Publications 2021

Here you will find publications of the DZHK in chronological order. First authors in grey are members of the Young DZHK. For more publications, please also check out the websites of the individual research institutions that participate in the DZHK.

DZHK Papers of the Month


Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption. Karabegovic, I., Portilla-Fernandez, E., Li, Y., Ma, J., Maas, S. C. E., Sun, D., Hu, E. A., Kuhnel, B., Zhang, Y., Ambatipudi, S., Fiorito, G., Huang, J., Castillo-Fernandez, J. E., Wiggins, K. L., de Klein, N., Grioni, S., Swenson, B. R., Polidoro, S., Treur, J. L., Cuenin, C. et al. Nature communications 12, 2830 (2021).  

Distribution of estimated glomerular filtration rate and determinants of its age dependent loss in a German population-based study. Waas, T., Schulz, A., Lotz, J., Rossmann, H., Pfeiffer, N., Beutel, M. E., Schmidtmann, I., Munzel, T., Wild, P. S. & Lackner, K. J. Scientific reports 11, 10165 (2021).  

Prognostic value of long-term trajectories of depression for incident diabetes mellitus in patients with stable coronary heart disease. Peter, R. S., Jaensch, A., Mons, U., Schottker, B., Schmucker, R., Koenig, W., Brenner, H. & Rothenbacher, D. Cardiovascular diabetology 20, 108 (2021).  

Impact of Percutaneous Coronary Intervention on Outcomes in Patients With Heart Failure: JACC State-of-the-Art Review. Parikh, P. B., Bhatt, D. L., Bhasin, V., Anker, S. D., Skopicki, H. A., Claessen, B. E., Fonarow, G. C., Hernandez, A. F., Mehran, R., Petrie, M. C. & Butler, J. Journal of the American College of Cardiology 77, 2432-2447 (2021).  

A National Comparative Investigation of Twins With Congenital Heart Defects for Neurodevelopmental Outcomes and Quality of Life (Same Same, but Different?): Protocol for a Prospective Observational Study. Remmele, J., Helm, P. C., Oberhoffer-Fritz, R., Bauer, U. M., Pickardt, T., Ewert, P. & Tutarel, O. JMIR Res Protoc 10, e26404 (2021).  

Modeling chemotherapy induced neurotoxicity with human induced pluripotent stem cell (iPSC) -derived sensory neurons. Schinke, C., Vallone, V. F., Ivanov, A., Peng, Y., Kortvelyessy, P., Nolte, L., Huehnchen, P., Beule, D., Stachelscheid, H., Boehmerle, W. & Endres, M. Neurobiol Dis, 105391 (2021).  

Genetics of atrial fibrillation - practical applications for clinical management: If not now, when and how? Kany, S., Reissmann, B., Metzner, A., Kirchhof, P., Darbar, D. & Schnabel, R. B. Cardiovascular research (2021).   

Ouabain worsens diastolic sarcomere length in myocytes from a cardiomyopathy mouse model. Dusener, S., Flenner, F., Maack, C., Kohlhaas, M., Bay, J., Carrier, L. & Friedrich, F. W. European journal of pharmacology, 174170 (2021).  

Relationship between markers of inflammation and hemodynamic stress and death in patients with out-of-hospital cardiac arrest. Zelniker, T. A., Kaya, Z., Gamerdinger, E., Spaich, S., Stiepak, J., Giannitsis, E., Katus, H. A. & Preusch, M. R. Scientific reports 11, 9954 (2021).  

Altered alcohol consumption during COVID-19 pandemic lockdown. Steffen, J., Schlichtiger, J., Huber, B. C. & Brunner, S. Nutr J 20, 44 (2021).  

Identification of dynamic RNA-binding proteins uncovers a Cpeb4-controlled regulatory cascade during pathological cell growth of cardiomyocytes. Riechert, E., Kmietczyk, V., Stein, F., Schwarzl, T., Sekaran, T., Jurgensen, L., Kamuf-Schenk, V., Varma, E., Hofmann, C., Rettel, M., Gur, K., Olschlager, J., Kuhl, F., Martin, J., Ramirez-Pedraza, M., Fernandez, M., Doroudgar, S., Mendez, R., Katus, H. A., Hentze, M. W. et al. Cell reports 35, 109100 (2021).  

Surveillance of Fontan associated liver disease in childhood and adolescence. Hansen, J. H., Khodami, J. K., Moritz, J. D., Rinne, K., Voges, I., Scheewe, J., Kramer, H. H. & Uebing, A. Seminars in thoracic and cardiovascular surgery (2021).  

Assessment of significance of conditionally independent GWAS signals. Ghasemi, S., Teumer, A., Wuttke, M. & Becker, T. Bioinformatics (2021).  

Acute coronary syndrome by two different spontaneous coronary artery dissection types in two different vessels. Abdelwahed, Y. S., Zanders, L., Landmesser, U. & Leistner, D. M. Cardiovasc Interv Ther (2021).  

Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke. Schlemm, E., Ingwersen, T., Konigsberg, A., Boutitie, F., Ebinger, M., Endres, M., Fiebach, J. B., Fiehler, J., Galinovic, I., Lemmens, R., Muir, K. W., Nighoghossian, N., Pedraza, S., Puig, J., Simonsen, C. Z., Thijs, V., Wouters, A., Gerloff, C., Thomalla, G. & Cheng, B. Nature communications 12, 2590 (2021).  

Piezo1 and BKCa channels in human atrial fibroblasts: Interplay and remodelling in atrial fibrillation. Jakob, D., Klesen, A., Allegrini, B., Darkow, E., Aria, D., Emig, R., Chica, A. S., Rog-Zielinska, E. A., Guth, T., Beyersdorf, F., Kari, F. A., Proksch, S., Hatem, S. N., Karck, M., Kunzel, S. R., Guizouarn, H., Schmidt, C., Kohl, P., Ravens, U. & Peyronnet, R. Journal of molecular and cellular cardiology (2021).  

Elevated serum SDMA and ADMA at hospital admission predict in-hospital mortality of COVID-19 patients. Hannemann, J., Balfanz, P., Schwedhelm, E., Hartmann, B., Ule, J., Muller-Wieland, D., Dahl, E., Dreher, M., Marx, N. & Boger, R. Scientific reports 11, 9895 (2021).   

Proximity to the descending aorta predicts regional fibrosis in the adjacent left atrial wall: aetiopathogenic and prognostic implications. Caixal, G., Althoff, T., Garre, P., Alarcon, F., NunezGarcia, M., Benito, E. M., Borras, R., Perea, R. J., Prat-Gonzalez, S., Gunturiz, C., Sanchez, P., Olivas, D., Tolosana, J. M., Arbelo, E., Roca-Luque, I., Brugada, J., Sitges, M., Guasch, E. & Mont, L. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2021).  

Physics-based reconstruction methods for magnetic resonance imaging. Wang, X., Tan, Z., Scholand, N., Roeloffs, V. & Uecker, M. Philos Trans A Math Phys Eng Sci 379, 20200196 (2021).  

EACVI survey on the evaluation of left ventricular diastolic function. Sitges, M., Ajmone Marsan, N., Cameli, M., D'Andrea, A., Carvalho, R. F., Holte, E., Michalski, B., Podlesnikar, T., Popescu, B. A., Schulz-Menger, J., Stankovic, I., Haugaa, K. H. & Dweck, M. R. European heart journal cardiovascular Imaging (2021).  

Alcohol and atrial fibrillation: dose matters, not so much the type. Csengeri, D., Sprunker, N. A. & Schnabel, R. B. European heart journal (2021).  

Not all myocardial infarctions are created equal: The potential of circulating microRNAs to discern coronary artery dissection. Santovito, D. & Weber, C. EBioMedicine 67, 103366 (2021).  

New challenges in cardiac intensive care units. Lusebrink, E., Kellnar, A., Scherer, C., Krieg, K., Orban, M., Petzold, T., Peterss, S., Kaab, S., Brunner, S., Braun, D., Hagl, C., Hausleiter, J., Massberg, S. & Orban, M. Clinical research in cardiology : official journal of the German Cardiac Society (2021).  

Future of preventive cardiology: EAPC vision 2020-22. Halle, M., Davos, C. H., Dendale, P., Papadakis, M., Pfaff, C. & Krankel, N. European journal of preventive cardiology 28, 356-358 (2021).  

Editorial: Special Issue "Implications of oxidative stress and redox biochemistry for heart disease and cardioprotection - The EU-CARDIOPROTECTION COST Action (CA16225)". Daiber, A., Andreadou, I., Schulz, R. & Hausenloy, D. J. Free radical biology & medicine (2021).  

Comparison of 2D and 3D quiescent-interval slice-selective non-contrast MR angiography in patients with peripheral artery disease. Varga-Szemes, A., Aouad, P., Schoepf, U. J., Emrich, T., Yacoub, B., Todoran, T. M., Koktzoglou, I. & Edelman, R. R. MAGMA (2021).  

Association between meal-specific daily protein intake and lean mass in older adults: results of the cross-sectional BASE-II study. Nikolov, J., Norman, K., Buchmann, N., Spranger, J., Demuth, I., Steinhagen-Thiessen, E., Spira, D. & Mai, K. Am J Clin Nutr (2021).  

Running in polluted air is a two-edged sword - physical exercise in low air pollution areas is cardioprotective but detrimental for the heart in high air pollution areas. Munzel, T., Hahad, O. & Daiber, A. European heart journal (2021).  

Interplay between inflammation and thrombosis in cardiovascular pathology. Stark, K. & Massberg, S. Nature reviews. Cardiology, 1-17 (2021).  

