A. M. & Dimmeler, S. Nature communications 12, 3964 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34172720  

Traveling Volunteers: A Multi-Vendor, Multi-Center Study on Reproducibility and Comparability of 4D Flow Derived Aortic Hemodynamics in Cardiovascular Magnetic Resonance. Demir, A., Wiesemann, S., Erley, J., Schmitter, S., Trauzeddel, R. F., Pieske, B., Hansmann, J., Kelle, S. & Schulz-Menger, J. J Magn Reson Imaging (2021). https://www.ncbi.nlm.nih.gov/pubmed/34173297  

SMG5-SMG7 authorize nonsense-mediated mRNA decay by enabling SMG6 endonucleolytic activity. Boehm, V., Kueckelmann, S., Gerbracht, J. V., Kallabis, S., Britto-Borges, T., Altmuller, J., Kruger, M., Dieterich, C. & Gehring, N. H. Nature communications 12, 3965 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34172724  

Sodium-glucose co-transporter 2 inhibitors in heart failure with preserved ejection fraction: reasons for optimism. Anker, S. D., Khan, M. S., Shahid, I., Filippatos, G., Coats, A. J. S. & Butler, J. European journal of heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34173305  

Baseline characteristics of patients in the PARALLAX trial: insights into quality of life and exercise capacity in heart failure with preserved ejection fraction. Shah, S. J., Cowie, M. R., Wachter, R., Szecsody, P., Shi, V., Ibram, G., Hu, M., Zhao, Z., Gong, J. & Pieske, B. European journal of heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34170062  

Effect of acute altitude exposure on ventilatory thresholds in recreational athletes. Schuttler, D., Weckbach, L. T., Hamm, W., Maier, F., Kassem, S., Schier, J., Lackermair, K. & Brunner, S. Respir Physiol Neurobiol 293, 103723 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34171484  

Cardiovascular profiling in the diabetic continuum: results from the population-based Gutenberg Health Study. Schmitt, V. H., Leuschner, A., Junger, C., Pinto, A., Hahad, O., Schulz, A., Arnold, N., Trobs, S. O., Panova-Noeva, M., Keller, K., Zeller, T., Beutel, M., Pfeiffer, N., Strauch, K., Blankenberg, S., Lackner, K. J., Prochaska, J. H., Wild, P. S. & Munzel, T. Clinical research in cardiology : official journal of the German Cardiac Society (2021). https://www.ncbi.nlm.nih.gov/pubmed/34169342   

Association of hepatic steatosis derived from ultrasound and quantitative MRI with prediabetes in the general population. Naeem, M., Bulow, R., Schipf, S., Werner, N., Dorr, M., Lerch, M. M., Kuhn, J. P., Rathmann, W., Nauck, M., Markus, M. R. P., Ittermann, T. & Volzke, H. Scientific reports 11, 13276 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34168217  

Impact of acute ethanol intake on cardiac autonomic regulation. Brunner, S., Winter, R., Werzer, C., von Stulpnagel, L., Clasen, I., Hameder, A., Stover, A., Graw, M., Bauer, A. & Sinner, M. F. Scientific reports 11, 13255 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34168256  

Caloric restriction disrupts the microbiota and colonization resistance. von Schwartzenberg, R. J., Bisanz, J. E., Lyalina, S., Spanogiannopoulos, P., Ang, Q. Y., Cai, J., Dickmann, S., Friedrich, M., Liu, S. Y., Collins, S. L., Ingebrigtsen, D., Miller, S., Turnbaugh, J. A., Patterson, A. D., Pollard, K. S., Mai, K., Spranger, J. & Turnbaugh, P. J. Nature 595, 272-277 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34163067  

The impact of Wilson disease on myocardial tissue and function: a cardiovascular magnetic resonance study. Salatzki, J., Mohr, I., Heins, J., Cerci, M. H., Ochs, A., Paul, O., Riffel, J., Andre, F., Hirschberg, K., Muller-Hennessen, M., Giannitsis, E., Friedrich, M. G., Merle, U., Weiss, K. H., Katus, H. A. & Ochs, M. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 23, 84 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34162411   

Impact of mitral regurgitation in patients with worsening heart failure: insights from BIOSTAT-CHF. Pagnesi, M., Adamo, M., Sama, I. E., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G. S., Lang, C. C., Ng, L. L., Ponikowski, P., Ravera, A., Samani, N. J., Zannad, F., van Veldhuisen, D. J., Voors, A. A. & Metra, M. European journal of heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34164895  

Cohort profile: follow-up of a Berlin Aging Study II (BASE-II) subsample as part of the GendAge study. Demuth, I., Banszerus, V., Drewelies, J., Duzel, S., Seeland, U., Spira, D., Tse, E., Braun, J., Steinhagen-Thiessen, E., Bertram, L., Thiel, A., Lindenberger, U., Regitz-Zagrosek, V., Gerstorf, D. & Additional, B.-I. I. G. i. BMJ open 11, e045576 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34162642

Glycolysis and Inflammation: Partners in Crime! Brandes, R. P. & Rezende, F. Circulation research 129, 30-32 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34166079  

Safety and Efficacy of Intravenous Ferric Derisomaltose Compared to Iron Sucrose for Iron Deficiency Anemia in Patients with Chronic Kidney Disease With and Without Heart Failure. Ambrosy, A. P., von Haehling, S., Kalra, P. R., Court, E., Bhandari, S., McDonagh, T. & Cleland, J. G. F. The American journal of cardiology 152, 138-145 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34162484  

Correction: Brain structural abnormalities in obesity: relation to age, genetic risk, and common psychiatric disorders. Opel, N., Thalamuthu, A., Milaneschi, Y., Grotegerd, D., Flint, C., Leenings, R., Goltermann, J., Richter, M., Hahn, T., Woditsch, G., Berger, K., Hermesdorf, M., McIntosh, A., Whalley, H. C., Harris, M. A., MacMaster, F. P., Walter, H., Veer, I. M., Frodl, T., Carballedo, A. et al. Molecular psychiatry (2021). https://www.ncbi.nlm.nih.gov/pubmed/34158622  

Correction to: Competing interplay between systemic and periodontal inflammation: obesity overrides the impact of oral periphery. Meisel, P., Pink, C., Pitchika, V., Nauck, M., Volzke, H. & Kocher, T. Clin Oral Investig 25, 5123 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34160702  

Prevention of coronary obstruction in patients at risk undergoing transcatheter aortic valve implantation: the Hamburg BASILICA experience. Westermann, D., Ludwig, S., Kalbacher, D., Spink, C., Linder, M., Bhadra, O. D., Nikorowitsch, J., Waldschmidt, L., Demal, T., Voigtlander, L., Schaefer, A., Seiffert, M., Pecha, S., Schofer, N., Greenbaum, A. B., Reichenspurner, H., Blankenberg, S., Conradi, L. & Schirmer, J. Clinical research in cardiology : official journal of the German Cardiac Society (2021). https://www.ncbi.nlm.nih.gov/pubmed/34156524  

Safety of Contemporary Heart Failure Therapy in Patients with Continuous-Flow Left Ventricular Assist Devices. Schnettler, J. K., Roehrich, L., Just, I. A., Pergantis, P., Stein, J., Mueller, M., Mulzer, J., Knierim, J., Falk, V., Potapov, F. E. & Schoenrath, F. Journal of cardiac failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34157393  

Deep and accurate detection of m6A RNA modifications using miCLIP2 and m6Aboost machine learning. Kortel, N., Ruckle, C., Zhou, Y., Busch, A., Hoch-Kraft, P., Sutandy, F. X. R., Haase, J., Pradhan, M., Musheev, M., Ostareck, D., Ostareck-Lederer, A., Dieterich, C., Huttelmaier, S., Niehrs, C., Rausch, O., Dominissini, D., Konig, J. & Zarnack, K. Nucleic acids research (2021). https://www.ncbi.nlm.nih.gov/pubmed/34157120  

Ten-year clinical outcomes of polymer-free versus durable polymer new-generation drug-eluting stent in patients with coronary artery disease with and without diabetes mellitus : Results of the Intracoronary Stenting and Angiographic Results: Test Efficacy of Sirolimus- and Probucol- and Zotarolimus-Eluting Stents (ISAR-TEST 5) trial. Koch, T., Lenz, T., Joner, M., Xhepa, E., Koppara, T., Wiebe, J., Coughlan, J. J., Aytekin, A., Ibrahim, T., Kessler, T., Cassese, S., Laugwitz, K. L., Schunkert, H., Kastrati, A., Kufner, S., Intracoronary, S., Angiographic Results: Test Efficacy of, S. & Probucol-Eluting Versus Zotarolimus- Eluting Stents, I. Clinical research in cardiology : official journal of the German Cardiac Society (2021). https://www.ncbi.nlm.nih.gov/pubmed/34156521  

Transcatheter mitral valve repair may increase eligibility for heart transplant listing in patients with end-stage heart failure and severe secondary mitral regurgitation. Doldi, P. M., Buech, J., Orban, M., Samson-Himmelstjerna, P., Wilbert-Lampen, U., Hagl, C., Massberg, S., Nabauer, M., Hausleiter, J. & Braun, D. International journal of cardiology 338, 72-78 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34157353  

Assessing the (anti)-inflammatory potential of diets. Bahr, L. S., Franz, K. & Mahler, A. Current opinion in clinical nutrition and metabolic care (2021). https://www.ncbi.nlm.nih.gov/pubmed/34155152  

Accuracy of high-sensitive troponin depending on renal function for clinical outcome prediction in patients with acute heart failure. Ledwoch, J., Krauth, A., Kraxenberger, J., Schneider, A., Leidgschwendner, K., Schneider, V., Muller, A., Laugwitz, K. L., Kupatt, C. & Martens, E. Heart and vessels (2021). https://www.ncbi.nlm.nih.gov/pubmed/34152442  

Human BIN1 isoforms grow, maintain and regenerate excitation-contraction couplons in adult rat and human stem cell-derived cardiomyocytes. Guo, J., Tian, Q., Barth, M., Xian, W., Ruppenthal, S., Schaefers, H. J., Chen, Z., Moretti, A., Laugwitz, K. L. & Lipp, P. Cardiovascular research (2021). https://www.ncbi.nlm.nih.gov/pubmed/34152414  

The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression. Gentile, A., Bensimon-Brito, A., Priya, R., Maischein, H. M., Piesker, J., Guenther, S., Gunawan, F. & Stainier, D. Y. eLife 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34152269   

Mobile health for walking on the tightrope of optimal physical activity to reduce the risk of atrial fibrillation. Schnabel, R. B., Fabritz, L. & Kirchhof, P. European heart journal 42, 2484-2486 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34148079

The ACURATE neo2 valve system for transcatheter aortic valve implantation: 30-day and 1-year outcomes. Mollmann, H., Holzhey, D. M., Hilker, M., Toggweiler, S., Schafer, U., Treede, H., Joner, M., Sondergaard, L., Christen, T., Allocco, D. J. & Kim, W. K. Clinical research in cardiology : official journal of the German Cardiac Society (2021). https://www.ncbi.nlm.nih.gov/pubmed/34148125  

Takotsubo Syndrome-Is There a Need for CMR? Jensch, P. J., Stiermaier, T. & Eitel, I. Current heart failure reports 18, 200-210 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34148183

 

 

Eligibility for mechanical circulatory support devices based on current and past randomised cardiogenic shock trials. Schrage, B., Beer, B. N., Savarese, G., Dabboura, S., Yan, I., Sundermeyer, J., Becher, P. M., Grahn, H., Seiffert, M., Bernhardt, A., Thiele, H., Møller, J. E., Kluge, S., Reichenspurner, H., Kirchhof, P., Blankenberg, S. & Westermann, D. European journal of heart failure (2021).

Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease. Lacy, M., Bürger, C., Shami, A., Ahmadsei, M., Winkels, H., Nitz, K., van Tiel, C. M., Seijkens, T. T. P., Kusters, P. J. H., Karshovka, E., Prange, K. H. M., Wu, Y., Brouns, S. L. N., Unterlugauer, S., Kuijpers, M. J. E., Reiche, M. E., Steffens, S., Edsfeldt, A., Megens, R. T. A., Heemskerk, J. W. M. et al. Nature communications 12, 3754 (2021).

Expert opinion paper on cardiac imaging after ischemic stroke. Schnabel, R. B., Camen, S., Knebel, F., Hagendorff, A., Bavendiek, U., Böhm, M., Doehner, W., Endres, M., Gröschel, K., Goette, A., Huttner, H. B., Jensen, C., Kirchhof, P., Korosoglou, G., Laufs, U., Liman, J., Morbach, C., Nabavi, D. G., Neumann-Haefelin, T., Pfeilschifter, W. et al. Clinical Research in Cardiology (2021).

Pro-arrhythmic effects of elevated branched chain amino acid levels. Portero, V., Nicol, T., Podliesna, S., Marchal, G. A., Baartscheer, A., Casini, S., Tadros, R., Treur, J. L., Tanck, M. W. T., Cox, I. J., Probert, F., Hough, T. A., Falcone, S., Beekman, L., Müller-Nurasyid, M., Kastenmüller, G., Gieger, C., Peters, A., Kääb, S., Sinner, M. F. et al. Cardiovascular research (2021).

Total numbers and in-hospital mortality of patients with myocardial infarction in Germany during the FIFA soccer world cup 2014. Keller, K., Hobohm, L., Schmitt, V. H., Engelhardt, M., Wenzel, P., Post, F., Münzel, T., Gori, T. & Friedmann-Bette, B. Scientific reports 11, 11330 (2021).

Cardiovascular magnetic resonance demonstrates structural cardiac changes following transjugular intrahepatic portosystemic shunt. Radunski, U. K., Kluwe, J., Klein, M., Galante, A., Lund, G. K., Sinning, C., Bohnen, S., Tahir, E., Starekova, J., Bannas, P., Stehning, C., Adam, G., Lohse, A. W., Blankenberg, S., Muellerleile, K. & Benten, D. Scientific reports 11, 12719 (2021).

Plasma Proteomics of Renal Function: A Trans-ethnic Meta-analysis and Mendelian Randomization Study. Matías-García, P., Wilson, R., Guo, Q., Zaghlool, S., Eales, J., Xu, X., Charchar, F., Dormer, J., Maalmi, H., Schlosser, P., Elhadad, M., Nano, J., Sharma, S., Peters, A., Fornoni, A., Mook-Kanamori, D., Winkelmann, J., Danesh, J., Di Angelantonio, E., Ouwehand, W. et al. Journal of the American Society of Nephrology (2021).

Prognostic impact of echocardiographic mean transvalvular gradients in patients with aortic stenosis and low flow undergoing transcatheter aortic valve implantation. Fischer‐Rasokat, U., Renker, M., Liebetrau, C., Weferling, M., Rolf, A., Doss, M., Hamm, C. W. & Kim, W. K. Catheterization and Cardiovascular Interventions (2021).

Artificial intelligence‐based analysis of body composition in Marfan: skeletal muscle density and psoas muscle index predict aortic enlargement. Beetz, N. L., Maier, C., Shnayien, S., Trippel, T. D., Gehle, P., Fehrenbach, U. & Geisel, D. Journal of Cachexia, Sarcopenia and Muscle (2021).

Impact of Dose Reduction Strategies on Image Quality of Coronary CTA in Real World Clinical Practice: A Subanalysis of PROTECTION VI Registry Data. Stocker, T. J., Nühlen, N., Schmermund, A., Leipsic, J., Grove, E. L., Deseive, S., Bax, J. J., Maurovich-Horvat, P., Otton, J., Hadamitzky, M., Chen, M. Y., Naoum, C., Andreini, D., Rubinshtein, R., Massberg, S. & Hausleiter, J. American Journal of Roentgenology (2021).

Tubulin-folding cofactor E deficiency promotes vascular dysfunction by increased endoplasmic reticulum stress. Efentakis, P., Molitor, M., Kossmann, S., Bochenek, M. L., Wild, J., Lagrange, J., Finger, S., Jung, R., Karbach, S., Schäfer, K., Schulz, A., Wild, P., Münzel, T. & Wenzel, P. European heart journal (2021).

Ticagrelor or Prasugrel in Patients With Acute Coronary Syndrome Undergoing Complex Percutaneous Coronary Intervention. Coughlan, J. J., Aytekin, A., Ndrepepa, G., Schüpke, S., Bernlochner, I., Mayer, K., Neumann, F. J., Menichelli, M., Richardt, G., Wöhrle, J., Witzenbichler, B., Gewalt, S., Xhepa, E., Kufner, S., Sager, H. B., Joner, M., Ibrahim, T., Fusaro, M., Laugwitz, K. L., Schunkert, H. et al. Circulation: Cardiovascular Interventions, Circinterventions121010565 (2021).

Influence of Heart Rate on Image Quality and Radiation Dose Exposure in Coronary CT Angiography. Stocker, T. J., Leipsic, J., Chen, M. Y., Achenbach, S., Knuuti, J., Newby, D. & Hausleiter, J. Radiology, 210245 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34128722  

[Cardiac diagnostics after ischemic stroke or transitory ischemic attack]. Schnabel, R. B. & Hausler, K. G. Deutsche medizinische Wochenschrift 146, 801-808 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34130322  

Detection of relevant extracardiac findings on coronary computed tomography angiography vs. invasive coronary angiography. Laskowski, D., Feger, S., Bosserdt, M., Zimmermann, E., Mohamed, M., Kendziora, B., Rief, M., Dreger, H., Estrella, M. & Dewey, M. European radiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34129067  

Multiparametric Early Detection and Prediction of Cardiotoxicity Using Myocardial Strain, T1 and T2 Mapping, and Biochemical Markers: A Longitudinal Cardiac Resonance Imaging Study During 2 Years of Follow-Up. Giusca, S., Korosoglou, G., Montenbruck, M., Gersak, B., Schwarz, A. K., Esch, S., Kelle, S., Wulfing, P., Dent, S., Lenihan, D. & Steen, H. Circulation. Cardiovascular imaging 14, e012459 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34126756  

Efficacy and safety of ticagrelor versus prasugrel in smokers and nonsmokers with acute coronary syndromes. Lahu, S., Ndrepepa, G., Gewalt, S., Schupke, S., Pellegrini, C., Bernlochner, I., Aytekin, A., Neumann, F. J., Menichelli, M., Richardt, G., Cassese, S., Xhepa, E., Kufner, S., Sager, H. B., Joner, M., Ibrahim, T., Fusaro, M., Laugwitz, K. L., Schunkert, H., Kastrati, A. et al. International journal of cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34126130  

Outcome of patients with different clinical presentations of high-risk pulmonary embolism. Ebner, M., Sentler, C., Harjola, V. P., Bueno, H., Lerchbaumer, M. H., Hasenfuss, G., Eckardt, K. U., Konstantinides, S. V. & Lankeit, M. Eur Heart J Acute Cardiovasc Care (2021). https://www.ncbi.nlm.nih.gov/pubmed/34125186  

Ten-year trends in DMF-S and DMF-T in a north-east German adult population. Schmoeckel, J., Haq, J. A., Samietz, S., Santamaria, R. M., Mourad, M. S., Volzke, H., Kocher, T., Splieth, C. H. & Holtfreter, B. J Dent, 103727 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34119612  

COVID-19 related cardiac complications - from clinical evidences to basic mechanisms. Opinion paper of the ESC Working Group on Cellular Biology of the Heart. Pesce, M., Agostoni, P., Botker, H. E., Brundel, B., Davidson, S. M., De Caterina, R., Ferdinandy, P., Girao, H., Gyongyosi, M., Hulot, J. S., Lecour, S., Perrino, C., Schulz, R., Sluijter, J. P. G., Steffens, S., Tancevski, I., Gollmann-Tepekoylu, C., Tschope, C., van Linthout, S. & Madonna, R. Cardiovascular research (2021). https://www.ncbi.nlm.nih.gov/pubmed/34117887  

Incidence, predictors and clinical impact of permanent pacemaker insertion in women following transcatheter aortic valve implantation: Insights from a prospective multinational registry. Nicolas, J., Guedeney, P., Claessen, B. E., Mehilli, J., Petronio, A. S., Sartori, S., Lefevre, T., Presbitero, P., Capranzano, P., Iadanza, A., Cao, D., Chiarito, M., Goel, R., Roumeliotis, A., Chandiramani, R., Chen, S., Sardella, G., Van Mieghem, N. M., Sorrentino, S., Meliga, E. et al. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions (2021). https://www.ncbi.nlm.nih.gov/pubmed/34117817  

Rare variants in KDR, encoding VEGF Receptor 2, are associated with tetralogy of Fallot. Skoric-Milosavljevic, D., Lahrouchi, N., Bosada, F. M., Dombrowsky, G., Williams, S. G., Lesurf, R., Tjong, F. V. Y., Walsh, R., El Bouchikhi, I., Breckpot, J., Audain, E., Ilgun, A., Beekman, L., Ratbi, I., Strong, A., Muenke, M., Heide, S., Muir, A. M., Hababa, M., Cross, L. et al. Genet Med (2021). https://www.ncbi.nlm.nih.gov/pubmed/34113005  

Saturation recovery-prepared magnetic resonance angiography for assessment of left atrial and esophageal anatomy. Siebermair, J., Kholmovski, E. G., Sheffer, D., Schroeder, J., Jensen, L., Kheirkhahan, M., Baher, A. A., Ibrahim, M. M., Reiter, T., Rassaf, T., Wakili, R., Marrouche, N. F., McGann, C. J. & Wilson, B. D. The British journal of radiology 94, 20210048 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34111982  

Thrombus or No Thrombus: Is That the Embolic Question? Kirchhof, P. & Sinning, C. Journal of the American College of Cardiology 77, 2887-2889 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34112316

Progress in cardiac research - from rebooting cardiac regeneration to a complete cell atlas of the heart. Davidson, S. M., Padro, T., Bollini, S., Vilahur, G., Duncker, D. J., Evans, P. C., Guzik, T., Hoefer, I. E., Waltenberger, J., Wojta, J. & Weber, C. Cardiovascular research (2021). https://www.ncbi.nlm.nih.gov/pubmed/34114614  

Telmisartan induces a specific gut microbiota signature which may mediate its antiobesity effect. Beckmann, L., Kunstner, A., Freschi, M. L., Huber, G., Stolting, I., Ibrahim, S. M., Hirose, M., Freitag, M., Langan, E. A., Matschl, U., Galuska, C. E., Fuchs, B., Knobloch, J. K., Busch, H. & Raasch, W. Pharmacol Res 170, 105724 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34116209  

Differential regulation of KCa 2.1 (KCNN1) K(+) channel expression by histone deacetylases in atrial fibrillation with concomitant heart failure. Rahm, A. K., Wieder, T., Gramlich, D., Muller, M. E., Wunsch, M. N., El Tahry, F. A., Heimberger, T., Sandke, S., Weis, T., Most, P., Katus, H. A., Thomas, D. & Lugenbiel, P. Physiol Rep 9, e14835 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34111326  

Triglyceride-Rich Lipoproteins, Apolipoproteins, and Atherosclerotic Cardiovascular Events Among Patients with Diabetes Mellitus and End-Stage Renal Disease on Hemodialysis. Lamprea-Montealegre, J. A., Katz, R., Scharnagl, H., Silbernagel, G., Marz, W., Drechsler, C., Wanner, C. & de Boer, I. H. The American journal of cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34108090  

Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes. Goodrich, J. K., Singer-Berk, M., Son, R., Sveden, A., Wood, J., England, E., Cole, J. B., Weisburd, B., Watts, N., Caulkins, L., Dornbos, P., Koesterer, R., Zappala, Z., Zhang, H., Maloney, K. A., Dahl, A., Aguilar-Salinas, C. A., Atzmon, G., Barajas-Olmos, F., Barzilai, N. et al. Nature communications 12, 3505 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34108472  

Announcing the Editorial Board Fellowship Program of the American Journal of Physiology-Lung Cellular and Molecular Physiology. Shimoda, L. A., Bai, C., Bartlett, N. W., Bastarache, J. A., Feghali-Bostwick, C. A., Kuebler, W. M., Prakash, Y. S., Schmidt, E. P. & Morty, R. E. American journal of physiology. Lung cellular and molecular physiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34105373  

Relative Efficacy of Different Strategies for Inhibition of in Vitro Glycolysis. Fischer, M. M., Hannemann, A., Winter, T., Schafer, C., Petersmann, A. & Nauck, M. Clinical chemistry (2021). https://www.ncbi.nlm.nih.gov/pubmed/34104943  

Myocardial hypoxic stress mediates functional cardiac extracellular vesicle release. Anselmo, A., Frank, D., Papa, L., Viviani Anselmi, C., Di Pasquale, E., Mazzola, M., Panico, C., Clemente, F., Soldani, C., Pagiatakis, C., Hinkel, R., Thalmann, R., Kozlik-Feldmann, R., Miragoli, M., Carullo, P., Vacchiano, M., Chaves-Sanjuan, A., Santo, N., Losi, M. A., Ferrari, M. C. et al. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/34104945  

Frequency and phenotype of thalamic aphasia. Rangus, I., Fritsch, M., Endres, M., Udke, B. & Nolte, C. H. Journal of neurology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34100990  

The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets. Nording, H., Baron, L., Haberthur, D., Emschermann, F., Mezger, M., Sauter, M., Sauter, R., Patzelt, J., Knoepp, K., Nording, A., Meusel, M., Meyer-Saraei, R., Hlushchuk, R., Sedding, D., Borst, O., Eitel, I., Karsten, C. M., Feil, R., Pichler, B., Erdmann, J. et al. Nature communications 12, 3352 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34099640  

Chemodivergent manganese-catalyzed C-H activation: modular synthesis of fluorogenic probes. Kaplaneris, N., Son, J., Mendive-Tapia, L., Kopp, A., Barth, N. D., Maksso, I., Vendrell, M. & Ackermann, L. Nature communications 12, 3389 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34099672  

Antithrombotic therapy with or without aspirin after percutaneous coronary intervention or acute coronary syndrome in patients taking oral anticoagulation: A meta-analysis and network analysis of randomized controlled trials. Colleran, R., Byrne, R. A., Ndrepepa, G., Alvarez-Covarrubias, H. A., Mayer, K., Kuna, C., Rai, H., Kastrati, A. & Cassese, S. Cardiovascular revascularization medicine : including molecular interventions (2021). https://www.ncbi.nlm.nih.gov/pubmed/34099410  

Glucocorticoid induced TNF receptor family-related protein (GITR) - A novel driver of atherosclerosis. Bosmans, L. A., Shami, A., Atzler, D., Weber, C., Goncalves, I. & Lutgens, E. Vascul Pharmacol, 106884 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34102305  

Analyzing Long-Term Electrocardiography Recordings to Detect Arrhythmias in Mice. Tomsits, P., Chataut, K. R., Chivukula, A. S., Mo, L., Xia, R., Schuttler, D. & Clauss, S. Journal of visualized experiments : JoVE (2021). https://www.ncbi.nlm.nih.gov/pubmed/34096914   

Cardiac Response to beta-Adrenergic Stimulation Determined by Pressure-Volume Loop Analysis. Medert, R., Bacmeister, L., Segin, S., Freichel, M. & Camacho Londono, J. E. Journal of visualized experiments : JoVE (2021). https://www.ncbi.nlm.nih.gov/pubmed/34096910  

Inflammation and Cardiovascular Disease: The Future. Arnold, N., Lechner, K., Waldeyer, C., Shapiro, M. D. & Koenig, W. Eur Cardiol 16, e20 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34093741  

Cardiac biomarkers in chronic kidney disease are independently associated with myocardial edema and diffuse fibrosis by cardiovascular magnetic resonance. Arcari, L., Engel, J., Freiwald, T., Zhou, H., Zainal, H., Gawor, M., Buettner, S., Geiger, H., Hauser, I., Nagel, E. & Puntmann, V. O. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 23, 71 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34092229  

Direct comparison of inorganic nitrite and nitrate on vascular dysfunction and oxidative damage in experimental arterial hypertension. Stamm, P., Oelze, M., Steven, S., Kroller-Schon, S., Kvandova, M., Kalinovic, S., Jasztal, A., Kij, A., Kuntic, M., Bayo Jimenez, M. T., Proniewski, B., Li, H., Schulz, E., Chlopicki, S., Daiber, A. & Munzel, T. Nitric Oxide 113-114, 57-69 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34091009  

Meta-analysis of epigenome-wide association studies of carotid intima-media thickness. Portilla-Fernandez, E., Hwang, S. J., Wilson, R., Maddock, J., Hill, W. D., Teumer, A., Mishra, P. P., Brody, J. A., Joehanes, R., Ligthart, S., Ghanbari, M., Kavousi, M., Roks, A. J. M., Danser, A. H. J., Levy, D., Peters, A., Ghasemi, S., Schminke, U., Dorr, M., Grabe, H. J. et al. European journal of epidemiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34091768  

A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression. Zacharias, H. U., Hertel, J., Johar, H., Pietzner, M., Lukaschek, K., Atasoy, S., Kunze, S., Volzke, H., Nauck, M., Friedrich, N., Kastenmuller, G., Grabe, H. J., Gieger, C., Krumsiek, J. & Ladwig, K. H. Molecular psychiatry (2021). https://www.ncbi.nlm.nih.gov/pubmed/34088979  

Visualization of beta-adrenergic receptor dynamics and differential localization in cardiomyocytes. Bathe-Peters, M., Gmach, P., Boltz, H. H., Einsiedel, J., Gotthardt, M., Hubner, H., Gmeiner, P., Lohse, M. J. & Annibale, P. Proceedings of the National Academy of Sciences of the United States of America 118 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34088840   

Population Pharmacokinetics and Pharmacodynamics of Vericiguat in Patients with Heart Failure and Reduced Ejection Fraction. Ruehs, H., Klein, D., Frei, M., Grevel, J., Austin, R., Becker, C., Roessig, L., Pieske, B., Garmann, D. & Meyer, M. Clin Pharmacokinet (2021). https://www.ncbi.nlm.nih.gov/pubmed/34086190  

Mental involvement in heart failure. Doehner, W. Rev Port Cardiol (Engl Ed) (2021). https://www.ncbi.nlm.nih.gov/pubmed/34083100   

Reclassification, Thromboembolic, and Major Bleeding Outcomes Using Different Estimates of Renal Function in Anticoagulated Patients With Atrial Fibrillation: Insights From the PREFER-in-AF and PREFER-in-AF Prolongation Registries. Rohla, M., Pecen, L., Cemin, R., Patti, G., Siller-Matula, J. M., Schnabel, R. B., Huber, K., Kirchhof, P. & De Caterina, R. Circ Cardiovasc Qual Outcomes 14, e006852 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34078099  

Methodology for comprehensive cell-level analysis of wound healing experiments using deep learning in MATLAB. Oldenburg, J., Maletzki, L., Strohbach, A., Belle, P., Siewert, S., Busch, R., Felix, S. B., Schmitz, K. P. & Stiehm, M. BMC Mol Cell Biol 22, 32 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34078283   

DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function. Matias-Garcia, P. R., Ward-Caviness, C. K., Raffield, L. M., Gao, X., Zhang, Y., Wilson, R., Gao, X., Nano, J., Bostom, A., Colicino, E., Correa, A., Coull, B., Eaton, C., Hou, L., Just, A. C., Kunze, S., Lange, L., Lange, E., Lin, X., Liu, S. et al. Clinical epigenetics 13, 121 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34078457   

Chronic Kidney Disease and Cerebrovascular Disease: Consensus and Guidance From a KDIGO Controversies Conference. Kelly, D. M., Ademi, Z., Doehner, W., Lip, G. Y. H., Mark, P., Toyoda, K., Wong, C. X., Sarnak, M., Cheung, M., Herzog, C. A., Johansen, K. L., Reinecke, H. & Sood, M. M. Stroke, STROKEAHA120029680 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34078109  

The effect of intravenous ferric carboxymaltose on health-related quality of life in iron-deficient patients with acute heart failure: the results of the AFFIRM-AHF study. Jankowska, E. A., Kirwan, B. A., Kosiborod, M., Butler, J., Anker, S. D., McDonagh, T., Dorobantu, M., Drozdz, J., Filippatos, G., Keren, A., Khintibidze, I., Kragten, H., Martinez, F. A., Metra, M., Milicic, D., Nicolau, J. C., Ohlsson, M., Parkhomenko, A., Pascual-Figal, D. A., Ruschitzka, F. et al. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/34080008  

Risk stratification of patients with Brugada syndrome : The impact of myocardial strain analysis using cardiac magnetic resonance feature tracking. Hohneck, A., Overhoff, D., Rutsch, M., Rudic, B., Tulumen, E., Wolpert, C., Hetjens, S., Akin, I., Borggrefe, M. & Papavassiliu, T. Hellenic J Cardiol (2021). https://www.ncbi.nlm.nih.gov/pubmed/34082115  

Going after COVID-19 myocarditis. Doeblin, P. & Kelle, S. European heart journal cardiovascular Imaging (2021). https://www.ncbi.nlm.nih.gov/pubmed/34080005  

Comparison of genetic risk prediction models to improve prediction of coronary heart disease in two large cohorts of the MONICA/KORA study. Bauer, A., Zierer, A., Gieger, C., Buyukozkan, M., Muller-Nurasyid, M., Grallert, H., Meisinger, C., Strauch, K., Prokisch, H., Roden, M., Peters, A., Krumsiek, J., Herder, C., Koenig, W., Thorand, B. & Huth, C. Genetic epidemiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34082474   

Impact of fully automated assessment on interstudy reproducibility of biventricular volumes and function in cardiac magnetic resonance imaging. Backhaus, S. J., Schuster, A., Lange, T., Stehning, C., Billing, M., Lotz, J., Pieske, B., Hasenfuss, G., Kelle, S. & Kowallick, J. T. Scientific reports 11, 11648 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34078942  

The C0-C1f Region of Cardiac Myosin Binding Protein-C Induces Pro-Inflammatory Responses in Fibroblasts via TLR4 Signaling. Yogeswaran, A., Troidl, C., McNamara, J. W., Wilhelm, J., Truschel, T., Widmann, L., Aslam, M., Hamm, C. W., Sadayappan, S. & Lipps, C. Cells 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34073556   

The Amino Acid Transporter Mct10/Tat1 Is Important to Maintain the TSH Receptor at Its Canonical Basolateral Localization and Assures Regular Turnover of Thyroid Follicle Cells in Male Mice. Venugopalan, V., Al-Hashimi, A., Weber, J., Rehders, M., Qatato, M., Wirth, E. K., Schweizer, U., Heuer, H., Verrey, F. & Brix, K. International journal of molecular sciences 22 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34071318  

Alexithymia is associated with reduced vitamin D levels, but not polymorphisms of the vitamin D binding-protein gene. Terock, J., Hannemann, A., Weihs, A., Janowitz, D. & Grabe, H. J. Psychiatr Genet (2021). https://www.ncbi.nlm.nih.gov/pubmed/34074948  

Age-Related Alterations in the Testicular Proteome of a Non-Human Primate. Stockl, J. B., Schmid, N., Flenkenthaler, F., Drummer, C., Behr, R., Mayerhofer, A., Arnold, G. J. & Frohlich, T. Cells 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34074003  

Outcome of Unilateral Pulmonary Edema after Minimal-Invasive Mitral Valve Surgery: 10-Year Follow-Up. Puehler, T., Friedrich, C., Lutter, G., Kornhuber, M., Salem, M., Schoettler, J., Ernst, M., Saad, M., Seoudy, H., Frank, D., Schoeneich, F., Cremer, J. & Haneya, A. Journal of clinical medicine 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34072399  

Macrophage Migration Inhibitory Factor-An Innovative Indicator for Free Flap Ischemia after Microsurgical Reconstruction. Megas, I. F., Simons, D., Kim, B. S., Stoppe, C., Piatkowski, A., Fikatas, P., Fuchs, P. C., Bastiaanse, J., Pallua, N., Bernhagen, J. & Grieb, G. Healthcare (Basel) 9 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34063809  

Ten-Year Clinical Outcomes of Biodegradable Versus Durable Polymer New-Generation Drug-Eluting Stent in Patients With Coronary Artery Disease With and Without Diabetes Mellitus. Lenz, T., Koch, T., Joner, M., Xhepa, E., Wiebe, J., Coughlan, J. J., Aytekin, A., Ibrahim, T., Fusaro, M., Cassese, S., Laugwitz, K. L., Schunkert, H., Kastrati, A., Kufner, S. & dagger, I.-T. I. Journal of the American Heart Association 10, e020165 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34075784  

Effect of Differences in the Microbiome of Cyp17a1-Deficient Mice on Atherosclerotic Background. Kunstner, A., Aherrahrou, R., Hirose, M., Bruse, P., Ibrahim, S. M., Busch, H., Erdmann, J. & Aherrahrou, Z. Cells 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34070975  

Effects of Dietary Protein Intake on Cutaneous and Systemic Inflammation in Mice with Acute Experimental Psoriasis. Knopp, T., Bieler, T., Jung, R., Ringen, J., Molitor, M., Jurda, A., Munzel, T., Waisman, A., Wenzel, P., Karbach, S. H. & Wild, J. Nutrients 13 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34072973  

Exercise intensity assessment and prescription in cardiovascular rehabilitation and beyond: why and how: a position statement from the Secondary Prevention and Rehabilitation Section of the European Association of Preventive Cardiology. Hansen, D., Abreu, A., Ambrosetti, M., Cornelissen, V., Gevaert, A., Kemps, H., Laukkanen, J. A., Pedretti, R., Simonenko, M., Wilhelm, M., Davos, C. H., Doehner, W., Iliou, M. C., Krankel, N., Voller, H. & Piepoli, M. European journal of preventive cardiology (2021). www.ncbi.nlm.nih.gov/pubmed/34077542

Coronary Vasculitis. Gori, T. Biomedicines 9 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34072772  

Low-Dose Empagliflozin Improves Systolic Heart Function after Myocardial Infarction in Rats: Regulation of MMP9, NHE1, and SERCA2a. Goerg, J., Sommerfeld, M., Greiner, B., Lauer, D., Seckin, Y., Kulikov, A., Ivkin, D., Kintscher, U., Okovityi, S. & Kaschina, E. International journal of molecular sciences 22 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34063987  

Comparative Transcriptomics of Immune Checkpoint Inhibitor Myocarditis Identifies Guanylate Binding Protein 5 and 6 Dysregulation. Finke, D., Heckmann, M. B., Salatzki, J., Riffel, J., Herpel, E., Heinzerling, L. M., Meder, B., Volkers, M., Muller, O. J., Frey, N., Katus, H. A., Leuschner, F., Kaya, Z. & Lehmann, L. H. Cancers 13 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34065419  

Toll-Like Receptors: Are They Taking a Toll on the Heart in Viral Myocarditis? Favere, K., Bosman, M., Klingel, K., Heymans, S., Van Linthout, S., Delputte, P. L., De Sutter, J., Heidbuchel, H. & Guns, P. J. Viruses 13 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34072044  

Implications of SGLT Inhibition on Redox Signalling in Atrial Fibrillation. Bode, D., Semmler, L., Oeing, C. U., Alogna, A., Schiattarella, G. G., B, M. P., Heinzel, F. R. & Hohendanner, F. International journal of molecular sciences 22 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34073033  

Pharmacological inhibition of adipose tissue Adipose Triglyceride Lipase (ATGL) by Atglistatin prevents catecholamine-induced myocardial damage. Thiele, A., Luettges, K., Ritter, D., Beyhoff, N., Smeir, E., Grune, J., Steinhoff, J. S., Schupp, M., Klopfleisch, R., Rothe, M., Wilck, N., Bartolomaeus, H., Migglautsch, A. K., Breinbauer, R., Kershaw, E. E., Grabner, G. F., Zechner, R., Kintscher, U. & Foryst-Ludwig, A. Cardiovascular research (2021). https://www.ncbi.nlm.nih.gov/pubmed/34061169  

Association between different dimensions of childhood traumatization and plasma micro-RNA levels in a clinical psychiatric sample. Van der Auwera, S., Ameling, S., Nauck, M., Volzke, H., Volker, U. & Grabe, H. J. J Psychiatr Res 139, 113-119 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34058649  

Successful Case of Adjunctive Intravenous Bacteriophage Therapy to treat Left Ventricular Assist Device Infection. Tkhilaishvili, T., Merabishvili, M., Pirnay, J. P., Starck, C., Potapov, E., Falk, V. & Schoenrath, F. J Infect (2021). https://www.ncbi.nlm.nih.gov/pubmed/34058260  

Cardiovascular magnetic resonance detects microvascular dysfunction in a mouse model of hypertrophic cardiomyopathy. Ku, M. C., Kober, F., Lai, Y. C., Pohlmann, A., Qadri, F., Bader, M., Carrier, L. & Niendorf, T. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 23, 63 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34053450


May

Trigger-Specific Remodeling of K(Ca)2 Potassium Channels in Models of Atrial Fibrillation. Rahm, A. K., Gramlich, D., Wieder, T., Müller, M. E., Schoeffel, A., El Tahry, F. A., Most, P., Heimberger, T., Sandke, S., Weis, T., Ullrich, N. D., Korff, T., Lugenbiel, P., Katus, H. A. & Thomas, D. Pharmgenomics Pers Med 14, 579-590 (2021).