Patient delay and benefit of timely reperfusion in ST-segment elevation myocardial infarction. Scholz, K. H., Meyer, T., Lengenfelder, B., Vahlhaus, C., Tongers, J., Schnupp, S., Burckhard, R., von Beckerath, N., Grusnick, H. M., Jeron, A., Winter, K. D., Maier, S. K. G., Danner, M., Vom Dahl, J., Neef, S., Stefanow, S. & Friede, T. Open heart 8 (2021).  

Coronary Microvascular Adaptations Distal to Epicardial Artery Stenosis. Merkus, D., Muller-Delp, J. & Heaps, C. L. American journal of physiology. Heart and circulatory physiology (2021).   

Bidimensional structure and measurement equivalence of the Patient Health Questionnaire-9: sex-sensitive assessment of depressive symptoms in three representative German cohort studies. Tibubos, A. N., Otten, D., Zoller, D., Binder, H., Wild, P. S., Fleischer, T., Johar, H., Atasoy, S., Schulze, L., Ladwig, K. H., Schomerus, G., Linkohr, B., Grabe, H. J., Kruse, J., Schmidt, C. O., Munzel, T., Konig, J., Brahler, E. & Beutel, M. E. BMC Psychiatry 21, 238 (2021).  

Serum creatinine and cystatin C-based estimates of glomerular filtration rate are misleading in acute heart failure. Swolinsky, J. S., Nerger, N. P., Leistner, D. M., Edelmann, F., Knebel, F., Tuvshinbat, E., Lemke, C., Roehle, R., Haase, M., Costanzo, M. R., Rauch, G., Mitrovic, V., Gasanin, E., Meier, D., McCullough, P. A., Eckardt, K. U., Molitoris, B. A. & Schmidt-Ott, K. M. ESC heart failure (2021).  

Homoarginine and methylarginines independently predict long-term outcome in patients presenting with suspicion of venous thromboembolism. Rodionov, R. N., Beyer-Westendorf, J., Bode-Boger, S. M., Eggebrecht, L., Konstantinides, S., Martens-Lobenhoffer, J., Nagler, M., Prochaska, J. & Wild, P. Scientific reports 11, 9569 (2021).  

Translational investigation of electrophysiology in hypertrophic cardiomyopathy. Flenner, F., Jungen, C., Kupker, N., Ibel, A., Kruse, M., Koivumaki, J. T., Rinas, A., Zech, A. T. L., Rhoden, A., Wijnker, P. J. M., Lemoine, M. D., Steenpass, A., Girdauskas, E., Eschenhagen, T., Meyer, C., van der Velden, J., Patten-Hamel, M., Christ, T. & Carrier, L. Journal of molecular and cellular cardiology 157, 77-89 (2021).  

Adjuvant breast cancer treatments cardiotoxicity and modern methods of detection and prevention of cardiac complications. Bikiewicz, A., Banach, M., von Haehling, S., Maciejewski, M. & Bielecka-Dabrowa, A. ESC heart failure (2021).  

Feasibility of remote speech analysis in evaluation of dynamic fluid overload in heart failure patients undergoing haemodialysis treatment. Amir, O., Anker, S. D., Gork, I., Abraham, W. T., Pinney, S. P., Burkhoff, D., Shallom, I. D., Haviv, R., Edelman, E. R. & Lotan, C. ESC heart failure (2021).  

Ubiquitin-proteasome-system and enzymes of energy metabolism in skeletal muscle of patients with HFpEF and HFrEF. Adams, V., Wunderlich, S., Mangner, N., Hommel, J., Esefeld, K., Gielen, S., Halle, M., Ellingsen, O., Van Craenenbroeck, E. M., Wisloff, U., Pieske, B., Linke, A. & Winzer, E. B. ESC heart failure (2021).  

Nucleoside Analogue Reverse Transcriptase Inhibitors Improve Clinical Outcome in Transcriptional Active Human Parvovirus B19-Positive Patients. Schultheiss, H. P., Bock, T., Pietsch, H., Aleshcheva, G., Baumeier, C., Fruhwald, F. & Escher, F. Journal of clinical medicine 10 (2021).  

Characterization of the HCN Interaction Partner TRIP8b/PEX5R in the Intracardiac Nervous System of TRIP8b-Deficient and Wild-Type Mice. Scherschel, K., Brauninger, H., Molders, A., Erlenhardt, N., Amin, E., Jungen, C., Pape, U., Lindner, D., Chetkovich, D. M., Klocker, N. & Meyer, C. International journal of molecular sciences 22 (2021).  

Hepatic Wnt1 Inducible Signaling Pathway Protein 1 (WISP-1/CCN4) Associates with Markers of Liver Fibrosis in Severe Obesity. Pivovarova-Ramich, O., Loske, J., Hornemann, S., Markova, M., Seebeck, N., Rosenthal, A., Klauschen, F., Castro, J. P., Buschow, R., Grune, T., Lange, V., Rudovich, N. & Ouwens, D. M. Cells 10 (2021).   

Leveraging clinical epigenetics in heart failure with preserved ejection fraction: a call for individualized therapies. Hamdani, N., Costantino, S., Mugge, A., Lebeche, D., Tschope, C., Thum, T. & Paneni, F. European heart journal (2021).  

Hospitalizations for heart failure: still major differences between East and West Germany 30 years after reunification. Dorr, M., Riemer, U., Christ, M., Bauersachs, J., Bosch, R., Laufs, U., Neumann, A., Scherer, M., Stork, S. & Wachter, R. ESC heart failure (2021).   

Integrated microRNA and mRNA Expression Profiling Identifies Novel Targets and Networks Associated with Ebstein's Anomaly. Abu-Halima, M., Wagner, V., Becker, L. S., Ayesh, B. M., Abd El-Rahman, M., Fischer, U., Meese, E. & Abdul-Khaliq, H. Cells 10 (2021).  

ADP-induced platelet reactivity and bleeding events in patients with acute myocardial infarction complicated by cardiogenic shock. Scherer, C., Lusebrink, E., Kupka, D., Stocker, T. J., Stark, K., Kleeberger, J., Orban, M., Kellnar, A., Petzold, T., Deseive, S., Krieg, K., Wurbel, S., Kika, S., Istrefi, M., Brunner, S., Braun, D., Hagl, C., Hausleiter, J., Massberg, S., Sibbing, D. et al. Platelets, 1-10 (2021).  

Factors Affecting Health-Related Quality of Life After the Arterial Switch Operation. Cleuziou, J., Huber, A. K., Strbad, M., Ono, M., Hager, A., Horer, J. & Lange, R. World journal for pediatric & congenital heart surgery 12, 344-351 (2021).  

Five-year outcome in 18 010 patients from the German Aortic Valve Registry. Beyersdorf, F., Bauer, T., Freemantle, N., Walther, T., Frerker, C., Herrmann, E., Bleiziffer, S., Mollmann, H., Landwehr, S., Ensminger, S., Bekeredjian, R., Cremer, J., Kuck, K. H., Fujita, B., Gummert, J., Muller, L., Beckmann, A., Hamm, C. W. & Board, G. E. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021).  

Prognostication after intracerebral hemorrhage: a review. Witsch, J., Siegerink, B., Nolte, C. H., Sprugel, M., Steiner, T., Endres, M. & Huttner, H. B. Neurol Res Pract 3, 22 (2021).  

Mechanical thrombectomy in patients with cervical artery dissection and stroke in the anterior or posterior circulation - a multicenter analysis from the German Stroke Registry. Schlemm, L., von Rennenberg, R., Siebert, E., Bohner, G., Flottmann, F., Petzold, G. C., Thomalla, G., Endres, M., Nolte, C. H. & investigators, G.-E. Neurol Res Pract 3, 20 (2021).  

Feasibility of two-dimensional speckle-tracking echocardiography of aortic valve in patients with calcific aortic valve disease. Nemchyna, O., Knierim, J., Dandel, M., Solowjowa, N., Schoenrath, F., Unbehaun, A., Kempfert, J., Stein, J., Knosalla, C., Falk, V. & Soltani, S. J Biomech 122, 110474 (2021).  

Prognostic impact of muscle and fat mass in patients with heart failure. Konishi, M., Akiyama, E., Matsuzawa, Y., Sato, R., Kikuchi, S., Nakahashi, H., Maejima, N., Iwahashi, N., Kosuge, M., Ebina, T., Hibi, K., Misumi, T., von Haehling, S., Anker, S. D., Tamura, K. & Kimura, K. J Cachexia Sarcopenia Muscle (2021).  

Statins Do More Than Lower Cholesterol-Depending on What You Eat? Eschenhagen, T. & Laufs, U. Circulation 143, 1793-1796 (2021).  

The impact of platelet indices on clinical outcome in heart failure: results from the MyoVasc study. Dahlen, B., Schulz, A., Gobel, S., Trobs, S. O., Schwuchow-Thonke, S., Spronk, H. M., Prochaska, J. H., Arnold, N., Lackner, K. J., Gori, T., Ten Cate, H., Munzel, T., Wild, P. S. & Panova-Noeva, M. ESC heart failure (2021).  

Low testosterone concentrations and prediction of future heart failure in men and in women: evidence from the large FINRISK97 study. Schafer, S., Aydin, M. A., Appelbaum, S., Kuulasmaa, K., Palosaari, T., Ojeda, F., Blankenberg, S., Jousilahti, P., Salomaa, V. & Karakas, M. ESC heart failure (2021).  

Patients profiling in Heart Failure for tailoring medical therapy A consensus document of the Heart Failure Association of the European Society of Cardiology. Rosano, G. M. C., Moura, B., Metra, M., Bauersachs, J., Gal, T. B., Adamopoulos, S., Abdelhamid, M., Bistola, V., Bohm, M., Celutkien, J., Chioncel, O., Farmakis, D., Ferrari, R., Filippatos, G., Hill, L., Jankowska, E. A., Jaarsma, T., Jhund, P., Lainscak, M., Lopatin, Y. et al. European journal of heart failure (2021).  

Iron deficiency in heart failure. Loncar, G., Obradovic, D., Thiele, H., von Haehling, S. & Lainscak, M. ESC heart failure (2021).  

Quantification of Myocardial Deformation Applying CMR-Feature-Tracking-All About the Left Ventricle? Lange, T. & Schuster, A. Current heart failure reports (2021).  

Heart Failure with preserved ejection fraction according to the HFA-PEFF score in COVID-19 patients: clinical correlates and echocardiographic findings. Hadzibegovic, S., Lena, A., Churchill, T. W., Ho, J. E., Potthoff, S., Denecke, C., Rosnick, L., Heim, K. M., Kleinschmidt, M., Sander, L. E., Witzenrath, M., Suttorp, N., Krannich, A., Porthun, J., Friede, T., Butler, J., Wilkenshoff, U., Pieske, B., Landmesser, U., Anker, S. D. et al. European journal of heart failure (2021).  

Wearable cardioverter-defibrillator: friend or foe in suspected myocarditis? Blaschke, F., Lacour, P., Dang, P. L., Parwani, A. S., Hohendanner, F., Walter, T., Klingel, K., Kuhl, U., Heinzel, F. R., Sherif, M., Boldt, L. H., Pieske, B. & Tschope, C. ESC heart failure (2021).  

A greasy business: Identification of a diacylglycerol binding site in human TRPC5 channels by cryo-EM. Storch, U., Mederos, Y. S. M. & Gudermann, T. Cell calcium 97, 102414 (2021).  

Dietary Essential Amino Acid Restriction Promotes Hyperdipsia via Hepatic FGF21. Rusu, P. M., Chan, A. Y., Heikenwalder, M., Muller, O. J. & Rose, A. J. Nutrients 13 (2021).  

Ablation of lysozyme M-positive cells prevents aircraft noise-induced vascular damage without improving cerebral side effects. Frenis, K., Helmstadter, J., Ruan, Y., Schramm, E., Kalinovic, S., Kroller-Schon, S., Bayo Jimenez, M. T., Hahad, O., Oelze, M., Jiang, S., Wenzel, P., Sommer, C. J., Frauenknecht, K. B. M., Waisman, A., Gericke, A., Daiber, A., Munzel, T. & Steven, S. Basic research in cardiology 116, 31 (2021).  

Impact of Anesthesia Strategy and Valve Type on Clinical Outcomes After Transcatheter Aortic Valve Replacement. Feistritzer, H. J., Kurz, T., Stachel, G., Hartung, P., Lurz, P., Eitel, I., Marquetand, C., Nef, H., Doerr, O., Vigelius-Rauch, U., Lauten, A., Landmesser, U., Treskatsch, S., Abdel-Wahab, M., Sandri, M., Holzhey, D., Borger, M., Ender, J., Ince, H., Oner, A. et al. Journal of the American College of Cardiology 77, 2204-2215 (2021).  

Regulation of Cardiac PKA Signaling by cAMP and Oxidants. Cuello, F., Herberg, F. W., Stathopoulou, K., Henning, P. & Diering, S. Antioxidants 10 (2021).


Pregnancy outcomes in women with a systemic right ventricle and transposition of the great arteries results from the ESC-EORP Registry of Pregnancy and Cardiac disease (ROPAC). Tutarel, O., Baris, L., Budts, W., Gamal Abd-El Aziz, M., Liptai, C., Majdalany, D., Jovanova, S., Frogoudaki, A., Connolly, H. M., Johnson, M. R., Maggioni, A. P., Hall, R., Roos-Hesselink, J. W. & Group, R. I. Heart (2021).  

Distribution Patterns of Intra- and Extramyocellular Fat by Magnetic Resonance Imaging in Subjects with Diabetes, Prediabetes and Normoglycemic Controls. Kiefer, L. S., Fabian, J., Rospleszcz, S., Lorbeer, R., Machann, J., Kraus, M. S., Roemer, F., Rathmann, W., Meisinger, C., Heier, M., Nikolaou, K., Peters, A., Storz, C., Diallo, T. D., Schlett, C. L. & Bamberg, F. Diabetes Obes Metab (2021).  

The gut microbiota is associated with the small intestinal paracellular permeability and the development of the immune system in healthy children during the first two years of life. Kaczmarczyk, M., Lober, U., Adamek, K., Wegrzyn, D., Skonieczna-Zydecka, K., Malinowski, D., Loniewski, I., Marko, L., Ulas, T., Forslund, S. K. & Loniewska, B. Journal of translational medicine 19, 177 (2021).  

MondoA Drives B-ALL Malignancy through Enhanced Adaptation to Metabolic Stress. Sipol, A., Hameister, E., Xue, B., Hofstetter, J., Barenboim, M., Ollinger, R., Jain, G., Prexler, C., Rubio, R. A., Baldauf, M. C., Franchina, D. G., Petry, A., Schmah, J., Thiel, U., Gorlach, A., Cario, G., Brenner, D., Richter, G., Grunewald, T. G. P., Rad, R. et al. Blood (2021).  

RhoA: a dubious molecule in cardiac pathophysiology. Kilian, L. S., Voran, J., Frank, D. & Rangrez, A. Y. J Biomed Sci 28, 33 (2021).  

Salt Transiently Inhibits Mitochondrial Energetics in Mononuclear Phagocytes. Geisberger, S., Bartolomaeus, H., Neubert, P., Willebrand, R., Zasada, C., Bartolomaeus, T., McParland, V., Swinnen, D., Geuzens, A., Maifeld, A., Krampert, L., Vogl, M., Mahler, A., Wilck, N., Marko, L., Tilic, E., Forslund, S. K., Binger, K. J., Stegbauer, J., Dechend, R. et al. Circulation (2021).

Transradial closure of a large ascending aortic pseudoaneurysm with a Duct Occluder II - A case report. Weferling, M., Haas, M. & Hamm, C. W. Cardiovascular revascularization medicine : including molecular interventions (2021).  

Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7-related osteopetrosis. Rossler, U., Hennig, A. F., Stelzer, N., Bose, S., Kopp, J., Soe, K., Cyganek, L., Zifarelli, G., Ali, S., von der Hagen, M., Strassler, E., Hahn, G., Pusch, M., Stauber, T., Izsvak, Z., Gossen, M., Stachelscheid, H. & Kornak, U. J Bone Miner Res (2021).  

Depression and Incident Cardiovascular Disease. El-Battrawy, I., Behnes, M. & Akin, I. JAMA : the journal of the American Medical Association 325, 1679-1680 (2021).  

Impact of Morphine Treatment With and Without Metoclopramide Coadministration on Myocardial and Microvascular Injury in Acute Myocardial Infarction: Insights From the Randomized MonAMI Trial. Stiermaier, T., Schaefer, P., Meyer-Saraei, R., Saad, M., de Waha-Thiele, S., Poss, J., Fuernau, G., Graf, T., Kurz, T., Frydrychowicz, A., Barkhausen, J., Desch, S., Thiele, H. & Eitel, I. Journal of the American Heart Association 10, e018881 (2021).  

Thyroid function and mood disorders: a Mendelian Randomization study. Kus, A., Kjaergaard, A. D., Marouli, E., Del Greco, M. F., Sterenborg, R., Chaker, L., Peeters, R. P., Bednarczuk, T., Asvold, B. O., Burgess, S., Deloukas, P., Teumer, A., Ellervik, C. & Medici, M. Thyroid : official journal of the American Thyroid Association (2021).  

Do we need to rethink treatment of aortic valve pathologies in younger patients? Krane, M., Wirth, F., Boehm, J. & Lange, R. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021).  

Supervised Obesity Reduction Trial for AF Ablation Patients: Results from the SORT-AF trial. Gessler, N., Willems, S., Steven, D., Aberle, J., Akbulak, R. O., Gosau, N., Hoffmann, B. A., Meyer, C., Sultan, A., Tilz, R., Vogler, J., Wohlmuth, P., Scholz, S., Gunawardene, M. A., Eickholt, C. & Luker, J. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2021).

ENIGMA-Sleep: Challenges, opportunities, and the road map. Tahmasian, M., Aleman, A., Andreassen, O. A., Arab, Z., Baillet, M., Benedetti, F., Bresser, T., Bright, J., Chee, M. W. L., Chylinski, D., Cheng, W., Deantoni, M., Dresler, M., Eickhoff, S. B., Eickhoff, C. R., Elvsashagen, T., Feng, J., Foster-Dingley, J. C., Ganjgahi, H., Grabe, H. J. et al. J Sleep Res, e13347 (2021).  

Sulforaphane exposure impairs contractility and mitochondrial function in three-dimensional engineered heart tissue. Rhoden, A., Friedrich, F. W., Brandt, T., Raabe, J., Schweizer, M., Meisterknecht, J., Wittig, I., Ulmer, B. M., Klampe, B., Uebeler, J., Piasecki, A., Lorenz, K., Eschenhagen, T., Hansen, A. & Cuello, F. Redox biology 41, 101951 (2021).  

c-Kit inhibition: From promising cancer therapy to culprit in atherosclerosis. van der Vorst, E. P. C. Atherosclerosis 324, 115-116 (2021).  

Hyperinflammation as underlying mechanism predisposing patients with cardiovascular diseases for severe COVID-19. Landmesser, U., Lehmann, I. & Eils, R. European heart journal 42, 1720-1721 (2021).  