Heart Failure Association, Heart Failure Society of America, and Japanese Heart Failure Society Position Statement on Endomyocardial Biopsy. Seferovic, P. M., Tsutsui, H., McNamara, D. M., Ristic, A. D., Basso, C., Bozkurt, B., Cooper, L. T., Filippatos, G., Ide, T., Inomata, T., Klingel, K., Linhart, A., Lyon, A. R., Mehra, M. R., Polovina, M., Milinkovic, I., Nakamura, K., Anker, S. D., Veljic, I., Ohtani, T., Okumura, T., Thum, T., Tschope, C., Rosano, G., Coats, A. J. S. & Starling, R. C. Journal of cardiac failure 27, 727-743 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34022400  

The smoking paradox in ischemic stroke patients treated with intra-arterial thrombolysis in combination with mechanical thrombectomy-VISTA-Endovascular. Kufner, A., Ali, H. F., Ebinger, M., Fiebach, J. B., Liebeskind, D. S., Endres, M. & Siegerink, B. PloS one 16, e0251888 (2021).

CD200 Limits Monopoiesis and Monocyte Recruitment in Atherosclerosis. Kassiteridi, C., Cole, J. E., Griseri, T., Falck-Hansen, M., Goddard, M. E., Seneviratne, A. N., Green, P. A., Park, I., Shami, A. G., Pattarabanjird, T., Upadhye, A., Taylor, A. M., Handa, A., Channon, K. M., Lutgens, E., McNamara, C. A., Williams, R. O. & Monaco, C. Circulation research 129, 280-295 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33975450  

Work-life conflict and cardiovascular health: 5-year follow-up of the Gutenberg Health Study. Hegewald, J., Romero Starke, K., Garthus-Niegel, S., Schulz, A., Nübling, M., Latza, U., Jankowiak, S., Liebers, F., Rossnagel, K., Riechmann-Wolf, M., Letzel, S., Arnold, N., Beutel, M., Gianicolo, E., Pfeiffer, N., Lackner, K., Münzel, T., Wild, P. & Seidler, A. PloS one 16, e0251260 (2021).

Feasibility of fast cardiovascular magnetic resonance strain imaging in patients presenting with acute chest pain. Riffel, J. H., Siry, D., Salatzki, J., Andre, F., Ochs, M., Weberling, L. D., Giannitsis, E., Katus, H. A. & Friedrich, M. G. PloS one 16, e0251040 (2021).

 

Incidence and Clinical Impact of Right Ventricular Involvement (Biventricular ballooning)in Takotsubo syndrome: Results from the GEIST Registry. El-Battrawy, I., Santoro, F., Stiermaier, T., Moller, C., Guastafierro, Novo, G., Novo, S., Mariano, E., Romeo, F., Romeo, F., Thiele, H., Guerra, F., Capucci, A., Giannini, I., Brunetti, N. D., Eitel, I. & Akin, I. Chest (2021). https://www.ncbi.nlm.nih.gov/pubmed/34052189  

Effect of periodontal treatment on preclinical Alzheimer's disease-Results of a trial emulation approach. Schwahn, C., Frenzel, S., Holtfreter, B., Van der Auwera, S., Pink, C., Bulow, R., Friedrich, N., Volzke, H., Biffar, R., Kocher, T., Grabe, H. J. & Alzheimer's Disease Neuroimaging, I. Alzheimer's & dementia : the journal of the Alzheimer's Association (2021). https://www.ncbi.nlm.nih.gov/pubmed/34050719  

Roles of allostatic load, lifestyle and clinical risk factors in mediating the association between education and coronary heart disease risk in Europe. Hicks, B., Veronesi, G., Ferrario, M. M., Forrest, H., Whitehead, M., Diderichsen, F., Tunstall-Pedoe, H., Kuulasmaa, K., Sans, S., Salomaa, V., Thorand, B., Peters, A., Soderberg, S., Cesana, G., Bobak, M., Iacoviello, L., Palmieri, L., Zeller, T., Blankenberg, S., Kee, F. et al. J Epidemiol Community Health (2021). https://www.ncbi.nlm.nih.gov/pubmed/34049926  

Prognostic value of right atrial dilation in patients with pulmonary embolism. Lerchbaumer, M. H., Ebner, M., Ritter, C. O., Steimke, L., Rogge, N. I. J., Sentler, C., Thielmann, A., Hobohm, L., Keller, K., Lotz, J., Hasenfuss, G., Wachter, R., Hamm, B., Konstantinides, S. V., Aviram, G. & Lankeit, M. ERJ Open Res 7 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34046488

Author Correction: Optoacoustic imaging in endocrinology and metabolism. Karlas, A., Pleitez, M. A., Aguirre, J. & Ntziachristos, V. Nat Rev Endocrinol (2021). https://www.ncbi.nlm.nih.gov/pubmed/34045732

Homoarginine and blood pressure: a 10-year prospective relationship in normotensives. Mokhaneli, M. C., Botha-Le Roux, S., Fourie, C. M. T., Boger, R., Schwedhelm, E. & Mels, C. M. C. J Hum Hypertens (2021). https://www.ncbi.nlm.nih.gov/pubmed/34040153  

The non-invasive assessment of myocardial work by pressure-strain analysis: clinical applications. Abawi, D., Rinaldi, T., Faragli, A., Pieske, B., Morris, D. A., Kelle, S., Tschope, C., Zito, C. & Alogna, A. Heart failure reviews (2021). https://www.ncbi.nlm.nih.gov/pubmed/34041679  

Cardiac phenotype and tissue sodium content in adolescents with defects in the melanocortin system. Puder, L., Roth, S., Krabusch, P., Wiegand, S., Opitz, R., Bald, M., Fluck, C., Schulz, E., Voss, E., Marko, L., Linz, P., Berger, F., Muller, D. N., Kuehne, T., Litt, M. J., Cone, R. D., Kuhnen, P. & Kelm, M. The Journal of clinical endocrinology and metabolism (2021). https://www.ncbi.nlm.nih.gov/pubmed/34036349

Membrane-destabilizing ionizable phospholipids: Novel components for organ-selective mRNA delivery and CRISPR-Cas gene editing. Meng, N. & Grimm, D. Signal Transduct Target Ther 6, 206 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34035211  

Additive contribution of microRNA-34a/b/c to human arterial ageing and atherosclerosis. Gatsiou, A., Georgiopoulos, G., Vlachogiannis, N. I., Pfisterer, L., Fischer, A., Sachse, M., Laina, A., Bonini, F., Delialis, D., Tual-Chalot, S., Zormpas, E., Achangwa, R., Jiang, L., Kontogiannis, C., Patras, R., Hermeking, H., Zeiher, A. M., Stamatelopoulos, K., Dimmeler, S. & Stellos, K. Atherosclerosis 327, 49-58 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34038763  

Tricento transcatheter heart valve implantation in a redo setting for the treatment of torrential tricuspid valve regurgitation. Van Praet, K. M., Kukucka, M., Kofler, M., Klein, C., Falk, V., Kempfert, J. & Unbehaun, A. Multimed Man Cardiothorac Surg 2021 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34032394  

Effects of Marathon Running on Cognition and Retinal Vascularization: A Longitudinal Observational Study. Roeh, A., Schoenfeld, J., Raab, R., Landes, V., Papazova, I., Haller, B., Strube, W., Halle, M., Falkai, P., Hasan, A. & Scherr, J. Medicine and science in sports and exercise (2021). https://www.ncbi.nlm.nih.gov/pubmed/34033620   

Clinical utility gene card for: Long-QT syndrome. Beckmann, B. M., Scheiper-Welling, S., Wilde, A. A. M., Kaab, S., Schulze-Bahr, E. & Kauferstein, S. European journal of human genetics : EJHG (2021). https://www.ncbi.nlm.nih.gov/pubmed/34031550  

Treatment of atrial fibrillation with doxapram: TASK-1 potassium channel inhibition as a novel pharmacological strategy. Wiedmann, F., Beyersdorf, C., Zhou, X. B., Kraft, M., Paasche, A., Javorszky, N., Rinne, S., Sutanto, H., Buscher, A., Foerster, K. I., Blank, A., El-Battrawy, I., Li, X., Lang, S., Tochtermann, U., Kremer, J., Arif, R., Karck, M., Decher, N., van Loon, G. et al. Cardiovascular research (2021). https://www.ncbi.nlm.nih.gov/pubmed/34028533  

Arrhythmia Mechanism and Dynamics in a Humanized Mouse Model of Inherited Cardiomyopathy Due to Phospholamban R14del Mutation. Raad, N., Bittihn, P., Cacheux, M., Jeong, D., Ilkan, Z., Ceholski, D., Kohlbrenner, E., Zhang, L., Cai, C. L., Kranias, E. G., Hajjar, R. J., Stillitano, F. & Akar, F. G. Circulation (2021). https://www.ncbi.nlm.nih.gov/pubmed/34024116  

Safety and efficacy of coronary sinus narrowing in chronic refractory angina: Insights from the RESOURCE study. Ponticelli, F., Khokhar, A. A., Leenders, G., Konigstein, M., Zivelonghi, C., Agostoni, P., van Kuijk, J. P., Ajmi, I., Lindsay, S., Bunc, M., Tebaldi, M., Cafaro, A., Cheng, K., Ielasi, A., Patterson, T., Wolter, J. S., Sgura, F., De Marco, F., Ioanes, D., D'Amico, G. et al. International journal of cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/34029618  

Comprehensive Computed Tomography Imaging of Vessel-specific and Lesion-specific Myocardial Ischemia. Patel, P., Emrich, T., Schoepf, U. J., Mehta, V., Bayer, R. R., von Assen, M., Giovagnoli, V., Jeudy, J., Varga-Szemes, A. & White, C. Journal of thoracic imaging (2021). https://www.ncbi.nlm.nih.gov/pubmed/34029280  

Insights into therapeutic products, preclinical research models, and clinical trials in cardiac regenerative and reparative medicine: where are we now and the way ahead. Current opinion paper of the ESC Working Group on Cardiovascular Regenerative and Reparative Medicine. Grigorian-Shamagian, L., Sanz-Ruiz, R., Climent, A., Badimon, L., Barile, L., Bolli, R., Chamuleau, S., Grobbee, D. E., Janssens, S., Kastrup, J., Kragten-Tabatabaie, L., Madonna, R., Mathur, A., Menasche, P., Pompilio, G., Prosper, F., Sena, E., Smart, N., Zimmermann, W. H. & Fernandez-Aviles, F. Cardiovascular research 117, 1428-1433 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33258961  

Significance of Mast Cell Formed Extracellular Traps in Microbial Defense. Elieh Ali Komi, D. & Kuebler, W. M. Clin Rev Allergy Immunol, 1-20 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34024033  

Comparison of cine and real-time cardiac MRI in rhesus macaques. Moussavi, A., Missbach, S., Serrano Ferrel, C., Ghasemipour, H., Kotz, K., Drummer, C., Behr, R., Zimmermann, W. H. & Boretius, S. Scientific reports 11, 10713 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34021218  

Point-of-care lung ultrasound in COVID-19 patients: inter- and intra-observer agreement in a prospective observational study. Lerchbaumer, M. H., Lauryn, J. H., Bachmann, U., Enghard, P., Fischer, T., Grune, J., Hegemann, N., Khadzhynov, D., Kruse, J. M., Lehner, L. J., Lindner, T., Oezkan, T., Zickler, D., Kuebler, W. M., Hamm, B., Eckardt, K. U. & Muench, F. Scientific reports 11, 10678 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34021219   

Durable mechanical circulatory support in patients with heart failure with preserved ejection fraction. Lanmueller, P., Eulert-Grehn, J. J., Schoenrath, F., Pieske, B., Mulzer, J., Mueller, M., Falk, V. & Potapov, E. Interactive cardiovascular and thoracic surgery (2021). https://www.ncbi.nlm.nih.gov/pubmed/34021333  

Systematic monitoring for detection of atrial fibrillation in patients with acute ischaemic stroke (MonDAFIS): a randomised, open-label, multicentre study. Haeusler, K. G., Kirchhof, P., Kunze, C., Tutuncu, S., Fiessler, C., Malsch, C., Olma, M. C., Jawad-Ul-Qamar, M., Kramer, M., Wachter, R., Michalski, D., Kraft, A., Rizos, T., Groschel, K., Thomalla, G., Nabavi, D. G., Rother, J., Laufs, U., Veltkamp, R., Heuschmann, P. U. et al. Lancet Neurol 20, 426-436 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34022169  

Emergency department management of patients with adult congenital heart disease: a consensus paper from the ESC Working Group on Adult Congenital Heart Disease, the European Society for Emergency Medicine (EUSEM), the European Association for Cardio-Thoracic Surgery (EACTS), and the Association for Acute Cardiovascular Care (ACVC). Chessa, M., Brida, M., Gatzoulis, M. A., Diller, G. P., Roos-Hesselink, J. W., Dimopoulos, K., Behringer, W., Mockel, M., Giamberti, A., Galletti, L., Price, S., Baumgartner, H., Gallego, P. & Tutarel, O. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/34021343  

Stent Thrombosis in Patients Treated for Acute or Chronic Coronary Syndrome. Kastrati, A., Coughlan, J. J. & Pellegrini, C. JACC. Cardiovascular interventions 14, 1091-1093 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34016405  

Antithrombotic therapy for stroke prevention in patients with atrial fibrillation who survive an intracerebral haemorrhage: results of an EHRA survey. Ivany, E., Lane, D. A., Dan, G. A., Doehner, W., Farkowski, M. M., Iliodromitis, K., Lenarczyk, R. & Potpara, T. S. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 23, 806-814 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34020460  

Ruthenium(II)- and Palladium(II)-catalyzed position-divergent CH oxygenations of arylated quinones: Identification of hydroxylated quinonoid compounds with potent trypanocidal activity. Gontijo, T. B., de Carvalho, R. L., Dantas-Pereira, L., Menna-Barreto, R. F. S., Rogge, T., Ackermann, L. & da Silva Junior, E. N. Bioorg Med Chem 40, 116164 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34020276  

Metabolic syndrome and the plasma proteome: from association to causation. Elhadad, M. A., Wilson, R., Zaghlool, S. B., Huth, C., Gieger, C., Grallert, H., Graumann, J., Rathmann, W., Koenig, W., Sinner, M. F., Hveem, K., Suhre, K., Thorand, B., Jonasson, C., Waldenberger, M. & Peters, A. Cardiovascular diabetology 20, 111 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34016094  

Let-7f miRNA regulates SDF-1alpha- and hypoxia-promoted migration of mesenchymal stem cells and attenuates mammary tumor growth upon exosomal release. Egea, V., Kessenbrock, K., Lawson, D., Bartelt, A., Weber, C. & Ries, C. Cell death & disease 12, 516 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34016957  

HAND2 is a novel obesity-linked adipogenic transcription factor regulated by glucocorticoid signalling. Giroud, M., Tsokanos, F. F., Caratti, G., Kotschi, S., Khani, S., Jouffe, C., Vogl, E. S., Irmler, M., Glantschnig, C., Gil-Lozano, M., Hass, D., Khan, A. A., Garcia, M. R., Mattijssen, F., Maida, A., Tews, D., Fischer-Posovszky, P., Feuchtinger, A., Virtanen, K. A., Beckers, J. et al. Diabetologia (2021). https://www.ncbi.nlm.nih.gov/pubmed/34014371  

Improving 1-year mortality prediction in ACS patients using machine learning. Weichwald, S., Candreva, A., Burkholz, R., Klingenberg, R., Raber, L., Heg, D., Manka, R., Gencer, B., Mach, F., Nanchen, D., Rodondi, N., Windecker, S., Laaksonen, R., Hazen, S. L., von Eckardstein, A., Ruschitzka, F., Luscher, T. F., Buhmann, J. M. & Matter, C. M. Eur Heart J Acute Cardiovasc Care (2021). https://www.ncbi.nlm.nih.gov/pubmed/34015112  

Increased angiotensin II formation in the brain modulates cardiovascular homeostasis and erythropoiesis. Rodrigues, A. F., Todiras, M., Qadri, F., Campagnole-Santos, M. J., Alenina, N. & Bader, M. Clin Sci (Lond) 135, 1353-1367 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34013320  

Ethnic comparison in takotsubo syndrome: novel insights from the International Takotsubo Registry. Imori, Y., Kato, K., Cammann, V. L., Szawan, K. A., Wischnewsky, M., Dreiding, S., Wurdinger, M., Schonberger, M., Petkova, V., Niederseer, D., Levinson, R. A., Di Vece, D., Gili, S., Seifert, B., Wakita, M., Suzuki, N., Citro, R., Bossone, E., Heiner, S., Knorr, M. et al. Clinical research in cardiology : official journal of the German Cardiac Society (2021). https://www.ncbi.nlm.nih.gov/pubmed/34013386  

Electrocardiographic parameters of left ventricular hypertrophy and prediction of mortality in hemodialysis patients. Braunisch, M. C., Gundel, P., Werfel, S., Mayer, C. C., Bauer, A., Haller, B., Gunthner, R., Lorenz, G., Angermann, S., Matschkal, J., Schaller, C., Holzmann-Littig, C., Kemmner, S., Mann, J., Krieter, A., Renders, L., Wassertheurer, S., Schmidt, G., Heemann, U., Malik, M. et al. J Nephrol (2021). https://www.ncbi.nlm.nih.gov/pubmed/34014512  

Simulating the dynamics of atherosclerosis to the incidence of myocardial infarction, applied to the KORA population. Simonetto, C., Rospleszcz, S., Heier, M., Meisinger, C., Peters, A. & Kaiser, J. C. Statistics in medicine 40, 3299-3312 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34008245  

Heart Failure Association of the ESC, Heart Failure Society of America and Japanese Heart Failure Society Position statement on endomyocardial biopsy. Seferovic, P. M., Tsutsui, H., McNamara, D. M., Ristic, A. D., Basso, C., Bozkurt, B., Cooper, L. T., Jr., Filippatos, G., Ide, T., Inomata, T., Klingel, K., Linhart, A., Lyon, A. R., Mehra, M. R., Polovina, M., Milinkovic, I., Nakamura, K., Anker, S. D., Veljic, I., Ohtani, T. et al. European journal of heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34010472  

Sphingosine-1-Phosphate, Motor Severity, and Progression in Parkinson's Disease (MARK-PD). Schwedhelm, E., Englisch, C., Niemann, L., Lezius, S., von Lucadou, M., Marmann, K., Boger, R., Peine, S., Daum, G., Gerloff, C. & Choe, C. U. Movement disorders : official journal of the Movement Disorder Society (2021). https://www.ncbi.nlm.nih.gov/pubmed/34008894  

Initial experience with the new type A arch dissection stent: restoration of supra-aortic vessel perfusion. Montagner, M., Kofler, M., Heck, R., Buz, S., Starck, C., Kurz, S., Falk, V. & Kempfert, J. Interactive cardiovascular and thoracic surgery (2021). https://www.ncbi.nlm.nih.gov/pubmed/34010408

Common atrioventricular valve surgery in children with functional single ventricle. Mayr, B., Burri, M., Strbad, M., Cleuziou, J., Hager, A., Ewert, P., Horer, J., Lange, R. & Ono, M. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021). https://www.ncbi.nlm.nih.gov/pubmed/34008032  

Low serum TSH levels are associated with low values of fat-free mass and body cell mass in the elderly. Ittermann, T., Markus, M. R. P., Bahls, M., Felix, S. B., Steveling, A., Nauck, M., Volzke, H. & Dorr, M. Scientific reports 11, 10547 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34006958  

Adipocyte calcium sensing receptor is not involved in visceral adipose tissue inflammation or atherosclerosis development in hyperlipidemic Apoe(-/-) mice. Sundararaman, S. S., Peters, L. J. F., Jansen, Y., Gencer, S., Yan, Y., Nazir, S., Bonnin Marquez, A., Kahles, F., Lehrke, M., Biessen, E. A. L., Jankowski, J., Weber, C., Doring, Y. & van der Vorst, E. P. C. Scientific reports 11, 10409 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34001955  

Heart healthy cities: genetics loads the gun but the environment pulls the trigger. Munzel, T., Sorensen, M., Lelieveld, J., Hahad, O., Al-Kindi, S., Nieuwenhuijsen, M., Giles-Corti, B., Daiber, A. & Rajagopalan, S. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/34005032  

Long-term clinical experience with cardiac contractility modulation therapy delivered by the Optimizer Smart system. Kuschyk, J., Falk, P., Demming, T., Marx, O., Morley, D., Rao, I. & Burkhoff, D. European journal of heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34002440  

Right-ventricular dysfunction in HFpEF is linked to altered cardiomyocyte Ca(2+) homeostasis and myofilament sensitivity. Hegemann, N., Primessnig, U., Bode, D., Wakula, P., Beindorff, N., Klopfleisch, R., Michalick, L., Grune, J., Hohendanner, F., Messroghli, D., Pieske, B., Kuebler, W. M. & Heinzel, F. R. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/34002482  

Defining the optimal temporal and spatial resolution for cardiovascular magnetic resonance imaging feature tracking. Backhaus, S. J., Metschies, G., Billing, M., Schmidt-Rimpler, J., Kowallick, J. T., Gertz, R. J., Lapinskas, T., Pieske-Kraigher, E., Pieske, B., Lotz, J., Bigalke, B., Kutty, S., Hasenfuss, G., Kelle, S. & Schuster, A. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 23, 60 (2021). https://www.ncbi.nlm.nih.gov/pubmed/34001175  

Clopidogrel vs. prasugrel vs. ticagrelor in patients with acute myocardial infarction complicated by cardiogenic shock: a pooled IABP-SHOCK II and CULPRIT-SHOCK trial sub-analysis. Orban, M., Kleeberger, J., Ouarrak, T., Freund, A., Feistritzer, H. J., Fuernau, G., Geisler, T., Huber, K., Dudek, D., Noc, M., Montalescot, G., Neumer, A., Haller, P., Clemmensen, P., Zeymer, U., Desch, S., Massberg, S., Schneider, S., Thiele, H. & Hausleiter, J. Clinical research in cardiology : official journal of the German Cardiac Society (2021). https://www.ncbi.nlm.nih.gov/pubmed/33999281  

Neutrophil-to-lymphocyte ratio and outcomes in patients with new-onset or worsening heart failure with reduced and preserved ejection fraction. Curran, F. M., Bhalraam, U., Mohan, M., Singh, J. S., Anker, S. D., Dickstein, K., Doney, A. S., Filippatos, G., George, J., Metra, M., Ng, L. L., Palmer, C. N., Samani, N. J., van Veldhuisen, D. J., Voors, A. A., Lang, C. C. & Mordi, I. R. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33998162

Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation. Cuello, F., Knaust, A. E., Saleem, U., Loos, M., Raabe, J., Mosqueira, D., Laufer, S., Schweizer, M., van der Kraak, P., Flenner, F., Ulmer, B. M., Braren, I., Yin, X., Theofilatos, K., Ruiz-Orera, J., Patone, G., Klampe, B., Schulze, T., Piasecki, A., Pinto, Y. et al. EMBO molecular medicine 13, e13074 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33998164  

Association between up-titration of medical therapy and total hospitalizations and mortality in patients with recent worsening heart failure across the ejection fraction spectrum. Bistola, V., Simitsis, P., Parissis, J., Ouwerkerk, W., van Veldhuisen, D. J., Cleland, J. G., Anker, S. D., Samani, N. J., Metra, M., Zannad, F., Polyzogopoulou, E., Keramida, K., Farmakis, D., Voors, A. A. & Filippatos, G. European journal of heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33998113  

Association Between Achieved omega-3 Fatty Acid Levels and Major Adverse Cardiovascular Outcomes in Patients With High Cardiovascular Risk: A Secondary Analysis of the STRENGTH Trial. Nissen, S. E., Lincoff, A. M., Wolski, K., Ballantyne, C. M., Kastelein, J. J. P., Ridker, P. M., Ray, K. K., McGuire, D. K., Mozaffarian, D., Koenig, W., Davidson, M. H., Garcia, M., Katona, B. G., Himmelmann, A., Loss, L. E., Poole, M., Menon, V. & Nicholls, S. J. JAMA cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33993205  

Phenylalanine hydroxylase contributes to serotonin synthesis in mice. Mordhorst, A., Dhandapani, P., Matthes, S., Mosienko, V., Rothe, M., Todiras, M., Self, J., Schunck, W. H., Schutz, A., Bader, M. & Alenina, N. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 35, e21648 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33993565  

Aggrecan: a new biomarker for acute type A aortic dissection. Konig, K. C., Lahm, H., Dressen, M., Doppler, S. A., Eichhorn, S., Beck, N., Kraehschuetz, K., Doll, S., Holdenrieder, S., Kastrati, A., Lange, R. & Krane, M. Scientific reports 11, 10371 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33990642  

Special issue "Implications of oxidative stress and redox biochemistry for heart disease and cardioprotection - The EU-CARDIOPROTECTION COST action (CA16225)". Daiber, A., Andreadou, I., Schulz, R. & Hausenloy, D. J. Free radical biology & medicine 171, 314-318 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33965564

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption. Karabegovic, I., Portilla-Fernandez, E., Li, Y., Ma, J., Maas, S. C. E., Sun, D., Hu, E. A., Kuhnel, B., Zhang, Y., Ambatipudi, S., Fiorito, G., Huang, J., Castillo-Fernandez, J. E., Wiggins, K. L., de Klein, N., Grioni, S., Swenson, B. R., Polidoro, S., Treur, J. L., Cuenin, C. et al. Nature communications 12, 2830 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33990564  

Distribution of estimated glomerular filtration rate and determinants of its age dependent loss in a German population-based study. Waas, T., Schulz, A., Lotz, J., Rossmann, H., Pfeiffer, N., Beutel, M. E., Schmidtmann, I., Munzel, T., Wild, P. S. & Lackner, K. J. Scientific reports 11, 10165 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33986324  

Prognostic value of long-term trajectories of depression for incident diabetes mellitus in patients with stable coronary heart disease. Peter, R. S., Jaensch, A., Mons, U., Schottker, B., Schmucker, R., Koenig, W., Brenner, H. & Rothenbacher, D. Cardiovascular diabetology 20, 108 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33985516  

Impact of Percutaneous Coronary Intervention on Outcomes in Patients With Heart Failure: JACC State-of-the-Art Review. Parikh, P. B., Bhatt, D. L., Bhasin, V., Anker, S. D., Skopicki, H. A., Claessen, B. E., Fonarow, G. C., Hernandez, A. F., Mehran, R., Petrie, M. C. & Butler, J. Journal of the American College of Cardiology 77, 2432-2447 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33985688  

A National Comparative Investigation of Twins With Congenital Heart Defects for Neurodevelopmental Outcomes and Quality of Life (Same Same, but Different?): Protocol for a Prospective Observational Study. Remmele, J., Helm, P. C., Oberhoffer-Fritz, R., Bauer, U. M., Pickardt, T., Ewert, P. & Tutarel, O. JMIR Res Protoc 10, e26404 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33983133  

Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC) -derived sensory neurons. Schinke, C., Vallone, V. F., Ivanov, A., Peng, Y., Kortvelyessy, P., Nolte, L., Huehnchen, P., Beule, D., Stachelscheid, H., Boehmerle, W. & Endres, M. Neurobiol Dis, 105391 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33984509  

Genetics of atrial fibrillation - practical applications for clinical management: If not now, when and how? Kany, S., Reissmann, B., Metzner, A., Kirchhof, P., Darbar, D. & Schnabel, R. B. Cardiovascular research (2021). https://www.ncbi.nlm.nih.gov/pubmed/33982075   

Ouabain worsens diastolic sarcomere length in myocytes from a cardiomyopathy mouse model. Dusener, S., Flenner, F., Maack, C., Kohlhaas, M., Bay, J., Carrier, L. & Friedrich, F. W. European journal of pharmacology, 174170 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33984298  

Relationship between markers of inflammation and hemodynamic stress and death in patients with out-of-hospital cardiac arrest. Zelniker, T. A., Kaya, Z., Gamerdinger, E., Spaich, S., Stiepak, J., Giannitsis, E., Katus, H. A. & Preusch, M. R. Scientific reports 11, 9954 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33976254  

Altered alcohol consumption during COVID-19 pandemic lockdown. Steffen, J., Schlichtiger, J., Huber, B. C. & Brunner, S. Nutr J 20, 44 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33975597  

Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes. Riechert, E., Kmietczyk, V., Stein, F., Schwarzl, T., Sekaran, T., Jurgensen, L., Kamuf-Schenk, V., Varma, E., Hofmann, C., Rettel, M., Gur, K., Olschlager, J., Kuhl, F., Martin, J., Ramirez-Pedraza, M., Fernandez, M., Doroudgar, S., Mendez, R., Katus, H. A., Hentze, M. W. et al. Cell reports 35, 109100 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33979607  

Surveillance of Fontan associated liver disease in childhood and adolescence. Hansen, J. H., Khodami, J. K., Moritz, J. D., Rinne, K., Voges, I., Scheewe, J., Kramer, H. H. & Uebing, A. Seminars in thoracic and cardiovascular surgery (2021). https://www.ncbi.nlm.nih.gov/pubmed/33979666  

Assessment of significance of conditionally independent GWAS signals. Ghasemi, S., Teumer, A., Wuttke, M. & Becker, T. Bioinformatics (2021). https://www.ncbi.nlm.nih.gov/pubmed/33978749  

Acute coronary syndrome by two different spontaneous coronary artery dissection types in two different vessels. Abdelwahed, Y. S., Zanders, L., Landmesser, U. & Leistner, D. M. Cardiovasc Interv Ther (2021). https://www.ncbi.nlm.nih.gov/pubmed/33977421  

Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke. Schlemm, E., Ingwersen, T., Konigsberg, A., Boutitie, F., Ebinger, M., Endres, M., Fiebach, J. B., Fiehler, J., Galinovic, I., Lemmens, R., Muir, K. W., Nighoghossian, N., Pedraza, S., Puig, J., Simonsen, C. Z., Thijs, V., Wouters, A., Gerloff, C., Thomalla, G. & Cheng, B. Nature communications 12, 2590 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33972513  

Piezo1 and BKCa channels in human atrial fibroblasts: Interplay and remodelling in atrial fibrillation. Jakob, D., Klesen, A., Allegrini, B., Darkow, E., Aria, D., Emig, R., Chica, A. S., Rog-Zielinska, E. A., Guth, T., Beyersdorf, F., Kari, F. A., Proksch, S., Hatem, S. N., Karck, M., Kunzel, S. R., Guizouarn, H., Schmidt, C., Kohl, P., Ravens, U. & Peyronnet, R. Journal of molecular and cellular cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33974928  

Elevated serum SDMA and ADMA at hospital admission predict in-hospital mortality of COVID-19 patients. Hannemann, J., Balfanz, P., Schwedhelm, E., Hartmann, B., Ule, J., Muller-Wieland, D., Dahl, E., Dreher, M., Marx, N. & Boger, R. Scientific reports 11, 9895 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33972591   

Proximity to the descending aorta predicts regional fibrosis in the adjacent left atrial wall: aetiopathogenic and prognostic implications. Caixal, G., Althoff, T., Garre, P., Alarcon, F., NunezGarcia, M., Benito, E. M., Borras, R., Perea, R. J., Prat-Gonzalez, S., Gunturiz, C., Sanchez, P., Olivas, D., Tolosana, J. M., Arbelo, E., Roca-Luque, I., Brugada, J., Sitges, M., Guasch, E. & Mont, L. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33975341  

Physics-based reconstruction methods for magnetic resonance imaging. Wang, X., Tan, Z., Scholand, N., Roeloffs, V. & Uecker, M. Philos Trans A Math Phys Eng Sci 379, 20200196 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33966457  

EACVI survey on the evaluation of left ventricular diastolic function. Sitges, M., Ajmone Marsan, N., Cameli, M., D'Andrea, A., Carvalho, R. F., Holte, E., Michalski, B., Podlesnikar, T., Popescu, B. A., Schulz-Menger, J., Stankovic, I., Haugaa, K. H. & Dweck, M. R. European heart journal cardiovascular Imaging (2021). https://www.ncbi.nlm.nih.gov/pubmed/33969402  

Alcohol and atrial fibrillation: dose matters, not so much the type. Csengeri, D., Sprunker, N. A. & Schnabel, R. B. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/33969396  

Not all myocardial infarctions are created equal: The potential of circulating microRNAs to discern coronary artery dissection. Santovito, D. & Weber, C. EBioMedicine 67, 103366 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33965874  

New challenges in cardiac intensive care units. Lusebrink, E., Kellnar, A., Scherer, C., Krieg, K., Orban, M., Petzold, T., Peterss, S., Kaab, S., Brunner, S., Braun, D., Hagl, C., Hausleiter, J., Massberg, S. & Orban, M. Clinical research in cardiology : official journal of the German Cardiac Society (2021). https://www.ncbi.nlm.nih.gov/pubmed/33966127  

Future of preventive cardiology: EAPC vision 2020-22. Halle, M., Davos, C. H., Dendale, P., Papadakis, M., Pfaff, C. & Krankel, N. European journal of preventive cardiology 28, 356-358 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33966077  