Detection of extracellular superoxide in isolated human immune cells and in an animal model of arterial hypertension using hydropropidine probe and HPLC analysis. Kalinovic, S., Stamm, P., Oelze, M., Steven, S., Kroller-Schon, S., Kvandova, M., Zielonka, J., Munzel, T. & Daiber, A. Free radical biology & medicine 168, 214-225 (2021).

Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease. Zheng, T., Ellinghaus, D., Juzenas, S., Cossais, F., Burmeister, G., Mayr, G., Jorgensen, I. F., Teder-Laving, M., Skogholt, A. H., Chen, S., Strege, P. R., Ito, G., Banasik, K., Becker, T., Bokelmann, F., Brunak, S., Buch, S., Clausnitzer, H., Datz, C., Consortium, D. et al. Gut (2021).

Benefit of a wearable cardioverter defibrillator for detection and therapy of arrhythmias in patients with myocarditis. Tscholl, V., Wielander, D., Kelch, F., Stroux, A., Attanasio, P., Tschope, C., Landmesser, U., Roser, M., Huemer, M., Heidecker, B. & Nagel, P. ESC heart failure (2021).  

Development, validation, and implementation of biomarker testing in cardiovascular medicine state-of-the-art: proceedings of the European Society of Cardiology-Cardiovascular Round Table. Elliott, P., Cowie, M. R., Franke, J., Ziegler, A., Antoniades, C., Bax, J., Bucciarelli-Ducci, C., Flachskampf, F. A., Hamm, C., Jensen, M. T., Katus, H., Maisel, A., McDonagh, T., Mittmann, C., Muntendam, P., Nagel, E., Rosano, G., Twerenbold, R. & Zannad, F. Cardiovascular research 117, 1248-1256 (2021).  

Enhanced Ca(2+) signaling, mild primary aldosteronism, and hypertension in a familial hyperaldosteronism mouse model (Cacna1h (M1560V/+) ). Seidel, E., Schewe, J., Zhang, J., Dinh, H. A., Forslund, S. K., Marko, L., Hellmig, N., Peters, J., Muller, D. N., Lifton, R. P., Nottoli, T., Stolting, G. & Scholl, U. I. Proceedings of the National Academy of Sciences of the United States of America 118 (2021).  

Can we trust a smartwatch ECG? Potential and Limitations. Haverkamp, W., Butler, J. & Anker, S. D. European journal of heart failure (2021).  

Cis-epistasis at the LPA locus and risk of cardiovascular diseases. Zeng, L., Moser, S., Mirza-Schreiber, N., Lamina, C., Coassin, S., Nelson, C. P., Annilo, T., Franzen, O., Kleber, M. E., Mack, S., Andlauer, T. F. M., Jiang, B., Stiller, B., Li, L., Willenborg, C., Munz, M., Kessler, T., Kastrati, A., Laugwitz, K. L., Erdmann, J. et al. Cardiovascular research (2021).  

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SLL-PEEP Ventilation to Improve Exposure in Minimally Invasive Right Anterolateral Minithoracotomy Aortic Valve Replacement. Richter, G., Van Praet, K. M., Hommel, M., Sundermann, S. H., Kofler, M., Meyer, A., Unbehaun, A., Starck, C., Jacobs, S., Falk, V. & Kempfert, J. Innovations (Phila), 15569845211004265 (2021).  

Association between duration of drug-coated balloon inflation and efficacy in patients with drug-eluting stent restenosis. Koch, T., Voll, F., Xhepa, E., Wiebe, J., Cassese, S., Tolg, R., Laugwitz, K. L., Neumann, F. J., Kastrati, A. & Kufner, S. Coronary artery disease (2021).  

Optoacoustic imaging in endocrinology and metabolism. Karlas, A., Pleitez, M. A., Aguirre, J. & Ntziachristos, V. Nat Rev Endocrinol (2021).  

Validity of the 6-Minute Walk Test in Patients with End-Stage Lung Diseases Wearing an Oronasal Surgical Mask in Times of the COVID-19 Pandemic. Just, I. A., Schoenrath, F., Passinger, P., Stein, J., Kemper, D., Knosalla, C., Falk, V. & Knierim, J. Respiration, 1-6 (2021).  

Hand grip strength and fatigability: correlation with clinical parameters and diagnostic suitability in ME/CFS. Jakel, B., Kedor, C., Grabowski, P., Wittke, K., Thiel, S., Scherbakov, N., Doehner, W., Scheibenbogen, C. & Freitag, H. Journal of translational medicine 19, 159 (2021).  

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Fibroblast GATA-4 and GATA-6 promote myocardial adaptation to pressure overload by enhancing cardiac angiogenesis. Dittrich, G. M., Froese, N., Wang, X., Kroeger, H., Wang, H., Szaroszyk, M., Malek-Mohammadi, M., Cordero, J., Keles, M., Korf-Klingebiel, M., Wollert, K. C., Geffers, R., Mayr, M., Conway, S. J., Dobreva, G., Bauersachs, J. & Heineke, J. Basic research in cardiology 116, 26 (2021).  

EHRA expert consensus statement and practical guide on optimal implantation technique for conventional pacemakers and implantable cardioverter-defibrillators: endorsed by the Heart Rhythm Society (HRS), the Asia Pacific Heart Rhythm Society (APHRS), and the Latin-American Heart Rhythm Society (LAHRS). Burri, H., Starck, C., Auricchio, A., Biffi, M., Burri, M., D'Avila, A. L. R., Deharo, J. C., Glikson, M., Israel, C., Lau, C. A. R., Leclercq, C., Love, C., Nielsen, J. C., Vernooy, K., Dagres, N. R. C., Boveda, S. R. C., Butter, C., Marijon, E., Braunschweig, F., Mairesse, G. H. et al. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2021).  

Staying on the ball during COVID-19 pandemic: impact on training modalities in football players. Schuttler, D., Hamm, W., Krammer, S., Steffen, J., Deuster, E., Lauseker, M., Egger, F., Meyer, T. & Brunner, S. J Sports Med Phys Fitness (2021).   

Combined vaccine-immune-checkpoint inhibition constitutes a promising strategy for treatment of dMMR tumors. Salewski, I., Kuntoff, S., Kuemmel, A., Feldtmann, R., Felix, S. B., Henze, L., Junghanss, C. & Maletzki, C. Cancer Immunol Immunother (2021).  

Propensity score-based analysis of long-term follow-up in patients supported with durable centrifugal left ventricular assist devices: the EUROMACS analysis. Potapov, E. V., Nersesian, G., Lewin, D., Ozbaran, M., de By, T., Stein, J., Pya, Y., Gummert, J., Ramjankhan, F., Zembala, M. O., Damman, K., Carrel, T., Meyns, B., Zimpfer, D. & Netuka, I. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021).  

Magnetic resonance imaging-based changes in vascular morphology and cerebral perfusion in subacute ischemic stroke. Kufner, A., Khalil, A. A., Galinovic, I., Kellner, E., Mekle, R., Rackoll, T., Boehm-Sturm, P., Fiebach, J. B., Floel, A., Ebinger, M., Endres, M. & Nave, A. H. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 271678X211010071 (2021).  

Efficacy and Safety of Ticagrelor Versus Prasugrel in Women and Men with Acute Coronary Syndrome: A Pre-specified, Sex-Specific Analysis of the ISAR-REACT 5 Trial. Gewalt, S., Lahu, S., Ndrepepa, G., Pellegrini, C., Bernlochner, I., Neumann, F. J., Menichelli, M., Morath, T., Witzenbichler, B., Wohrle, J., Hoppe, K., Richardt, G., Laugwitz, K. L., Schunkert, H., Kastrati, A., Schupke, S. & Mayer, K. J Atheroscler Thromb (2021).  

Impaired High-Density Lipoprotein Function in Patients With Heart Failure. Emmens, J. E., Jia, C., Ng, L. L., van Veldhuisen, D. J., Dickstein, K., Anker, S. D., Lang, C. C., Filippatos, G., Cleland, J. G. F., Metra, M., Voors, A. A., de Boer, R. A. & Tietge, U. J. F. Journal of the American Heart Association, e019123 (2021).  

Anticoagulation in atrial fibrillation and liver disease: a pooled-analysis of > 20000 patients. Chen, S., Purerfellner, H., Meyer, C., Sommer, P., Galindo Kiuchi, M., Martinek, M., Futyma, P., Zanchi, S., Zhu, L., Schratter, A., Wang, J., Acou, W. J., Liu, S., Ling, Z., Yin, Y., Ouyang, F., Chun, J. K. R. & Schmidt, B. European heart journal. Cardiovascular pharmacotherapy (2021).  

Guided P2Y12 inhibitor therapy after percutaneous coronary intervention. Sibbing, D. & Kastrati, A. Lancet 397, 1423-1425 (2021).  

Hyperventilation/Breath-Hold Maneuver to Detect Myocardial Ischemia by Strain-Encoded CMR: Diagnostic Accuracy of a Needle-Free Stress Protocol. Ochs, M. M., Kajzar, I., Salatzki, J., Ochs, A. T., Riffel, J., Osman, N., Katus, H. A. & Friedrich, M. G. JACC. Cardiovascular imaging (2021).  

Myocardial Fibrosis and Inflammation by CMR Predict Cardiovascular Outcome in People Living With HIV. de Leuw, P., Arendt, C. T., Haberl, A. E., Froadinadl, D., Kann, G., Wolf, T., Stephan, C., Schuettfort, G., Vasquez, M., Arcari, L., Zhou, H., Zainal, H., Gawor, M., Vidalakis, E., Kolentinis, M., Albrecht, M. H., Escher, F., Vogl, T. J., Zeiher, A. M., Nagel, E. et al. JACC. Cardiovascular imaging (2021).  

Dietary-challenged mice with Alzheimer-like pathology show increased energy expenditure and reduced adipocyte hypertrophy and steatosis. Schreyer, S., Berndt, N., Eckstein, J., Mulleder, M., Hemmati-Sadeghi, S., Klein, C., Abuelnor, B., Panzel, A., Meierhofer, D., Spranger, J., Steiner, B. & Brachs, S. Aging 13 (2021).  

Heart-lung interactions in COVID-19: prognostic impact and usefulness of bedside echocardiography for monitoring of the right ventricle involvement. Dandel, M. Heart failure reviews, 1-15 (2021).  

Definition of acute kidney injury impacts prevalence and prognosis in ACS patients undergoing coronary angiography. Weferling, M., Liebetrau, C., Kraus, D., Zierentz, P., von Jeinsen, B., Dorr, O., Weber, M., Nef, H., Hamm, C. W. & Keller, T. BMC cardiovascular disorders 21, 183 (2021).  

Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure. Wang, H., Noordam, R., Cade, B. E., Schwander, K., Winkler, T. W., Lee, J., Sung, Y. J., Bentley, A. R., Manning, A. K., Aschard, H., Kilpelainen, T. O., Ilkov, M., Brown, M. R., Horimoto, A. R., Richard, M., Bartz, T. M., Vojinovic, D., Lim, E., Nierenberg, J. L., Liu, Y. et al. Molecular psychiatry (2021).  

Genetic insight into sick sinus syndrome. Is there a pill for it or how far are we on the translational road to personalized medicine? Tomsits, P., Clauss, S. & Kaab, S. European heart journal (2021).   

Imaging of cardiac fibroblast activation in a patient after acute myocardial infarction using (68)Ga-FAPI-04. Notohamiprodjo, S., Nekolla, S. G., Robu, S., Villagran Asiares, A., Kupatt, C., Ibrahim, T., Laugwitz, K. L., Makowski, M. R., Schwaiger, M., Weber, W. A. & Varasteh, Z. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology (2021).  

Novel Cryoballoon Ablation System for Single Shot Pulmonary Vein Isolation- The Prospective ICE-AGE-X Study. Tilz, R. R., Meyer-Saraei, R., Eitel, C., Fink, T., Sciacca, V., Lopez, L. D., Kirstein, B., Schluter, M., Vogler, J., Kuck, K. H. & Heeger, C. H. Circulation journal : official journal of the Japanese Circulation Society (2021).  

Blood pressure and resting heart rate in 3-17-year-olds in Germany in 2003-2006 and 2014-2017. Sarganas, G., Schienkiewitz, A., Finger, J. D. & Neuhauser, H. K. J Hum Hypertens (2021).  

The European Association of Preventive Cardiology Aviation and Occupational Cardiology Task Force. Nicol, E. D., Holdsworth, D. A., Halle, M. & Davos, C. H. European heart journal (2021).  

Performance of a cardiac lipid panel compared to four prognostic scores in chronic heart failure. McGranaghan, P., Saxena, A., Dungen, H. D., Rubens, M., Appunni, S., Salami, J., Veledar, E., Lacour, P., Blaschke, F., Obradovic, D., Loncar, G., Tahirovic, E., Edelmann, F., Pieske, B. & Trippel, T. D. Scientific reports 11, 8164 (2021).   

eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction. Liang, Y., Piao, C., Beuschel, C. B., Toppe, D., Kollipara, L., Bogdanow, B., Maglione, M., Lutzkendorf, J., See, J. C. K., Huang, S., Conrad, T. O. F., Kintscher, U., Madeo, F., Liu, F., Sickmann, A. & Sigrist, S. J. Cell reports 35, 108941 (2021).  

Dietary Macronutrient Composition in Relation to Circulating HDL and Non-HDL Cholesterol: A Federated Individual-Level Analysis of Cross-Sectional Data from Adolescents and Adults in 8 European Studies. Pinart, M., Jeran, S., Boeing, H., Stelmach-Mardas, M., Standl, M., Schulz, H., Harris, C., von Berg, A., Herberth, G., Koletzko, S., Linseisen, J., Breuninger, T. A., Nothlings, U., Barbaresko, J., Benda, S., Lachat, C., Yang, C., Gasparini, P., Robino, A., Rojo-Martinez, G. et al. J Nutr (2021).  

Mechanical unloading by miniature axial flow pumps in late cardiac allograft failure due to acute rejection. Just, I. A., Potapov, E., Knosalla, C. & Schoenrath, F. J Artif Organs (2021).  

Ligand-activated RXFP1 gene therapy ameliorates pressure overload-induced cardiac dysfunction. Sasipong, N., Schlegel, P., Wingert, J., Lederer, C., Meinhardt, E., Ziefer, A., Schmidt, C., Rapti, K., Thoni, C., Frey, N., Most, P., Katus, H. A. & Raake, P. W. J. Molecular therapy : the journal of the American Society of Gene Therapy (2021).  

Changes of Right Ventricular Function after Transcatheter Aortic Valve Replacement and Association with Outcome. Poch, F., Thalmann, R., Olbrich, I., Fellner, C., Stundl, A., Barthel, P., Bradaric, C., Laugwitz, K. L., Kupatt, C. & Ledwoch, J. Journal of cardiac failure (2021).  

Combined effect of work stress and impaired sleep on coronary and cardiovascular mortality in hypertensive workers: The MONICA/KORA cohort study. Li, J., Atasoy, S., Fang, X., Angerer, P. & Ladwig, K. H. European journal of preventive cardiology 28, 220-226 (2021).  

Modifiable lifestyle risk factors and C-reactive protein in patients with coronary artery disease: Implications for an anti-inflammatory treatment target population. Blaum, C., Brunner, F. J., Kroger, F., Braetz, J., Lorenz, T., Gossling, A., Ojeda, F., Koester, L., Karakas, M., Zeller, T., Westermann, D., Schnabel, R., Blankenberg, S., Seiffert, M. & Waldeyer, C. European journal of preventive cardiology 28, 152-158 (2021).  

A proteomic atlas of the neointima identifies novel druggable targets for preventive therapy. Wierer, M., Werner, J., Wobst, J., Kastrati, A., Cepele, G., Aherrahrou, R., Sager, H. B., Erdmann, J., Dichgans, M., Flockerzi, V., Civelek, M., Dietrich, A., Mann, M., Schunkert, H. & Kessler, T. European heart journal (2021).  

Prevention of cardiovascular disease: does 'every step counts' apply for occupational work? Halle, M. & Heitkamp, M. European heart journal 42, 1512-1515 (2021).  

Monocyte-Chemoattractant Protein-1 Levels in Human Atherosclerotic Lesions Associate With Plaque Vulnerability. Georgakis, M. K., van der Laan, S. W., Asare, Y., Mekke, J. M., Haitjema, S., Schoneveld, A. H., de Jager, S. C. A., Nurmohamed, N. S., Kroon, J., Stroes, E. S. G., de Kleijn, D. P. V., de Borst, G. J., Maegdefessel, L., Soenhlein, O., Pasterkamp, G. & Dichgans, M. Arteriosclerosis, thrombosis, and vascular biology, ATVBAHA121316091 (2021).  

Best of most possible worlds: Hybrid gene therapy vectors based on parvoviruses and heterologous viruses. Fakhiri, J. & Grimm, D. Molecular therapy : the journal of the American Society of Gene Therapy (2021).  

Left and right ventricular strain using fast strain-encoded cardiovascular magnetic resonance for the diagnostic classification of patients with chronic non-ischemic heart failure due to dilated, hypertrophic cardiomyopathy or cardiac amyloidosis. Steen, H., Giusca, S., Montenbruck, M., Patel, A. R., Pieske, B., Florian, A., Erley, J., Kelle, S. & Korosoglou, G. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 23, 45 (2021).  

Association of late gadolinium enhancement with biomarkers in patients with myocardial infarction. Schneider, J. N., Neumann, J. T., Bohnen, S., Sorensen, N. A., Cavus, E., Schafer, S., Hartikainen, T. S., Gossling, A., Tahir, E., Lund, G. K., Adam, G., Blankenberg, S., Muellerleile, K., Westermann, D. & Radunski, U. K. Coronary artery disease (2021).  

Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19. Bonaventura, A., Vecchie, A., Dagna, L., Martinod, K., Dixon, D. L., Van Tassell, B. W., Dentali, F., Montecucco, F., Massberg, S., Levi, M. & Abbate, A. Nature reviews. Immunology, 1-11 (2021).  

Management of antithrombotic therapy in patients undergoing transcatheter aortic valve implantation: a consensus document of the ESC Working Group on Thrombosis and the European Association of Percutaneous Cardiovascular Interventions (EAPCI), in collaboration with the ESC Council on Valvular Heart Disease. Ten Berg, J., Sibbing, D., Rocca, B., Van Belle, E., Chevalier, B., Collet, J. P., Dudek, D., Gilard, M., Gorog, D. A., Grapsa, J., Grove, E. L., Lancellotti, P., Petronio, A. S., Rubboli, A., Torracca, L., Vilahur, G., Witkowski, A. & Mehilli, J. European heart journal (2021).  

Longitudinal analyses of gender differences in first authorship publications related to COVID-19. Lerchenmuller, C., Schmallenbach, L., Jena, A. B. & Lerchenmueller, M. J. BMJ open 11, e045176 (2021).  

Complement, inflammation and thrombosis. Rawish, E., Sauter, M., Sauter, R., Nording, H. & Langer, H. F. British journal of pharmacology (2021).