Editorial: Special Issue "Implications of oxidative stress and redox biochemistry for heart disease and cardioprotection - The EU-CARDIOPROTECTION COST Action (CA16225)". Daiber, A., Andreadou, I., Schulz, R. & Hausenloy, D. J. Free radical biology & medicine (2021). https://www.ncbi.nlm.nih.gov/pubmed/33965564  

Comparison of 2D and 3D quiescent-interval slice-selective non-contrast MR angiography in patients with peripheral artery disease. Varga-Szemes, A., Aouad, P., Schoepf, U. J., Emrich, T., Yacoub, B., Todoran, T. M., Koktzoglou, I. & Edelman, R. R. MAGMA (2021). https://www.ncbi.nlm.nih.gov/pubmed/33963454  

Association between meal-specific daily protein intake and lean mass in older adults: results of the cross-sectional BASE-II study. Nikolov, J., Norman, K., Buchmann, N., Spranger, J., Demuth, I., Steinhagen-Thiessen, E., Spira, D. & Mai, K. Am J Clin Nutr (2021). https://www.ncbi.nlm.nih.gov/pubmed/33963728  

Running in polluted air is a two-edged sword - physical exercise in low air pollution areas is cardioprotective but detrimental for the heart in high air pollution areas. Munzel, T., Hahad, O. & Daiber, A. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/33963403  

Interplay between inflammation and thrombosis in cardiovascular pathology. Stark, K. & Massberg, S. Nature reviews. Cardiology, 1-17 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33958774  

Patient delay and benefit of timely reperfusion in ST-segment elevation myocardial infarction. Scholz, K. H., Meyer, T., Lengenfelder, B., Vahlhaus, C., Tongers, J., Schnupp, S., Burckhard, R., von Beckerath, N., Grusnick, H. M., Jeron, A., Winter, K. D., Maier, S. K. G., Danner, M., Vom Dahl, J., Neef, S., Stefanow, S. & Friede, T. Open heart 8 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33958491  

Coronary Microvascular Adaptations Distal to Epicardial Artery Stenosis. Merkus, D., Muller-Delp, J. & Heaps, C. L. American journal of physiology. Heart and circulatory physiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33961506   

Bidimensional structure and measurement equivalence of the Patient Health Questionnaire-9: sex-sensitive assessment of depressive symptoms in three representative German cohort studies. Tibubos, A. N., Otten, D., Zoller, D., Binder, H., Wild, P. S., Fleischer, T., Johar, H., Atasoy, S., Schulze, L., Ladwig, K. H., Schomerus, G., Linkohr, B., Grabe, H. J., Kruse, J., Schmidt, C. O., Munzel, T., Konig, J., Brahler, E. & Beutel, M. E. BMC Psychiatry 21, 238 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33952234  

Serum creatinine and cystatin C-based estimates of glomerular filtration rate are misleading in acute heart failure. Swolinsky, J. S., Nerger, N. P., Leistner, D. M., Edelmann, F., Knebel, F., Tuvshinbat, E., Lemke, C., Roehle, R., Haase, M., Costanzo, M. R., Rauch, G., Mitrovic, V., Gasanin, E., Meier, D., McCullough, P. A., Eckardt, K. U., Molitoris, B. A. & Schmidt-Ott, K. M. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33955699  

Homoarginine and methylarginines independently predict long-term outcome in patients presenting with suspicion of venous thromboembolism. Rodionov, R. N., Beyer-Westendorf, J., Bode-Boger, S. M., Eggebrecht, L., Konstantinides, S., Martens-Lobenhoffer, J., Nagler, M., Prochaska, J. & Wild, P. Scientific reports 11, 9569 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33953241  

Translational investigation of electrophysiology in hypertrophic cardiomyopathy. Flenner, F., Jungen, C., Kupker, N., Ibel, A., Kruse, M., Koivumaki, J. T., Rinas, A., Zech, A. T. L., Rhoden, A., Wijnker, P. J. M., Lemoine, M. D., Steenpass, A., Girdauskas, E., Eschenhagen, T., Meyer, C., van der Velden, J., Patten-Hamel, M., Christ, T. & Carrier, L. Journal of molecular and cellular cardiology 157, 77-89 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33957110  

Adjuvant breast cancer treatments cardiotoxicity and modern methods of detection and prevention of cardiac complications. Bikiewicz, A., Banach, M., von Haehling, S., Maciejewski, M. & Bielecka-Dabrowa, A. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33955207  

Feasibility of remote speech analysis in evaluation of dynamic fluid overload in heart failure patients undergoing haemodialysis treatment. Amir, O., Anker, S. D., Gork, I., Abraham, W. T., Pinney, S. P., Burkhoff, D., Shallom, I. D., Haviv, R., Edelman, E. R. & Lotan, C. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33955187  

Ubiquitin-proteasome-system and enzymes of energy metabolism in skeletal muscle of patients with HFpEF and HFrEF. Adams, V., Wunderlich, S., Mangner, N., Hommel, J., Esefeld, K., Gielen, S., Halle, M., Ellingsen, O., Van Craenenbroeck, E. M., Wisloff, U., Pieske, B., Linke, A. & Winzer, E. B. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33955206  

Nucleoside Analogue Reverse Transcriptase Inhibitors Improve Clinical Outcome in Transcriptional Active Human Parvovirus B19-Positive Patients. Schultheiss, H. P., Bock, T., Pietsch, H., Aleshcheva, G., Baumeier, C., Fruhwald, F. & Escher, F. Journal of clinical medicine 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33946917  

Characterization of the HCN Interaction Partner TRIP8b/PEX5R in the Intracardiac Nervous System of TRIP8b-Deficient and Wild-Type Mice. Scherschel, K., Brauninger, H., Molders, A., Erlenhardt, N., Amin, E., Jungen, C., Pape, U., Lindner, D., Chetkovich, D. M., Klocker, N. & Meyer, C. International journal of molecular sciences 22 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33946275  

Hepatic Wnt1 Inducible Signaling Pathway Protein 1 (WISP-1/CCN4) Associates with Markers of Liver Fibrosis in Severe Obesity. Pivovarova-Ramich, O., Loske, J., Hornemann, S., Markova, M., Seebeck, N., Rosenthal, A., Klauschen, F., Castro, J. P., Buschow, R., Grune, T., Lange, V., Rudovich, N. & Ouwens, D. M. Cells 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33946738   

Leveraging clinical epigenetics in heart failure with preserved ejection fraction: a call for individualized therapies. Hamdani, N., Costantino, S., Mugge, A., Lebeche, D., Tschope, C., Thum, T. & Paneni, F. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/33948637  

Hospitalizations for heart failure: still major differences between East and West Germany 30 years after reunification. Dorr, M., Riemer, U., Christ, M., Bauersachs, J., Bosch, R., Laufs, U., Neumann, A., Scherer, M., Stork, S. & Wachter, R. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33949148   

Integrated microRNA and mRNA Expression Profiling Identifies Novel Targets and Networks Associated with Ebstein's Anomaly. Abu-Halima, M., Wagner, V., Becker, L. S., Ayesh, B. M., Abd El-Rahman, M., Fischer, U., Meese, E. & Abdul-Khaliq, H. Cells 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33946378  

ADP-induced platelet reactivity and bleeding events in patients with acute myocardial infarction complicated by cardiogenic shock. Scherer, C., Lusebrink, E., Kupka, D., Stocker, T. J., Stark, K., Kleeberger, J., Orban, M., Kellnar, A., Petzold, T., Deseive, S., Krieg, K., Wurbel, S., Kika, S., Istrefi, M., Brunner, S., Braun, D., Hagl, C., Hausleiter, J., Massberg, S., Sibbing, D. et al. Platelets, 1-10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33941008  

Factors Affecting Health-Related Quality of Life After the Arterial Switch Operation. Cleuziou, J., Huber, A. K., Strbad, M., Ono, M., Hager, A., Horer, J. & Lange, R. World journal for pediatric & congenital heart surgery 12, 344-351 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33942696  

Five-year outcome in 18 010 patients from the German Aortic Valve Registry. Beyersdorf, F., Bauer, T., Freemantle, N., Walther, T., Frerker, C., Herrmann, E., Bleiziffer, S., Mollmann, H., Landwehr, S., Ensminger, S., Bekeredjian, R., Cremer, J., Kuck, K. H., Fujita, B., Gummert, J., Muller, L., Beckmann, A., Hamm, C. W. & Board, G. E. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021). https://www.ncbi.nlm.nih.gov/pubmed/33942061  

Prognostication after intracerebral hemorrhage: a review. Witsch, J., Siegerink, B., Nolte, C. H., Sprugel, M., Steiner, T., Endres, M. & Huttner, H. B. Neurol Res Pract 3, 22 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33934715  

Mechanical thrombectomy in patients with cervical artery dissection and stroke in the anterior or posterior circulation - a multicenter analysis from the German Stroke Registry. Schlemm, L., von Rennenberg, R., Siebert, E., Bohner, G., Flottmann, F., Petzold, G. C., Thomalla, G., Endres, M., Nolte, C. H. & investigators, G.-E. Neurol Res Pract 3, 20 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33934710  

Feasibility of two-dimensional speckle-tracking echocardiography of aortic valve in patients with calcific aortic valve disease. Nemchyna, O., Knierim, J., Dandel, M., Solowjowa, N., Schoenrath, F., Unbehaun, A., Kempfert, J., Stein, J., Knosalla, C., Falk, V. & Soltani, S. J Biomech 122, 110474 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33940512  

Prognostic impact of muscle and fat mass in patients with heart failure. Konishi, M., Akiyama, E., Matsuzawa, Y., Sato, R., Kikuchi, S., Nakahashi, H., Maejima, N., Iwahashi, N., Kosuge, M., Ebina, T., Hibi, K., Misumi, T., von Haehling, S., Anker, S. D., Tamura, K. & Kimura, K. J Cachexia Sarcopenia Muscle (2021). https://www.ncbi.nlm.nih.gov/pubmed/33939328  

Statins Do More Than Lower Cholesterol-Depending on What You Eat? Eschenhagen, T. & Laufs, U. Circulation 143, 1793-1796 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33939531  

The impact of platelet indices on clinical outcome in heart failure: results from the MyoVasc study. Dahlen, B., Schulz, A., Gobel, S., Trobs, S. O., Schwuchow-Thonke, S., Spronk, H. M., Prochaska, J. H., Arnold, N., Lackner, K. J., Gori, T., Ten Cate, H., Munzel, T., Wild, P. S. & Panova-Noeva, M. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33939298  

Low testosterone concentrations and prediction of future heart failure in men and in women: evidence from the large FINRISK97 study. Schafer, S., Aydin, M. A., Appelbaum, S., Kuulasmaa, K., Palosaari, T., Ojeda, F., Blankenberg, S., Jousilahti, P., Salomaa, V. & Karakas, M. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33934533  

Patients profiling in Heart Failure for tailoring medical therapy A consensus document of the Heart Failure Association of the European Society of Cardiology. Rosano, G. M. C., Moura, B., Metra, M., Bauersachs, J., Gal, T. B., Adamopoulos, S., Abdelhamid, M., Bistola, V., Bohm, M., Celutkien, J., Chioncel, O., Farmakis, D., Ferrari, R., Filippatos, G., Hill, L., Jankowska, E. A., Jaarsma, T., Jhund, P., Lainscak, M., Lopatin, Y. et al. European journal of heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33932268  

Iron deficiency in heart failure. Loncar, G., Obradovic, D., Thiele, H., von Haehling, S. & Lainscak, M. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33932115  

Quantification of Myocardial Deformation Applying CMR-Feature-Tracking-All About the Left Ventricle? Lange, T. & Schuster, A. Current heart failure reports (2021). https://www.ncbi.nlm.nih.gov/pubmed/33931818  

Heart Failure with preserved ejection fraction according to the HFA-PEFF score in COVID-19 patients: clinical correlates and echocardiographic findings. Hadzibegovic, S., Lena, A., Churchill, T. W., Ho, J. E., Potthoff, S., Denecke, C., Rosnick, L., Heim, K. M., Kleinschmidt, M., Sander, L. E., Witzenrath, M., Suttorp, N., Krannich, A., Porthun, J., Friede, T., Butler, J., Wilkenshoff, U., Pieske, B., Landmesser, U., Anker, S. D. et al. European journal of heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33932255  

Wearable cardioverter-defibrillator: friend or foe in suspected myocarditis? Blaschke, F., Lacour, P., Dang, P. L., Parwani, A. S., Hohendanner, F., Walter, T., Klingel, K., Kuhl, U., Heinzel, F. R., Sherif, M., Boldt, L. H., Pieske, B. & Tschope, C. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33932118  

A greasy business: Identification of a diacylglycerol binding site in human TRPC5 channels by cryo-EM. Storch, U., Mederos, Y. S. M. & Gudermann, T. Cell calcium 97, 102414 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33930818  

Dietary Essential Amino Acid Restriction Promotes Hyperdipsia via Hepatic FGF21. Rusu, P. M., Chan, A. Y., Heikenwalder, M., Muller, O. J. & Rose, A. J. Nutrients 13 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33926065  

Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects. Frenis, K., Helmstadter, J., Ruan, Y., Schramm, E., Kalinovic, S., Kroller-Schon, S., Bayo Jimenez, M. T., Hahad, O., Oelze, M., Jiang, S., Wenzel, P., Sommer, C. J., Frauenknecht, K. B. M., Waisman, A., Gericke, A., Daiber, A., Munzel, T. & Steven, S. Basic research in cardiology 116, 31 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33929610  

Impact of Anesthesia Strategy and Valve Type on Clinical Outcomes After Transcatheter Aortic Valve Replacement. Feistritzer, H. J., Kurz, T., Stachel, G., Hartung, P., Lurz, P., Eitel, I., Marquetand, C., Nef, H., Doerr, O., Vigelius-Rauch, U., Lauten, A., Landmesser, U., Treskatsch, S., Abdel-Wahab, M., Sandri, M., Holzhey, D., Borger, M., Ender, J., Ince, H., Oner, A. et al. Journal of the American College of Cardiology 77, 2204-2215 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33926657  

Regulation of Cardiac PKA Signaling by cAMP and Oxidants. Cuello, F., Herberg, F. W., Stathopoulou, K., Henning, P. & Diering, S. Antioxidants 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33923287


April

cAMP Imaging at Ryanodine Receptors Reveals beta2-Adrenoceptor Driven Arrhythmias. Berisha, F., Gotz, K. R., Wegener, J. W., Brandenburg, S., Subramanian, H., Molina, C. E., Ruffer, A., Petersen, J., Bernhardt, A., Girdauskas, E., Jungen, C., Pape, U., Kraft, A. E., Warnke, S., Lindner, D., Westermann, D., Blankenberg, S., Meyer, C., Hasenfuss, G., Lehnart, S. E. & Nikolaev, V. O. Circulation research 129, 81-94 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33902292  

Serum uric acid and outcomes in patients with chronic heart failure through the whole spectrum of ejection fraction phenotypes: Analysis of the ESC-EORP Heart Failure Long-Term (HF LT) Registry. Ambrosio, G., Leiro, M. G. C., Lund, L. H., Coiro, S., Cardona, A., Filippatos, G., Ferrari, R., Piepoli, M. F., Coats, A. J. S., Anker, S. D., Laroche, C., Almenar-Bonet, L., Poder, P., Valero, D. B., Frisinghelli, A. & Maggioni, A. P. European journal of internal medicine 89, 65-75 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33896684  

Testing for heterotopia formation in rats after developmental exposure to selected in vitro inhibitors of thyroperoxidase. Ramhoj, L., Fradrich, C., Svingen, T., Scholze, M., Wirth, E. K., Rijntjes, E., Kohrle, J., Kortenkamp, A. & Axelstad, M. Environ Pollut 283, 117135 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33892370  

Distribution patterns of intramyocellular and extramyocellular fat by magnetic resonance imaging in subjects with diabetes, prediabetes and normoglycaemic controls. Kiefer, L. S., Fabian, J., Rospleszcz, S., Lorbeer, R., Machann, J., Kraus, M. S., Roemer, F., Rathmann, W., Meisinger, C., Heier, M., Nikolaou, K., Peters, A., Storz, C., Diallo, T. D., Schlett, C. L. & Bamberg, F. Diabetes Obes Metab 23, 1868-1878 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33914415  

Monocyte-Chemoattractant Protein-1 Levels in Human Atherosclerotic Lesions Associate With Plaque Vulnerability. Georgakis, M. K., van der Laan, S. W., Asare, Y., Mekke, J. M., Haitjema, S., Schoneveld, A. H., de Jager, S. C. A., Nurmohamed, N. S., Kroon, J., Stroes, E. S. G., de Kleijn, D. P. V., de Borst, G. J., Maegdefessel, L., Soehnlein, O., Pasterkamp, G. & Dichgans, M. Arteriosclerosis, thrombosis, and vascular biology 41, 2038-2048 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33827260  

How Does SARS-CoV-2 Infection Affect Survival of Emergency Cardiovascular Patients? A Cohort Study From a German Insurance Claims Database. Behrendt, C. A., Seiffert, M., Gerloff, C., L'Hoest, H., Acar, L. & Thomalla, G. Eur J Vasc Endovasc Surg 62, 119-125 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33824066

Pregnancy outcomes in women with a systemic right ventricle and transposition of the great arteries results from the ESC-EORP Registry of Pregnancy and Cardiac disease (ROPAC). Tutarel, O., Baris, L., Budts, W., Gamal Abd-El Aziz, M., Liptai, C., Majdalany, D., Jovanova, S., Frogoudaki, A., Connolly, H. M., Johnson, M. R., Maggioni, A. P., Hall, R., Roos-Hesselink, J. W. & Group, R. I. Heart (2021). https://www.ncbi.nlm.nih.gov/pubmed/33911009  

Distribution Patterns of Intra- and Extramyocellular Fat by Magnetic Resonance Imaging in Subjects with Diabetes, Prediabetes and Normoglycemic Controls. Kiefer, L. S., Fabian, J., Rospleszcz, S., Lorbeer, R., Machann, J., Kraus, M. S., Roemer, F., Rathmann, W., Meisinger, C., Heier, M., Nikolaou, K., Peters, A., Storz, C., Diallo, T. D., Schlett, C. L. & Bamberg, F. Diabetes Obes Metab (2021). https://www.ncbi.nlm.nih.gov/pubmed/33914415  

The gut microbiota is associated with the small intestinal paracellular permeability and the development of the immune system in healthy children during the first two years of life. Kaczmarczyk, M., Lober, U., Adamek, K., Wegrzyn, D., Skonieczna-Zydecka, K., Malinowski, D., Loniewski, I., Marko, L., Ulas, T., Forslund, S. K. & Loniewska, B. Journal of translational medicine 19, 177 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33910577  

MondoA Drives B-ALL Malignancy through Enhanced Adaptation to Metabolic Stress. Sipol, A., Hameister, E., Xue, B., Hofstetter, J., Barenboim, M., Ollinger, R., Jain, G., Prexler, C., Rubio, R. A., Baldauf, M. C., Franchina, D. G., Petry, A., Schmah, J., Thiel, U., Gorlach, A., Cario, G., Brenner, D., Richter, G., Grunewald, T. G. P., Rad, R. et al. Blood (2021). https://www.ncbi.nlm.nih.gov/pubmed/33908607  

RhoA: a dubious molecule in cardiac pathophysiology. Kilian, L. S., Voran, J., Frank, D. & Rangrez, A. Y. J Biomed Sci 28, 33 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33906663  

Salt Transiently Inhibits Mitochondrial Energetics in Mononuclear Phagocytes. Geisberger, S., Bartolomaeus, H., Neubert, P., Willebrand, R., Zasada, C., Bartolomaeus, T., McParland, V., Swinnen, D., Geuzens, A., Maifeld, A., Krampert, L., Vogl, M., Mahler, A., Wilck, N., Marko, L., Tilic, E., Forslund, S. K., Binger, K. J., Stegbauer, J., Dechend, R. et al. Circulation (2021). https://www.ncbi.nlm.nih.gov/pubmed/33906377

Transradial closure of a large ascending aortic pseudoaneurysm with a Duct Occluder II - A case report. Weferling, M., Haas, M. & Hamm, C. W. Cardiovascular revascularization medicine : including molecular interventions (2021). https://www.ncbi.nlm.nih.gov/pubmed/33935002  

Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7-related osteopetrosis. Rossler, U., Hennig, A. F., Stelzer, N., Bose, S., Kopp, J., Soe, K., Cyganek, L., Zifarelli, G., Ali, S., von der Hagen, M., Strassler, E., Hahn, G., Pusch, M., Stauber, T., Izsvak, Z., Gossen, M., Stachelscheid, H. & Kornak, U. J Bone Miner Res (2021). https://www.ncbi.nlm.nih.gov/pubmed/33905594  

Depression and Incident Cardiovascular Disease. El-Battrawy, I., Behnes, M. & Akin, I. JAMA : the journal of the American Medical Association 325, 1679-1680 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33904876  

Impact of Morphine Treatment With and Without Metoclopramide Coadministration on Myocardial and Microvascular Injury in Acute Myocardial Infarction: Insights From the Randomized MonAMI Trial. Stiermaier, T., Schaefer, P., Meyer-Saraei, R., Saad, M., de Waha-Thiele, S., Poss, J., Fuernau, G., Graf, T., Kurz, T., Frydrychowicz, A., Barkhausen, J., Desch, S., Thiele, H. & Eitel, I. Journal of the American Heart Association 10, e018881 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33899498  

Thyroid function and mood disorders: a Mendelian Randomization study. Kus, A., Kjaergaard, A. D., Marouli, E., Del Greco, M. F., Sterenborg, R., Chaker, L., Peeters, R. P., Bednarczuk, T., Asvold, B. O., Burgess, S., Deloukas, P., Teumer, A., Ellervik, C. & Medici, M. Thyroid : official journal of the American Thyroid Association (2021). https://www.ncbi.nlm.nih.gov/pubmed/33899528  

Do we need to rethink treatment of aortic valve pathologies in younger patients? Krane, M., Wirth, F., Boehm, J. & Lange, R. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021). https://www.ncbi.nlm.nih.gov/pubmed/33899098  

Supervised Obesity Reduction Trial for AF Ablation Patients: Results from the SORT-AF trial. Gessler, N., Willems, S., Steven, D., Aberle, J., Akbulak, R. O., Gosau, N., Hoffmann, B. A., Meyer, C., Sultan, A., Tilz, R., Vogler, J., Wohlmuth, P., Scholz, S., Gunawardene, M. A., Eickholt, C. & Luker, J. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33895833

ENIGMA-Sleep: Challenges, opportunities, and the road map. Tahmasian, M., Aleman, A., Andreassen, O. A., Arab, Z., Baillet, M., Benedetti, F., Bresser, T., Bright, J., Chee, M. W. L., Chylinski, D., Cheng, W., Deantoni, M., Dresler, M., Eickhoff, S. B., Eickhoff, C. R., Elvsashagen, T., Feng, J., Foster-Dingley, J. C., Ganjgahi, H., Grabe, H. J. et al. J Sleep Res, e13347 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33913199  

Sulforaphane exposure impairs contractility and mitochondrial function in three-dimensional engineered heart tissue. Rhoden, A., Friedrich, F. W., Brandt, T., Raabe, J., Schweizer, M., Meisterknecht, J., Wittig, I., Ulmer, B. M., Klampe, B., Uebeler, J., Piasecki, A., Lorenz, K., Eschenhagen, T., Hansen, A. & Cuello, F. Redox biology 41, 101951 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33831709  

c-Kit inhibition: From promising cancer therapy to culprit in atherosclerosis. van der Vorst, E. P. C. Atherosclerosis 324, 115-116 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33824002  

Hyperinflammation as underlying mechanism predisposing patients with cardiovascular diseases for severe COVID-19. Landmesser, U., Lehmann, I. & Eils, R. European heart journal 42, 1720-1721 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33822037  

Detection of extracellular superoxide in isolated human immune cells and in an animal model of arterial hypertension using hydropropidine probe and HPLC analysis. Kalinovic, S., Stamm, P., Oelze, M., Steven, S., Kroller-Schon, S., Kvandova, M., Zielonka, J., Munzel, T. & Daiber, A. Free radical biology & medicine 168, 214-225 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33823245

 

Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease. Zheng, T., Ellinghaus, D., Juzenas, S., Cossais, F., Burmeister, G., Mayr, G., Jorgensen, I. F., Teder-Laving, M., Skogholt, A. H., Chen, S., Strege, P. R., Ito, G., Banasik, K., Becker, T., Bokelmann, F., Brunak, S., Buch, S., Clausnitzer, H., Datz, C., Consortium, D. et al. Gut (2021). https://www.ncbi.nlm.nih.gov/pubmed/33888516

Benefit of a wearable cardioverter defibrillator for detection and therapy of arrhythmias in patients with myocarditis. Tscholl, V., Wielander, D., Kelch, F., Stroux, A., Attanasio, P., Tschope, C., Landmesser, U., Roser, M., Huemer, M., Heidecker, B. & Nagel, P. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33887109  

Development, validation, and implementation of biomarker testing in cardiovascular medicine state-of-the-art: proceedings of the European Society of Cardiology-Cardiovascular Round Table. Elliott, P., Cowie, M. R., Franke, J., Ziegler, A., Antoniades, C., Bax, J., Bucciarelli-Ducci, C., Flachskampf, F. A., Hamm, C., Jensen, M. T., Katus, H., Maisel, A., McDonagh, T., Mittmann, C., Muntendam, P., Nagel, E., Rosano, G., Twerenbold, R. & Zannad, F. Cardiovascular research 117, 1248-1256 (2021). https://www.ncbi.nlm.nih.gov/pubmed/32960964  

Enhanced Ca(2+) signaling, mild primary aldosteronism, and hypertension in a familial hyperaldosteronism mouse model (Cacna1h (M1560V/+) ). Seidel, E., Schewe, J., Zhang, J., Dinh, H. A., Forslund, S. K., Marko, L., Hellmig, N., Peters, J., Muller, D. N., Lifton, R. P., Nottoli, T., Stolting, G. & Scholl, U. I. Proceedings of the National Academy of Sciences of the United States of America 118 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33879608  

Can we trust a smartwatch ECG? Potential and Limitations. Haverkamp, W., Butler, J. & Anker, S. D. European journal of heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33880842  

Cis-epistasis at the LPA locus and risk of cardiovascular diseases. Zeng, L., Moser, S., Mirza-Schreiber, N., Lamina, C., Coassin, S., Nelson, C. P., Annilo, T., Franzen, O., Kleber, M. E., Mack, S., Andlauer, T. F. M., Jiang, B., Stiller, B., Li, L., Willenborg, C., Munz, M., Kessler, T., Kastrati, A., Laugwitz, K. L., Erdmann, J. et al. Cardiovascular research (2021). https://www.ncbi.nlm.nih.gov/pubmed/33878186  

Extracellular histones are a target in myocardial ischaemia reperfusion injury. Shah, M., He, Z., Rauf, A., Kalkhoran, S. B., Heiestad, C. M., Stenslokken, K. O., Parish, C. R., Soehnlein, O., Arjun, S., Davidson, S. M. & Yellon, D. Cardiovascular research (2021). https://www.ncbi.nlm.nih.gov/pubmed/33878183  

SLL-PEEP Ventilation to Improve Exposure in Minimally Invasive Right Anterolateral Minithoracotomy Aortic Valve Replacement. Richter, G., Van Praet, K. M., Hommel, M., Sundermann, S. H., Kofler, M., Meyer, A., Unbehaun, A., Starck, C., Jacobs, S., Falk, V. & Kempfert, J. Innovations (Phila), 15569845211004265 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33877924  

Association between duration of drug-coated balloon inflation and efficacy in patients with drug-eluting stent restenosis. Koch, T., Voll, F., Xhepa, E., Wiebe, J., Cassese, S., Tolg, R., Laugwitz, K. L., Neumann, F. J., Kastrati, A. & Kufner, S. Coronary artery disease (2021). https://www.ncbi.nlm.nih.gov/pubmed/33878075  

Optoacoustic imaging in endocrinology and metabolism. Karlas, A., Pleitez, M. A., Aguirre, J. & Ntziachristos, V. Nat Rev Endocrinol (2021). https://www.ncbi.nlm.nih.gov/pubmed/33875856  

Validity of the 6-Minute Walk Test in Patients with End-Stage Lung Diseases Wearing an Oronasal Surgical Mask in Times of the COVID-19 Pandemic. Just, I. A., Schoenrath, F., Passinger, P., Stein, J., Kemper, D., Knosalla, C., Falk, V. & Knierim, J. Respiration, 1-6 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33878758  

Hand grip strength and fatigability: correlation with clinical parameters and diagnostic suitability in ME/CFS. Jakel, B., Kedor, C., Grabowski, P., Wittke, K., Thiel, S., Scherbakov, N., Doehner, W., Scheibenbogen, C. & Freitag, H. Journal of translational medicine 19, 159 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33874961  

Taking the heavy load off Arrhythmogenic Right Ventricular Cardiomyopathy: Editorial comment on the paper by Kalantarian et al in Heart Rhythm. Fabritz, L., Patten, M. & Kirchhof, P. Heart rhythm (2021). https://www.ncbi.nlm.nih.gov/pubmed/33878457  

Fibroblast GATA-4 and GATA-6 promote myocardial adaptation to pressure overload by enhancing cardiac angiogenesis. Dittrich, G. M., Froese, N., Wang, X., Kroeger, H., Wang, H., Szaroszyk, M., Malek-Mohammadi, M., Cordero, J., Keles, M., Korf-Klingebiel, M., Wollert, K. C., Geffers, R., Mayr, M., Conway, S. J., Dobreva, G., Bauersachs, J. & Heineke, J. Basic research in cardiology 116, 26 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33876316  

EHRA expert consensus statement and practical guide on optimal implantation technique for conventional pacemakers and implantable cardioverter-defibrillators: endorsed by the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS), and the Latin-American Heart Rhythm Society (LAHRS). Burri, H., Starck, C., Auricchio, A., Biffi, M., Burri, M., D'Avila, A. L. R., Deharo, J. C., Glikson, M., Israel, C., Lau, C. A. R., Leclercq, C., Love, C., Nielsen, J. C., Vernooy, K., Dagres, N. R. C., Boveda, S. R. C., Butter, C., Marijon, E., Braunschweig, F., Mairesse, G. H. et al. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33878762  

Staying on the ball during COVID-19 pandemic: impact on training modalities in football players. Schuttler, D., Hamm, W., Krammer, S., Steffen, J., Deuster, E., Lauseker, M., Egger, F., Meyer, T. & Brunner, S. J Sports Med Phys Fitness (2021). https://www.ncbi.nlm.nih.gov/pubmed/33871243   

Combined vaccine-immune-checkpoint inhibition constitutes a promising strategy for treatment of dMMR tumors. Salewski, I., Kuntoff, S., Kuemmel, A., Feldtmann, R., Felix, S. B., Henze, L., Junghanss, C. & Maletzki, C. Cancer Immunol Immunother (2021). https://www.ncbi.nlm.nih.gov/pubmed/33870463  

Propensity score-based analysis of long-term follow-up in patients supported with durable centrifugal left ventricular assist devices: the EUROMACS analysis. Potapov, E. V., Nersesian, G., Lewin, D., Ozbaran, M., de By, T., Stein, J., Pya, Y., Gummert, J., Ramjankhan, F., Zembala, M. O., Damman, K., Carrel, T., Meyns, B., Zimpfer, D. & Netuka, I. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021). https://www.ncbi.nlm.nih.gov/pubmed/33871594  

Magnetic resonance imaging-based changes in vascular morphology and cerebral perfusion in subacute ischemic stroke. Kufner, A., Khalil, A. A., Galinovic, I., Kellner, E., Mekle, R., Rackoll, T., Boehm-Sturm, P., Fiebach, J. B., Floel, A., Ebinger, M., Endres, M. & Nave, A. H. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 271678X211010071 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33866849  

Efficacy and Safety of Ticagrelor Versus Prasugrel in Women and Men with Acute Coronary Syndrome: A Pre-specified, Sex-Specific Analysis of the ISAR-REACT 5 Trial. Gewalt, S., Lahu, S., Ndrepepa, G., Pellegrini, C., Bernlochner, I., Neumann, F. J., Menichelli, M., Morath, T., Witzenbichler, B., Wohrle, J., Hoppe, K., Richardt, G., Laugwitz, K. L., Schunkert, H., Kastrati, A., Schupke, S. & Mayer, K. J Atheroscler Thromb (2021). https://www.ncbi.nlm.nih.gov/pubmed/33867409  

Impaired High-Density Lipoprotein Function in Patients With Heart Failure. Emmens, J. E., Jia, C., Ng, L. L., van Veldhuisen, D. J., Dickstein, K., Anker, S. D., Lang, C. C., Filippatos, G., Cleland, J. G. F., Metra, M., Voors, A. A., de Boer, R. A. & Tietge, U. J. F. Journal of the American Heart Association, e019123 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33870728  

Anticoagulation in atrial fibrillation and liver disease: a pooled-analysis of > 20000 patients. Chen, S., Purerfellner, H., Meyer, C., Sommer, P., Galindo Kiuchi, M., Martinek, M., Futyma, P., Zanchi, S., Zhu, L., Schratter, A., Wang, J., Acou, W. J., Liu, S., Ling, Z., Yin, Y., Ouyang, F., Chun, J. K. R. & Schmidt, B. European heart journal. Cardiovascular pharmacotherapy (2021). https://www.ncbi.nlm.nih.gov/pubmed/33871577  

Guided P2Y12 inhibitor therapy after percutaneous coronary intervention. Sibbing, D. & Kastrati, A. Lancet 397, 1423-1425 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33865482  

Hyperventilation/Breath-Hold Maneuver to Detect Myocardial Ischemia by Strain-Encoded CMR: Diagnostic Accuracy of a Needle-Free Stress Protocol. Ochs, M. M., Kajzar, I., Salatzki, J., Ochs, A. T., Riffel, J., Osman, N., Katus, H. A. & Friedrich, M. G. JACC. Cardiovascular imaging (2021). https://www.ncbi.nlm.nih.gov/pubmed/33865775  

Myocardial Fibrosis and Inflammation by CMR Predict Cardiovascular Outcome in People Living With HIV. de Leuw, P., Arendt, C. T., Haberl, A. E., Froadinadl, D., Kann, G., Wolf, T., Stephan, C., Schuettfort, G., Vasquez, M., Arcari, L., Zhou, H., Zainal, H., Gawor, M., Vidalakis, E., Kolentinis, M., Albrecht, M. H., Escher, F., Vogl, T. J., Zeiher, A. M., Nagel, E. et al. JACC. Cardiovascular imaging (2021). https://www.ncbi.nlm.nih.gov/pubmed/33865770  

Dietary-challenged mice with Alzheimer-like pathology show increased energy expenditure and reduced adipocyte hypertrophy and steatosis. Schreyer, S., Berndt, N., Eckstein, J., Mulleder, M., Hemmati-Sadeghi, S., Klein, C., Abuelnor, B., Panzel, A., Meierhofer, D., Spranger, J., Steiner, B. & Brachs, S. Aging 13 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33864446  

Heart-lung interactions in COVID-19: prognostic impact and usefulness of bedside echocardiography for monitoring of the right ventricle involvement. Dandel, M. Heart failure reviews, 1-15 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33864580  

Definition of acute kidney injury impacts prevalence and prognosis in ACS patients undergoing coronary angiography. Weferling, M., Liebetrau, C., Kraus, D., Zierentz, P., von Jeinsen, B., Dorr, O., Weber, M., Nef, H., Hamm, C. W. & Keller, T. BMC cardiovascular disorders 21, 183 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33858335  

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure. Wang, H., Noordam, R., Cade, B. E., Schwander, K., Winkler, T. W., Lee, J., Sung, Y. J., Bentley, A. R., Manning, A. K., Aschard, H., Kilpelainen, T. O., Ilkov, M., Brown, M. R., Horimoto, A. R., Richard, M., Bartz, T. M., Vojinovic, D., Lim, E., Nierenberg, J. L., Liu, Y. et al. Molecular psychiatry (2021). https://www.ncbi.nlm.nih.gov/pubmed/33859359  

Genetic insight into sick sinus syndrome. Is there a pill for it or how far are we on the translational road to personalized medicine? Tomsits, P., Clauss, S. & Kaab, S. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/33860310   

Imaging of cardiac fibroblast activation in a patient after acute myocardial infarction using (68)Ga-FAPI-04. Notohamiprodjo, S., Nekolla, S. G., Robu, S., Villagran Asiares, A., Kupatt, C., Ibrahim, T., Laugwitz, K. L., Makowski, M. R., Schwaiger, M., Weber, W. A. & Varasteh, Z. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33860458  

Novel Cryoballoon Ablation System for Single Shot Pulmonary Vein Isolation- The Prospective ICE-AGE-X Study. Tilz, R. R., Meyer-Saraei, R., Eitel, C., Fink, T., Sciacca, V., Lopez, L. D., Kirstein, B., Schluter, M., Vogler, J., Kuck, K. H. & Heeger, C. H. Circulation journal : official journal of the Japanese Circulation Society (2021). https://www.ncbi.nlm.nih.gov/pubmed/33854004  