Sex-Related Clinical Characteristics and Outcomes of Patients Undergoing Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation. Park, S. D., Orban, M., Karam, N., Lubos, E., Kalbacher, D., Braun, D., Stolz, L., Neuss, M., Butter, C., Praz, F., Kassar, M., Petrescu, A., Pfister, R., Iliadis, C., Unterhuber, M., Lurz, P., Thiele, H., Baldus, S., von Bardeleben, S., Blankenberg, S. et al. JACC. Cardiovascular interventions (2021).

RhoGEF17-An Essential Regulator of Endothelial Cell Death and Growth. Weber, P., Baltus, D., Jatho, A., Drews, O., Zelarayan, L. C., Wieland, T. & Lutz, S. Cells 10 (2021).

CALINCA-A Novel Pipeline for the Identification of lncRNAs in Podocyte Disease. Talyan, S., Filipów, S., Ignarski, M., Smieszek, M., Chen, H., Kühne, L., Butt, L., Göbel, H., Hoyer-Allo, K. J. R., Koehler, F. C., Altmüller, J., Brinkkötter, P., Schermer, B., Benzing, T., Kann, M., Müller, R. U. & Dieterich, C. Cells 10 (2021).

Reduced Liver Autophagy in High-Fat Diet Induced Liver Steatosis in New Zealand Obese Mice. Korovila, I., Höhn, A., Jung, T., Grune, T. & Ott, C. Antioxidants 10 (2021).

Novel Blood Biomarkers for a Diagnostic Workup of Acute Aortic Dissection. Forrer, A., Schoenrath, F., Torzewski, M., Schmid, J., Franke, U. F. W., Göbel, N., Aujesky, D., Matter, C. M., Lüscher, T. F., Mach, F., Nanchen, D., Rodondi, N., Falk, V., von Eckardstein, A. & Gawinecka, J. Diagnostics 11 (2021).

Broad Metabolome Alterations Associated with the Intake of Oral Contraceptives Are Mediated by Cortisol in Premenopausal Women. Eick, C., Klinger-König, J., Zylla, S., Hannemann, A., Budde, K., Henning, A. K., Pietzner, M., Nauck, M., Völzke, H., Grabe, H. J. & Hertel, J. Metabolites 11 (2021).

Non-viral Induction of Transgene-free iPSCs from Somatic Fibroblasts of Multiple Mammalian Species. Yoshimatsu, S., Nakajima, M., Iguchi, A., Sanosaka, T., Sato, T., Nakamura, M., Nakajima, R., Arai, E., Ishikawa, M., Imaizumi, K., Watanabe, H., Okahara, J., Noce, T., Takeda, Y., Sasaki, E., Behr, R., Edamura, K., Shiozawa, S. & Okano, H. Stem cell reports (2021).

Presence of contractile impairment appears crucial for structural remodeling in idiopathic left bundle-branch block. Salatzki, J., Fischer, T., Riffel, J., André, F., Hirschberg, K., Ochs, A., Hund, H., Müller-Hennessen, M., Giannitsis, E., Friedrich, M. G., Scholz, E., Frey, N., Katus, H. A. & Ochs, M. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 23, 39 (2021).

Telomere length is independently associated with all-cause mortality in chronic heart failure. Romaine, S. P. R., Denniff, M., Codd, V., Nath, M., Koekemoer, A., Anker, S. D., Cleland, J. G., Filippatos, G., Levin, D., Metra, M., Mordi, I. R., Ouwerkerk, W., Ter Maaten, J. M., van Veldhuisen, D. J., Zannad, F., Ng, L. L., van der Harst, P., Lang, C. C., Voors, A. A., Nelson, C. P. et al. Heart (2021).

Transportation noise pollution and cardiovascular disease. Münzel, T., Sørensen, M. & Daiber, A. Nature reviews. Cardiology (2021).

The Gut Microbiome in Hypertension: Recent Advances and Future Perspectives. Avery, E. G., Bartolomaeus, H., Maifeld, A., Marko, L., Wiig, H., Wilck, N., Rosshart, S. P., Forslund, S. K. & Müller, D. N. Circulation research 128, 934-950 (2021).

Nox4-Dependent Upregulation of S100A4 after Peripheral Nerve Injury Modulates Neuropathic Pain Processing. Wack, G., Metzner, K., Kuth, M. S., Wang, E., Bresnick, A., Brandes, R. P., Schröder, K., Wittig, I., Schmidtko, A. & Kallenborn-Gerhardt, W. Free radical biology & medicine (2021).

Trimethyllysine, vascular risk factors and outcome in acute ischemic stroke (MARK-STROKE). Schwedhelm, E., von Lucadou, M., Peine, S., Lezius, S., Thomalla, G., Böger, R., Gerloff, C. & Choe, C. U. Amino Acids (2021).

Dynamic contrast-enhanced magnetic resonance imaging for monitoring neovascularization during bone regeneration-a randomized in vivo study in rabbits. Righesso, L. A. R., Terekhov, M., Götz, H., Ackermann, M., Emrich, T., Schreiber, L. M., Müller, W. E. G., Jung, J., Rojas, J. P. & Al-Nawas, B. Clin Oral Investig (2021).

Noninvasive sampling of the distal airspace via HME-filter fluid is not useful to detect SARS-CoV-2 in intubated patients. Reifart, J., Liebetrau, C., Troidl, C., Madlener, K. & Rolf, A. Crit Care 25, 126 (2021).

Consensus Transcriptional Landscape of Human End-Stage Heart Failure. Ramirez Flores, R. O., Lanzer, J. D., Holland, C. H., Leuschner, F., Most, P., Schultz, J. H., Levinson, R. T. & Saez-Rodriguez, J. Journal of the American Heart Association, e019667 (2021).

Efficacy and Safety of Revacept, a Novel Lesion-Directed Competitive Antagonist to Platelet Glycoprotein VI, in Patients Undergoing Elective Percutaneous Coronary Intervention for Stable Ischemic Heart Disease: The Randomized, Double-blind, Placebo-Controlled ISAR-PLASTER Phase 2 Trial. Mayer, K., Hein-Rothweiler, R., Schüpke, S., Janisch, M., Bernlochner, I., Ndrepepa, G., Sibbing, D., Gori, T., Borst, O., Holdenrieder, S., Kupka, D., Petzold, T., Bradaric, C., Okrojek, R., Leistner, D. M., Trippel, T. D., Münzel, T., Landmesser, U., Pieske, B., Zeiher, A. M. et al. JAMA cardiology (2021).

Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients. Maifeld, A., Bartolomaeus, H., Löber, U., Avery, E. G., Steckhan, N., Markó, L., Wilck, N., Hamad, I., Šušnjar, U., Mähler, A., Hohmann, C., Chen, C. Y., Cramer, H., Dobos, G., Lesker, T. R., Strowig, T., Dechend, R., Bzdok, D., Kleinewietfeld, M., Michalsen, A. et al. Nature communications 12, 1970 (2021).


CRIP1 expression in monocytes related to hypertension. Schweigert, O., Adler, J., Langst, N., Aissi, D., Duque Escobar, J., Tong, T., Muller, C., Tregouet, D. A., Lukowski, R. & Zeller, T. Clin Sci (Lond) 135, 911-924 (2021).  

Promyelocytic leukemia protein promotes the phenotypic switch of smooth muscle cells in atherosclerotic plaques of human coronary arteries. Karle, W., Becker, S., Stenzel, P., Knosalla, C., Siegel, G., Baum, O., Zakrzewicz, A. & Berkholz, J. Clin Sci (Lond) 135, 887-905 (2021).  

Immunomodulation Therapy Using Tolerogenic Macrophages in a Rodent Model of Pulmonary Hypertension. Guihaire, J., Deuse, T., Wang, D., Spin, J. M., Blankenberg, F. G., Fadel, E., Reichenspurner, H. & Schrepfer, S. Stem Cells Dev (2021).  

Physical Fitness Training in Patients with Subacute Stroke (PHYS-STROKE): Safety analyses of a randomized clinical trial. Rackoll, T., A, H. N., Ebinger, M., Endres, M., Grittner, U., Floel, A. & for the, P.-S. s. g. International journal of stroke : official journal of the International Stroke Society, 17474930211006286 (2021).  

Do beta-Blockers Cause Depression?: Systematic Review and Meta-Analysis of Psychiatric Adverse Events During beta-Blocker Therapy. Riemer, T. G., Villagomez Fuentes, L. E., Algharably, E. A. E., Schafer, M. S., Mangelsen, E., Furtig, M. A., Bittner, N., Bar, A., Zaidi Touis, L., Wachtell, K., Majic, T., Dinges, M. J. & Kreutz, R. Hypertension 77, 1539-1548 (2021).

The association between genetically determined ABO blood types and major depressive disorder. Garvert, L., Baune, B. T., Berger, K., Boomsma, D. I., Breen, G., Greinacher, A., Hamilton, S. P., Levinson, D. F., Lewis, C. M., Lucae, S., Magnusson, P. K. E., Martin, N. G., McIntosh, A. M., Mors, O., Muller-Myhsok, B., Penninx, B., Perlis, R. H., Pistis, G., Potash, J. B., Preisig, M. et al. Psychiatry Res 299, 113837 (2021).  

MIR503HG Loss Promotes Endothelial-to-Mesenchymal Transition in Vascular Disease. Monteiro, J. P., Rodor, J., Caudrillier, A., Scanlon, J. P., Spiroski, A. M., Dudnakova, T., Pfluger-Muller, B., Shmakova, A., von Kriegsheim, A., Deng, L., Taylor, R. S., Wilson-Kanamori, J. R., Chen, S. H., Stewart, K., Thomson, A., Mitic, T., McClure, J. D., Iynikkel, J., Hadoke, P. W. F., Denby, L. et al. Circulation research 128, 1173-1190 (2021).  