Blood pressure and resting heart rate in 3-17-year-olds in Germany in 2003-2006 and 2014-2017. Sarganas, G., Schienkiewitz, A., Finger, J. D. & Neuhauser, H. K. J Hum Hypertens (2021). https://www.ncbi.nlm.nih.gov/pubmed/33854175  

The European Association of Preventive Cardiology Aviation and Occupational Cardiology Task Force. Nicol, E. D., Holdsworth, D. A., Halle, M. & Davos, C. H. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/33855347  

Performance of a cardiac lipid panel compared to four prognostic scores in chronic heart failure. McGranaghan, P., Saxena, A., Dungen, H. D., Rubens, M., Appunni, S., Salami, J., Veledar, E., Lacour, P., Blaschke, F., Obradovic, D., Loncar, G., Tahirovic, E., Edelmann, F., Pieske, B. & Trippel, T. D. Scientific reports 11, 8164 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33854188   

eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction. Liang, Y., Piao, C., Beuschel, C. B., Toppe, D., Kollipara, L., Bogdanow, B., Maglione, M., Lutzkendorf, J., See, J. C. K., Huang, S., Conrad, T. O. F., Kintscher, U., Madeo, F., Liu, F., Sickmann, A. & Sigrist, S. J. Cell reports 35, 108941 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33852845  

Dietary Macronutrient Composition in Relation to Circulating HDL and Non-HDL Cholesterol: A Federated Individual-Level Analysis of Cross-Sectional Data from Adolescents and Adults in 8 European Studies. Pinart, M., Jeran, S., Boeing, H., Stelmach-Mardas, M., Standl, M., Schulz, H., Harris, C., von Berg, A., Herberth, G., Koletzko, S., Linseisen, J., Breuninger, T. A., Nothlings, U., Barbaresko, J., Benda, S., Lachat, C., Yang, C., Gasparini, P., Robino, A., Rojo-Martinez, G. et al. J Nutr (2021). https://www.ncbi.nlm.nih.gov/pubmed/33847346  

Mechanical unloading by miniature axial flow pumps in late cardiac allograft failure due to acute rejection. Just, I. A., Potapov, E., Knosalla, C. & Schoenrath, F. J Artif Organs (2021). https://www.ncbi.nlm.nih.gov/pubmed/33846899  

Ligand-activated RXFP1 gene therapy ameliorates pressure overload-induced cardiac dysfunction. Sasipong, N., Schlegel, P., Wingert, J., Lederer, C., Meinhardt, E., Ziefer, A., Schmidt, C., Rapti, K., Thoni, C., Frey, N., Most, P., Katus, H. A. & Raake, P. W. J. Molecular therapy : the journal of the American Society of Gene Therapy (2021). https://www.ncbi.nlm.nih.gov/pubmed/33839322  

Changes of Right Ventricular Function after Transcatheter Aortic Valve Replacement and Association with Outcome. Poch, F., Thalmann, R., Olbrich, I., Fellner, C., Stundl, A., Barthel, P., Bradaric, C., Laugwitz, K. L., Kupatt, C. & Ledwoch, J. Journal of cardiac failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33839289  

Combined effect of work stress and impaired sleep on coronary and cardiovascular mortality in hypertensive workers: The MONICA/KORA cohort study. Li, J., Atasoy, S., Fang, X., Angerer, P. & Ladwig, K. H. European journal of preventive cardiology 28, 220-226 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33838034  

Modifiable lifestyle risk factors and C-reactive protein in patients with coronary artery disease: Implications for an anti-inflammatory treatment target population. Blaum, C., Brunner, F. J., Kroger, F., Braetz, J., Lorenz, T., Gossling, A., Ojeda, F., Koester, L., Karakas, M., Zeller, T., Westermann, D., Schnabel, R., Blankenberg, S., Seiffert, M. & Waldeyer, C. European journal of preventive cardiology 28, 152-158 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33838040  

A proteomic atlas of the neointima identifies novel druggable targets for preventive therapy. Wierer, M., Werner, J., Wobst, J., Kastrati, A., Cepele, G., Aherrahrou, R., Sager, H. B., Erdmann, J., Dichgans, M., Flockerzi, V., Civelek, M., Dietrich, A., Mann, M., Schunkert, H. & Kessler, T. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/33829256  

Prevention of cardiovascular disease: does 'every step counts' apply for occupational work? Halle, M. & Heitkamp, M. European heart journal 42, 1512-1515 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33831947  

Monocyte-Chemoattractant Protein-1 Levels in Human Atherosclerotic Lesions Associate With Plaque Vulnerability. Georgakis, M. K., van der Laan, S. W., Asare, Y., Mekke, J. M., Haitjema, S., Schoneveld, A. H., de Jager, S. C. A., Nurmohamed, N. S., Kroon, J., Stroes, E. S. G., de Kleijn, D. P. V., de Borst, G. J., Maegdefessel, L., Soenhlein, O., Pasterkamp, G. & Dichgans, M. Arteriosclerosis, thrombosis, and vascular biology, ATVBAHA121316091 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33827260  

Best of most possible worlds: Hybrid gene therapy vectors based on parvoviruses and heterologous viruses. Fakhiri, J. & Grimm, D. Molecular therapy : the journal of the American Society of Gene Therapy (2021). https://www.ncbi.nlm.nih.gov/pubmed/33831556  

Left and right ventricular strain using fast strain-encoded cardiovascular magnetic resonance for the diagnostic classification of patients with chronic non-ischemic heart failure due to dilated, hypertrophic cardiomyopathy or cardiac amyloidosis. Steen, H., Giusca, S., Montenbruck, M., Patel, A. R., Pieske, B., Florian, A., Erley, J., Kelle, S. & Korosoglou, G. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 23, 45 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33823860  

Association of late gadolinium enhancement with biomarkers in patients with myocardial infarction. Schneider, J. N., Neumann, J. T., Bohnen, S., Sorensen, N. A., Cavus, E., Schafer, S., Hartikainen, T. S., Gossling, A., Tahir, E., Lund, G. K., Adam, G., Blankenberg, S., Muellerleile, K., Westermann, D. & Radunski, U. K. Coronary artery disease (2021). https://www.ncbi.nlm.nih.gov/pubmed/33826534  

Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19. Bonaventura, A., Vecchie, A., Dagna, L., Martinod, K., Dixon, D. L., Van Tassell, B. W., Dentali, F., Montecucco, F., Massberg, S., Levi, M. & Abbate, A. Nature reviews. Immunology, 1-11 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33824483  

Management of antithrombotic therapy in patients undergoing transcatheter aortic valve implantation: a consensus document of the ESC Working Group on Thrombosis and the European Association of Percutaneous Cardiovascular Interventions (EAPCI), in collaboration with the ESC Council on Valvular Heart Disease. Ten Berg, J., Sibbing, D., Rocca, B., Van Belle, E., Chevalier, B., Collet, J. P., Dudek, D., Gilard, M., Gorog, D. A., Grapsa, J., Grove, E. L., Lancellotti, P., Petronio, A. S., Rubboli, A., Torracca, L., Vilahur, G., Witkowski, A. & Mehilli, J. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/33822924  

Longitudinal analyses of gender differences in first authorship publications related to COVID-19. Lerchenmuller, C., Schmallenbach, L., Jena, A. B. & Lerchenmueller, M. J. BMJ open 11, e045176 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33820790  

Complement, inflammation and thrombosis. Rawish, E., Sauter, M., Sauter, R., Nording, H. & Langer, H. F. British journal of pharmacology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33817781

 

Sex-Related Clinical Characteristics and Outcomes of Patients Undergoing Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation. Park, S. D., Orban, M., Karam, N., Lubos, E., Kalbacher, D., Braun, D., Stolz, L., Neuss, M., Butter, C., Praz, F., Kassar, M., Petrescu, A., Pfister, R., Iliadis, C., Unterhuber, M., Lurz, P., Thiele, H., Baldus, S., von Bardeleben, S., Blankenberg, S. et al. JACC. Cardiovascular interventions (2021).

RhoGEF17-An Essential Regulator of Endothelial Cell Death and Growth. Weber, P., Baltus, D., Jatho, A., Drews, O., Zelarayan, L. C., Wieland, T. & Lutz, S. Cells 10 (2021).

CALINCA-A Novel Pipeline for the Identification of lncRNAs in Podocyte Disease. Talyan, S., Filipów, S., Ignarski, M., Smieszek, M., Chen, H., Kühne, L., Butt, L., Göbel, H., Hoyer-Allo, K. J. R., Koehler, F. C., Altmüller, J., Brinkkötter, P., Schermer, B., Benzing, T., Kann, M., Müller, R. U. & Dieterich, C. Cells 10 (2021).

Reduced Liver Autophagy in High-Fat Diet Induced Liver Steatosis in New Zealand Obese Mice. Korovila, I., Höhn, A., Jung, T., Grune, T. & Ott, C. Antioxidants 10 (2021).

Novel Blood Biomarkers for a Diagnostic Workup of Acute Aortic Dissection. Forrer, A., Schoenrath, F., Torzewski, M., Schmid, J., Franke, U. F. W., Göbel, N., Aujesky, D., Matter, C. M., Lüscher, T. F., Mach, F., Nanchen, D., Rodondi, N., Falk, V., von Eckardstein, A. & Gawinecka, J. Diagnostics 11 (2021).

Broad Metabolome Alterations Associated with the Intake of Oral Contraceptives Are Mediated by Cortisol in Premenopausal Women. Eick, C., Klinger-König, J., Zylla, S., Hannemann, A., Budde, K., Henning, A. K., Pietzner, M., Nauck, M., Völzke, H., Grabe, H. J. & Hertel, J. Metabolites 11 (2021).

Non-viral Induction of Transgene-free iPSCs from Somatic Fibroblasts of Multiple Mammalian Species. Yoshimatsu, S., Nakajima, M., Iguchi, A., Sanosaka, T., Sato, T., Nakamura, M., Nakajima, R., Arai, E., Ishikawa, M., Imaizumi, K., Watanabe, H., Okahara, J., Noce, T., Takeda, Y., Sasaki, E., Behr, R., Edamura, K., Shiozawa, S. & Okano, H. Stem cell reports (2021).

Presence of contractile impairment appears crucial for structural remodeling in idiopathic left bundle-branch block. Salatzki, J., Fischer, T., Riffel, J., André, F., Hirschberg, K., Ochs, A., Hund, H., Müller-Hennessen, M., Giannitsis, E., Friedrich, M. G., Scholz, E., Frey, N., Katus, H. A. & Ochs, M. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 23, 39 (2021).

Telomere length is independently associated with all-cause mortality in chronic heart failure. Romaine, S. P. R., Denniff, M., Codd, V., Nath, M., Koekemoer, A., Anker, S. D., Cleland, J. G., Filippatos, G., Levin, D., Metra, M., Mordi, I. R., Ouwerkerk, W., Ter Maaten, J. M., van Veldhuisen, D. J., Zannad, F., Ng, L. L., van der Harst, P., Lang, C. C., Voors, A. A., Nelson, C. P. et al. Heart (2021).

Transportation noise pollution and cardiovascular disease. Münzel, T., Sørensen, M. & Daiber, A. Nature reviews. Cardiology (2021).

The Gut Microbiome in Hypertension: Recent Advances and Future Perspectives. Avery, E. G., Bartolomaeus, H., Maifeld, A., Marko, L., Wiig, H., Wilck, N., Rosshart, S. P., Forslund, S. K. & Müller, D. N. Circulation research 128, 934-950 (2021).

Nox4-Dependent Upregulation of S100A4 after Peripheral Nerve Injury Modulates Neuropathic Pain Processing. Wack, G., Metzner, K., Kuth, M. S., Wang, E., Bresnick, A., Brandes, R. P., Schröder, K., Wittig, I., Schmidtko, A. & Kallenborn-Gerhardt, W. Free radical biology & medicine (2021).

Trimethyllysine, vascular risk factors and outcome in acute ischemic stroke (MARK-STROKE). Schwedhelm, E., von Lucadou, M., Peine, S., Lezius, S., Thomalla, G., Böger, R., Gerloff, C. & Choe, C. U. Amino Acids (2021).

Dynamic contrast-enhanced magnetic resonance imaging for monitoring neovascularization during bone regeneration-a randomized in vivo study in rabbits. Righesso, L. A. R., Terekhov, M., Götz, H., Ackermann, M., Emrich, T., Schreiber, L. M., Müller, W. E. G., Jung, J., Rojas, J. P. & Al-Nawas, B. Clin Oral Investig (2021).

Noninvasive sampling of the distal airspace via HME-filter fluid is not useful to detect SARS-CoV-2 in intubated patients. Reifart, J., Liebetrau, C., Troidl, C., Madlener, K. & Rolf, A. Crit Care 25, 126 (2021).

Consensus Transcriptional Landscape of Human End-Stage Heart Failure. Ramirez Flores, R. O., Lanzer, J. D., Holland, C. H., Leuschner, F., Most, P., Schultz, J. H., Levinson, R. T. & Saez-Rodriguez, J. Journal of the American Heart Association, e019667 (2021).

Efficacy and Safety of Revacept, a Novel Lesion-Directed Competitive Antagonist to Platelet Glycoprotein VI, in Patients Undergoing Elective Percutaneous Coronary Intervention for Stable Ischemic Heart Disease: The Randomized, Double-blind, Placebo-Controlled ISAR-PLASTER Phase 2 Trial. Mayer, K., Hein-Rothweiler, R., Schüpke, S., Janisch, M., Bernlochner, I., Ndrepepa, G., Sibbing, D., Gori, T., Borst, O., Holdenrieder, S., Kupka, D., Petzold, T., Bradaric, C., Okrojek, R., Leistner, D. M., Trippel, T. D., Münzel, T., Landmesser, U., Pieske, B., Zeiher, A. M. et al. JAMA cardiology (2021).

Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients. Maifeld, A., Bartolomaeus, H., Löber, U., Avery, E. G., Steckhan, N., Markó, L., Wilck, N., Hamad, I., Šušnjar, U., Mähler, A., Hohmann, C., Chen, C. Y., Cramer, H., Dobos, G., Lesker, T. R., Strowig, T., Dechend, R., Bzdok, D., Kleinewietfeld, M., Michalsen, A. et al. Nature communications 12, 1970 (2021).


March

Promyelocytic leukemia protein promotes the phenotypic switch of smooth muscle cells in atherosclerotic plaques of human coronary arteries. Karle, W., Becker, S., Stenzel, P., Knosalla, C., Siegel, G., Baum, O., Zakrzewicz, A. & Berkholz, J. Clin Sci (Lond) 135, 887-905 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33764440  

Exercise training and high-sensitivity cardiac troponin T in patients with heart failure with reduced ejection fraction. Koppen, E., Omland, T., Larsen, A. I., Karlsen, T., Linke, A., Prescott, E., Halle, M., Dalen, H., Delagardelle, C., Hole, T., van Craenenbroeck, E. M., Beckers, P., Ellingsen, O., Feiereisen, P., Valborgland, T., Videm, V. & Group, S.-H. S. ESC heart failure 8, 2183-2192 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33754453  

Preoperative Anemia and Outcomes After Corrective Surgery in Neonates With Dextro-Transposition of the Great Arteries. Boos, V., Buhrer, C. & Berger, F. Journal of cardiothoracic and vascular anesthesia 35, 2900-2906 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33745834  

Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Surendran, P., Feofanova, E. V., Lahrouchi, N., Ntalla, I., Karthikeyan, S., Cook, J., Chen, L., Mifsud, B., Yao, C., Kraja, A. T., Cartwright, J. H., Hellwege, J. N., Giri, A., Tragante, V., Thorleifsson, G., Liu, D. J., Prins, B. P., Stewart, I. D., Cabrera, C. P., Eales, J. M., Akbarov, A., Auer, P. L., Bielak, L. F., Bis, J. C., Braithwaite, V. S., Brody, J. A., Daw, E. W., Warren, H. R., Drenos, F., Nielsen, S. F., Faul, J. D., Fauman, E. B., Fava, C., Ferreira, T., Foley, C. N., Franceschini, N., Gao, H., Giannakopoulou, O., Giulianini, F., Gudbjartsson, D. F., Guo, X., Harris, S. E., Havulinna, A. S., Helgadottir, A., Huffman, J. E., Hwang, S. J., Kanoni, S., Kontto, J., Larson, M. G., Li-Gao, R., Lindstrom, J., Lotta, L. A., Lu, Y., Luan, J., Mahajan, A., Malerba, G., Masca, N. G. D., Mei, H., Menni, C., Mook-Kanamori, D. O., Mosen-Ansorena, D., Muller-Nurasyid, M., Pare, G., Paul, D. S., Perola, M., Poveda, A., Rauramaa, R., Richard, M., Richardson, T. G., Sepulveda, N., Sim, X., Smith, A. V., Smith, J. A., Staley, J. R., Stanakova, A., Sulem, P., Theriault, S., Thorsteinsdottir, U., Trompet, S., Varga, T. V., Velez Edwards, D. R., Veronesi, G., Weiss, S., Willems, S. M., Yao, J., Young, R., Yu, B., Zhang, W., Zhao, J. H., Zhao, W., Zhao, W., Evangelou, E., Aeschbacher, S., Asllanaj, E., Blankenberg, S., Bonnycastle, L. L., Bork-Jensen, J., Brandslund, I., Braund, P. S., Burgess, S., Cho, K., Christensen, C., Connell, J., Mutsert, R., Dominiczak, A. F., Dorr, M., Eiriksdottir, G., Farmaki, A. E., Gaziano, J. M., Grarup, N., Grove, M. L., Hallmans, G., Hansen, T., Have, C. T., Heiss, G., Jorgensen, M. E., Jousilahti, P., Kajantie, E., Kamat, M., Karajamaki, A., Karpe, F., Koistinen, H. A., Kovesdy, C. P., Kuulasmaa, K., Laatikainen, T., Lannfelt, L., Lee, I. T., Lee, W. J., LifeLines Cohort, S., Linneberg, A., Martin, L. W., Moitry, M., Nadkarni, G., Neville, M. J., Palmer, C. N. A., Papanicolaou, G. J., Pedersen, O., Peters, J., Poulter, N., Rasheed, A., Rasmussen, K. L., Rayner, N. W., Magi, R., Renstrom, F., Rettig, R., Rossouw, J., Schreiner, P. J., Sever, P. S., Sigurdsson, E. L., Skaaby, T., Sun, Y. V., Sundstrom, J., Thorgeirsson, G., Esko, T., Trabetti, E., Tsao, P. S., Tuomi, T., Turner, S. T., Tzoulaki, I., Vaartjes, I., Vergnaud, A. C., Willer, C. J., Wilson, P. W. F., Witte, D. R., Yonova-Doing, E., Zhang, H., Aliya, N., Almgren, P., Amouyel, P., Asselbergs, F. W., Barnes, M. R., Blakemore, A. I., Boehnke, M., Bots, M. L., Bottinger, E. P., Buring, J. E., Chambers, J. C., Chen, Y. I., Chowdhury, R., Conen, D., Correa, A., Davey Smith, G., Boer, R. A., Deary, I. J., Dedoussis, G., Deloukas, P., Di Angelantonio, E., Elliott, P., Epic, C. V. D., InterAct, E., Felix, S. B., Ferrieres, J., Ford, I., Fornage, M., Franks, P. W., Franks, S., Frossard, P., Gambaro, G., Gaunt, T. R., Groop, L., Gudnason, V., Harris, T. B., Hayward, C., Hennig, B. J., Herzig, K. H., Ingelsson, E., Tuomilehto, J., Jarvelin, M. R., Jukema, J. W., Kardia, S. L. R., Kee, F., Kooner, J. S., Kooperberg, C., Launer, L. J., Lind, L., Loos, R. J. F., Majumder, A. A. S., Laakso, M., McCarthy, M. I., Melander, O., Mohlke, K. L., Murray, A. D., Nordestgaard, B. G., Orho-Melander, M., Packard, C. J., Padmanabhan, S., Palmas, W., Polasek, O., Porteous, D. J., Prentice, A. M., Province, M. A., Relton, C. L., Rice, K., Ridker, P. M., Rolandsson, O., Rosendaal, F. R., Rotter, J. I., Rudan, I., Salomaa, V., Samani, N. J., Sattar, N., Sheu, W. H., Smith, B. H., Soranzo, N., Spector, T. D., Starr, J. M., Sebert, S., Taylor, K. D., Lakka, T. A., Timpson, N. J., Tobin, M. D., Understanding Society Scientific, G., van der Harst, P., van der Meer, P., Ramachandran, V. S., Verweij, N., Virtamo, J., Volker, U., Weir, D. R., Zeggini, E., Charchar, F. J., Million Veteran, P., Wareham, N. J., Langenberg, C., Tomaszewski, M., Butterworth, A. S., Caulfield, M. J., Danesh, J., Edwards, T. L., Holm, H., Hung, A. M., Lindgren, C. M., Liu, C., Manning, A. K., Morris, A. P., Morrison, A. C., O'Donnell, C. J., Psaty, B. M., Saleheen, D., Stefansson, K., Boerwinkle, E., Chasman, D. I., Levy, D., Newton-Cheh, C., Munroe, P. B. & Howson, J. M. M. Nature genetics 53, 762 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33727701

Immunomodulation Therapy Using Tolerogenic Macrophages in a Rodent Model of Pulmonary Hypertension. Guihaire, J., Deuse, T., Wang, D., Spin, J. M., Blankenberg, F. G., Fadel, E., Reichenspurner, H. & Schrepfer, S. Stem Cells Dev (2021). https://www.ncbi.nlm.nih.gov/pubmed/33726521  

Physical Fitness Training in Patients with Subacute Stroke (PHYS-STROKE): Safety analyses of a randomized clinical trial. Rackoll, T., A, H. N., Ebinger, M., Endres, M., Grittner, U., Floel, A. & for the, P.-S. s. g. International journal of stroke : official journal of the International Stroke Society, 17474930211006286 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33724085  

Do beta-Blockers Cause Depression?: Systematic Review and Meta-Analysis of Psychiatric Adverse Events During beta-Blocker Therapy. Riemer, T. G., Villagomez Fuentes, L. E., Algharably, E. A. E., Schafer, M. S., Mangelsen, E., Furtig, M. A., Bittner, N., Bar, A., Zaidi Touis, L., Wachtell, K., Majic, T., Dinges, M. J. & Kreutz, R. Hypertension 77, 1539-1548 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33719510

The association between genetically determined ABO blood types and major depressive disorder. Garvert, L., Baune, B. T., Berger, K., Boomsma, D. I., Breen, G., Greinacher, A., Hamilton, S. P., Levinson, D. F., Lewis, C. M., Lucae, S., Magnusson, P. K. E., Martin, N. G., McIntosh, A. M., Mors, O., Muller-Myhsok, B., Penninx, B., Perlis, R. H., Pistis, G., Potash, J. B., Preisig, M., Rietschel, M., Shi, J., Smoller, J. W., Tiemeier, H., Uher, R., Volker, U., Volzke, H., Weissman, M. M., Major Depressive Disorder Working Group of the Psychiatric Genomics, C., Grabe, H. J. & Van der Auwera, S. Psychiatry Res 299, 113837 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33721783

Glycosylation-dependent cleavage of the human beta1-adrenoceptor. Ahles, A. & Engelhardt, S. Journal of molecular and cellular cardiology 154, 154-155 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33711343

MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease. Monteiro, J. P., Rodor, J., Caudrillier, A., Scanlon, J. P., Spiroski, A. M., Dudnakova, T., Pfluger-Muller, B., Shmakova, A., von Kriegsheim, A., Deng, L., Taylor, R. S., Wilson-Kanamori, J. R., Chen, S. H., Stewart, K., Thomson, A., Mitic, T., McClure, J. D., Iynikkel, J., Hadoke, P. W. F., Denby, L., Bradshaw, A. C., Caruso, P., Morrell, N. W., Kovacic, J. C., Ulitsky, I., Henderson, N. C., Caporali, A., Leisegang, M. S., Brandes, R. P. & Baker, A. H. Circulation research 128, 1173-1190 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33703914

Metabolism and Inflammation in Cardiovascular Health and Diseases: Mechanisms to Therapies. Schiattarella, G. G., Wang, Y., Tian, R. & Hill, J. A. Journal of molecular and cellular cardiology 157, 113-114 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33667418

Safe procedures despite ultra low radiation doses during catheter ablations of atrial and ventricular arrhythmias-A multicenter experience. Attanasio, P., Huemer, M., Kaehler, N., Keller, T., Schreiber, T., Niehues, R., Katsani-Potempa, D., Klein, R. M., Landmesser, U., Deisenhofer, I., Tutdibi, O. & Bourier, F. Pacing and clinical electrophysiology : PACE 44, 807-813 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33665850

CRIP1 expression in monocytes related to hypertension. Schweigert, O., Adler, J., Langst, N., Aissi, D., Duque Escobar, J., Tong, T., Muller, C., Tregouet, D. A., Lukowski, R. & Zeller, T. Clin Sci (Lond) 135, 911-924 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33782695  

Promyelocytic leukemia protein promotes the phenotypic switch of smooth muscle cells in atherosclerotic plaques of human coronary arteries. Karle, W., Becker, S., Stenzel, P., Knosalla, C., Siegel, G., Baum, O., Zakrzewicz, A. & Berkholz, J. Clin Sci (Lond) 135, 887-905 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33764440  

Immunomodulation Therapy Using Tolerogenic Macrophages in a Rodent Model of Pulmonary Hypertension. Guihaire, J., Deuse, T., Wang, D., Spin, J. M., Blankenberg, F. G., Fadel, E., Reichenspurner, H. & Schrepfer, S. Stem Cells Dev (2021). https://www.ncbi.nlm.nih.gov/pubmed/33726521  

Physical Fitness Training in Patients with Subacute Stroke (PHYS-STROKE): Safety analyses of a randomized clinical trial. Rackoll, T., A, H. N., Ebinger, M., Endres, M., Grittner, U., Floel, A. & for the, P.-S. s. g. International journal of stroke : official journal of the International Stroke Society, 17474930211006286 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33724085  

Do beta-Blockers Cause Depression?: Systematic Review and Meta-Analysis of Psychiatric Adverse Events During beta-Blocker Therapy. Riemer, T. G., Villagomez Fuentes, L. E., Algharably, E. A. E., Schafer, M. S., Mangelsen, E., Furtig, M. A., Bittner, N., Bar, A., Zaidi Touis, L., Wachtell, K., Majic, T., Dinges, M. J. & Kreutz, R. Hypertension 77, 1539-1548 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33719510

The association between genetically determined ABO blood types and major depressive disorder. Garvert, L., Baune, B. T., Berger, K., Boomsma, D. I., Breen, G., Greinacher, A., Hamilton, S. P., Levinson, D. F., Lewis, C. M., Lucae, S., Magnusson, P. K. E., Martin, N. G., McIntosh, A. M., Mors, O., Muller-Myhsok, B., Penninx, B., Perlis, R. H., Pistis, G., Potash, J. B., Preisig, M. et al. Psychiatry Res 299, 113837 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33721783  

MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease. Monteiro, J. P., Rodor, J., Caudrillier, A., Scanlon, J. P., Spiroski, A. M., Dudnakova, T., Pfluger-Muller, B., Shmakova, A., von Kriegsheim, A., Deng, L., Taylor, R. S., Wilson-Kanamori, J. R., Chen, S. H., Stewart, K., Thomson, A., Mitic, T., McClure, J. D., Iynikkel, J., Hadoke, P. W. F., Denby, L. et al. Circulation research 128, 1173-1190 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33703914  

 

 

Effect of Carillon Mitral Contour System on patient-reported outcomes in functional mitral regurgitation: an individual participant data meta-analysis. Khan, M. S., Friede, T., Anker, S. D. & Butler, J. ESC heart failure (2021).

Community-wide experimental evaluation of the PROSS stability-design method. Peleg, Y., Vincentelli, R., Collins, B. M., Chen, K. E., Livingstone, E. K., Weeratunga, S., Leneva, N., Guo, Q., Remans, K., Perez, K., G, E. K. B., Larsen, Ø., Vaněk, O., Skořepa, O., Jacquemin, S., Poterszman, A., Kjaer, S., Christodoulou, E., Albeck, S., Dym, O. et al. J Mol Biol, 166964 (2021).

Maternal Angiotensin Increases Placental Leptin in Early Gestation via an Alternative Renin-Angiotensin System Pathway: Suggesting a Link to Preeclampsia. Nonn, O., Fischer, C., Geisberger, S., El-Heliebi, A., Kroneis, T., Forstner, D., Desoye, G., Staff, A. C., Sugulle, M., Dechend, R., Pecks, U., Kollmann, M., Stern, C., Cartwright, J. E., Whitley, G. S., Thilaganathan, B., Wadsack, C., Huppertz, B., Herse, F. & Gauster, M. Hypertension, Hypertensionaha12016425 (2021).

Beware of TOSCA's kiss or metabolic and hormonal aspects of heart failure. Lainscak, M., Dora, E., Doehner, W., Obradovic, D. & Loncar, G. European journal of preventive cardiology (2021).

Initial experience with a novel, modular, minimalistic approach for transfemoral aortic valve implantation. Kim, W. K., Doerr, O., Renker, M., Choi, Y. H., Liakopoulos, O., Hamm, C. W. & Nef, H. International journal of cardiology (2021).

Compressed sensing acceleration of cardiac cine imaging allows reliable and reproducible assessment of volumetric and functional parameters of the left and right atrium. Altmann, S., Halfmann, M. C., Abidoye, I., Yacoub, B., Schmidt, M., Wenzel, P., Forman, C., Schoepf, U. J., Xiong, F., Dueber, C., Kreitner, K. F., Varga-Szemes, A. & Emrich, T. European radiology (2021).

Reply to: Dumping adherence: a person-centred response for primary care. Eisele, M., Harder, M., Rakebrandt, A., Boczor, S., Marx, G., Blozik, E., Träder, J. M., Störk, S., Herrmann-Lingen, C. & Scherer, M. Fam Pract 38, 198-199 (2021).

Physical activity, sedentary behavior and risk of coronary artery disease, myocardial infarction and ischemic stroke: a two-sample Mendelian randomization study. Bahls, M., Leitzmann, M. F., Karch, A., Teumer, A., Dörr, M., Felix, S. B., Meisinger, C., Baumeister, S. E. & Baurecht, H. Clinical research in cardiology : official journal of the German Cardiac Society (2021).

Generation and Cultivation of Transgene-Free Macaque and Baboon iPSCs Under Chemically Defined Conditions. Rodríguez-Polo, I., Stauske, M. & Behr, R. Methods in molecular biology (2021).

Eye Tracking Supported Human Factors Testing Improving Patient Training. Weiss, K. E., Hoermandinger, C., Mueller, M., Schmid Daners, M., Potapov, E. V., Falk, V., Meboldt, M. & Lohmeyer, Q. J Med Syst 45, 55 (2021).

Therapies with CCL25 require controlled release via microparticles to avoid strong inflammatory reactions. Spinnen, J., Fröhlich, K., Sinner, N., Stolk, M., Ringe, J., Shopperly, L., Sittinger, M., Dehne, T. & Seifert, M. Journal of nanobiotechnology 19, 83 (2021).

Discordance of High-Sensitivity Troponin Assays in Patients With Suspected Acute Coronary Syndromes. Karády, J., Mayrhofer, T., Ferencik, M., Nagurney, J. T., Udelson, J. E., Kammerlander, A. A., Fleg, J. L., Peacock, W. F., Januzzi, J. L., Jr., Koenig, W. & Hoffmann, U. Journal of the American College of Cardiology 77, 1487-1499 (2021).

Effects of different exercise modalities on cardiac dysfunction in heart failure with preserved ejection fraction. Bode, D., Rolim, N. P. L., Guthof, T., Hegemann, N., Wakula, P., Primessnig, U., Berre, A. M. O., Adams, V., Wisløff, U., Pieske, B. M., Heinzel, F. R. & Hohendanner, F. ESC heart failure (2021).

GLP-1 receptor agonists and their cardiovascular benefits - the role of the GLP-1 receptor. Helmstädter, J., Keppeler, K., Küster, L., Münzel, T., Daiber, A. & Steven, S. British journal of pharmacology (2021).

CMR for myocardial characterization in ischemic heart disease: state-of-the-art and future developments. Emrich, T., Halfmann, M., Schoepf, U. J. & Kreitner, K. F. Eur Radiol Exp 5, 14 (2021).

Sex differences in patients with cardiogenic shock. Yan, I., Schrage, B., Weimann, J., Dabboura, S., Hilal, R., Beer, B. N., Becher, P. M., Seiffert, M., Magnussen, C., R, B. S., Kirchhof, P., Blankenberg, S. & Westermann, D. ESC heart failure (2021).

Frailty in patients undergoing transcatheter aortic valve replacement: prognostic value of the Geriatric Nutritional Risk Index. Seoudy, H., Al-Kassou, B., Shamekhi, J., Sugiura, A., Frank, J., Saad, M., Bramlage, P., Seoudy, A. K., Puehler, T., Lutter, G., Schulte, D. M., Laudes, M., Nickenig, G., Frey, N., Sinning, J. M. & Frank, D. J Cachexia Sarcopenia Muscle (2021).

Author Correction: Assessment of nanoindentation in stiffness measurement of soft biomaterials: kidney, liver, spleen and uterus. Wu, G., Gotthardt, M. & Gollasch, M. Scientific reports 11, 7035 (2021).

Center procedural volume and adverse in-hospital outcomes for patients undergoing percutaneous transvenous edge-to-edge mitral valve repair using MitraClip® technique in Germany. Keller, K., Hobohm, L., Schmidtmann, I., Münzel, T., Baldus, S. & von Bardeleben, R. S. European journal of heart failure (2021).

Experience and procedural efficacy of pulmonary vein isolation using the fourth and second generation cryoballoon: The shorter, the better? Heeger, C. H., Bohnen, J. E., Popescu, S., Meyer-Saraei, R., Fink, T., Sciacca, V., Kirstein, B., Hatahet, S., Traub, A., Lopez, L. D., Schlüter, M., Kuck, K. H., Eitel, C., Vogler, J. & Richard Tilz, R. Journal of cardiovascular electrophysiology (2021).

Personalized exercise prescription in the prevention and treatment of arterial hypertension: a Consensus Document from the European Association of Preventive Cardiology (EAPC) and the ESC Council on Hypertension. Hanssen, H., Boardman, H., Deiseroth, A., Moholdt, T., Simonenko, M., Kränkel, N., Niebauer, J., Tiberi, M., Abreu, A., Solberg, E. E., Pescatello, L., Brguljan, J., Coca, A. & Leeson, P. European journal of preventive cardiology (2021).

Non-adherence to heart failure medications predicts clinical outcomes: Assessment in a single spot urine sample by liquid chromatography - tandem mass spectrometry (results of a prospective multicentre study). Gupta, P., Voors, A. A., Patel, P., Lane, D., Anker, S. D., Cleland, J. G. F., Dickstein, K., Filippatos, G., Lang, C. C., van Veldhuisen, D. J., Metra, M., Zannad, F., Samani, N. J., Jones, D. J. L., Squire, I. B. & Ng, L. L. European journal of heart failure (2021).

Surgical Cutdown Avoids Vascular Complications in Transcatheter Aortic Valve Replacement in Calcified and Small Femoral Arteries. Burri, M., Ruge, H., Erlebach, M. & Lange, R. The Thoracic and cardiovascular surgeon (2021).

Epigenome-wide association study of whole blood gene expression in Framingham Heart Study participants provides molecular insight into the potential role of CHRNA5 in cigarette smoking-related lung diseases. Yao, C., Joehanes, R., Wilson, R., Tanaka, T., Ferrucci, L., Kretschmer, A., Prokisch, H., Schramm, K., Gieger, C., Peters, A., Waldenberger, M., Marzi, C., Herder, C. & Levy, D. Clinical epigenetics 13, 60 (2021).

A hierarchical regulatory network analysis of the vitamin D induced transcriptome reveals novel regulators and complete VDR dependency in monocytes. Warwick, T., Schulz, M. H., Günther, S., Gilsbach, R., Neme, A., Carlberg, C., Brandes, R. P. & Seuter, S. Scientific reports 11, 6518 (2021).

Role of the Ambulatory Assessed Apnea-Hypopnea Index for Predicting Recurring Atrial Fibrillation After Ablation Therapy. Trenkwalder, T., Grebmer, C., Tydecks, M., Blažek, P., Kottmaier, M., Weigand, S., Bourier, F., Reents, T., Reinhard, W., Lennerz, C., Hessling, G., Deisenhofer, I. & Kolb, C. The American journal of cardiology (2021).

Exercise training and high-sensitivity cardiac troponin T in patients with heart failure with reduced ejection fraction. Koppen, E., Omland, T., Larsen, A. I., Karlsen, T., Linke, A., Prescott, E., Halle, M., Dalen, H., Delagardelle, C., Hole, T., van Craenenbroeck, E. M., Beckers, P., Ellingsen, Ø., Feiereisen, P., Valborgland, T. & Videm, V. ESC heart failure (2021).

Beyond pacemaking: HCN channels in sinoatrial node function. Hennis, K., Biel, M., Wahl-Schott, C. & Fenske, S. Progress in biophysics and molecular biology (2021).

Fusion imaging guided implantation of a Tricento transcatheter heart valve for severe tricuspid regurgitation. Boeder, N. F., Bayer, M., Dörr, O. & Nef, H. M. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions (2021).

Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality. Schunk, S. J., Kleber, M. E., März, W., Pang, S., Zewinger, S., Triem, S., Ege, P., Reichert, M. C., Krawczyk, M., Weber, S. N., Jaumann, I., Schmit, D., Sarakpi, T., Wagenpfeil, S., Kramann, R., Boerwinkle, E., Ballantyne, C. M., Grove, M. L., Tragante, V., Pilbrow, A. P. et al. European heart journal (2021).

One-Year Outcomes of a Randomized Trial Comparing a Self-Expanding With a Balloon-Expandable Transcatheter Aortic Valve. Kim, W. K., Walther, T., Burgdorf, C., Möllmann, H., Linke, A., Redwood, S., Thilo, C., Hilker, M., Joner, M., Thiele, H., Conzelmann, L., Conradi, L., Kerber, S., Schymik, G., Prendergast, B., Husser, O., Blumenstein, J., Stortecky, S., Heg, D., Künzi, A. et al. Circulation 143, 1267-1269 (2021).

THE YEAR IN BASIC VASCULAR BIOLOGY RESEARCH: FROM MECHANORECEPTORS AND NETS TO SMARTPHONE DATA AND OMICS. Evans, P., Wojta, J., Hoefer, I. E., Waltenberger, J., Guzik, T., Badimon, L. & Weber, C. Cardiovascular research (2021).

The value of spot urinary creatinine as a marker of muscle wasting in patients with new-onset or worsening heart failure. Pandhi, P., Streng, K. W., Anker, S. D., Cleland, J. G., Damman, K., Dickstein, K., Pellicori, P., Lang, C. C., Ng, L., Samani, N. J., Zannad, F., Metra, M., Rossignol, P., Filippatos, G., van Veldhuisen, D. J., Voors, A. A. & Ter Maaten, J. M. J Cachexia Sarcopenia Muscle (2021).

Are atrial human pluripotent stem cell-derived cardiomyocytes ready to identify drugs that beat atrial fibrillation? Christ, T., Lemoine, M. D. & Eschenhagen, T. Nature communications 12, 1725 (2021).

Dipeptidyl peptidase 3, a marker of the antagonist pathway of the renin-angiotensin-aldosterone system in patients with heart failure. Boorsma, E. M., Ter Maaten, J. M., Damman, K., van Veldhuisen, D. J., Dickstein, K., Anker, S. D., Filippatos, G., Lang, C. C., Metra, M., Santos, K. & Voors, A. A. European journal of heart failure (2021).

Induced Pluripotent Stem Cells (iPSCs) in Vascular Research: from Two- to Three-Dimensional Organoids. Trillhaase, A., Maertens, M., Aherrahrou, Z. & Erdmann, J. Stem Cell Rev Rep, 1-13 (2021).

Spinocerebellar ataxia type 14: refining clinicogenetic diagnosis in a rare adult-onset disorder. Schmitz-Hübsch, T., Lux, S., Bauer, P., Brandt, A. U., Schlapakow, E., Greschus, S., Scheel, M., Gärtner, H., Kirlangic, M. E., Gras, V., Timmann, D., Synofzik, M., Giorgetti, A., Carloni, P., Shah, J. N., Schöls, L., Kopp, U., Bußenius, L., Oberwahrenbrock, T., Zimmermann, H. et al. Ann Clin Transl Neurol (2021).

Atrial resting membrane potential confers sodium current sensitivity to propafenone, flecainide, and dronedarone. Holmes, A. P., Saxena, P., Kabir, S. N., O'Shea, C., Kuhlmann, S. M., Gupta, S., Fobian, D., Apicella, C., O'Reilly, M., Syeda, F., Reyat, J. S., Smith, G. L., Workman, A. J., Pavlovic, D., Fabritz, L. & Kirchhof, P. Heart rhythm (2021).

Effects of acute alcohol consumption on cardiac excitation, conduction, and repolarization: results from the Munich Beer Related Electrocardiogram Workup Study (MunichBREW). Brunner, S., Drobesch, C., Herbel, R. & Sinner, M. F. Clinical research in cardiology : official journal of the German Cardiac Society (2021).

Diffuse myocardial fibrosis by T1 mapping is associated with heart failure in pediatric primary dilated cardiomyopathy. Al-Wakeel-Marquard, N., Seidel, F., Herbst, C., Kühnisch, J., Kuehne, T., Berger, F., Klaassen, S. & Messroghli, D. R. International journal of cardiology (2021).

Long-Term Outcomes of Patients Undergoing the Ross Procedure. Aboud, A., Charitos, E. I., Fujita, B., Stierle, U., Reil, J. C., Voth, V., Liebrich, M., Andreas, M., Holubec, T., Bening, C., Albert, M., Fila, P., Ondrasek, J., Murin, P., Lange, R., Reichenspurner, H., Franke, U., Gorski, A., Moritz, A., Laufer, G. et al. Journal of the American College of Cardiology 77, 1412-1422 (2021).

Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine. Rajewsky, N., Almouzni, G., Gorski, S. A., Aerts, S., Amit, I., Bertero, M. G., Bock, C., Bredenoord, A. L., Cavalli, G., Chiocca, S., Clevers, H., De Strooper, B., Eggert, A., Ellenberg, J., Fernández, X. M., Figlerowicz, M., Gasser, S. M., Hubner, N., Kjems, J., Knoblich, J. A. et al. Nature 592, E8 (2021).

Generation of Marmoset Monkey iPSCs with Self-Replicating VEE-mRNAs in Feeder-Free Conditions. Petkov, S. G. & Behr, R. Methods in molecular biology (2021).

Telmisartan prevents high-fat diet-induced neurovascular impairments and reduces anxiety-like behavior. Huber, G., Ogrodnik, M., Wenzel, J., Stölting, I., Huber, L., Will, O., Peschke, E., Matschl, U., Hövener, J. B., Schwaninger, M., Jurk, D. & Raasch, W. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 271678x211003497 (2021).

The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis. Fidler, T. P., Xue, C., Yalcinkaya, M., Hardaway, B., Abramowicz, S., Xiao, T., Liu, W., Thomas, D. G., Hajebrahimi, M. A., Pircher, J., Silvestre-Roig, C., Kotini, A. G., Luchsinger, L. L., Wei, Y., Westerterp, M., Snoeck, H. W., Papapetrou, E. P., Schulz, C., Massberg, S., Soehnlein, O. et al. Nature (2021).

The management of secondary mitral regurgitation in patients with heart failure: a joint position statement from the Heart Failure Association (HFA), European Association of Cardiovascular Imaging (EACVI), European Heart Rhythm Association (EHRA), and European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC. Coats, A. J. S., Anker, S. D., Baumbach, A., Alfieri, O., von Bardeleben, R. S., Bauersachs, J., Bax, J. J., Boveda, S., Čelutkienė, J., Cleland, J. G., Dagres, N., Deneke, T., Farmakis, D., Filippatos, G., Hausleiter, J., Hindricks, G., Jankowska, E. A., Lainscak, M., Leclercq, C., Lund, L. H. et al. European heart journal (2021).

Advanced cancer is also a heart failure syndrome: a hypothesis. Anker, M. S., Sanz, A. P., Zamorano, J. L., Mehra, M. R., Butler, J., Riess, H., Coats, A. J. S. & Anker, S. D. J Cachexia Sarcopenia Muscle (2021).

Comparison of the prognosis and outcome of heart failure with reduced ejection fraction patients treated with sacubitril/valsartan according to age. Abumayyaleh, M., El-Battrawy, I., Kummer, M., Pilsinger, C., Sattler, K., Kuschyk, J., Aweimer, A., Mügge, A., Borggrefe, M. & Akin, I. Future cardiology (2021).

The genetic predisposition to longevity acts through behavioral phenotypes in females. Van der Auwera, S., Garvert, L., Fuellen, G., Nauck, M., Völzke, H., Völker, U. & Grabe, H. J. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 45, 1-14 (2021).

Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction. Schiattarella, G. G., Altamirano, F., Kim, S. Y., Tong, D., Ferdous, A., Piristine, H., Dasgupta, S., Wang, X., French, K. M., Villalobos, E., Spurgin, S. B., Waldman, M., Jiang, N., May, H. I., Hill, T. M., Luo, Y., Yoo, H., Zaha, V. G., Lavandero, S., Gillette, T. G. et al. Nature communications 12, 1684 (2021).

Quality of life in men and women with heart failure: association with outcome, and comparison of the Kansas City Cardiomyopathy Questionnaire and the EuroQol 5 dimensions questionnaire. Ravera, A., Santema, B. T., Sama, I. E., Meyer, S., Lombardi, C. M., Carubelli, V., Ferreira, J. P., Lang, C. C., Dickstein, K., Anker, S. D., Samani, N. J., Zannad, F., van Veldhuisen, D. J., Teerlink, J. R., Metra, M. & Voors, A. A. European journal of heart failure (2021).

Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases. Paloschi, V., Sabater-Lleal, M., Middelkamp, H., Vivas, A., Johansson, S., van der Meer, A., Tenje, M. & Maegdefessel, L. Cardiovascular research (2021).

Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival. Muzerelle, A., Soiza-Reilly, M., Hainer, C., Ruet, P. L., Lesch, K. P., Bader, M., Alenina, N., Scotto-Lomassese, S. & Gaspar, P. Scientific reports 11, 6004 (2021).

The current evidence of Takotsubo syndrome. El-Battrawy, I., Borggrefe, M. & Akin, I. Future cardiology (2021).

Left Ventricular Pathology in Ebstein's Anomaly-Myocardium in Motion: CMR Insights Into Left Ventricular Fibrosis, Deformation, and Exercise Capacity. Steinmetz, M. & Schuster, A. Circulation. Cardiovascular imaging, Circimaging121012285 (2021).

Noninvasive peripheral vascular function, incident cardiovascular disease, and mortality in the general population. Schnabel, R. B., Magnussen, C., Schulz, A., Ojeda, F. M., Schmitt, V. H., Arnold, N., Sinning, C. R., Beutel, M. E., Schmidtmann, I., Pfeiffer, N., Leuschner, A., Lackner, K. J., Gori, T., Benjamin, E. J., Binder, H., Wild, P. S., Blankenberg, S. & Münzel, T. Cardiovascular research (2021).

Targeting angiotensin type 2 receptors located on pressor neurons in the nucleus of the solitary tract to relieve hypertension in mice. Mohammed, M., Johnson, D. N., Wang, L. A., Harden, S. W., Sheng, W., Spector, E. A., Elsaafien, K., Bader, M., Steckelings, U. M., Scott, K. A., Frazier, C. J., Sumners, C., Krause, E. G. & de Kloet, A. D. Cardiovascular research (2021).

Do β-Blockers Cause Depression?: Systematic Review and Meta-Analysis of Psychiatric Adverse Events During β-Blocker Therapy. Riemer, T. G., Villagomez Fuentes, L. E., Algharably, E. A. E., Schäfer, M. S., Mangelsen, E., Fürtig, M. A., Bittner, N., Bär, A., Zaidi Touis, L., Wachtell, K., Majic, T., Dinges, M. J. & Kreutz, R. Hypertension, Hypertensionaha12016590 (2021).

 

 

Prognostic impact of acute pulmonary triggers in patients with takotsubo syndrome: new insights from the International Takotsubo Registry. Kato, K., Cammann, V. L., Napp, L. C., Szawan, K. A., Micek, J., Dreiding, S., Levinson, R. A., Petkova, V., Wurdinger, M., Patrascu, A., Sumalinog, R., Gili, S., Clarenbach, C. F., Kohler, M., Wischnewsky, M., Citro, R., Vecchione, C., Bossone, E., Neuhaus, M., Franke, J. et al. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33713566  

Glycosylation-dependent cleavage of the human beta1-adrenoceptor. Ahles, A. & Engelhardt, S. Journal of molecular and cellular cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33711343  

Antithrombotic treatment in primary percutaneous coronary intervention. Voll, F., Kuna, C., Ndrepepa, G., Kastrati, A. & Cassese, S. Expert Rev Cardiovasc Ther (2021). https://www.ncbi.nlm.nih.gov/pubmed/33705211  

Prosaposin mediates inflammation in atherosclerosis. van Leent, M. M. T., Beldman, T. J., Toner, Y. C., Lameijer, M. A., Rother, N., Bekkering, S., Teunissen, A. J. P., Zhou, X., van der Meel, R., Malkus, J., Nauta, S. A., Klein, E. D., Fay, F., Sanchez-Gaytan, B. L., Perez-Medina, C., Kluza, E., Ye, Y. X., Wojtkiewicz, G., Fisher, E. A., Swirski, F. K. et al. Sci Transl Med 13 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33692130  

Case Report: Early Transplant Rejection of a Methanol-Intoxicated Donor Heart in a Young Female Patient. A Diagnostic Approach With CMR, Cardiac Biopsy, and Genetic Risk Assessment. Stoiber, L., Schoenrath, F., Knosalla, C., Milting, H., Klingel, K., Tschope, C., Tanacli, R., Gebker, R., Berger, A., Pieske, B. & Kelle, S. Frontiers in immunology 11, 575635 (2020). https://www.ncbi.nlm.nih.gov/pubmed/33692775   

Network-driven discovery yields new insight into Shox2-dependent cardiac rhythm control. Hoffmann, S., Schmitteckert, S., Raedecke, K., Rheinert, D., Diebold, S., Roeth, R., Weiss, B., Granzow, M., Niesler, B., Griesbeck, A., Eckstein, V., Zimmermann, W. H., Just, S. & Rappold, G. A. Biochimica et biophysica acta. Gene regulatory mechanisms, 194702 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33706013  

Change of the Physical Activity Scale for the Elderly (PASE) score after COVID-19 outbreak. Huber, B. C., Schlichtiger, J., Drey, M., Steffen, J. & Brunner, S. J Sports Med Phys Fitness (2021). https://www.ncbi.nlm.nih.gov/pubmed/33688710  

Editorial on "Full-length dhh and N-terminal shh act as competitive antagonists to regulateangiogenesis and vascular permeability". Fleming, I. Cardiovascular research (2021). https://www.ncbi.nlm.nih.gov/pubmed/33690797  

The "TIDE"-Algorithm for the Weaning of Patients With Cardiogenic Shock and Temporarily Mechanical Left Ventricular Support With Impella Devices. A Cardiovascular Physiology-Based Approach. Tschope, C., Spillmann, F., Potapov, E., Faragli, A., Rapis, K., Nelki, V., Post, H., Schmidt, G. & Alogna, A. Frontiers in cardiovascular medicine 8, 563484 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33681302  

Hepatic steatosis and hepatic iron overload modify the association of iron markers with glucose metabolism disorders and metabolic syndrome. Pitchika, A., Kuhn, J. P., Schipf, S., Nauck, M., Dorr, M., Lerch, M. M., Kromrey, M. L., Felix, S. B., Markus, M. R. P., Rathmann, W., Volzke, H. & Ittermann, T. Liver Int (2021). https://www.ncbi.nlm.nih.gov/pubmed/33683798  

The CAD risk locus 9p21 increases the risk of vascular calcification in an iPSC-derived VSMC model. Trillhaase, A., Schmidt, B., Martens, M., Haferkamp, U., Erdmann, J. & Aherrahrou, Z. Stem Cell Res Ther 12, 166 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33676559  

Regulation of basal and norepinephrine-induced cAMP and ICa in hiPSC-cardiomyocytes: Effects of culture conditions and comparison to adult human atrial cardiomyocytes. Iqbal, Z., Ismaili, D., Dolce, B., Petersen, J., Reichenspurner, H., Hansen, A., Kirchhof, P., Eschenhagen, T., Nikolaev, V. O., Molina, C. E. & Christ, T. Cellular signalling, 109970 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33677066  

Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23. Garnier, S., Harakalova, M., Weiss, S., Mokry, M., Regitz-Zagrosek, V., Hengstenberg, C., Cappola, T. P., Isnard, R., Arbustini, E., Cook, S. A., van Setten, J., Calis, J. J. A., Hakonarson, H., Morley, M. P., Stark, K., Prasad, S. K., Li, J., O'Regan, D. P., Grasso, M., Muller-Nurasyid, M. et al. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/33677556  

Speckle Tracking Analysis Reveals Altered Left Atrial and Ventricular Myocardial Deformation in Patients with End-Stage Liver Disease. von Kockritz, F., Braun, A., Schmuck, R. B., Dobrindt, E. M., Eurich, D., Heinzel, F. R., Pieske, B., Escher, F. & Zhang, K. Journal of clinical medicine 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33668295  

Deciphering the Role of Wnt and Rho Signaling Pathway in iPSC-Derived ARVC Cardiomyocytes by In Silico Mathematical Modeling. Parrotta, E. I., Procopio, A., Scalise, S., Esposito, C., Nicoletta, G., Santamaria, G., De Angelis, M. T., Dorn, T., Moretti, A., Laugwitz, K. L., Montefusco, F., Cosentino, C. & Cuda, G. International journal of molecular sciences 22 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33670616   

MicroRNAs and Long Non-Coding RNAs as Potential Candidates to Target Specific Motifs of SARS-CoV-2. Natarelli, L., Parca, L., Mazza, T., Weber, C., Virgili, F. & Fratantonio, D. Non-coding RNA 7 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33670580  

"Empowering" Cardiac Cells via Stem Cell Derived Mitochondrial Transplantation- Does Age Matter? Mietsch, M. & Hinkel, R. International journal of molecular sciences 22 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33673127  

Inflammation-Related Risk Loci in Genome-Wide Association Studies of Coronary Artery Disease. Mauersberger, C., Schunkert, H. & Sager, H. B. Cells 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33669721   

The lack of evidence-based therapeutic strategies for left ventricular unloading during venoarterial extracorporeal membrane oxygenation therapy calls for randomized trials. Lusebrink, E., Massberg, S. & Orban, M. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/33675639  

Accelerated Aging and Age-Related Diseases (CVD and Neurological) Due to Air Pollution and Traffic Noise Exposure. Hahad, O., Frenis, K., Kuntic, M., Daiber, A. & Munzel, T. International journal of molecular sciences 22 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33670865  

Energy Metabolites as Biomarkers in Ischemic and Dilated Cardiomyopathy. Haas, J., Frese, K. S., Sedaghat-Hamedani, F., Kayvanpour, E., Tappu, R., Nietsch, R., Tugrul, O. F., Wisdom, M., Dietrich, C., Amr, A., Weis, T., Niederdrank, T., Murphy, M. P., Krieg, T., Dorr, M., Volker, U., Fielitz, J., Frey, N., Felix, S. B., Keller, A. et al. International journal of molecular sciences 22 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33670449  

The ElonginB/C-Cullin5-SOCS-Box-Complex Is a Potential Biomarker for Growth Hormone Disorders. Gossing, W., Radke, L., Biering, H., Diederich, S., Mai, K. & Frohme, M. Biomedicines 9 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33671326  

Physical Activity Improves Mental Health in Children and Adolescents Irrespective of the Diagnosis of Attention Deficit Hyperactivity Disorder (ADHD)-A Multi-Wave Analysis Using Data from the KiGGS Study. Ganjeh, P., Meyer, T., Hagmayer, Y., Kuhnert, R., Ravens-Sieberer, U., von Steinbuechel, N., Rothenberger, A. & Becker, A. Int J Environ Res Public Health 18 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33668090  

Generation and Breeding of EGFP-Transgenic Marmoset Monkeys: Cell Chimerism and Implications for Disease Modeling. Drummer, C., Vogt, E. J., Heistermann, M., Roshani, B., Becker, T., Matz-Rensing, K., Kues, W. A., Kugler, S. & Behr, R. Cells 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33673402  

Clinical Factors Associated with Atrial Fibrillation Detection on Single-Time Point Screening Using a Hand-Held Single-Lead ECG Device. Boriani, G., Palmisano, P., Malavasi, V. L., Fantecchi, E., Vitolo, M., Bonini, N., Imberti, J. F., Valenti, A. C., Schnabel, R. B. & Freedman, B. Journal of clinical medicine 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33673209  

Regulation of Mitochondrial Homeostasis by sAC-Derived cAMP Pool: Basic and Translational Aspects. Aslam, M. & Ladilov, Y. Cells 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33671810   

Pooled Patient-Level Analysis of Inclisiran Trials in Patients With Familial Hypercholesterolemia or Atherosclerosis. Wright, R. S., Ray, K. K., Raal, F. J., Kallend, D. G., Jaros, M., Koenig, W., Leiter, L. A., Landmesser, U., Schwartz, G. G., Friedman, A., Wijngaard, P. L. J., Garcia Conde, L., Kastelein, J. J. P. & Investigators, O. P. I. Journal of the American College of Cardiology 77, 1182-1193 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33663735   

Risk factors, physical and mental health burden of male and female pathological gamblers in the German general population aged 40-80. Wejbera, M., Wolfling, K., Dreier, M., Michal, M., Brahler, E., Wiltink, J., Schulz, A., Wild, P. S., Munzel, T., Konig, J., Lackner, K., Pfeiffer, N. & Beutel, M. E. BMC Psychiatry 21, 123 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33663432

Is there a Future for Remote Ischemic Conditioning in Acute Myocardial Infarction? Stiermaier, T., Birnbaum, Y. & Eitel, I. Cardiovascular drugs and therapy (2021). https://www.ncbi.nlm.nih.gov/pubmed/33666821   

Cardiometabolic disease: Mechanisms to therapies. Schiattarella, G. G., Wang, Y., Tian, R. & Hill, J. A. Journal of molecular and cellular cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33667418  

A universal protocol for isolating retinal ON bipolar cells across species via fluorescence-activated cell sorting. Murenu, E., Pavlou, M., Richter, L., Rapti, K., Just, S., Cehajic-Kapetanovic, J., Tafrishi, N., Hayes, A., Scholey, R., Lucas, R., Buning, H., Grimm, D. & Michalakis, S. Mol Ther Methods Clin Dev 20, 587-600 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33665228  

MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm. Gao, P., Gao, P., Zhao, J., Shan, S., Luo, W., Slivano, O. J., Zhang, W., Tabuchi, A., LeMaire, S. A., Maegdefessel, L., Shen, Y. H., Miano, J. M., Singer, H. A. & Long, X. Redox biology 41, 101903 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33667992  

Developmental regulation of barrier- and non-barrier blood vessels in the CNS. Ben-Zvi, A. & Liebner, S. Journal of internal medicine (2021). https://www.ncbi.nlm.nih.gov/pubmed/33665890  

Local cyclic adenosine monophosphate signalling cascades-Roles and targets in chronic kidney disease. Sholokh, A. & Klussmann, E. Acta physiologica, e13641 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33660401  

Impact of effective regurgitant orifice area on outcome of secondary mitral regurgitation transcatheter repair. Karam, N., Orban, M., Kalbacher, D., Butter, C., Praz, F., Lubos, E., Bannehr, M., Kassar, M., Petrescu, A., Iliadis, C., Unterhuber, M., Asselin, A., Thiele, H., Pfister, R., Windecker, S., Lurz, P., von Bardeleben, S., Hausleiter, J. & Euro, S. M. R. i. Clinical research in cardiology : official journal of the German Cardiac Society (2021). https://www.ncbi.nlm.nih.gov/pubmed/33661372  

Is Continuous Eruption Related to Periodontal Changes? A 16-Year Follow-up. Wiedemann, C., Pink, C., Daboul, A., Samietz, S., Volzke, H., Schulz-Kornas, E., Krey, K. F., Holtfreter, B. & Kocher, T. J Dent Res, 22034521999363 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33655796  

Improvement of renal function after transcatheter aortic valve replacement and its impact on survival. Kylies, D., Freitag-Wolf, S., Fulisch, F., Seoudy, H., Kuhn, C., Kihm, L. P., Puhler, T., Lutter, G., Dempfle, A., Frey, N., Feldkamp, T. & Frank, D. BMC Nephrol 22, 77 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33653283  

Effect of intravenous alteplase on post-stroke depression in the WAKE UP trial. Konigsberg, A., Sehner, S., Arlt, S., Cheng, B., Simonsen, C. Z., Boutitie, F., Serena, J., Thijs, V., Ebinger, M., Endres, M., Fiebach, J. B., Lemmens, R., Muir, K. W., Nighoghossian, N., Pedraza, S., Gerloff, C., Thomalla, G. & investigators, W.-U. European journal of neurology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33657675  

Periodontitis Is Related to Exercise Capacity: Two Cross-sectional Studies. Holtfreter, B., Stubbe, B., Glaser, S., Trabandt, J., Volzke, H., Ewert, R., Kocher, T., Ittermann, T. & Schaper, C. J Dent Res, 22034521995428 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33655783  

Machine learning based on biomarker profiles identifies distinct subgroups of heart failure with preserved ejection fraction. Woolley, R. J., Ceelen, D., Ouwerkerk, W., Tromp, J., Figarska, S. M., Anker, S. D., Dickstein, K., Filippatos, G., Zannad, F., Marco, M., Ng, L., Samani, N., van Veldhuisen, D., Lang, C., Lam, C. S. & Voors, A. European journal of heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33651430  

Human Engineered Heart Tissue Patches Remuscularize the Injured Heart in a Dose-Dependent Manner. Querdel, E., Reinsch, M., Castro, L., Kose, D., Bahr, A., Reich, S., Geertz, B., Ulmer, B., Schulze, M., Lemoine, M. D., Krause, T., Lemme, M., Sani, J., Shibamiya, A., Studemann, T., Kohne, M., von Bibra, C. V., Hornaschewitz, N., Pecha, S., Nejahsie, Y. et al. Circulation (2021). https://www.ncbi.nlm.nih.gov/pubmed/33648345  

Feasibility and diagnostic reliability of quantitative flow ratio in the assessment of non-culprit lesions in acute coronary syndrome. Erbay, A., Penzel, L., Abdelwahed, Y. S., Klotsche, J., Schatz, A. S., Steiner, J., Haghikia, A., Landmesser, U., Stahli, B. E. & Leistner, D. M. The international journal of cardiovascular imaging (2021). https://www.ncbi.nlm.nih.gov/pubmed/33651231   

The dawn of radiofrequency catheter ablation for cardiac arrhythmias. Breithardt, G. & Borggrefe, M. Heart rhythm 18, 485-486 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33648658  

Nidogen-1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration. Zbinden, A., Layland, S. L., Urbanczyk, M., Carvajal Berrio, D. A., Marzi, J., Zauner, M., Hammerschmidt, A., Brauchle, E. M., Sudrow, K., Fink, S., Templin, M., Liebscher, S., Klein, G., Deb, A., Duffy, G. P., Crooks, G. M., Eble, J. A., Mikkola, H. K. A., Nsair, A., Seifert, M. et al. Adv Sci (Weinh) 8, 2002500 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33643791  

Treatment of acute cardiac tamponade: A retrospective analysis of classical intermittent versus continuous pericardial drainage. Stremmel, C., Scherer, C., Lusebrink, E., Kupka, D., Schmid, T., Stocker, T., Kellnar, A., Kleeberger, J., Sinner, M. F., Petzold, T., Mehilli, J., Braun, D., Orban, M., Hausleiter, J., Massberg, S. & Orban, M. International journal of cardiology. Heart & vasculature 32, 100722 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33644296  

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice. Rotzer, R. D., Brox, V. F., Hennis, K., Thalhammer, S. B., Biel, M., Wahl-Schott, C. & Fenske, S. Journal of visualized experiments : JoVE (2021). https://www.ncbi.nlm.nih.gov/pubmed/33645573   

Impact of Ventricular Stroke Work Indices on Mortality in Heart Failure Patients After Percutaneous Mitral Valve Repair. Osteresch, R., Diehl, K., Dierks, P., Schmucker, J., Ammar, A. B., Fach, A., Langer, H., Eitel, I., Hambrecht, R. & Wienbergen, H. The American journal of cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33647268  

Circulatory efficiency in patients with severe aortic valve stenosis before and after aortic valve replacement. Nordmeyer, S., Lee, C. B., Goubergrits, L., Knosalla, C., Berger, F., Falk, V., Ghorbani, N., Hireche-Chikaoui, H., Zhu, M., Kelle, S., Kuehne, T. & Kelm, M. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 23, 15 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33641670  

Venoarterial extracorporeal membrane oxygenation as bridge to effective treatment in a 19-year-old woman with acute adrenal crisis: a case report. Lusebrink, E., Krieg, K., Massberg, S. & Orban, M. European heart journal. Case reports 5, ytab031 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33644667  

Mechanobiological Principles Influence the Immune Response in Regeneration: Implications for Bone Healing. Knecht, R. S., Bucher, C. H., Van Linthout, S., Tschope, C., Schmidt-Bleek, K. & Duda, G. N. Front Bioeng Biotechnol 9, 614508 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33644014  

Optical Coherence Tomography Assessment in Patients Treated With Rotational Atherectomy Versus Modified Balloons: PREPARE-CALC OCT. Hemetsberger, R., Gori, T., Toelg, R., Byrne, R., Allali, A., El-Mawardy, M., Rheude, T., Weissner, M., Sulimov, D. S., Robinson, D. R., Richardt, G. & Abdel-Wahab, M. Circulation. Cardiovascular interventions, CIRCINTERVENTIONS120009819 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33641372  

The novel cystatin C, lactate, interleukin-6, and N-terminal pro-B-type natriuretic peptide (CLIP)-based mortality risk score in cardiogenic shock after acute myocardial infarction. Ceglarek, U., Schellong, P., Rosolowski, M., Scholz, M., Willenberg, A., Kratzsch, J., Zeymer, U., Fuernau, G., de Waha-Thiele, S., Buttner, P., Jobs, A., Freund, A., Desch, S., Feistritzer, H. J., Isermann, B., Thiery, J., Poss, J. & Thiele, H. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/33647946  

Optimized High Quality DNA Extraction from Formalin-Fixed Paraffin-Embedded Human Atherosclerotic Lesions. Bauer, S., Pauli, J. & Pelisek, J. Journal of visualized experiments : JoVE (2021). https://www.ncbi.nlm.nih.gov/pubmed/33645556  

A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention. Wei, S. C., Meijers, W. C., Axelrod, M. L., Anang, N. A. S., Screever, E. M., Wescott, E. C., Johnson, D. B., Whitley, E., Lehmann, L., Courand, P. Y., Mancuso, J. J., Himmel, L. E., Lebrun-Vignes, B., Wleklinski, M. J., Knollmann, B. C., Srinivasan, J., Li, Y., Atolagbe, O. T., Rao, X., Zhao, Y. et al. Cancer Discov 11, 614-625 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33257470  


February

The need for PCSK9 inhibitors and associated treatment costs according to the 2019 ESC dyslipidaemia guidelines vs. the risk-based allocation algorithm of the 2017 ESC consensus statement: a simulation study in a contemporary CAD cohort. Blaum, C., Seiffert, M., Goßling, A., Kröger, F., Bay, B., Lorenz, T., Braetz, J., Graef, A., Zeller, T., Schnabel, R., Clemmensen, P., Westermann, D., Blankenberg, S., Brunner, F. J. & Waldeyer, C. European journal of preventive cardiology 28, 47-56 (2021).

Patient factors associated with titration of medical therapy in patients with heart failure with reduced ejection fraction: data from the QUALIFY international registry. Cowie, M. R., Schöpe, J., Wagenpfeil, S., Tavazzi, L., Böhm, M., Ponikowski, P., Anker, S. D., Filippatos, G. S. & Komajda, M. ESC heart failure 8, 861-871 (2021).

MicroRNA-21-Dependent Macrophage-to-Fibroblast Signaling Determines the Cardiac Response to Pressure Overload. Ramanujam, D., Schon, A. P., Beck, C., Vaccarello, P., Felician, G., Dueck, A., Esfandyari, D., Meister, G., Meitinger, T., Schulz, C. & Engelhardt, S. Circulation 143, 1513-1525 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33550817  

Single-Use Capture Purification of Adeno-Associated Viral Gene Transfer Vectors by Membrane-Based Steric Exclusion Chromatography. Marichal-Gallardo, P., Börner, K., Pieler, M. M., Sonntag-Buck, V., Obr, M., Bejarano, D., Wolff, M. W., Kräusslich, H. G., Reichl, U. & Grimm, D. Hum Gene Ther (2021).

Redox-related biomarkers in human cardiovascular disease - classical footprints and beyond. Daiber, A., Hahad, O., Andreadou, I., Steven, S., Daub, S. & Munzel, T. Redox biology 42, 101875 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33541847  

Completion of neuronal remodeling prompts myelination along developing motor axon branches. Wang, M., Kleele, T., Xiao, Y., Plucinska, G., Avramopoulos, P., Engelhardt, S., Schwab, M. H., Kneussel, M., Czopka, T., Sherman, D. L., Brophy, P. J., Misgeld, T. & Brill, M. S. The Journal of cell biology 220 (2021).

Protein expression profiling suggests relevance of noncanonical pathways in isolated pulmonary embolism. Ten Cate, V., Prochaska, J. H., Schulz, A., Koeck, T., Pallares Robles, A., Lenz, M., Eggebrecht, L., Rapp, S., Panova-Noeva, M., Ghofrani, H. A., Meyer, F. J., Espinola-Klein, C., Lackner, K. J., Michal, M., Schuster, A. K., Strauch, K., Zink, A. M., Laux, V., Heitmeier, S., Konstantinides, S. V., Munzel, T., Andrade-Navarro, M. A., Leineweber, K. & Wild, P. S. Blood 137, 2681-2693 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33529319  

Single versus double use of a suture-based closure device for transfemoral aortic valve implantation. Reifart, J., Liebetrau, C., Weferling, M., Dörr, O., Renker, M., Bhumimuang, K., Liakopoulos, O., Choi, Y. H., Nef, H., Hamm, C. W. & Kim, W. K. International journal of cardiology 331, 183-188 (2021).

Secreted modular calcium-binding protein 1 binds and activates thrombin to account for platelet hyperreactivity in diabetes. Delgado Lagos, F., Elgheznawy, A., Kyselova, A., Meyer Zu Heringdorf, D., Ratiu, C., Randriamboavonjy, V., Mann, A. W., Fisslthaler, B., Siragusa, M. & Fleming, I. Blood 137, 1641-1651 (2021).

Delphi consensus recommendations on how to provide cardiovascular rehabilitation in the COVID-19 era. Ambrosetti, M., Abreu, A., Cornelissen, V., Hansen, D., Iliou, M. C., Kemps, H., Pedretti, R. F. E., Voller, H., Wilhelm, M., Piepoli, M. F., Beccaluva, C. G., Beckers, P., Berger, T., Davos, C. H., Dendale, P., Doehner, W., Frederix, I., Gaita, D., Gevaert, A., Kouidi, E., Kraenkel, N., Laukkanen, J., Maranta, F., Mazza, A., Mendes, M., Neunhaeuserer, D., Niebauer, J., Pavy, B., Gil, C. P., Rauch, B., Sarzi Braga, S., Simonenko, M., Cohen-Solal, A., Sommaruga, M., Venturini, E. & Vigorito, C. European journal of preventive cardiology 28, 541-557 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33624042

In-hospital outcomes of catheter-directed thrombolysis in patients with pulmonary embolism. Hobohm, L., Schmidt, F. P., Gori, T., Schmidtmann, I., Barco, S., Munzel, T., Lankeit, M., Konstantinides, S. V. & Keller, K. Eur Heart J Acute Cardiovasc Care 10, 258-264 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33620441

Precisely Tuned Inhibition of HIF Prolyl Hydroxylases Is Key for Cardioprotection After Ischemia. Jatho, A., Zieseniss, A., Brechtel-Curth, K., Yamamoto, A., Coleman, M. L., Vergel Leon, A. M., Biggs, D., Davies, B., Pugh, C. W., Ratcliffe, P. J. & Katschinski, D. M. Circulation research 128, 1208-1210 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33626887  

The need for PCSK9 inhibitors and associated treatment costs according to the 2019 ESC dyslipidaemia guidelines vs. the risk-based allocation algorithm of the 2017 ESC consensus statement: a simulation study in a contemporary CAD cohort. Blaum, C., Seiffert, M., Goßling, A., Kröger, F., Bay, B., Lorenz, T., Braetz, J., Graef, A., Zeller, T., Schnabel, R., Clemmensen, P., Westermann, D., Blankenberg, S., Brunner, F. J. & Waldeyer, C. European journal of preventive cardiology 28, 47-56 (2021).

Patient factors associated with titration of medical therapy in patients with heart failure with reduced ejection fraction: data from the QUALIFY international registry. Cowie, M. R., Schöpe, J., Wagenpfeil, S., Tavazzi, L., Böhm, M., Ponikowski, P., Anker, S. D., Filippatos, G. S. & Komajda, M. ESC heart failure 8, 861-871 (2021).