Effect of Carillon Mitral Contour System on patient-reported outcomes in functional mitral regurgitation: an individual participant data meta-analysis. Khan, M. S., Friede, T., Anker, S. D. & Butler, J. ESC heart failure (2021).

Community-wide experimental evaluation of the PROSS stability-design method. Peleg, Y., Vincentelli, R., Collins, B. M., Chen, K. E., Livingstone, E. K., Weeratunga, S., Leneva, N., Guo, Q., Remans, K., Perez, K., G, E. K. B., Larsen, Ø., Vaněk, O., Skořepa, O., Jacquemin, S., Poterszman, A., Kjaer, S., Christodoulou, E., Albeck, S., Dym, O. et al. J Mol Biol, 166964 (2021).

Maternal Angiotensin Increases Placental Leptin in Early Gestation via an Alternative Renin-Angiotensin System Pathway: Suggesting a Link to Preeclampsia. Nonn, O., Fischer, C., Geisberger, S., El-Heliebi, A., Kroneis, T., Forstner, D., Desoye, G., Staff, A. C., Sugulle, M., Dechend, R., Pecks, U., Kollmann, M., Stern, C., Cartwright, J. E., Whitley, G. S., Thilaganathan, B., Wadsack, C., Huppertz, B., Herse, F. & Gauster, M. Hypertension, Hypertensionaha12016425 (2021).

Beware of TOSCA's kiss or metabolic and hormonal aspects of heart failure. Lainscak, M., Dora, E., Doehner, W., Obradovic, D. & Loncar, G. European journal of preventive cardiology (2021).

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Compressed sensing acceleration of cardiac cine imaging allows reliable and reproducible assessment of volumetric and functional parameters of the left and right atrium. Altmann, S., Halfmann, M. C., Abidoye, I., Yacoub, B., Schmidt, M., Wenzel, P., Forman, C., Schoepf, U. J., Xiong, F., Dueber, C., Kreitner, K. F., Varga-Szemes, A. & Emrich, T. European radiology (2021).

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Physical activity, sedentary behavior and risk of coronary artery disease, myocardial infarction and ischemic stroke: a two-sample Mendelian randomization study. Bahls, M., Leitzmann, M. F., Karch, A., Teumer, A., Dörr, M., Felix, S. B., Meisinger, C., Baumeister, S. E. & Baurecht, H. Clinical research in cardiology : official journal of the German Cardiac Society (2021).

Generation and Cultivation of Transgene-Free Macaque and Baboon iPSCs Under Chemically Defined Conditions. Rodríguez-Polo, I., Stauske, M. & Behr, R. Methods in molecular biology (2021).

Eye Tracking Supported Human Factors Testing Improving Patient Training. Weiss, K. E., Hoermandinger, C., Mueller, M., Schmid Daners, M., Potapov, E. V., Falk, V., Meboldt, M. & Lohmeyer, Q. J Med Syst 45, 55 (2021).

Therapies with CCL25 require controlled release via microparticles to avoid strong inflammatory reactions. Spinnen, J., Fröhlich, K., Sinner, N., Stolk, M., Ringe, J., Shopperly, L., Sittinger, M., Dehne, T. & Seifert, M. Journal of nanobiotechnology 19, 83 (2021).

Discordance of High-Sensitivity Troponin Assays in Patients With Suspected Acute Coronary Syndromes. Karády, J., Mayrhofer, T., Ferencik, M., Nagurney, J. T., Udelson, J. E., Kammerlander, A. A., Fleg, J. L., Peacock, W. F., Januzzi, J. L., Jr., Koenig, W. & Hoffmann, U. Journal of the American College of Cardiology 77, 1487-1499 (2021).

Effects of different exercise modalities on cardiac dysfunction in heart failure with preserved ejection fraction. Bode, D., Rolim, N. P. L., Guthof, T., Hegemann, N., Wakula, P., Primessnig, U., Berre, A. M. O., Adams, V., Wisløff, U., Pieske, B. M., Heinzel, F. R. & Hohendanner, F. ESC heart failure (2021).

GLP-1 receptor agonists and their cardiovascular benefits - the role of the GLP-1 receptor. Helmstädter, J., Keppeler, K., Küster, L., Münzel, T., Daiber, A. & Steven, S. British journal of pharmacology (2021).

CMR for myocardial characterization in ischemic heart disease: state-of-the-art and future developments. Emrich, T., Halfmann, M., Schoepf, U. J. & Kreitner, K. F. Eur Radiol Exp 5, 14 (2021).

Sex differences in patients with cardiogenic shock. Yan, I., Schrage, B., Weimann, J., Dabboura, S., Hilal, R., Beer, B. N., Becher, P. M., Seiffert, M., Magnussen, C., R, B. S., Kirchhof, P., Blankenberg, S. & Westermann, D. ESC heart failure (2021).

Frailty in patients undergoing transcatheter aortic valve replacement: prognostic value of the Geriatric Nutritional Risk Index. Seoudy, H., Al-Kassou, B., Shamekhi, J., Sugiura, A., Frank, J., Saad, M., Bramlage, P., Seoudy, A. K., Puehler, T., Lutter, G., Schulte, D. M., Laudes, M., Nickenig, G., Frey, N., Sinning, J. M. & Frank, D. J Cachexia Sarcopenia Muscle (2021).

Author Correction: Assessment of nanoindentation in stiffness measurement of soft biomaterials: kidney, liver, spleen and uterus. Wu, G., Gotthardt, M. & Gollasch, M. Scientific reports 11, 7035 (2021).

Center procedural volume and adverse in-hospital outcomes for patients undergoing percutaneous transvenous edge-to-edge mitral valve repair using MitraClip® technique in Germany. Keller, K., Hobohm, L., Schmidtmann, I., Münzel, T., Baldus, S. & von Bardeleben, R. S. European journal of heart failure (2021).

Experience and procedural efficacy of pulmonary vein isolation using the fourth and second generation cryoballoon: The shorter, the better? Heeger, C. H., Bohnen, J. E., Popescu, S., Meyer-Saraei, R., Fink, T., Sciacca, V., Kirstein, B., Hatahet, S., Traub, A., Lopez, L. D., Schlüter, M., Kuck, K. H., Eitel, C., Vogler, J. & Richard Tilz, R. Journal of cardiovascular electrophysiology (2021).

Personalized exercise prescription in the prevention and treatment of arterial hypertension: a Consensus Document from the European Association of Preventive Cardiology (EAPC) and the ESC Council on Hypertension. Hanssen, H., Boardman, H., Deiseroth, A., Moholdt, T., Simonenko, M., Kränkel, N., Niebauer, J., Tiberi, M., Abreu, A., Solberg, E. E., Pescatello, L., Brguljan, J., Coca, A. & Leeson, P. European journal of preventive cardiology (2021).

Non-adherence to heart failure medications predicts clinical outcomes: Assessment in a single spot urine sample by liquid chromatography - tandem mass spectrometry (results of a prospective multicentre study). Gupta, P., Voors, A. A., Patel, P., Lane, D., Anker, S. D., Cleland, J. G. F., Dickstein, K., Filippatos, G., Lang, C. C., van Veldhuisen, D. J., Metra, M., Zannad, F., Samani, N. J., Jones, D. J. L., Squire, I. B. & Ng, L. L. European journal of heart failure (2021).

Surgical Cutdown Avoids Vascular Complications in Transcatheter Aortic Valve Replacement in Calcified and Small Femoral Arteries. Burri, M., Ruge, H., Erlebach, M. & Lange, R. The Thoracic and cardiovascular surgeon (2021).

Epigenome-wide association study of whole blood gene expression in Framingham Heart Study participants provides molecular insight into the potential role of CHRNA5 in cigarette smoking-related lung diseases. Yao, C., Joehanes, R., Wilson, R., Tanaka, T., Ferrucci, L., Kretschmer, A., Prokisch, H., Schramm, K., Gieger, C., Peters, A., Waldenberger, M., Marzi, C., Herder, C. & Levy, D. Clinical epigenetics 13, 60 (2021).

A hierarchical regulatory network analysis of the vitamin D induced transcriptome reveals novel regulators and complete VDR dependency in monocytes. Warwick, T., Schulz, M. H., Günther, S., Gilsbach, R., Neme, A., Carlberg, C., Brandes, R. P. & Seuter, S. Scientific reports 11, 6518 (2021).

Role of the Ambulatory Assessed Apnea-Hypopnea Index for Predicting Recurring Atrial Fibrillation After Ablation Therapy. Trenkwalder, T., Grebmer, C., Tydecks, M., Blažek, P., Kottmaier, M., Weigand, S., Bourier, F., Reents, T., Reinhard, W., Lennerz, C., Hessling, G., Deisenhofer, I. & Kolb, C. The American journal of cardiology (2021).

Exercise training and high-sensitivity cardiac troponin T in patients with heart failure with reduced ejection fraction. Koppen, E., Omland, T., Larsen, A. I., Karlsen, T., Linke, A., Prescott, E., Halle, M., Dalen, H., Delagardelle, C., Hole, T., van Craenenbroeck, E. M., Beckers, P., Ellingsen, Ø., Feiereisen, P., Valborgland, T. & Videm, V. ESC heart failure (2021).

Beyond pacemaking: HCN channels in sinoatrial node function. Hennis, K., Biel, M., Wahl-Schott, C. & Fenske, S. Progress in biophysics and molecular biology (2021).