MicroRNA-21-Dependent Macrophage-to-Fibroblast Signaling Determines the Cardiac Response to Pressure Overload. Ramanujam, D., Schon, A. P., Beck, C., Vaccarello, P., Felician, G., Dueck, A., Esfandyari, D., Meister, G., Meitinger, T., Schulz, C. & Engelhardt, S. Circulation 143, 1513-1525 (2021). www.ncbi.nlm.nih.gov/pubmed/33550817

Single-Use Capture Purification of Adeno-Associated Viral Gene Transfer Vectors by Membrane-Based Steric Exclusion Chromatography. Marichal-Gallardo, P., Börner, K., Pieler, M. M., Sonntag-Buck, V., Obr, M., Bejarano, D., Wolff, M. W., Kräusslich, H. G., Reichl, U. & Grimm, D. Hum Gene Ther (2021).

Completion of neuronal remodeling prompts myelination along developing motor axon branches. Wang, M., Kleele, T., Xiao, Y., Plucinska, G., Avramopoulos, P., Engelhardt, S., Schwab, M. H., Kneussel, M., Czopka, T., Sherman, D. L., Brophy, P. J., Misgeld, T. & Brill, M. S. The Journal of cell biology 220 (2021).

Single versus double use of a suture-based closure device for transfemoral aortic valve implantation. Reifart, J., Liebetrau, C., Weferling, M., Dörr, O., Renker, M., Bhumimuang, K., Liakopoulos, O., Choi, Y. H., Nef, H., Hamm, C. W. & Kim, W. K. International journal of cardiology 331, 183-188 (2021).

Secreted modular calcium-binding protein 1 binds and activates thrombin to account for platelet hyperreactivity in diabetes. Delgado Lagos, F., Elgheznawy, A., Kyselova, A., Meyer Zu Heringdorf, D., Ratiu, C., Randriamboavonjy, V., Mann, A. W., Fisslthaler, B., Siragusa, M. & Fleming, I. Blood 137, 1641-1651 (2021).

Late-stage stitching enabled by manganese-catalyzed C horizontal line H activation: Peptide ligation and access to cyclopeptides. Kaplaneris, N., Kaltenhuser, F., Sirvinskaite, G., Fan, S., De Oliveira, T., Conradi, L. C. & Ackermann, L. Science advances 7 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33637533  

Correction to: Neurological update: use of cardiac troponin in patients with stroke. Scheitz, J. F., Stengl, H., Nolte, C. H., Landmesser, U. & Endres, M. Journal of neurology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33634339  

BDNF serum concentrations in 2053 participants of the Berlin Aging Study II. Kronenberg, G., Gertz, K., Schoner, J., Bertram, L., Liman, T., Steinhagen-Thiessen, E., Demuth, I., Endres, M. & Hellweg, R. Neurobiol Aging 101, 221-223 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33636574  

Modulating the Biomechanical Properties of Engineered Connective Tissues by Chitosan-Coated Multiwall Carbon Nanotubes. Kittana, N., Assali, M., Zimmermann, W. H., Liaw, N., Santos, G. L., Rehman, A. & Lutz, S. Int J Nanomedicine 16, 989-1000 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33633447  

Hemodynamic Modeling of Biological Aortic Valve Replacement Using Preoperative Data Only. Hellmeier, F., Bruning, J., Sundermann, S., Jarmatz, L., Schafstedde, M., Goubergrits, L., Kuhne, T. & Nordmeyer, S. Frontiers in cardiovascular medicine 7, 593709 (2020). https://www.ncbi.nlm.nih.gov/pubmed/33634167  

Histopathological Findings Predict Renal Recovery in Severe ANCA-Associated Vasculitis Requiring Intensive Care Treatment. Hakroush, S., Tampe, D., Korsten, P., Strobel, P., Zeisberg, M. & Tampe, B. Frontiers in medicine 7, 622028 (2020). https://www.ncbi.nlm.nih.gov/pubmed/33634143  

[Acute ischemic stroke and elevated troponin: Diagnostic work-up and therapeutic consequences]. Grassl, N., Baumann, S., Kruska, M., Fatar, M., Akin, I., Platten, M., Borggrefe, M., Alonso, A., Szabo, K. & Fastner, C. Deutsche medizinische Wochenschrift (2021). https://www.ncbi.nlm.nih.gov/pubmed/33636737

Critical appraisal of the 2020 ESC guideline recommendations on diagnosis and risk assessment in patients with suspected non-ST-segment elevation acute coronary syndrome. Giannitsis, E., Blankenberg, S., Christenson, R. H., Frey, N., von Haehling, S., Hamm, C. W., Inoue, K., Katus, H. A., Lee, C. C., McCord, J., Mockel, M., Chieh, J. T. W., Tubaro, M., Wollert, K. C. & Huber, K. Clinical research in cardiology : official journal of the German Cardiac Society (2021). https://www.ncbi.nlm.nih.gov/pubmed/33635437   

Association of lipid levels with motor and cognitive function and decline in advanced Parkinson's disease in the Mark-PD study. Choe, C. U., Petersen, E., Lezius, S., Cheng, B., Schulz, R., Buhmann, C., Potter-Nerger, M., Daum, G., Blankenberg, S., Gerloff, C., Schwedhelm, E. & Zeller, T. Parkinsonism Relat Disord 85, 5-10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33636481  

Specific domain V reduction of beta-2-glycoprotein I induces protein flexibility and alters pathogenic antibody binding. Buchholz, I., McDonnell, T., Nestler, P., Tharad, S., Kulke, M., Radziszewska, A., Ripoll, V. M., Schmidt, F., Hammer, E., Toca-Herrera, J. L., Rahman, A. & Delcea, M. Scientific reports 11, 4542 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33633190    

Revealing the role of the human blood plasma proteome in obesity using genetic drivers. Zaghlool, S. B., Sharma, S., Molnar, M., Matias-Garcia, P. R., Elhadad, M. A., Waldenberger, M., Peters, A., Rathmann, W., Graumann, J., Gieger, C., Grallert, H. & Suhre, K. Nature communications 12, 1279 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33627659  

The Transcription Factor MAFF Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism. von Scheidt, M., Zhao, Y., de Aguiar Vallim, T. Q., Che, N., Wierer, M., Seldin, M. M., Franzen, O., Kurt, Z., Pang, S., Bongiovanni, D., Yamamoto, M., Edwards, P. A., Ruusalepp, A., Kovacic, J. C., Mann, M., Bjorkegren, J. L. M., Lusis, A. J., Yang, X. & Schunkert, H. Circulation (2021). https://www.ncbi.nlm.nih.gov/pubmed/33626882   

Generation and cardiac differentiation of an induced pluripotent stem cell line from a patient with arrhythmia-induced cardiomyopathy. Rebs, S., Beier, J., Argyriou, L., Schill, T., Hasenfuss, G., Vollmann, D., Sossalla, S. & Streckfuss-Bomeke, K. Stem Cell Res 53, 102263 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33631417  

Epigenetic regulation of cardiac electrophysiology in atrial fibrillation: HDAC2 determines action potential duration and suppresses NRSF in cardiomyocytes. Lugenbiel, P., Govorov, K., Syren, P., Rahm, A. K., Wieder, T., Wunsch, M., Weiberg, N., Manolova, E., Gramlich, D., Rivinius, R., Finke, D., Lehmann, L. H., Schweizer, P. A., Frank, D., El Tahry, F. A., Bruehl, C., Heimberger, T., Sandke, S., Weis, T., Most, P. et al. Basic research in cardiology 116, 13 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33630168   

Mapping genetic changes in the cAMP-signaling cascade in human atria. Garnier, A., Bork, N. I., Jacquet, E., Zipfel, S., Munoz-Guijosa, C., Baczko, I., Reichenspurner, H., Donzeau-Gouge, P., Maier, L. S., Dobrev, D., Girdauskas, E., Nikolaev, V. O., Fischmeister, R. & Molina, C. E. Journal of molecular and cellular cardiology 155, 10-20 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33631188  

Mitral valve surgery: current status and future prospects of the minimally invasive approach. Van Praet, K. M., Kempfert, J., Jacobs, S., Stamm, C., Akansel, S., Kofler, M., Sundermann, S. H., Nazari Shafti, T. Z., Jakobs, K., Holzendorf, S., Unbehaun, A. & Falk, V. Expert review of medical devices (2021). https://www.ncbi.nlm.nih.gov/pubmed/33624569  

Screening for Atrial Fibrillation in the Older Population: A Randomized Clinical Trial. Gladstone, D. J., Wachter, R., Schmalstieg-Bahr, K., Quinn, F. R., Hummers, E., Ivers, N., Marsden, T., Thornton, A., Djuric, A., Suerbaum, J., von Grunhagen, D., McIntyre, W. F., Benz, A. P., Wong, J. A., Merali, F., Henein, S., Nichol, C., Connolly, S. J., Healey, J. S., Investigators, S.-A. et al. JAMA cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33625468  

Impact of renal function on outcomes of patients with cardiac troponin elevation and non-obstructive coronary arteries. Steiner, J., Kerschl, M., Erbay, A., Abdelwahed, Y. S., Jakob, P., Landmesser, U., Leistner, D. M. & Stahli, B. E. International journal of cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33621626  

Blunted beta-adrenoceptor-mediated inotropy in valvular cardiomyopathy: another piece of the puzzle in human aortic valve disease. Petersen, J., Kloth, B., Iqbal, S., Reichenspurner, H., Geelhoed, B., Schnabel, R., Eschenhagen, T., Christ, T. & Girdauskas, E. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021). https://www.ncbi.nlm.nih.gov/pubmed/33619556  

Single Nuclei Sequencing Reveals Novel Insights into the Regulation of Cellular Signatures in Children with Dilated Cardiomyopathy. Nicin, L., Abplanalp, W. T., Schanzer, A., Sprengel, A., John, D., Mellentin, H., Tombor, L., Keuper, M., Ullrich, E., Klingel, K., Dettmeyer, R. B., Hoffmann, J., Akintuerk, H., Jux, C., Schranz, D., Zeiher, A. M., Rupp, S. & Dimmeler, S. Circulation (2021). https://www.ncbi.nlm.nih.gov/pubmed/33618539  

The vasculature: a therapeutic target in heart failure? Luxan, G. & Dimmeler, S. Cardiovascular research (2021). https://www.ncbi.nlm.nih.gov/pubmed/33620071  

Functional outcomes with Carillon device over 1 year in patients with functional mitral regurgitation of Grades 2+ to 4+: results from the REDUCE-FMR trial. Khan, M. S., Siddiqi, T. J., Butler, J., Friede, T., Levy, W. C., Witte, K. K., Lipiecki, J., Sievert, H. & Coats, A. J. S. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33619896  

Preventing SARS-CoV-2 In-Hospital Infections in Cardiovascular Patients and Medical Staff: An Observational Study From the German Heart Center Berlin. Schoppenthau, D., Weiss, K. J., Estepa-Martinez, M., Hommel, M., Miera, O., Schoenrath, F., Hubler, S., Obermeier, M., Pieske, B. & Stawowy, P. Frontiers in medicine 7, 616648 (2020). https://www.ncbi.nlm.nih.gov/pubmed/33614675  

Antiplatelet and direct oral anticoagulation management after coronary artery bypass graft surgery: the Cinderella of current cardiovascular trials, please show me (some) evidence. Schoenrath, F., Just, I. A., Falk, V. & Emmert, M. Y. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/33615338  

Similarities and Differences of Mental Health in Women and Men: A Systematic Review of Findings in Three Large German Cohorts. Otten, D., Tibubos, A. N., Schomerus, G., Brahler, E., Binder, H., Kruse, J., Ladwig, K. H., Wild, P. S., Grabe, H. J. & Beutel, M. E. Front Public Health 9, 553071 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33614574   

Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature. Hooglugt, A., van der Stoel, M. M., Boon, R. A. & Huveneers, S. Frontiers in oncology 10, 612802 (2020). www.ncbi.nlm.nih.gov/pubmed/33614496

Blood Cholesterol and Outcome of Patients with Cancer under Regular Cardiological Surveillance. Hohneck, A. L., Rosenkaimer, S., Hofheinz, R. D., Akin, I., Borggrefe, M. & Gerhards, S. Curr Oncol 28, 863-872 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33617503  

Extent of FLAIR Hyperintense Vessels May Modify Treatment Effect of Thrombolysis: A Post hoc Analysis of the WAKE-UP Trial. Grosch, A. S., Kufner, A., Boutitie, F., Cheng, B., Ebinger, M., Endres, M., Fiebach, J. B., Fiehler, J., Konigsberg, A., Lemmens, R., Muir, K. W., Nighoghossian, N., Pedraza, S., Siemonsen, C. Z., Thijs, V., Wouters, A., Gerloff, C., Thomalla, G. & Galinovic, I. Front Neurol 11, 623881 (2020). https://www.ncbi.nlm.nih.gov/pubmed/33613422   

Deficiency of endothelial CD40 induces a stable plaque phenotype and limits inflammatory cell recruitment to atherosclerotic lesions in mice. Gissler, M. C., Scherrer, P., Anto Michel, N., Pennig, J., Hoppe, N., Funer, L., Hardtner, C., Stachon, P., Li, X., Mitre, L. S., Marchini, T., Madl, J., Wadle, C., Hilgendorf, I., von Zur Muhlen, C., Bode, C., Weber, C., Lutgens, E., Wolf, D., Gerdes, N. et al. Thrombosis and haemostasis (2021). https://www.ncbi.nlm.nih.gov/pubmed/33618394  

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat. Curini, L., Christopher, M. R., Grubitzsch, H., Landmesser, U., Amedei, A., Lauten, A. & Alushi, B. Journal of visualized experiments : JoVE (2021). https://www.ncbi.nlm.nih.gov/pubmed/33616094  

Cardiac events associated with immune checkpoint inhibitor therapy: the devil is in the detail. Anker, M. S., Coats, A. J. S. & Anker, S. D. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/33611381  

Risk stratification and management of women with cardiomyopathy/heart failure planning pregnancy or presenting during/after pregnancy: a position statement from the Heart Failure Association of the European Society of Cardiology Study Group on Peripartum Cardiomyopathy. Sliwa, K., van der Meer, P., Petrie, M. C., Frogoudaki, A., Johnson, M. R., Hilfiker-Kleiner, D., Hamdan, R., Jackson, A. M., Ibrahim, B., Mbakwem, A., Tschope, C., Regitz-Zagrosek, V., Omerovic, E., Roos-Hesselink, J., Gatzoulis, M., Tutarel, O., Price, S., Heymans, S., Coats, A. J., Muller, C. et al. European journal of heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33609068  

J-shaped association between circulating apoC-III and cardiovascular mortality. Silbernagel, G., Scharnagl, H., Kleber, M. E., Hoffmann, M. M., Delgado, G. E., Stojakovic, T., Gary, T., Zeng, L., Ritsch, A., Zewinger, S., Speer, T., Schunkert, H., Landmesser, U., Marz, W. & Grammer, T. B. European journal of preventive cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33609030  

Differences in Biomarkers of Inflammation Between Novel Subgroups of Recent-Onset Diabetes. Herder, C., Maalmi, H., Strassburger, K., Zaharia, O. P., Ratter, J. M., Karusheva, Y., Elhadad, M. A., Bodis, K., Bongaerts, B. W. C., Rathmann, W., Trenkamp, S., Waldenberger, M., Burkart, V., Szendroedi, J., Roden, M. & Group, G. D. S. Diabetes (2021). https://www.ncbi.nlm.nih.gov/pubmed/33608423  

Digital, risk-based screening for atrial fibrillation in the European community-the AFFECT-EU project funded by the European Union. Engler, D., Heidbuchel, H., Schnabel, R. B. & Investigators, A.-E. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/33608697  

Clinical results of fibroblast activation protein (FAP) specific PET for non-malignant indications: systematic review. Windisch, P., Zwahlen, D. R., Giesel, F. L., Scholz, E., Lugenbiel, P., Debus, J., Haberkorn, U. & Adeberg, S. EJNMMI research 11, 18 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33606104  

Ticagrelor Monotherapy After Coronary Stenting: Like a Twilight Through the Looking Glass. Sibbing, D. & Cassese, S. JACC. Cardiovascular interventions 14, 457-460 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33602442  

Temporal trends in incidence, causes, use of mechanical circulatory support and mortality in cardiogenic shock. Schrage, B., Becher, P. M., Gossling, A., Savarese, G., Dabboura, S., Yan, I., Beer, B., Soffker, G., Seiffert, M., Kluge, S., Kirchhof, P., Blankenberg, S. & Westermann, D. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33605565  

Plasma microRNA signature associated with retinopathy in patients with type 2 diabetes. Santovito, D., Toto, L., De Nardis, V., Marcantonio, P., D'Aloisio, R., Mastropasqua, A., De Cesare, D., Bucci, M., Paganelli, C., Natarelli, L., Weber, C., Consoli, A., Mastropasqua, R. & Cipollone, F. Scientific reports 11, 4136 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33602976  

Dynamics of SARS-CoV-2 shedding in the respiratory tract depends on the severity of disease in COVID-19 patients. Munker, D., Osterman, A., Stubbe, H., Muenchhoff, M., Veit, T., Weinberger, T., Barnikel, M., Mumm, J. N., Milger, K., Khatamzas, E., Klauss, S., Scherer, C., Hellmuth, J. C., Giessen-Jung, C., Zoller, M., Herold, T., Stecher, S., de Toni, E. N., Schulz, C., Kneidinger, N. et al. The European respiratory journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/33602859  

Alpha 1-adrenoceptor signalling contributes to toxic effects of catecholamine on electrical properties in cardiomyocytes. Huang, M., Fan, X., Yang, Z., Cyganek, L., Li, X., Yuecel, G., Lan, H., Li, Y., Wendel, A., Lang, S., Bieback, K., El-Battrawy, I., Zhou, X., Akin, I. & Borggrefe, M. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33604602  

Prediction of the dose range for adverse neurological effects of amiodarone in patients from an in vitro toxicity test by in vitro-in vivo extrapolation. Algharably, E. A. E., Di Consiglio, E., Testai, E., Kreutz, R. & Gundert-Remy, U. Arch Toxicol (2021). https://www.ncbi.nlm.nih.gov/pubmed/33606068  

Regenerative potential of epicardium-derived extracellular vesicles mediated by conserved miRNA transfer. Villa Del Campo, C., Liaw, N. Y., Gunadasa-Rohling, M., Matthaei, M., Braga, L., Kennedy, T., Salinas, G., Voigt, N., Giacca, M., Zimmermann, W. H. & Riley, P. R. Cardiovascular research (2021). https://www.ncbi.nlm.nih.gov/pubmed/33599250   

Extracting Robust Biomarkers From Multichannel EEG Time Series Using Nonlinear Dimensionality Reduction Applied to Ordinal Pattern Statistics and Spectral Quantities. Kottlarz, I., Berg, S., Toscano-Tejeida, D., Steinmann, I., Bahr, M., Luther, S., Wilke, M., Parlitz, U. & Schlemmer, A. Frontiers in physiology 11, 614565 (2020). https://www.ncbi.nlm.nih.gov/pubmed/33597891  

Reply to Pollari and Fischlein. Kofler, M., Unbehaun, A., Falk, V. & Kempfert, J. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021). https://www.ncbi.nlm.nih.gov/pubmed/33599266  

Regulation of dual leucine zipper kinase activity through its interaction with calcineurin. Duque Escobar, J., Kutschenko, A., Schroder, S., Blume, R., Koster, K. A., Painer, C., Lemcke, T., Maison, W. & Oetjen, E. Cellular signalling 82, 109953 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33600948  

Use of sodium-glucose co-transporter 2 inhibitors in patients with heart failure and type 2 diabetes mellitus: data from the Swedish Heart Failure Registry. Becher, P. M., Schrage, B., Ferrannini, G., Benson, L., Butler, J., Carrero, J. J., Cosentino, F., Dahlstrom, U., Mellbin, L., Rosano, G. M. C., Sinagra, G., Stolfo, D., Lund, L. H. & Savarese, G. European journal of heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33599357  

Multiple breath washout (MBW) testing using sulfur hexafluoride: reference values and influence of anthropometric parameters. Trinkmann, F., Maros, M., Roth, K., Hermanns, A., Schafer, J., Gawlitza, J., Saur, J., Akin, I., Borggrefe, M., Herth, F. J. F. & Ganslandt, T. Thorax (2021). https://www.ncbi.nlm.nih.gov/pubmed/33593931  

Non-classical monocytes in cardiovascular physiology and disease. Tahir, S. & Steffens, S. Am J Physiol Cell Physiol (2021). https://www.ncbi.nlm.nih.gov/pubmed/33596150   

A Brave New World: Toward Precision Phenotyping and Understanding of Coronary Artery Disease Using Radiomics Plaque Analysis. Schoepf, U. J. & Emrich, T. Radiology, 204456 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33595391  

Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years. Frangou, S., Modabbernia, A., Williams, S. C. R., Papachristou, E., Doucet, G. E., Agartz, I., Aghajani, M., Akudjedu, T. N., Albajes-Eizagirre, A., Alnaes, D., Alpert, K. I., Andersson, M., Andreasen, N. C., Andreassen, O. A., Asherson, P., Banaschewski, T., Bargallo, N., Baumeister, S., Baur-Streubel, R., Bertolino, A. et al. Hum Brain Mapp (2021). https://www.ncbi.nlm.nih.gov/pubmed/33595143   

Different genotypes of Brugada syndrome may present different clinical phenotypes: electrophysiology from bench to bedside. El-Battrawy, I., Lang, S., Zhou, X. & Akin, I. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/33595083  

Low-molecular-weight heparin administered by subcutaneous catheter is a safe and effective anti-coagulation regimen in selected inpatient infants and children with complex congenital heart disease. Pardun, N., Lemmer, J., Belker, K., Pringsheim, M., Ewert, P. & Wolf, C. M. Cardiology in the young, 1-6 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33588972  

[Nutrition and hypertension : What one should pay attention to in addition to the pharmaceutical treatment]. McParland, V. & Wilck, N. Der Internist 62, 269-276 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33590293  

TAMEP are brain tumor parenchymal cells controlling neoplastic angiogenesis and progression. Kalin, R. E., Cai, L., Li, Y., Zhao, D., Zhang, H., Cheng, J., Zhang, W., Wu, Y., Eisenhut, K., Janssen, P., Schmitt, L., Enard, W., Michels, F., Fluh, C., Hou, M., Kirchleitner, S. V., Siller, S., Schiemann, M., Andra, I., Montanez, E. et al. Cell Syst (2021). https://www.ncbi.nlm.nih.gov/pubmed/33592194  

Exposure to perfluoroalkyl substances and blood pressure in pregnancy among 1436 women from the Odense Child Cohort. Birukov, A., Andersen, L. B., Andersen, M. S., Nielsen, J. H., Nielsen, F., Kyhl, H. B., Jorgensen, J. S., Grandjean, P., Dechend, R. & Jensen, T. K. Environ Int 151, 106442 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33610053  

Safety and efficacy of transvenous lead extraction in octogenarians using powered extraction sheaths. Burger, H., Hakmi, S., Petersen, J., Yildirim, Y., Choi, Y. H., Willems, S., Reichenspurner, H., Ziegelhoeffer, T. & Pecha, S. Pacing and clinical electrophysiology : PACE (2021). https://www.ncbi.nlm.nih.gov/pubmed/33594705  

Monitoring mitochondrial translation in living cells. Yousefi, R., Fornasiero, E. F., Cyganek, L., Montoya, J., Jakobs, S., Rizzoli, S. O., Rehling, P. & Pacheu-Grau, D. EMBO reports, e51635 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33586863  

TTN Circular RNAs Create A Backsplice Motif Essential for SRSF10 Splicing. Tijsen, A. J., Cocera Ortega, L., Reckman, Y. J., Zhang, X., van der Made, I., Aufiero, S., Li, J., Kamps, S. C., van den Bout, A., Devalla, H. D., van Spaendonck-Zwarts, K., Engelhardt, S., Gepstein, L., Ware, J. S. & Pinto, Y. M. Circulation (2021). https://www.ncbi.nlm.nih.gov/pubmed/33583186  

Influence of cardiometabolic comorbidities on myocardial function, infarction, and cardioprotection: Role of cardiac redox signaling. Andreadou, I., Daiber, A., Baxter, G. F., Brizzi, M. F., Di Lisa, F., Kaludercic, N., Lazou, A., Varga, Z. V., Zuurbier, C. J., Schulz, R. & Ferdinandy, P. Free radical biology & medicine 166, 33-52 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33588049  

Prospective validation of an acoustic-based system for the detection of obstructive coronary artery disease in a high-prevalence population. Renker, M., Kriechbaum, S. D., Schmidt, S. E., Larsen, B. S., Wolter, J. S., Dorr, O., Fischer-Rasokat, U., Kim, W. K., Liebetrau, C., Bottcher, M., Nef, H., Bauer, T. & Hamm, C. W. Heart and vessels (2021). https://www.ncbi.nlm.nih.gov/pubmed/33582860  

Hypertrophic signaling compensates for contractile and metabolic consequences of DNA methyltransferase 3A loss in human cardiomyocytes. Madsen, A., Krause, J., Hoppner, G., Hirt, M. N., Tan, W. L. W., Lim, I., Hansen, A., Nikolaev, V. O., Foo, R. S. Y., Eschenhagen, T. & Stenzig, J. Journal of molecular and cellular cardiology 154, 115-123 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33582159

Determinants of paravalvular leakage following transcatheter aortic valve replacement in patients with bicuspid and tricuspid aortic stenosis. Kim, W. K., Bhumimuang, K., Renker, M., Fischer-Rasokat, U., Mollmann, H., Walther, T., Choi, Y. H., Nef, H. & Hamm, C. W. European heart journal cardiovascular Imaging (2021). https://www.ncbi.nlm.nih.gov/pubmed/33582771  

Multicenter Consistency Assessment of Valvular Flow Quantification With Automated Valve Tracking in 4D Flow CMR. Juffermans, J. F., Minderhoud, S. C. S., Wittgren, J., Kilburg, A., Ese, A., Fidock, B., Zheng, Y. C., Zhang, J. M., Blanken, C. P. S., Lamb, H. J., Goeman, J. J., Carlsson, M., Zhao, S., Planken, R. N., van Ooij, P., Zhong, L., Chen, X., Garg, P., Emrich, T., Hirsch, A. et al. JACC. Cardiovascular imaging (2021). https://www.ncbi.nlm.nih.gov/pubmed/33582060  

Transfemoral Transcatheter Tricuspid Valve Replacement With the EVOQUE System: A Multicenter, Observational, First-in-Human Experience. Fam, N. P., von Bardeleben, R. S., Hensey, M., Kodali, S. K., Smith, R. L., Hausleiter, J., Ong, G., Boone, R., Ruf, T., George, I., Szerlip, M., Nabauer, M., Ali, F. M., Moss, R., Bapat, V., Schnitzler, K., Kreidel, F., Ye, J., Deva, D. P., Mack, M. J. et al. JACC. Cardiovascular interventions 14, 501-511 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33582084  

Development and external validation of prediction models to predict implantable cardioverter-defibrillator efficacy in primary prevention of sudden cardiac death. Verstraelen, T. E., van Barreveld, M., van Dessel, P., Boersma, L. V. A., Delnoy, P., Tuinenburg, A. E., Theuns, D., van der Voort, P. H., Kimman, G. P., Buskens, E., Hulleman, M., Allaart, C. P., Strikwerda, S., Scholten, M. F., Meine, M., Abels, R., Maass, A. H., Firouzi, M., Widdershoven, J., Elders, J. et al. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33582797  

Development of an AAV9-RNAi-mediated silencing strategy to abrogate TRPM4 expression in the adult heart. Medert, R., Jungmann, A., Hildebrand, S., Busch, M., Grimm, D., Flockerzi, V., Muller, O. J., Most, P., Schumacher, D. & Freichel, M. Pflugers Archiv : European journal of physiology 473, 533-546 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33580817  

Rothia aeria and Rothia dentocariosa as biofilm builders in infective endocarditis. Greve, D., Moter, A., Kleinschmidt, M. C., Pfafflin, F., Stegemann, M. S., Kursawe, L., Grubitzsch, H., Falk, V. & Kikhney, J. Int J Med Microbiol 311, 151478 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33581548  

'Hit and run' therapy averts macular degeneration. Bubeck, F. & Grimm, D. Nat Biomed Eng 5, 132-133 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33580229  

Cross-sectional and prospective relationships of endogenous progestogens and estrogens with glucose metabolism in men and women: a KORA F4/FF4 Study. Lau, L. H. Y., Nano, J., Cecil, A., Schederecker, F., Rathmann, W., Prehn, C., Zeller, T., Lechner, A., Adamski, J., Peters, A. & Thorand, B. BMJ Open Diabetes Res Care 9 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33574134  

Deficiency of inactive rhomboid protein 2 (iRhom2) attenuates diet-induced hyperlipidemia and early atherogenesis. Hannemann, C., Schecker, J. H., Brettschneider, A., Grune, J., Rosener, N., Weller, A., Stangl, V., Fisher, E. A., Stangl, K., Ludwig, A. & Hewing, B. Cardiovascular research (2021). https://www.ncbi.nlm.nih.gov/pubmed/33576385  

From heterogeneous healthcare data to disease-specific biomarker networks: A hierarchical Bayesian network approach. Becker, A. K., Dorr, M., Felix, S. B., Frost, F., Grabe, H. J., Lerch, M. M., Nauck, M., Volker, U., Volzke, H. & Kaderali, L. PLoS computational biology 17, e1008735 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33577591  

Creatine kinase and bleeding in patients with acute coronary syndromes. Ndrepepa, G., Holdenrieder, S., Cassese, S. & Kastrati, A. European journal of clinical investigation, e13514 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33570770  

Haemodynamic documentation of epicardial coronary spasm. Gori, T. & Ahoopai, M. European heart journal. Case reports 5, ytab008 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33569529  

Non-immune risk predictors of cardiac allograft vasculopathy: Results from the U.S. organ procurement and transplantation network. Fluschnik, N., Geelhoed, B., Becher, P. M., Schrage, B., Brunner, F. J., Knappe, D., Bernhardt, A. M., Blankenberg, S., Kobashigawa, J., Reichenspurner, H., Schnabel, R. B. & Magnussen, C. International journal of cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33571561   

Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years. Dima, D., Modabbernia, A., Papachristou, E., Doucet, G. E., Agartz, I., Aghajani, M., Akudjedu, T. N., Albajes-Eizagirre, A., Alnaes, D., Alpert, K. I., Andersson, M., Andreasen, N. C., Andreassen, O. A., Asherson, P., Banaschewski, T., Bargallo, N., Baumeister, S., Baur-Streubel, R., Bertolino, A., Bonvino, A. et al. Hum Brain Mapp (2021). https://www.ncbi.nlm.nih.gov/pubmed/33570244  

Patient factors associated with titration of medical therapy in patients with heart failure with reduced ejection fraction: data from the QUALIFY international registry. Cowie, M. R., Schope, J., Wagenpfeil, S., Tavazzi, L., Bohm, M., Ponikowski, P., Anker, S. D., Filippatos, G. S., Komajda, M. & Investigators, Q. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33569926  

TAVR in nonagenarians: An analysis investigating safety, efficacy, symptomatic improvement, and long-term survival. Zadrozny, M., Hainzer, N., Mehilli, J., Jochheim, D., Gschwendtner, S., Steffen, J., Theiss, H., Braun, D., Hagl, C., Sadoni, S., Massberg, S., Hausleiter, J. & Deseive, S. J Cardiol (2021). https://www.ncbi.nlm.nih.gov/pubmed/33563507  

The diagnostic and prognostic value of galectin-3 in patients at risk for heart failure with preserved ejection fraction: results from the DIAST-CHF study. Trippel, T. D., Mende, M., Dungen, H. D., Hashemi, D., Petutschnigg, J., Nolte, K., Herrmann-Lingen, C., Binder, L., Hasenfuss, G., Pieske, B., Wachter, R. & Edelmann, F. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33566456  

Macrophage migration inhibitory factor inhibits neutrophil apoptosis by inducing cytokine release from mononuclear cells. Schindler, L., Zwissler, L., Krammer, C., Hendgen-Cotta, U., Rassaf, T., Hampton, M. B., Dickerhof, N. & Bernhagen, J. J Leukoc Biol (2021). https://www.ncbi.nlm.nih.gov/pubmed/33565160  

Starting Antihypertensive Drug Treatment With Combination Therapy: Controversies in Hypertension - Pro Side of the Argument. Persu, A., Lopez-Sublet, M., Algharably, E. A. E. & Kreutz, R. Hypertension 77, 800-805 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33566686  

Anticoagulation therapy in non-valvular atrial fibrillation in the COVID-19 era: is it time to reconsider our therapeutic strategy? Papakonstantinou, P. E., Borovac, J. A., Gasecka, A., Bongiovanni, D., Ehrlinder, H., Giustozzi, M., Parker, W. A. E. & Guerreiro, R. A. European journal of preventive cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33564838  

Impact of sinus rhythm versus atrial fibrillation on left ventricular remodeling after transcatheter aortic valve replacement. Ledwoch, J., Frohlich, C., Olbrich, I., Poch, F., Thalmann, R., Fellner, C., Bradaric, C., Laugwitz, K. L., Kupatt, C. & Hoppmann, P. Clinical research in cardiology : official journal of the German Cardiac Society (2021). https://www.ncbi.nlm.nih.gov/pubmed/33566184  

Measurement accuracy of prototype non-contrast, compressed sensing-based, respiratory motion-resolved whole heart cardiovascular magnetic resonance angiography for the assessment of thoracic aortic dilatation: comparison with computed tomography angiography. Yacoub, B., Stroud, R. E., Piccini, D., Schoepf, U. J., Heerfordt, J., Yerly, J., Di Sopra, L., Rollins, J. D., Turner, D. A., Emrich, T., Xiong, F., Suranyi, P. & Varga-Szemes, A. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 23, 7 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33557887  

Impella versus extracorporal life support in cardiogenic shock: a propensity score adjusted analysis. Wernly, B., Karami, M., Engstrom, A. E., Windecker, S., Hunziker, L., Luscher, T. F., Henriques, J. P., Ferrari, M. W., Binnebossel, S., Masyuk, M., Niederseer, D., Abel, P., Fuernau, G., Franz, M., Kelm, M., Busch, M. C., Felix, S. B., Thiele, H., Lauten, A. & Jung, C. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33560591  

Lifestyle Intervention in Chronic Ischaemic Heart Disease and Type 2 Diabetes (the LeIKD study): study protocol of a prospective, multicentre, randomised, controlled trial. von Korn, P., Sydow, H., Neubauer, S., Duvinage, A., Mocek, A., Dinges, S., Hackenberg, B., Weichenberger, M., Schoenfeld, J., Amelung, V., Mueller, S. & Halle, M. BMJ open 11, e042818 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33558354  

Correlation of cardiac function and cerebral perfusion in a murine model of subarachnoid hemorrhage. Neulen, A., Molitor, M., Kosterhon, M., Pantel, T., Holzbach, E., Rudi, W. S., Karbach, S. H., Wenzel, P., Ringel, F. & Thal, S. C. Scientific reports 11, 3317 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33558609  

Effect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity Advice on Peak Oxygen Consumption in Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial. Mueller, S., Winzer, E. B., Duvinage, A., Gevaert, A. B., Edelmann, F., Haller, B., Pieske-Kraigher, E., Beckers, P., Bobenko, A., Hommel, J., Van de Heyning, C. M., Esefeld, K., von Korn, P., Christle, J. W., Haykowsky, M. J., Linke, A., Wisloff, U., Adams, V., Pieske, B., van Craenenbroeck, E. M. et al. JAMA : the journal of the American Medical Association 325, 542-551 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33560320  

Unfolding and disentangling coronary vascular disease through genome-wide association studies. Erdmann, J. & van der Laan, S. W. European heart journal 42, 934-937 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33561196  

Venous lactate improves the prediction of in-hospital adverse outcomes in normotensive pulmonary embolism. Ebner, M., Pagel, C. F., Sentler, C., Harjola, V. P., Bueno, H., Lerchbaumer, M. H., Stangl, K., Pieske, B., Hasenfuss, G., Konstantinides, S. V. & Lankeit, M. European journal of internal medicine (2021). https://www.ncbi.nlm.nih.gov/pubmed/33558162  

Pharmacogenomics of the Efficacy and Safety of Colchicine in COLCOT. Dube, M. P., Legault, M. A., Lemacon, A., Lemieux Perreault, L. P., Fouodjio, R., Waters, D. D., Kouz, S., Pinto, F. J., Maggioni, A. P., Diaz, R., Berry, C., Koenig, W., Lopez-Sendon, J., Gamra, H., Kiwan, G. S., Asselin, G., Provost, S., Barhdadi, A., Sun, M., Cossette, M. et al. Circulation. Genomic and precision medicine (2021). https://www.ncbi.nlm.nih.gov/pubmed/33560138   

The interpretation of CHA2DS2-VASc score components in clinical practice: a joint survey by the European Heart Rhythm Association (EHRA) Scientific Initiatives Committee, the EHRA Young Electrophysiologists, the Association of Cardiovascular Nursing and Allied Professionals, and the European Society of Cardiology Council on Stroke. Zhang, J., Lenarczyk, R., Marin, F., Malaczynska-Rajpold, K., Kosiuk, J., Doehner, W., Van Gelder, I. C., Lee, G., Hendriks, J. M., Lip, G. Y. H. & Potpara, T. S. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 23, 314-322 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33554259  

Xenotransplantation in the era of a zoonotic pandemic. Schoenrath, F., Falk, V. & Emmert, M. Y. European heart journal (2021). https://www.ncbi.nlm.nih.gov/pubmed/33555006  

One-year results of the first-in-man study investigating the Atrial Flow Regulator for left atrial shunting in symptomatic heart failure patients: the PRELIEVE study. Paitazoglou, C., Bergmann, M. W., Ozdemir, R., Pfister, R., Bartunek, J., Kilic, T., Lauten, A., Schmeisser, A., Zoghi, M., Anker, S. D., Sievert, H., Mahfoud, F. & Investigators, A.-P. European journal of heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33555114  

MiR-21-Dependent Macrophage-to-Fibroblast Signaling Determines the Cardiac Response to Pressure Overload. Ramanujam, D., Schon, A. P., Beck, C., Vaccarello, P., Felician, G., Dueck, A., Esfandyari, D., Meister, G., Meitinger, T., Schulz, C. & Engelhardt, S. Circulation (2021). https://www.ncbi.nlm.nih.gov/pubmed/33550817  

Low-fat hypocaloric diet reduces neprilysin in overweight and obese human subjects. Henke, C., Haufe, S., Ziehl, D., Bornstein, S. R., Schulz-Menger, J., Heni, M., Engeli, S., Jordan, J. & Birkenfeld, A. L. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33638612  

Quality of Life Three and Twelve Months after Acute Pulmonary Embolism: Analysis from a Prospective Multicenter Cohort Study. Valerio, L., Barco, S., Jankowski, M., Rosenkranz, S., Lankeit, M., Held, M., Gerhardt, F., Bruch, L., Ewert, R., Faehling, M., Freise, J., Ghofrani, H. A., Grunig, E., Halank, M., Hoeper, M. M., Klok, F. A., Leuchte, H. H., Mayer, E., Meyer, F. J., Neurohr, C. et al. Chest (2021). https://www.ncbi.nlm.nih.gov/pubmed/33548221  

Impact of a surgical approach for implantation of durable left ventricular assist devices in patients on extracorporeal life support. Potapov, E., Loforte, A., Pappalardo, F., Morshuis, M., Schibilsky, D., Zimpfer, D., Lewin, D., Riebandt, J., Von Aspern, K., Stein, J., Attisani, M., Haneya, A., Ramjankhan, F., Donker, D. W., Jorde, U. P., Wieloch, R., Ayala, R., Cremer, J., Rinaldi, M., Montisci, A. et al. J Card Surg 36, 1344-1351 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33547707  

Synthesis and evaluation of novel cyclopentane urea FPR2 agonists and their potential application in the treatment of cardiovascular inflammation. Maciuszek, M., Ortega-Gomez, A., Maas, S. L., Perretti, M., Merritt, A., Soehnlein, O. & Chapman, T. M. Eur J Med Chem 214, 113194 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33548634  

Thyroid function, sex hormones and sexual function: a Mendelian randomization study. Kjaergaard, A. D., Marouli, E., Papadopoulou, A., Deloukas, P., Kus, A., Sterenborg, R., Teumer, A., Burgess, S., Asvold, B. O., Chasman, D. I., Medici, M. & Ellervik, C. European journal of epidemiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33548002  

Vasohibin 1 selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk. de Oliveira, M. B., Meier, K., Jung, S., Bartels-Klein, E., Coxam, B., Geudens, I., Szymborska, A., Skoczylas, R., Fechner, I., Koltowska, K. & Gerhardt, H. Development 148 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33547133  

Safety and Effectiveness of Edoxaban in Atrial Fibrillation Patients in Routine Clinical Practice: One-Year Follow-Up from the Global Noninterventional ETNA-AF Program. De Caterina, R., Kim, Y. H., Koretsune, Y., Wang, C. C., Yamashita, T., Chen, C., Reimitz, P. E., Unverdorben, M. & Kirchhof, P. Journal of clinical medicine 10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33546442  

Correction to: Impact of a 2year trial of nutritional ketosis on indices of cardiovascular disease risk in patients with type 2 diabetes. Athinarayanan, S. J., Hallberg, S. J., McKenzie, A. L., Lechner, K., King, S., McCarter, J. P., Volek, J. S., Phinney, S. D. & Krauss, R. M. Cardiovascular diabetology 20, 37 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33546666  

Cardiomyocyte Injury Following Acute Ischemic Stroke: Protocol for a Prospective Observational Cohort Study. Stengl, H., Ganeshan, R., Hellwig, S., Blaszczyk, E., Fiebach, J. B., Nolte, C. H., Bauer, A., Schulz-Menger, J., Endres, M. & Scheitz, J. F. JMIR Res Protoc 10, e24186 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33544087  

Effects of sarcopenia and malnutrition on morbidity and mortality in gynecologic cancer surgery: results of a prospective study. Sehouli, J., Mueller, K., Richter, R., Anker, M., Woopen, H., Rasch, J., Grabowski, J. P., Prinz-Theissing, E. & Inci, M. G. J Cachexia Sarcopenia Muscle (2021). https://www.ncbi.nlm.nih.gov/pubmed/33543597  

Experience with the novel unifemoral parallel sheath technique in percutaneous intervention of chronic total coronary occlusions. Reifart, J., Schilling, K., Hamm, C. W. & Reifart, N. Egypt Heart J 73, 14 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33544232  

The effect of spironolactone on diastolic function in haemodialysis patients. Hauser, T., Dornberger, V., Malzahn, U., Grebe, S. J., Liu, D., Stork, S., Nauck, M., Friedrich, N., Dorr, M., Wanner, C., Krane, V., Hammer, F., Mi, R. S. G. & Collaborating, i. The international journal of cardiovascular imaging (2021). https://www.ncbi.nlm.nih.gov/pubmed/33544240  

Transcatheter pulmonary valve replacement: a new polycarbonate urethane valve. Lutter, G., Topal, A., Hansen, J. H., Haneya, A., Santhanthan, J., Freitag-Wolf, S., Frank, D. & Puehler, T. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021). https://www.ncbi.nlm.nih.gov/pubmed/33538794  

Repeated Measurements of Cardiac Troponin T and N-Terminal Pro-B-Type Natriuretic Peptide to Assess Long-Term Mortality Risk in Subjects with Osteoarthritis. Rehm, M., Buchele, G., Brenner, R. E., Gunther, K. P., Brenner, H., Koenig, W. & Rothenbacher, D. Biomolecules 11 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33562838  

KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy. Kyriazis, I. D., Hoffman, M., Gaignebet, L., Lucchese, A. M., Markopoulou, E., Palioura, D., Wang, C., Bannister, T. D., Christofidou-Solomidou, M., Oka, S. I., Sadoshima, J., Koch, W. J., Goldberg, I. J., Yang, V. W., Bialkowska, A. B., Kararigas, G. & Drosatos, K. Circulation research 128, 335-357 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33539225  

Low muscle strength and increased arterial stiffness go hand in hand. Konig, M., Buchmann, N., Seeland, U., Spira, D., Steinhagen-Thiessen, E. & Demuth, I. Scientific reports 11, 2906 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33536474  

[Strategy for Chronic Coronary Syndrome - PCI or optimal medical therapy]. Kim, S. H., Behnes, M. & Akin, I. Ther Umsch 78, 2-10 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33538635  

Myocardial deformation assessed among heart failure entities by cardiovascular magnetic resonance imaging. Hashemi, D., Motzkus, L., Blum, M., Kraft, R., Tanacli, R., Tahirovic, E., Doeblin, P., Zieschang, V., Zamani, S. M., Kelm, M., Kuehne, T., Pieske, B., Alogna, A., Edelmann, F., Duengen, H. D. & Kelle, S. ESC heart failure (2021). https://www.ncbi.nlm.nih.gov/pubmed/33539681  

Hemoptysis due to a primary aortobronchial fistula of the ascending aorta. Eulert-Grehn, J. J., Veit, J., Falk, V. & Dusterhoft, V. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021). https://www.ncbi.nlm.nih.gov/pubmed/33537730   

On the preservation of vessel bifurcations during flow-mediated angiogenic remodelling. Edgar, L. T., Franco, C. A., Gerhardt, H. & Bernabeu, M. O. PLoS computational biology 17, e1007715 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33539345  

Association of Global Longitudinal Strain With Clinical Status and Mortality in Patients With Chronic Heart Failure. Trobs, S. O., Prochaska, J. H., Schwuchow-Thonke, S., Schulz, A., Muller, F., Heidorn, M. W., Gobel, S., Diestelmeier, S., Lerma Monteverde, J., Lackner, K. J., Gori, T., Munzel, T. & Wild, P. S. JAMA cardiology (2021). https://www.ncbi.nlm.nih.gov/pubmed/33533883  

Increased C reactive protein, cardiac troponin I and GLS are associated with myocardial inflammation in patients with non-ischemic heart failure. Schwuchow-Thonke, S., Gobel, S., Emrich, T., Schmitt, V. H., Fueting, F., Klank, C., Escher, F., Schultheiss, H. P., Munzel, T., Keller, K. & Wenzel, P. Scientific reports 11, 3008 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33542341  

Mapping strategies and ablation of premature atrial complexes. Riesinger, L., Siebermair, J. & Wakili, R. Herzschrittmachertherapie & Elektrophysiologie 32, 9-13 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33533993  

Genome editing for Duchenne muscular dystrophy: a glimpse of the future? Kupatt, C., Windisch, A., Moretti, A., Wolf, E., Wurst, W. & Walter, M. C. Gene therapy (2021). https://www.ncbi.nlm.nih.gov/pubmed/33531685  

Quantification of fibroblast growth factor 23 and N-terminal pro-B-type natriuretic peptide to identify patients with atrial fibrillation using a high-throughput platform: A validation study. Chua, W., Law, J. P., Cardoso, V. R., Purmah, Y., Neculau, G., Jawad-Ul-Qamar, M., Russell, K., Turner, A., Tull, S. P., Nehaj, F., Brady, P., Kastner, P., Ziegler, A., Gkoutos, G. V., Pavlovic, D., Ferro, C. J., Kirchhof, P. & Fabritz, L. PLoS medicine 18, e1003405 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33534825  

Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice. Zhang, H., Hanson, A., de Almeida, T. S., Emfinger, C., McClenaghan, C., Harter, T., Yan, Z., Cooper, P. E., Brown, G. S., Arakel, E. C., Mecham, R. P., Kovacs, A., Halabi, C. M., Schwappach, B., Remedi, M. S. & Nichols, C. G. JCI insight 6 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33529173  

Association Between Dispatch of Mobile Stroke Units and Functional Outcomes Among Patients With Acute Ischemic Stroke in Berlin. Ebinger, M., Siegerink, B., Kunz, A., Wendt, M., Weber, J. E., Schwabauer, E., Geisler, F., Freitag, E., Lange, J., Behrens, J., Erdur, H., Ganeshan, R., Liman, T., Scheitz, J. F., Schlemm, L., Harmel, P., Zieschang, K., Lorenz-Meyer, I., Napierkowski, I., Waldschmidt, C. et al. JAMA : the journal of the American Medical Association 325, 454-466 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33528537  

Impact of Statins on Hematoma, Edema, Seizures, Vascular Events, and Functional Recovery After Intracerebral Hemorrhage. Sprugel, M. I., Kuramatsu, J. B., Volbers, B., Saam, J. I., Sembill, J. A., Gerner, S. T., Balk, S., Hamer, H. M., Lucking, H., Holter, P., Nolte, C. H., Scheitz, J. F., Rocco, A., Endres, M. & Huttner, H. B. Stroke 52, 975-984 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33517701  

Clonal Hematopoiesis and Premature Menopause: Unexpected Liaison. Mas-Peiro, S., Cremer, S. & Zeiher, A. M. Circulation 143, 424-426 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33523729  

Residual inflammatory risk at 12 months after acute coronary syndromes is frequent and associated with combined adverse events. Klingenberg, R., Aghlmandi, S., Gencer, B., Nanchen, D., Raber, L., Carballo, D., Carballo, S., Stahli, B. E., Landmesser, U., Rodondi, N., Mach, F., Windecker, S., Bucher, H. C., von Eckardstein, A., Luscher, T. F. & Matter, C. M. Atherosclerosis 320, 31-37 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33524907  

Mitigated viral myocarditis in A/J mice by the immunoproteasome inhibitor ONX 0914 depends on inhibition of systemic inflammatory responses in CoxsackievirusB3 infection. Goetzke, C. C., Althof, N., Neumaier, H. L., Heuser, A., Kaya, Z., Kespohl, M., Klingel, K. & Beling, A. Basic research in cardiology 116, 7 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33523326


January

 

 

Interdisciplinary Clinical Target Volume Generation for Cardiac Radioablation: Multicenter Benchmarking for the RAdiosurgery for VENtricular TAchycardia (RAVENTA) Trial. Boda-Heggemann, J., Blanck, O., Mehrhof, F., Ernst, F., Buergy, D., Fleckenstein, J., Tulumen, E., Krug, D., Siebert, F. A., Zaman, A., Kluge, A. K., Parwani, A. S., Andratschke, N., Mayinger, M. C., Ehrbar, S., Saguner, A. M., Celik, E., Baus, W. W., Stauber, A., Vogel, L., Schweikard, A., Budach, V., Dunst, J., Boldt, L. H., Bonnemeier, H. & Rudic, B. Int J Radiat Oncol Biol Phys 110, 745-756 (2021). www.ncbi.nlm.nih.gov/pubmed/33508373  

Endothelial Dysfunction, Atherosclerosis, and Increase of von Willebrand Factor and Factor VIII: A Randomized Controlled Trial in Swine. Atiq, F., van de Wouw, J., Sorop, O., Heinonen, I., de Maat, M. P. M., Merkus, D., Duncker, D. J. & Leebeek, F. W. G. Thrombosis and haemostasis 121, 676-686 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33506473  

Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes. Peper, J., Kownatzki-Danger, D., Weninger, G., Seibertz, F., Pronto, J. R. D., Sutanto, H., Pacheu-Grau, D., Hindmarsh, R., Brandenburg, S., Kohl, T., Hasenfuss, G., Gotthardt, M., Rog-Zielinska, E. A., Wollnik, B., Rehling, P., Urlaub, H., Wegener, J., Heijman, J., Voigt, N., Cyganek, L., Lenz, C. & Lehnart, S. E. Circulation research 128, e102-e120 (2021).

Impaired complex I repair causes recessive Leber's hereditary optic neuropathy. Stenton, S. L., Sheremet, N. L., Catarino, C. B., Andreeva, N. A., Assouline, Z., Barboni, P., Barel, O., Berutti, R., Bychkov, I., Caporali, L., Capristo, M., Carbonelli, M., Cascavilla, M. L., Charbel Issa, P., Freisinger, P., Gerber, S., Ghezzi, D., Graf, E., Heidler, J., Hempel, M., Heon, E., Itkis, Y. S., Javasky, E., Kaplan, J., Kopajtich, R., Kornblum, C., Kovacs-Nagy, R., Krylova, T. D., Kunz, W. S., La Morgia, C., Lamperti, C., Ludwig, C., Malacarne, P. F., Maresca, A., Mayr, J. A., Meisterknecht, J., Nevinitsyna, T. A., Palombo, F., Pode-Shakked, B., Shmelkova, M. S., Strom, T. M., Tagliavini, F., Tzadok, M., van der Ven, A. T., Vignal-Clermont, C., Wagner, M., Zakharova, E. Y., Zhorzholadze, N. V., Rozet, J. M., Carelli, V., Tsygankova, P. G., Klopstock, T., Wittig, I. & Prokisch, H. The Journal of clinical investigation 131 (2021).

Apixaban or Vitamin K Antagonists and Aspirin or Placebo According to Kidney Function in Patients With Atrial Fibrillation After Acute Coronary Syndrome or Percutaneous Coronary Intervention: Insights From the AUGUSTUS Trial. Hijazi, Z., Alexander, J. H., Li, Z., Wojdyla, D. M., Mehran, R., Granger, C. B., Parkhomenko, A., Bahit, M. C., Windecker, S., Aronson, R., Berwanger, O., Halvorsen, S., de Waha-Thiele, S., Sinnaeve, P., Darius, H., Storey, R. F. & Lopes, R. D. Circulation 143, 1215-1223 (2021).

Fluorescence In Situ Hybridization and Polymerase Chain Reaction to Detect Infections in Patients With Left Ventricular Assist Devices. Schoenrath, F., Kursawe, L., Nersesian, G., Kikhney, J., Schmidt, J., Barthel, F., Kaufmann, F., Knierim, J., Knosalla, C., Hennig, F., Falk, V., Potapov, E. & Moter, A. ASAIO J 67, 536-545 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33417312  

Telomerase therapy attenuates cardiotoxic effects of doxorubicin. Chatterjee, S., Hofer, T., Costa, A., Lu, D., Batkai, S., Gupta, S. K., Bolesani, E., Zweigerdt, R., Megias, D., Streckfuss-Bomeke, K., Brandenberger, C., Thum, T. & Bar, C. Molecular therapy : the journal of the American Society of Gene Therapy 29, 1395-1410 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33388418  

A Panel of 6 Biomarkers Significantly Improves the Prediction of Type 2 Diabetes in the MONICA/KORA Study Population. Thorand, B., Zierer, A., Büyüközkan, M., Krumsiek, J., Bauer, A., Schederecker, F., Sudduth-Klinger, J., Meisinger, C., Grallert, H., Rathmann, W., Roden, M., Peters, A., Koenig, W., Herder, C. & Huth, C. The Journal of clinical endocrinology and metabolism 106, e1647-e1659 (2021).

Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes. Peper, J., Kownatzki-Danger, D., Weninger, G., Seibertz, F., Pronto, J. R. D., Sutanto, H., Pacheu-Grau, D., Hindmarsh, R., Brandenburg, S., Kohl, T., Hasenfuss, G., Gotthardt, M., Rog-Zielinska, E. A., Wollnik, B., Rehling, P., Urlaub, H., Wegener, J., Heijman, J., Voigt, N., Cyganek, L. et al. Circulation research 128, e102-e120 (2021).

Exercise Stress Real-Time Cardiac Magnetic Resonance Imaging for Noninvasive Characterization of Heart Failure With Preserved Ejection Fraction: The HFpEF-Stress Trial. Backhaus, S. J., Lange, T., George, E. F., Hellenkamp, K., Gertz, R. J., Billing, M., Wachter, R., Steinmetz, M., Kutty, S., Raaz, U., Lotz, J., Friede, T., Uecker, M., Hasenfuss, G., Seidler, T. & Schuster, A. Circulation 143, 1484-1498 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33472397  

Impaired complex I repair causes recessive Leber's hereditary optic neuropathy. Stenton, S. L., Sheremet, N. L., Catarino, C. B., Andreeva, N. A., Assouline, Z., Barboni, P., Barel, O., Berutti, R., Bychkov, I., Caporali, L., Capristo, M., Carbonelli, M., Cascavilla, M. L., Charbel Issa, P., Freisinger, P., Gerber, S., Ghezzi, D., Graf, E., Heidler, J., Hempel, M. et al. The Journal of clinical investigation 131 (2021).

Apixaban or Vitamin K Antagonists and Aspirin or Placebo According to Kidney Function in Patients With Atrial Fibrillation After Acute Coronary Syndrome or Percutaneous Coronary Intervention: Insights From the AUGUSTUS Trial. Hijazi, Z., Alexander, J. H., Li, Z., Wojdyla, D. M., Mehran, R., Granger, C. B., Parkhomenko, A., Bahit, M. C., Windecker, S., Aronson, R., Berwanger, O., Halvorsen, S., de Waha-Thiele, S., Sinnaeve, P., Darius, H., Storey, R. F. & Lopes, R. D. Circulation 143, 1215-1223 (2021).

Impact of chronic kidney disease in 29 893 patients undergoing transcatheter or surgical aortic valve replacement from the German Aortic Valve Registry. Mas-Peiro, S., Faerber, G., Bon, D., Herrmann, E., Bauer, T., Bleiziffer, S., Bekeredjian, R., Boning, A., Frerker, C., Beckmann, A., Mollmann, H., Vasa-Nicotera, M., Ensminger, S., Hamm, C. W., Beyersdorf, F., Fichtlscherer, S., Walther, T. & Board, G. A.-E. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 59, 532-544 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33454757  

Telomerase therapy attenuates cardiotoxic effects of doxorubicin. Chatterjee, S., Hofer, T., Costa, A., Lu, D., Batkai, S., Gupta, S. K., Bolesani, E., Zweigerdt, R., Megias, D., Streckfuss-Bomeke, K., Brandenberger, C., Thum, T. & Bar, C. Molecular therapy : the journal of the American Society of Gene Therapy 29, 1395-1410 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33388418  

A Panel of 6 Biomarkers Significantly Improves the Prediction of Type 2 Diabetes in the MONICA/KORA Study Population. Thorand, B., Zierer, A., Büyüközkan, M., Krumsiek, J., Bauer, A., Schederecker, F., Sudduth-Klinger, J., Meisinger, C., Grallert, H., Rathmann, W., Roden, M., Peters, A., Koenig, W., Herder, C. & Huth, C. The Journal of clinical endocrinology and metabolism 106, e1647-e1659 (2021).

Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect. Tadros, R., Francis, C., Xu, X., Vermeer, A. M. C., Harper, A. R., Huurman, R., Kelu Bisabu, K., Walsh, R., Hoorntje, E. T., Te Rijdt, W. P., Buchan, R. J., van Velzen, H. G., van Slegtenhorst, M. A., Vermeulen, J. M., Offerhaus, J. A., Bai, W., de Marvao, A., Lahrouchi, N., Beekman, L., Karper, J. C. et al. Nature genetics 53, 128-134 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33495596  

Valvular atrial fibrillation and a CHA2DS2-VASc score of 1-a statement of the ESC working group on cardiovascular pharmacotherapy and ESC council on stroke. Sulzgruber, P., Doehner, W. & Niessner, A. European heart journal 42, 541-543 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33496325  

Low serum vitamin D level associated with incident advanced liver disease in the general population - a prospective study. Mannisto, V., Jaaskelainen, T., Farkkila, M., Jula, A., Mannisto, S., Lundqvist, A., Zeller, T., Blankenberg, S., Salomaa, V., Perola, M. & Aberg, F. Scand J Gastroenterol 56, 299-303 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33478287  

Acid sphingomyelinase promotes SGK1-dependent vascular calcification. Luong, T. T. D., Tuffaha, R., Schuchardt, M., Moser, B., Schelski, N., Boehme, B., Gollmann-Tepekoylu, C., Schramm, C., Holfeld, J., Pieske, B., Gulbins, E., Tolle, M., van der Giet, M., Lang, F., Eckardt, K. U., Voelkl, J. & Alesutan, I. Clin Sci (Lond) 135, 515-534 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33479769  

miR-375- and miR-1-Regulated Coxsackievirus B3 Has No Pancreas and Heart Toxicity But Strong Antitumor Efficiency in Colorectal Carcinomas. Hazini, A., Dieringer, B., Pryshliak, M., Knoch, K. P., Heimann, L., Tolksdorf, B., Pappritz, K., El-Shafeey, M., Solimena, M., Beling, A., Kurreck, J., Klingel, K. & Fechner, H. Hum Gene Ther 32, 216-230 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33481658  

Detection of aberrant gene expression events in RNA sequencing data. Yepez, V. A., Mertes, C., Muller, M. F., Klaproth-Andrade, D., Wachutka, L., Fresard, L., Gusic, M., Scheller, I. F., Goldberg, P. F., Prokisch, H. & Gagneur, J. Nat Protoc 16, 1276-1296 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33462443  

Association of proton pump inhibitor use with endothelial function and metabolites of the nitric oxide pathway: A cross-sectional study. Nolde, M., Bahls, M., Friedrich, N., Dorr, M., Dreischulte, T., Felix, S. B., Ruckert-Eheberg, I. M., Ahn, N., Amann, U., Schwedhelm, E., Volzke, H., Lerch, M. M., Linseisen, J., Meisinger, C. & Baumeister, S. E. Pharmacotherapy 41, 198-204 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33465818  

Ablation of Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy: Treatment Strategy, Characteristics of Consecutive Atrial Tachycardia and Long-Term Outcome. Dinshaw, L., Munkler, P., Schaffer, B., Klatt, N., Jungen, C., Dickow, J., Tamenang, A., Schleberger, R., Pecha, S., Pinnschmidt, H., Patten, M., Reichenspurner, H., Willems, S. & Meyer, C. Journal of the American Heart Association 10, e017451 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33455428   

Vascular biotransformation of organic nitrates is independent of cytochrome P450 monooxygenases. Lopez, M., Malacarne, P. F., Gajos-Draus, A., Ding, X., Daiber, A., Lundberg, J. O., Offermanns, S., Brandes, R. P. & Rezende, F. British journal of pharmacology 178, 1495-1506 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33450066  

Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: The New Working Horse in Cardiovascular Pharmacology? Lemoine, M. D. & Christ, T. Journal of cardiovascular pharmacology 77, 265-266 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33433138  

[Personalized treatment concepts for arterial hypertension]. Lechner, K. & Schunkert, H. Herz 46, 91-104 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33433651  

Ythdf is a N6-methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila. Worpenberg, L., Paolantoni, C., Longhi, S., Mulorz, M. M., Lence, T., Wessels, H. H., Dassi, E., Aiello, G., Sutandy, F. X. R., Scheibe, M., Edupuganti, R. R., Busch, A., Mockel, M. M., Vermeulen, M., Butter, F., Konig, J., Notarangelo, M., Ohler, U., Dieterich, C., Quattrone, A. et al. The EMBO journal 40, e104975 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33428246  

Health-related quality of life, anxiety and depression up to 12 months post-stroke: Influence of sex, age, stroke severity and atrial fibrillation - A longitudinal subanalysis of the Find-AFRANDOMISED trial. Sadlonova, M., Wasser, K., Nagel, J., Weber-Kruger, M., Groschel, S., Uphaus, T., Liman, J., Hamann, G. F., Kermer, P., Groschel, K., Herrmann-Lingen, C. & Wachter, R. Journal of psychosomatic research 142, 110353 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33421630  

Quantitative analysis of three-dimensional left ventricular global strain using coronary computed tomography angiography in patients with heart failure: Comparison with 3T cardiac MR. Wang, R., Fang, Z., Wang, H., Schoepf, U. J., Emrich, T., Giovagnoli, D., Biles, E., Zhou, Z., Du, Z., Liu, T. & Xu, L. European journal of radiology 135, 109485 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33401113  

Risk markers of incident atrial fibrillation in patients with coronary heart disease. Tomasdottir, M. M., Held C Md, P., Hadziosmanovic, N., Westerbergh, J., Lindback, J., Aylward, P. E., Budaj, A., Cannon, C. P., Engdahl, J., Granger, C. B., Koenig, W., Manolis, A. J., Oldgren, J., Stewart, R. A. H., Svennberg, E., Vinereanu, D., White, H. D., Siegbahn, A., Wallentin, L. & Hijazi, Z. American heart journal 233, 92-101 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33400910  

Delayed onset hypophysitis after therapy with daclizumab for multiple sclerosis - A report of two cases. Stascheit, F., Li, L., Mai, K., Baum, K., Siebert, E. & Ruprecht, K. J Neuroimmunol 351, 577469 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33387829  

Major Depression and Anxiety Among Patients Hospitalized With Heart Failure. Sreenivasan, J., Khan, M. S., Ochani, R. K., Bhinder, J., Usman, M. S., Anker, S. D., Fonarow, G. C. & Butler, J. The American journal of cardiology 142, 153-155 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33383015  

Nutrition in the spotlight in cachexia, sarcopenia and muscle: avoiding the wildfire. Prado, C. M., Anker, S. D., Coats, A. J. S., Laviano, A. & von Haehling, S. J Cachexia Sarcopenia Muscle 12, 3-8 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33382196  

Weight loss, malnutrition, and cachexia in COVID-19: facts and numbers. Anker, M. S., Landmesser, U., von Haehling, S., Butler, J., Coats, A. J. S. & Anker, S. D. J Cachexia Sarcopenia Muscle 12, 9-13 (2021). https://www.ncbi.nlm.nih.gov/pubmed/33382211  

Clonal Hematopoiesis-Driver Dnmt3a Mutations Alter Immune Cells in Heart Failure. Abplanalp, W. T., Cremer, S., John, D., Hoffmann, J., Schuhmacher, B., Merten, M., Rieger, M. A., Vasa-Nicotera, M., Zeiher, A. M. & Dimmeler, S. Circ Res. 128, 216-28, (2021) www.ncbi.nlm.nih.gov/pubmed/33155517

Single-Cell Rna-Sequencing Reveals Profound Changes in Circulating Immune Cells in Patients with Heart Failure. Abplanalp, W. T., John, D., Cremer, S., Assmus, B., Dorsheimer, L., Hoffmann, J., Becker-Pergola, G., Rieger, M. A., Zeiher, A. M., Vasa-Nicotera, M. & Dimmeler, S. Cardiovasc Res. 117, 484-94, (2021) www.ncbi.nlm.nih.gov/pubmed/32311026

Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci. Ahluwalia, T. S., Prins, B. P., Abdollahi, M., Armstrong, N. J., Aslibekyan, S., Bain, L., Jefferis, B., Baumert, J., Beekman, M., Ben-Shlomo, Y., Bis, J. C., Mitchell, B. D., de Geus, E., Delgado, G. E., Marek, D., Eriksson, J., Kajantie, E., Kanoni, S., Kemp, J. P., Lu, C., Marioni, R. E., McLachlan, S., Milaneschi, Y., Nolte, I. M., Petrelis, A. M., Porcu, E., Sabater-Lleal, M., Naderi, E., Seppälä, I., Shah, T., Singhal, G., Standl, M., Teumer, A., Thalamuthu, A., Thiering, E., Trompet, S., Ballantyne, C. M., Benjamin, E. J., Casas, J. P., Toben, C., Dedoussis, G., Deelen, J., Durda, P., Engmann, J., Feitosa, M. F., Grallert, H., Hammarstedt, A., Harris, S. E., Homuth, G., Hottenga, J. J., Jalkanen, S., Jamshidi, Y., Jawahar, M. C., Jess, T., Kivimaki, M., Kleber, M. E., Lahti, J., Liu, Y., Marques-Vidal, P., Mellström, D., Mooijaart, S. P., Müller-Nurasyid, M., Penninx, B., Revez, J. A., Rossing, P., Räikkönen, K., Sattar, N., Scharnagl, H., Sennblad, B., Silveira, A., Pourcain, B. S., Timpson, N. J., Trollor, J., van Dongen, J., Van Heemst, D., Visvikis-Siest, S., Vollenweider, P., Völker, U., Waldenberger, M., Willemsen, G., Zabaneh, D., Morris, R. W., Arnett, D. K., Baune, B. T., Boomsma, D. I., Chang, Y. C., Deary, I. J., Deloukas, P., Eriksson, J. G., Evans, D. M., Ferreira, M. A., Gaunt, T., Gudnason, V., Hamsten, A., Heinrich, J., Hingorani, A., Humphries, S. E., Jukema, J. W., Koeing, W., Kumari, M., Kutalik, Z., Lawlor, D. A., Lehtimäki, T., März, W., Mather, K., Naitza, S., Nauck, M., Ohlsson, C., Price, J. F., Raitakari, O., Rice, K., Sachdev, P. S., Slagboom, E., Sørensen, T. I. A., Spector, T., Stacey, D., Stathopoulou, M. G., Tanaka, T., Wannamethee, S. G., Whincup, P., Rotter, J. I., Dehghan, A., Boerwinkle, E., Psaty, B. M., Snieder, H. & Alizadeh, B. Z. Hum Mol Genet. (2021)

Measuring Myocardial Extracellular Volume of the Right Ventricle in Patients with Congenital Heart Disease. Al-Wakeel-Marquard, N., Ferreira da Silva, T., Jeuthe, S., Rastin, S., Muench, F., D, O. H. I., Yilmaz, S., Berger, F., Kuehne, T. & Messroghli, D. R. Sci Rep. 11, 2679, (2021) www.ncbi.nlm.nih.gov/pubmed/33514806

Feasibility of a Culturally Adapted Dietary Weight-Loss Intervention among Ghanaian Migrants in Berlin, Germany: The Adapt Study. Amoah, S., Ennin, R., Sagoe, K., Steinbrecher, A., Pischon, T., Mockenhaupt, F. P. & Danquah, I. Int J Environ Res Public Health. 18, (2021)

Exercise-Stress Real-Time Cardiac Magnetic Resonance Imaging for Non-Invasive Characterisation of Heart Failure with Preserved Ejection Fraction: The Hfpef Stress Trial. Backhaus, S. J., Lange, T., George, E. F., Hellenkamp, K., Gertz, R. J., Billing, M., Wachter, R., Steinmetz, M., Kutty, S., Raaz, U., Lotz, J., Friede, T., Uecker, M., Hasenfuß, G., Seidler, T. & Schuster, A. Circulation. (2021) www.ncbi.nlm.nih.gov/pubmed/33472397

Effects of a Brief Alcohol Intervention Addressing the Full Spectrum of Drinking in an Adult General Population Sample: A Randomized Controlled Trial. Baumann, S., Staudt, A., Freyer-Adam, J., Bischof, G., Meyer, C. & John, U. Addiction. (2021)

Plasminogen Activator Inhibitor-1 Reduces Cardiac Fibrosis and Promotes M2 Macrophage Polarization in Inflammatory Cardiomyopathy. Baumeier, C., Escher, F., Aleshcheva, G., Pietsch, H. & Schultheiss, H. P. Basic Res Cardiol. 116, 1, (2021)

Brown Adipose Tissue Is Associated with Cardiometabolic Health. Becher, T., Palanisamy, S., Kramer, D. J., Eljalby, M., Marx, S. J., Wibmer, A. G., Butler, S. D., Jiang, C. S., Vaughan, R., Schöder, H., Mark, A. & Cohen, P. Nat Med. 27, 58-65, (2021)

Research Priorities in Atrial Fibrillation Screening: A Report from a National Heart, Lung, and Blood Institute Virtual Workshop. Benjamin, E. J., Go, A. S., Desvigne-Nickens, P., Anderson, C. D., Casadei, B., Chen, L. Y., Crijns, H., Freedman, B., Hills, M. T., Healey, J. S., Kamel, H., Kim, D. Y., Link, M. S., Lopes, R. D., Lubitz, S. A., McManus, D. D., Noseworthy, P. A., Perez, M. V., Piccini, J. P., Schnabel, R. B., Singer, D. E., Tieleman, R. G., Turakhia, M. P., Van Gelder, I. C., Cooper, L. S. & Al-Khatib, S. M. Circulation. 143, 372-88, (2021) www.ncbi.nlm.nih.gov/pubmed/33493033

Left and Right Ventricular Dysfunction in Patients with Covid-19-Associated Myocardial Injury. Bieber, S., Kraechan, A., Hellmuth, J. C., Muenchhoff, M., Scherer, C., Schroeder, I., Irlbeck, M., Kaeaeb, S., Massberg, S., Hausleiter, J., Grabmaier, U., Orban, M. & Weckbach, L. T. Infection. (2021) www.ncbi.nlm.nih.gov/pubmed/33515390

Interdisciplinary Clinical Target Volume Generation for Cardiac Radioablation: Multi-Center Benchmarking for the Radiosurgery for Ventricular Tachycardia (Raventa) Trial. Boda-Heggemann, J., Blanck, O., Mehrhof, F., Ernst, F., Buergy, D., Fleckenstein, J., Tülümen, E., Krug, D., Siebert, F. A., Zaman, A., Kluge, A. K., Parwani, A. S., Andratschke, N., Mayinger, M. C., Ehrbar, S., Saguner, A. M., Celik, E., Baus, W. W., Stauber, A., Vogel, L., Schweikard, A., Budach, V., Dunst, J., Boldt, L. H., Bonnemeier, H. & Rudic, B. Int J Radiat Oncol Biol Phys. (2021) www.ncbi.nlm.nih.gov/pubmed/33508373

Dual Sglt-1 and Sglt-2 Inhibition Improves Left Atrial Dysfunction in Hfpef. Bode, D., Semmler, L., Wakula, P., Hegemann, N., Primessnig, U., Beindorff, N., Powell, D., Dahmen, R., Ruetten, H., Oeing, C., Alogna, A., Messroghli, D., Pieske, B. M., Heinzel, F. R. & Hohendanner, F. Cardiovasc Diabetol. 20, 7, (2021)

Coxsackievirus B3 Infection of Human Ipsc Lines and Derived Primary Germ-Layer Cells Regarding Receptor Expression. Böhnke, J., Pinkert, S., Schmidt, M., Binder, H., Bilz, N. C., Jung, M., Reibetanz, U., Beling, A., Rujescu, D. & Claus, C. Int J Mol Sci. 22, (2021) www.ncbi.nlm.nih.gov/pubmed/33513663

Sars-Cov-2 Infection Is Associated with a Pro-Thrombotic Platelet Phenotype. Bongiovanni, D., Klug, M., Lazareva, O., Weidlich, S., Biasi, M., Ursu, S., Warth, S., Buske, C., Lukas, M., Spinner, C. D., Scheidt, M. V., Condorelli, G., Baumbach, J., Laugwitz, K. L., List, M. & Bernlochner, I. Cell Death Dis. 12, 50, (2021)

Risk Prediction of Atrial Fibrillation in the Community Combining Biomarkers and Genetics. Börschel, C. S., Ohlrogge, A. H., Geelhoed, B., Niiranen, T., Havulinna, A. S., Palosaari, T., Jousilahti, P., Rienstra, M., van der Harst, P., Blankenberg, S., Zeller, T., Salomaa, V. & Schnabel, R. B. Europace. (2021)

Dgk and Dzhk Position Paper on Genome Editing: Basic Science Applications and Future Perspective. Brandes, R. P., Dueck, A., Engelhardt, S., Kaulich, M., Kupatt, C., De Angelis, M. T., Leisegang, M. S., le Noble, F., Moretti, A., Müller, O. J., Skryabin, B. V., Thum, T. & Wurst, W. Basic Res Cardiol. 116, 2, (2021)

Empagliflozin and Health-Related Quality of Life Outcomes in Patients with Heart Failure with Reduced Ejection Fraction: The Emperor-Reduced Trial. Butler, J., Anker, S. D., Filippatos, G., Khan, M. S., Ferreira, J. P., Pocock, S. J., Giannetti, N., Januzzi, J. L., Piña, I. L., Lam, C. S. P., Ponikowski, P., Sattar, N., Verma, S., Brueckmann, M., Jamal, W., Vedin, O., Peil, B., Zeller, C., Zannad, F. & Packer, M. Eur Heart J. (2021)

Adult with Congenital Heart Disease We Need More Europe for a Better Care. Chessa, M. & Tutarel, O. Eur J Heart Fail. (2021) www.ncbi.nlm.nih.gov/pubmed/33496353

Variation in the Serpina6/Serpina1 Locus Alters Morning Plasma Cortisol, Hepatic Corticosteroid Binding Globulin Expression, Gene Expression in Peripheral Tissues, and Risk of Cardiovascular Disease. Crawford, A. A., Bankier, S., Altmaier, E., Barnes, C. L. K., Clark, D. W., Ermel, R., Friedrich, N., van der Harst, P., Joshi, P. K., Karhunen, V., Lahti, J., Mahajan, A., Mangino, M., Nethander, M., Neumann, A., Pietzner, M., Sukhavasi, K., Wang, C. A., Bakker, S. J. L., Bjorkegren, J. L. M., Campbell, H., Eriksson, J., Gieger, C., Hayward, C., Jarvelin, M. R., McLachlan, S., Morris, A. P., Ohlsson, C., Pennell, C. E., Price, J., Rudan, I., Ruusalepp, A., Spector, T., Tiemeier, H., Völzke, H., Wilson, J. F., Michoel, T., Timpson, N. J., Smith, G. D. & Walker, B. R. J Hum Genet. (2021) www.ncbi.nlm.nih.gov/pubmed/33469137

Alcohol Consumption, Cardiac Biomarkers, and Risk of Atrial Fibrillation and Adverse Outcomes. Csengeri, D., Sprünker, N. A., Di Castelnuovo, A., Niiranen, T., Vishram-Nielsen, J. K., Costanzo, S., Söderberg, S., Jensen, S. M., Vartiainen, E., Donati, M. B., Magnussen, C., Camen, S., Gianfagna, F., Løchen, M. L., Kee, F., Kontto, J., Mathiesen, E. B., Koenig, W., Stefan, B., de Gaetano, G., Jørgensen, T., Kuulasmaa, K., Zeller, T., Salomaa, V., Iacoviello, L. & Schnabel, R. B. Eur Heart J. (2021)

Phosphoproteomics Identify Arachidonic-Acid-Regulated Signal Transduction Pathways Modulating Macrophage Functions with Implications for Ovarian Cancer. Dietze, R., Hammoud, M. K., Gómez-Serrano, M., Unger, A., Bieringer, T., Finkernagel, F., Sokol, A. M., Nist, A., Stiewe, T., Reinartz, S., Ponath, V., Preußer, C., von Strandmann, E. P., Müller-Brüsselbach, S., Graumann, J. & Müller, R. Theranostics. 11, 1377-95, (2021)

Ablation of Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy: Treatment Strategy, Characteristics of Consecutive Atrial Tachycardia and Long-Term Outcome. Dinshaw, L., Münkler, P., Schäffer, B., Klatt, N., Jungen, C., Dickow, J., Tamenang, A., Schleberger, R., Pecha, S., Pinnschmidt, H., Patten, M., Reichenspurner, H., Willems, S. & Meyer, C. J Am Heart Assoc. e017451, (2021)

Cost Saving Analysis of Specialized, Ehealth-Based Management of Patients Receiving Oral Anticoagulation Therapy: Results from the Thrombeval Study. Eggebrecht, L., Ludolph, P., Göbel, S., Panova-Noeva, M., Arnold, N., Nagler, M., Bickel, C., Lauterbach, M., Hardt, R., Cate, H. T., Lackner, K. J., Espinola-Klein, C., Münzel, T., Prochaska, J. H. & Wild, P. S. Sci Rep. 11, 2577, (2021) www.ncbi.nlm.nih.gov/pubmed/33510343

Rationale and Design of the Cardiovascular Status in Patients with Endogenous Cortisol Excess Study (Cv-Cort-Ex): A Prospective Non-Interventional Follow-up Study. Ehrlich, K., Morbach, C., Reiter, T., Heuschmann, P. U., Hannemann, A., Fassnacht, M., Störk, S., Hahner, S. & Deutschbein, T. BMC Endocr Disord. 21, 11, (2021)

Inflammation Predicts New Onset of Depression in Men, but Not in Women within a Prospective, Representative Community Cohort. Ernst, M., Brähler, E., Otten, D., Werner, A. M., Tibubos, A. N., Reiner, I., Wicke, F., Wiltink, J., Michal, M., Nagler, M., Münzel, T., Wild, P. S., König, J., Pfeiffer, N., Borta, A., Lackner, K. J. & Beutel, M. E. Sci Rep. 11, 2271, (2021) www.ncbi.nlm.nih.gov/pubmed/33500534

Uncertainty Resolved? Falk, V. Innovations (Phila). 1556984520988796, (2021) www.ncbi.nlm.nih.gov/pubmed/33491537

An Overview of Anamorelin as a Treatment Option for Cancer-Associated Anorexia and Cachexia. Fonseca, G. & von Haehling, S. Expert Opin Pharmacother. 1-8, (2021) www.ncbi.nlm.nih.gov/pubmed/33491505

Impact of Oral Anticoagulation on Clinical Outcomes of Covid-19: A Nationwide Cohort Study of Hospitalized Patients in Germany. Fröhlich, G. M., Jeschke, E., Eichler, U., Thiele, H., Alhariri, L., Reinthaler, M., Kastrati, A., Leistner, D. M., Skurk, C., Landmesser, U. & Günster, C. Clin Res Cardiol. 1-10, (2021)

Corrigendum to "Interaction between Cieds and Modern Radiotherapy Techniques: Flattening Filter Free-Vmat, Dose-Rate Effects, Scatter Radiation, and Neutron-Generating Energies" [Radiother Oncol 152 (2020) 196-202]. Gauter-Fleckenstein, B., Nguyen, J., Jahnke, L., Gaiser, T., Rudic, B., Büttner, S., Wenz, F., Borggrefe, M. & Tülümen, E. Radiother Oncol. 154, 291, (2021)

Inflammatory Chemokines in Atherosclerosis. Gencer, S., Evans, B. R., van der Vorst, E. P. C., Döring, Y. & Weber, C. Cells. 10, (2021) www.ncbi.nlm.nih.gov/pubmed/33503867

Concomitant Tricuspid Regurgitation Severity and Its Secondary Reduction Determine Long-Term Prognosis after Transcatheter Mitral Valve Edge-to-Edge Repair. Geyer, M., Keller, K., Bachmann, K., Born, S., Tamm, A. R., Ruf, T. F., Kreidel, F., Hahad, O., Petrescu, A., Hell, M., Beiras-Fernandez, A., Kornberger, A., Schulz, E., Münzel, T. & von Bardeleben, R. S. Clin Res Cardiol. (2021)

Cardiomyocytes Stimulate Angiogenesis after Ischemic Injury in a Zeb2-Dependent Manner. Gladka, M. M., Kohela, A., Molenaar, B., Versteeg, D., Kooijman, L., Monshouwer-Kloots, J., Kremer, V., Vos, H. R., Huibers, M. M. H., Haigh, J. J., Huylebroeck, D., Boon, R. A., Giacca, M. & van Rooij, E. Nat Commun. 12, 84, (2021)

DNA Methylation and Lipid Metabolism: An Ewas of 226 Metabolic Measures. Gomez-Alonso, M. D. C., Kretschmer, A., Wilson, R., Pfeiffer, L., Karhunen, V., Seppälä, I., Zhang, W., Mittelstraß, K., Wahl, S., Matias-Garcia, P. R., Prokisch, H., Horn, S., Meitinger, T., Serrano-Garcia, L. R., Sebert, S., Raitakari, O., Loh, M., Rathmann, W., Müller-Nurasyid, M., Herder, C., Roden, M., Hurme, M., Jarvelin, M. R., Ala-Korpela, M., Kooner, J. S., Peters, A., Lehtimäki, T., Chambers, J. C., Gieger, C., Kettunen, J. & Waldenberger, M. Clin Epigenetics. 13, 7, (2021)

Associated Factors of White Matter Hyperintensity Volume: A Machine-Learning Approach. Grosu, S., Rospleszcz, S., Hartmann, F., Habes, M., Bamberg, F., Schlett, C. L., Galie, F., Lorbeer, R., Auweter, S., Selder, S., Buelow, R., Heier, M., Rathmann, W., Mueller-Peltzer, K., Ladwig, K. H., Grabe, H. J., Peters, A., Ertl-Wagner, B. B. & Stoecklein, S. Sci Rep. 11, 2325, (2021) www.ncbi.nlm.nih.gov/pubmed/33504924

Role of Cardiac Biomarkers in Epidemiology and Risk Outcomes. Haller, P. M., Beer, B. N., Tonkin, A. M., Blankenberg, S. & Neumann, J. T. Clin Chem. 67, 96-106, (2021)

Mir-375- and Mir-1-Regulated Coxsackievirus B3 Has No Pancreas and Heart Toxicity but Strong Antitumor Efficiency in Colorectal Carcinomas. Hazini, A., Dieringer, B., Pryshliak, M., Knoch, K. P., Heimann, L., Tolksdorf, B., Pappritz, K., El-Shafeey, M., Solimena, M., Beling, A., Kurreck, J., Klingel, K. & Fechner, H. Hum Gene Ther. (2021) www.ncbi.nlm.nih.gov/pubmed/33481658

Impaired in Vitro Growth Response of Plasma-Treated Cardiomyocytes Predicts Poor Outcome in Patients with Transthyretin Amyloidosis. Hein, S., Furkel, J., Knoll, M., Aus dem Siepen, F., Schönland, S., Hegenbart, U., Katus, H. A., Kristen, A. V. & Konstandin, M. H. Clin Res Cardiol. (2021) www.ncbi.nlm.nih.gov/pubmed/33481097

Apixaban or Vitamin K Antagonists and Aspirin or Placebo According to Kidney Function in Patients with Atrial Fibrillation after Acute Coronary Syndrome or Pci: Insights from the Augustus Trial. Hijazi, Z., Alexander, J. H., Li, Z., Wojdyla, D. M., Mehran, R., Granger, C. B., Parkhomenko, A., Bahit, M. C., Windecker, S., Aronson, R., Berwanger, O., Halvorsen, S., de Waha-Thiele, S., Sinnaeve, P., Darius, H., Storey, R. F. & Lopes, R. D. Circulation. (2021)

Randomized Study Defining the Optimum Target Interlesion Distance in Ablation Index-Guided Atrial Fibrillation Ablation: Authors' Reply. Hoffmann, P. & Althoff, T. F. Europace. (2021)

Prognostic Impact of Pretherapeutic Hemoglobin Levels on All-Cause Mortality in Cardiooncology. Hohneck, A., Rosenkaimer, S., Sieburg, T., Holzwarth, J., Hofheinz, R. D., Akin, I., Borggrefe, M. & Gerhards, S. Anticancer Res. 41, 369-78, (2021)

Epigenetic Gene Expression Links Heart Failure to Memory Impairment. Islam, M. R., Lbik, D., Sakib, M. S., Maximilian Hofmann, R., Berulava, T., Jiménez Mausbach, M., Cha, J., Goldberg, M., Vakhtang, E., Schiffmann, C., Zieseniss, A., Katschinski, D. M., Sananbenesi, F., Toischer, K. & Fischer, A. EMBO Mol Med. e11900, (2021) www.ncbi.nlm.nih.gov/pubmed/33471428

Prognostic Impact of Percutaneous Coronary Intervention of Chronic Total Occlusion in Acute and Periprocedural Myocardial Infarction. Kim, S. H., Behnes, M., Mashayekhi, K., Bufe, A., Meyer-Gessner, M., El-Battrawy, I. & Akin, I. J Clin Med. 10, (2021)

Proteomics in Kidney and Cardiovascular Clinical Research. Klein, O. Proteomics Clin Appl. 15, e1900132, (2021)

Empagliflozin Improves Endothelial and Cardiomyocyte Function in Human Heart Failure with Preserved Ejection Fraction Via Reduced Pro-Inflammatory-Oxidative Pathways and Protein Kinase Gα Oxidation. Kolijn, D., Pabel, S., Tian, Y., Lódi, M., Herwig, M., Carrizzo, A., Zhazykbayeva, S., Kovács, Á., Fülöp, G., Falcão-Pires, I., Reusch, P. H., Linthout, S. V., Papp, Z., van Heerebeek, L., Vecchione, C., Maier, L. S., Ciccarelli, M., Tschöpe, C., Mügge, A., Bagi, Z., Sossalla, S. & Hamdani, N. Cardiovasc Res. 117, 495-507, (2021) www.ncbi.nlm.nih.gov/pubmed/32396609

Fast Strain-Encoded Cardiac Magnetic Resonance for Diagnostic Classification and Risk Stratification of Heart Failure Patients. Korosoglou, G., Giusca, S., Montenbruck, M., Patel, A. R., Lapinskas, T., Götze, C., Zieschang, V., Al-Tabatabaee, S., Pieske, B., Florian, A., Erley, J., Katus, H. A., Kelle, S. & Steen, H. JACC Cardiovasc Imaging. (2021)

A Guide to Understanding Endoplasmic Reticulum Stress in Metabolic Disorders. Lemmer, I. L., Willemsen, N., Hilal, N. & Bartelt, A. Mol Metab. 101169, (2021) www.ncbi.nlm.nih.gov/pubmed/33484951

Human Induced Pluripotent Stem Cell Derived Cardiomyocytes: The New Working Horse in Cardiovascular Pharmacology? Lemoine, M. D. & Christ, T. J Cardiovasc Pharmacol. Publish Ahead of Print, (2021)

Association of Antecedent Cardiovascular Risk Factor Levels and Trajectories with Cardiovascular Magnetic Resonance-Derived Cardiac Function and Structure. Lorbeer, R., Rospleszcz, S., Schlett, C. L., Rado, S. D., Thorand, B., Meisinger, C., Rathmann, W., Heier, M., Vasan, R. S., Bamberg, F., Peters, A. & Lieb, W. J Cardiovasc Magn Reson. 23, 2, (2021)

The Multiple Options of Left Atrial and Ventricular Venting During Veno-Arterial Extra-Corporeal Membrane Oxygenation: Practical Considerations. Lüsebrink, E., Massberg, S. & Orban, M. Eur Heart J. (2021)

Cognitive Impairment in Patients with Atrial Fibrillation: Implications for Outcome in a Cohort Study. Malavasi, V. L., Zoccali, C., Brandi, M. C., Micali, G., Vitolo, M., Imberti, J. F., Mussi, C., Schnabel, R. B., Freedman, B. & Boriani, G. Int J Cardiol. 323, 83-89, (2021)

Low Serum Vitamin D Level Associated with Incident Advanced Liver Disease in the General Population - a Prospective Study. Männistö, V., Jääskeläinen, T., Färkkilä, M., Jula, A., Männistö, S., Lundqvist, A., Zeller, T., Blankenberg, S., Salomaa, V., Perola, M. & Åberg, F. Scand J Gastroenterol. 1-5, (2021) www.ncbi.nlm.nih.gov/pubmed/33478287

Trend-Db-a Transcriptome-Wide Atlas of the Dynamic Landscape of Alternative Polyadenylation. Marini, F., Scherzinger, D. & Danckwardt, S. Nucleic Acids Res. 49, D243-d53, (2021)

Impact of Chronic Kidney Disease in 29 893 Patients Undergoing Transcatheter or Surgical Aortic Valve Replacement from the German Aortic Valve Registry. Mas-Peiro, S., Faerber, G., Bon, D., Herrmann, E., Bauer, T., Bleiziffer, S., Bekeredjian, R., Böning, A., Frerker, C., Beckmann, A., Möllmann, H., Vasa-Nicotera, M., Ensminger, S., Hamm, C. W., Beyersdorf, F., Fichtlscherer, S. & Walther, T. Eur J Cardiothorac Surg. (2021)

Mental Disorders and Cardiovascular Disease: What Should We Be Looking out For? Michal, M. & Beutel, M. Heart. (2021) www.ncbi.nlm.nih.gov/pubmed/33509980

Current Use of Cardiac Magnetic Resonance in Tertiary Referral Centres for the Diagnosis of Cardiomyopathy: The Esc Eorp Cardiomyopathy/Myocarditis Registry. Mizia-Stec, K., Charron, P., Gimeno Blanes, J. R., Elliott, P., Kaski, J. P., Maggioni, A. P., Tavazzi, L., Tendera, M., Felix, S. B., Dominguez, F., Ojrzynska, N., Losi, M. A., Limongelli, G., Barriales-Villa, R., Seferovic, P. M., Biagini, E., Wybraniec, M., Laroche, C. & Caforio, A. L. P. Eur Heart J Cardiovasc Imaging. (2021)

Effects of Statins on Mitochondrial Pathways. Mollazadeh, H., Tavana, E., Fanni, G., Bo, S., Banach, M., Pirro, M., von Haehling, S., Jamialahmadi, T. & Sahebkar, A. J Cachexia Sarcopenia Muscle. (2021) www.ncbi.nlm.nih.gov/pubmed/33511728

Hybrid Arch Repair for Acute Type a Aortic Dissection: A New Concept and Step-by-Step Procedure. Montagner, M., Kofler, M., Buz, S. & Kempfert, J. Interact Cardiovasc Thorac Surg. (2021) www.ncbi.nlm.nih.gov/pubmed/33479734

Interdisciplinary Management of Acute Ischaemic Stroke: Current Evidence Training Requirements for Endovascular Stroke Treatment: Position Paper from the Esc Council on Stroke and the European Association for Percutaneous Cardiovascular Interventions with the Support of the European Board of Neurointervention. Nardai, S., Lanzer, P., Abelson, M., Baumbach, A., Doehner, W., Hopkins, L. N., Kovac, J., Meuwissen, M., Roffi, M., Sievert, H., Skrypnik, D., Sulzenko, J., van Zwam, W., Gruber, A., Ribo, M., Cognard, C., Szikora, I., Flodmark, O. & Widimsky, P. Eur Heart J. 42, 298-307, (2021) www.ncbi.nlm.nih.gov/pubmed/33160282

Gender Score Development in the Berlin Aging Study Ii: A Retrospective Approach. Nauman, A. T., Behlouli, H., Alexander, N., Kendel, F., Drewelies, J., Mantantzis, K., Berger, N., Wagner, G. G., Gerstorf, D., Demuth, I., Pilote, L. & Regitz-Zagrosek, V. Biol Sex Differ. 12, 15, (2021)

Surgical Implantation Techniques of Modern Continuous Flow Ventricular Assist Devices. Nersesian, G., Potapov, E., Starck, C. T., Nazari-Shafti, T. Z., Kofler, M., Kempfert, J., Falk, V. & Van Praet, K. M. Surg Technol Int. 38, (2021)

Endothelial Barrier Function after Stenting: Science-Fiction or Relevant Endpoint? Nicol, P. & Joner, M. Cardiovasc Revasc Med. (2021)

Association of Proton Pump Inhibitor Use with Endothelial Function and Metabolites of the Nitric Oxide Pathway: A Cross-Sectional Study. Nolde, M., Bahls, M., Friedrich, N., Dörr, M., Dreischulte, T., Felix, S. B., Rückert-Eheberg, I. M., Ahn, N., Amann, U., Schwedhelm, E., Völzke, H., Lerch, M. M., Linseisen, J., Meisinger, C. & Baumeister, S. E. Pharmacotherapy. (2021)

Molecular Mechanism of Autosomal Recessive Long Qt-Syndrome 1 without Deafness. Oertli, A., Rinné, S., Moss, R., Kääb, S., Seemann, G., Beckmann, B. M. & Decher, N. Int J Mol Sci. 22, (2021) www.ncbi.nlm.nih.gov/pubmed/33498651

Improving Translational Research in Sex-Specific Effects of Comorbidities and Risk Factors in Ischaemic Heart Disease and Cardioprotection: Position Paper and Recommendations of the Esc Working Group on Cellular Biology of the Heart. Perrino, C., Ferdinandy, P., Bøtker, H. E., Brundel, B., Collins, P., Davidson, S. M., den Ruijter, H. M., Engel, F. B., Gerdts, E., Girao, H., Gyöngyösi, M., Hausenloy, D. J., Lecour, S., Madonna, R., Marber, M., Murphy, E., Pesce, M., Regitz-Zagrosek, V., Sluijter, J. P. G., Steffens, S., Gollmann-Tepeköylü, C., Van Laake, L. W., Van Linthout, S., Schulz, R. & Ytrehus, K. Cardiovasc Res. 117, 367-85, (2021) www.ncbi.nlm.nih.gov/pubmed/32484892

History of Acute Coronary Syndrome: A Common, Maybe Underestimated, Risk Factor for Heart Failure with Preserved Ejection Fraction. Pieske, B. & Morris, D. A. Rev Esp Cardiol (Engl Ed). (2021)

Sex-Related Differences in D-Dimer Levels for Venous Thromboembolism Screening. Reagh, J. J., Zheng, H., Stolz, U., Parry, B. A., Chang, A. M., House, S. L., Giordano, N. J., Cohen, J., Singer, A. J., Francis, S., Prochaska, J. H., Zeserson, E., Wild, P. S., Limkakeng, A. T., Jr., Walters, E. L., LoVecchio, F., Theodoro, D., Hollander, J. E., Kabrhel, C. & Fermann, G. J. Acad Emerg Med. (2021) www.ncbi.nlm.nih.gov/pubmed/33497508

Age- and Gender-Related Reference Values of Cardiac Morphology and Function in Cardiovascular Magnetic Resonance. Riffel, J. H., Mayo, R., Mueller-Hennessen, M., Giannitsis, E., Katus, H. A. & Andre, F. Int J Cardiovasc Imaging. (2021) www.ncbi.nlm.nih.gov/pubmed/33483891

Health-Related Quality of Life, Anxiety and Depression up to 12 months Post-Stroke: Influence of Sex, Age, Stroke Severity and Atrial Fibrillation - a Longitudinal Subanalysis of the Find-Af(Randomised) Trial. Sadlonova, M., Wasser, K., Nagel, J., Weber-Krüger, M., Gröschel, S., Uphaus, T., Liman, J., Hamann, G. F., Kermer, P., Gröschel, K., Herrmann-Lingen, C. & Wachter, R. J Psychosom Res. 142, 110353, (2021)

Immune Cell-Based Cardiovascular Risk Assessment: Spotlight on the Neutrophil-Lymphocyte Ratio. Sager, H. B. & Koenig, W. Eur Heart J. (2021)

When Big Eaters Stop Feasting: Loss of Metabolic Control in Macrophages Exacerbates Hypertension in Obesity. Schäfer, K. & Wenzel, P. Cardiovasc Res. 117, 351-53, (2021) www.ncbi.nlm.nih.gov/pubmed/32298411

Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution. Schlein, C., Fischer, A. W., Sass, F., Worthmann, A., Tödter, K., Jaeckstein, M. Y., Behrens, J., Lynes, M. D., Kiebish, M. A., Narain, N. R., Bussberg, V., Darkwah, A., Jespersen, N. Z., Nielsen, S., Scheele, C., Schweizer, M., Braren, I., Bartelt, A., Tseng, Y. H., Heeren, J. & Scheja, L. Cell Rep. 34, 108624, (2021)

Proteomic and Functional Studies Reveal Detyrosinated Tubulin as Treatment Target in Sarcomere Mutation-Induced Hypertrophic Cardiomyopathy. Schuldt, M., Pei, J., Harakalova, M., Dorsch, L. M., Schlossarek, S., Mokry, M., Knol, J. C., Pham, T. V., Schelfhorst, T., Piersma, S. R., Dos Remedios, C., Dalinghaus, M., Michels, M., Asselbergs, F. W., Moutin, M. J., Carrier, L., Jimenez, C. R., van der Velden, J. & Kuster, D. W. D. Circ Heart Fail. 14, e007022, (2021)

Relation of Body Fat Mass and Fat-Free Mass to Total Mortality: Results from 7 Prospective Cohort Studies. Sedlmeier, A. M., Baumeister, S. E., Weber, A., Fischer, B., Thorand, B., Ittermann, T., Dörr, M., Felix, S. B., Völzke, H., Peters, A. & Leitzmann, M. F. Am J Clin Nutr. (2021)

Arterial Delivery of Vegf-C Stabilizes Atherosclerotic Lesions. Silvestre-Roig, C., Lemnitzer, P., Gall, J., Schwager, S., Toska, A., Yvan-Charvet, L., Detmar, M. & Soehnlein, O. Circ Res. 128, 284-86, (2021) www.ncbi.nlm.nih.gov/pubmed/33210556

Valvular Atrial Fibrillation and a Cha2ds2-Vasc Score of 1-a Statement of the Esc Working Group on Cardiovascular Pharmacotherapy and Esc Council on Stroke. Sulzgruber, P., Doehner, W. & Niessner, A. Eur Heart J. (2021) www.ncbi.nlm.nih.gov/pubmed/33496325

Shared Genetic Pathways Contribute to Risk of Hypertrophic and Dilated Cardiomyopathies with Opposite Directions of Effect. Tadros, R., Francis, C., Xu, X., Vermeer, A. M. C., Harper, A. R., Huurman, R., Kelu Bisabu, K., Walsh, R., Hoorntje, E. T., Te Rijdt, W. P., Buchan, R. J., van Velzen, H. G., van Slegtenhorst, M. A., Vermeulen, J. M., Offerhaus, J. A., Bai, W., de Marvao, A., Lahrouchi, N., Beekman, L., Karper, J. C., Veldink, J. H., Kayvanpour, E., Pantazis, A., Baksi, A. J., Whiffin, N., Mazzarotto, F., Sloane, G., Suzuki, H., Schneider-Luftman, D., Elliott, P., Richard, P., Ader, F., Villard, E., Lichtner, P., Meitinger, T., Tanck, M. W. T., van Tintelen, J. P., Thain, A., McCarty, D., Hegele, R. A., Roberts, J. D., Amyot, J., Dubé, M. P., Cadrin-Tourigny, J., Giraldeau, G., L'Allier, P. L., Garceau, P., Tardif, J. C., Boekholdt, S. M., Lumbers, R. T., Asselbergs, F. W., Barton, P. J. R., Cook, S. A., Prasad, S. K., O'Regan, D. P., van der Velden, J., Verweij, K. J. H., Talajic, M., Lettre, G., Pinto, Y. M., Meder, B., Charron, P., de Boer, R. A., Christiaans, I., Michels, M., Wilde, A. A. M., Watkins, H., Matthews, P. M., Ware, J. S. & Bezzina, C. R. Nat Genet. (2021) www.ncbi.nlm.nih.gov/pubmed/33495596

Connecting the Dots? Rate Control, Heart Failure, and Atrial Fibrillation. Toennis, T. & Kirchhof, P. Cardiovasc Res. 117, 336-37, (2021) www.ncbi.nlm.nih.gov/pubmed/33458743

Risk Markers of Incident Atrial Fibrillation in Patients with Coronary Heart Disease. Tomasdottir, M. M., Held C Md, P., Hadziosmanovic, N., Westerbergh, J., Lindbäck, J., Aylward, P. E., Budaj, A., Cannon, C. P., Engdahl, J., Granger, C. B., Koenig, W., Manolis, A. J., Oldgren, J., Stewart, R. A. H., Svennberg, E., Vinereanu, D., White, H. D., Siegbahn, A., Wallentin, L. & Hijazi, Z. Am Heart J. 233, 92-101, (2021)

Single Cell Sequencing Reveals Endothelial Plasticity with Transient Mesenchymal Activation after Myocardial Infarction. Tombor, L. S., John, D., Glaser, S. F., Luxán, G., Forte, E., Furtado, M., Rosenthal, N., Baumgarten, N., Schulz, M. H., Wittig, J., Rogg, E. M., Manavski, Y., Fischer, A., Muhly-Reinholz, M., Klee, K., Looso, M., Selignow, C., Acker, T., Bibli, S. I., Fleming, I., Patrick, R., Harvey, R. P., Abplanalp, W. T. & Dimmeler, S. Nat Commun. 12, 681, (2021) www.ncbi.nlm.nih.gov/pubmed/33514719

Kv1.1 Potassium Channel Subunit Deficiency Alters Ventricular Arrhythmia Susceptibility, Contractility, and Repolarization. Trosclair, K., Si, M., Watts, M., Gautier, N. M., Voigt, N., Traylor, J., Bitay, M., Baczko, I., Dobrev, D., Hamilton, K. A., Bhuiyan, M. S., Dominic, P. & Glasscock, E. Physiol Rep. 9, e14702, (2021)

Chitinase 3 Like 1 (Chi3l1) Is a Regulator of Smooth Muscle Cell Physiology and Atherosclerotic Lesion Stability. Tsantilas, P., Lao, S., Wu, Z., Eberhard, A., Winski, G., Vaerst, M., Nanda, V., Wang, Y., Kojima, Y., Ye, J., Flores, A., Jarr, K. U., Pelisek, J., Eckstein, H. H., Matic, L., Hedin, U., Tsao, P. S., Paloschi, V., Maegdefessel, L. & Leeper, N. J. Cardiovasc Res. (2021) www.ncbi.nlm.nih.gov/pubmed/33471078

Covid-19-Convalescence Phase Unmasks a Silent Myocardial Infarction Due to Coronary Plaque Rupture. Tschöpe, C., Sherif, M., Anker, M. S., Geisel, D., Kuehne, T. & Kelle, S. ESC Heart Fail. (2021)

Extent of Peri-Infarct Scar on Late Gadolinium Enhancement Cardiac Magnetic Resonance Imaging and Outcome in Patients with Ischemic Cardiomyopathy. Tülümen, E., Rudic, B., Ringlage, H., Hohneck, A., Röger, S., Liebe, V., Kuschyk, J., Overhoff, D., Budjan, J., Akin, I., Borggrefe, M. & Papavassiliu, T. Heart Rhythm. (2021) www.ncbi.nlm.nih.gov/pubmed/33515714

The Effect of a Video-Supported Assessment to Increase the Accuracy of Self-Reported Physical Activity. Ullrich, A., Voigt, L., Siewert-Markus, U., Meyer, C., Dörr, M. & Ulbricht, S. Scand J Med Sci Sports. (2021)

Imaging Atherosclerotic Plaques by Targeting Galectin-3 and Activated Macrophages Using ((89)Zr)-Dfo- Galectin3-F(Ab')(2) Mab. Varasteh, Z., De Rose, F., Mohanta, S., Li, Y., Zhang, X., Miritsch, B., Scafetta, G., Yin, C., Sager, H. B., Glasl, S., Gorpas, D., Habenicht, A. J. R., Ntziachristos, V., Weber, W. A., Bartolazzi, A., Schwaiger, M. & D'Alessandria, C. Theranostics. 11, 1864-76, (2021)

Clinical Impact and 'Natural' Course of Uncorrected Tricuspid Regurgitation after Implantation of a Left Ventricular Assist Device: An Analysis of the European Registry for Patients with Mechanical Circulatory Support (Euromacs). Veen, K. M., Mokhles, M. M., Soliman, O., de By, T., Mohacsi, P., Schoenrath, F., Paluszkiewicz, L., Netuka, I., Bogers, A., Takkenberg, J. J. M. & Caliskan, K. Eur J Cardiothorac Surg. 59, 207-16, (2021)

Complexity of the Eukaryotic Dolichol-Linked Oligosaccharide Scramblase Suggested by Activity Correlation Profiling Mass Spectrometry. Verchère, A., Cowton, A., Jenni, A., Rauch, M., Häner, R., Graumann, J., Bütikofer, P. & Menon, A. K. Sci Rep. 11, 1411, (2021)

Inflammation: A Putative Link between Phosphate Metabolism and Cardiovascular Disease. Voelkl, J., Egli-Spichtig, D., Alesutan, I. & Wagner, C. A. Clin Sci (Lond). 135, 201-27, (2021)

Plasma Proteins Associated with Cardiovascular Death in Patients with Chronic Coronary Heart Disease: A Retrospective Study. Wallentin, L., Eriksson, N., Olszowka, M., Grammer, T. B., Hagström, E., Held, C., Kleber, M. E., Koenig, W., März, W., Stewart, R. A. H., White, H. D., Åberg, M. & Siegbahn, A. PLoS Med. 18, e1003513, (2021)

Prospective Longitudinal Serosurvey of Health Care Workers in the First Wave of the Sars-Cov-2 Pandemic in a Quaternary Care Hospital in Munich, Germany. Weinberger, T., Steffen, J., Osterman, A., Mueller, T. T., Muenchhoff, M., Wratil, P. R., Graf, A., Krebs, S., Quartucci, C., Spaeth, P. M., Grabein, B., Adorjan, K., Blum, H., Keppler, O. T. & Klein, M. Clin Infect Dis. (2021)

Early Aspirin Discontinuation after Coronary Stenting: A Systematic Review and Meta-Analysis. Wiebe, J., Ndrepepa, G., Kufner, S., Lahmann, A. L., Xhepa, E., Kuna, C., Voll, F., Gosetti, R., Laugwitz, K. L., Joner, M., Kastrati, A. & Cassese, S. J Am Heart Assoc. 10, e018304, (2021)

Myeloid Cells, Tissue Homeostasis, and Anatomical Barriers as Innate Immune Effectors in Arterial Hypertension. Wild, J. & Wenzel, P. J Mol Med (Berl). (2021)

Ythdf Is a N6-Methyladenosine Reader That Modulates Fmr1 Target Mrna Selection and Restricts Axonal Growth in Drosophila. Worpenberg, L., Paolantoni, C., Longhi, S., Mulorz, M. M., Lence, T., Wessels, H. H., Dassi, E., Aiello, G., Sutandy, F. X. R., Scheibe, M., Edupuganti, R. R., Busch, A., Möckel, M. M., Vermeulen, M., Butter, F., König, J., Notarangelo, M., Ohler, U., Dieterich, C., Quattrone, A., Soldano, A. & Roignant, J. Y. Embo j. e104975, (2021)

Detection of Aberrant Gene Expression Events in Rna Sequencing Data. Yépez, V. A., Mertes, C., Müller, M. F., Klaproth-Andrade, D., Wachutka, L., Frésard, L., Gusic, M., Scheller, I. F., Goldberg, P. F., Prokisch, H. & Gagneur, J. Nat Protoc. (2021)

Longitudinal Associations between Ambient Air Pollution and Insulin Sensitivity: Results from the Kora Cohort Study. Zhang, S., Mwiberi, S., Pickford, R., Breitner, S., Huth, C., Koenig, W., Rathmann, W., Herder, C., Roden, M., Cyrys, J., Peters, A., Wolf, K. & Schneider, A. Lancet Planet Health. 5, e39-e49, (2021)

Multiscale Strategy to Resolve Stroma-Cardiac Fibroblast Interactions. Zimmermann, W. H. Circ Res. 128, 39-41, (2021)

Evl Regulates Vegf Receptor-2 Internalization and Signaling in Developmental Angiogenesis. Zink, J., Frye, M., Frömel, T., Carlantoni, C., John, D., Schreier, D., Weigert, A., Laban, H., Salinas, G., Stingl, H., Günther, L., Popp, R., Hu, J., Vanhollebeke, B., Schmidt, H., Acker-Palmer, A., Renné, T., Fleming, I. & Benz, P. M. EMBO Rep. e48961, (2021) www.ncbi.nlm.nih.gov/pubmed/33512764

Predictors and Prognostic Implications of Cardiac Arrhythmias in Patients Hospitalized for Covid-19. Zylla, M. M., Merle, U., Vey, J. A., Korosoglou, G., Hofmann, E., Müller, M., Herth, F., Schmidt, W., Blessing, E., Göggelmann, C., Weidner, N., Fiedler, M. O., Weigand, M. A., Kälble, F., Morath, C., Leiner, J., Kieser, M., Katus, H. A. & Thomas, D. J Clin Med. 10, (2021)