Fusion imaging guided implantation of a Tricento transcatheter heart valve for severe tricuspid regurgitation. Boeder, N. F., Bayer, M., Dörr, O. & Nef, H. M. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions (2021).

Genetically determined NLRP3 inflammasome activation associates with systemic inflammation and cardiovascular mortality. Schunk, S. J., Kleber, M. E., März, W., Pang, S., Zewinger, S., Triem, S., Ege, P., Reichert, M. C., Krawczyk, M., Weber, S. N., Jaumann, I., Schmit, D., Sarakpi, T., Wagenpfeil, S., Kramann, R., Boerwinkle, E., Ballantyne, C. M., Grove, M. L., Tragante, V., Pilbrow, A. P. et al. European heart journal (2021).

One-Year Outcomes of a Randomized Trial Comparing a Self-Expanding With a Balloon-Expandable Transcatheter Aortic Valve. Kim, W. K., Walther, T., Burgdorf, C., Möllmann, H., Linke, A., Redwood, S., Thilo, C., Hilker, M., Joner, M., Thiele, H., Conzelmann, L., Conradi, L., Kerber, S., Schymik, G., Prendergast, B., Husser, O., Blumenstein, J., Stortecky, S., Heg, D., Künzi, A. et al. Circulation 143, 1267-1269 (2021).

THE YEAR IN BASIC VASCULAR BIOLOGY RESEARCH: FROM MECHANORECEPTORS AND NETS TO SMARTPHONE DATA AND OMICS. Evans, P., Wojta, J., Hoefer, I. E., Waltenberger, J., Guzik, T., Badimon, L. & Weber, C. Cardiovascular research (2021).

The value of spot urinary creatinine as a marker of muscle wasting in patients with new-onset or worsening heart failure. Pandhi, P., Streng, K. W., Anker, S. D., Cleland, J. G., Damman, K., Dickstein, K., Pellicori, P., Lang, C. C., Ng, L., Samani, N. J., Zannad, F., Metra, M., Rossignol, P., Filippatos, G., van Veldhuisen, D. J., Voors, A. A. & Ter Maaten, J. M. J Cachexia Sarcopenia Muscle (2021).

Are atrial human pluripotent stem cell-derived cardiomyocytes ready to identify drugs that beat atrial fibrillation? Christ, T., Lemoine, M. D. & Eschenhagen, T. Nature communications 12, 1725 (2021).

Dipeptidyl peptidase 3, a marker of the antagonist pathway of the renin-angiotensin-aldosterone system in patients with heart failure. Boorsma, E. M., Ter Maaten, J. M., Damman, K., van Veldhuisen, D. J., Dickstein, K., Anker, S. D., Filippatos, G., Lang, C. C., Metra, M., Santos, K. & Voors, A. A. European journal of heart failure (2021).

Induced Pluripotent Stem Cells (iPSCs) in Vascular Research: from Two- to Three-Dimensional Organoids. Trillhaase, A., Maertens, M., Aherrahrou, Z. & Erdmann, J. Stem Cell Rev Rep, 1-13 (2021).

Spinocerebellar ataxia type 14: refining clinicogenetic diagnosis in a rare adult-onset disorder. Schmitz-Hübsch, T., Lux, S., Bauer, P., Brandt, A. U., Schlapakow, E., Greschus, S., Scheel, M., Gärtner, H., Kirlangic, M. E., Gras, V., Timmann, D., Synofzik, M., Giorgetti, A., Carloni, P., Shah, J. N., Schöls, L., Kopp, U., Bußenius, L., Oberwahrenbrock, T., Zimmermann, H. et al. Ann Clin Transl Neurol (2021).

Atrial resting membrane potential confers sodium current sensitivity to propafenone, flecainide, and dronedarone. Holmes, A. P., Saxena, P., Kabir, S. N., O'Shea, C., Kuhlmann, S. M., Gupta, S., Fobian, D., Apicella, C., O'Reilly, M., Syeda, F., Reyat, J. S., Smith, G. L., Workman, A. J., Pavlovic, D., Fabritz, L. & Kirchhof, P. Heart rhythm (2021).

Effects of acute alcohol consumption on cardiac excitation, conduction, and repolarization: results from the Munich Beer Related Electrocardiogram Workup Study (MunichBREW). Brunner, S., Drobesch, C., Herbel, R. & Sinner, M. F. Clinical research in cardiology : official journal of the German Cardiac Society (2021).

Diffuse myocardial fibrosis by T1 mapping is associated with heart failure in pediatric primary dilated cardiomyopathy. Al-Wakeel-Marquard, N., Seidel, F., Herbst, C., Kühnisch, J., Kuehne, T., Berger, F., Klaassen, S. & Messroghli, D. R. International journal of cardiology (2021).

Long-Term Outcomes of Patients Undergoing the Ross Procedure. Aboud, A., Charitos, E. I., Fujita, B., Stierle, U., Reil, J. C., Voth, V., Liebrich, M., Andreas, M., Holubec, T., Bening, C., Albert, M., Fila, P., Ondrasek, J., Murin, P., Lange, R., Reichenspurner, H., Franke, U., Gorski, A., Moritz, A., Laufer, G. et al. Journal of the American College of Cardiology 77, 1412-1422 (2021).

Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine. Rajewsky, N., Almouzni, G., Gorski, S. A., Aerts, S., Amit, I., Bertero, M. G., Bock, C., Bredenoord, A. L., Cavalli, G., Chiocca, S., Clevers, H., De Strooper, B., Eggert, A., Ellenberg, J., Fernández, X. M., Figlerowicz, M., Gasser, S. M., Hubner, N., Kjems, J., Knoblich, J. A. et al. Nature 592, E8 (2021).

Generation of Marmoset Monkey iPSCs with Self-Replicating VEE-mRNAs in Feeder-Free Conditions. Petkov, S. G. & Behr, R. Methods in molecular biology (2021).

Telmisartan prevents high-fat diet-induced neurovascular impairments and reduces anxiety-like behavior. Huber, G., Ogrodnik, M., Wenzel, J., Stölting, I., Huber, L., Will, O., Peschke, E., Matschl, U., Hövener, J. B., Schwaninger, M., Jurk, D. & Raasch, W. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 271678x211003497 (2021).

The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis. Fidler, T. P., Xue, C., Yalcinkaya, M., Hardaway, B., Abramowicz, S., Xiao, T., Liu, W., Thomas, D. G., Hajebrahimi, M. A., Pircher, J., Silvestre-Roig, C., Kotini, A. G., Luchsinger, L. L., Wei, Y., Westerterp, M., Snoeck, H. W., Papapetrou, E. P., Schulz, C., Massberg, S., Soehnlein, O. et al. Nature (2021).

The management of secondary mitral regurgitation in patients with heart failure: a joint position statement from the Heart Failure Association (HFA), European Association of Cardiovascular Imaging (EACVI), European Heart Rhythm Association (EHRA), and European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC. Coats, A. J. S., Anker, S. D., Baumbach, A., Alfieri, O., von Bardeleben, R. S., Bauersachs, J., Bax, J. J., Boveda, S., Čelutkienė, J., Cleland, J. G., Dagres, N., Deneke, T., Farmakis, D., Filippatos, G., Hausleiter, J., Hindricks, G., Jankowska, E. A., Lainscak, M., Leclercq, C., Lund, L. H. et al. European heart journal (2021).

Advanced cancer is also a heart failure syndrome: a hypothesis. Anker, M. S., Sanz, A. P., Zamorano, J. L., Mehra, M. R., Butler, J., Riess, H., Coats, A. J. S. & Anker, S. D. J Cachexia Sarcopenia Muscle (2021).

Comparison of the prognosis and outcome of heart failure with reduced ejection fraction patients treated with sacubitril/valsartan according to age. Abumayyaleh, M., El-Battrawy, I., Kummer, M., Pilsinger, C., Sattler, K., Kuschyk, J., Aweimer, A., Mügge, A., Borggrefe, M. & Akin, I. Future cardiology (2021).

The genetic predisposition to longevity acts through behavioral phenotypes in females. Van der Auwera, S., Garvert, L., Fuellen, G., Nauck, M., Völzke, H., Völker, U. & Grabe, H. J. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 45, 1-14 (2021).

Xbp1s-FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction. Schiattarella, G. G., Altamirano, F., Kim, S. Y., Tong, D., Ferdous, A., Piristine, H., Dasgupta, S., Wang, X., French, K. M., Villalobos, E., Spurgin, S. B., Waldman, M., Jiang, N., May, H. I., Hill, T. M., Luo, Y., Yoo, H., Zaha, V. G., Lavandero, S., Gillette, T. G. et al. Nature communications 12, 1684 (2021).

Quality of life in men and women with heart failure: association with outcome, and comparison of the Kansas City Cardiomyopathy Questionnaire and the EuroQol 5 dimensions questionnaire. Ravera, A., Santema, B. T., Sama, I. E., Meyer, S., Lombardi, C. M., Carubelli, V., Ferreira, J. P., Lang, C. C., Dickstein, K., Anker, S. D., Samani, N. J., Zannad, F., van Veldhuisen, D. J., Teerlink, J. R., Metra, M. & Voors, A. A. European journal of heart failure (2021).

Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases. Paloschi, V., Sabater-Lleal, M., Middelkamp, H., Vivas, A., Johansson, S., van der Meer, A., Tenje, M. & Maegdefessel, L. Cardiovascular research (2021).

Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival. Muzerelle, A., Soiza-Reilly, M., Hainer, C., Ruet, P. L., Lesch, K. P., Bader, M., Alenina, N., Scotto-Lomassese, S. & Gaspar, P. Scientific reports 11, 6004 (2021).

The current evidence of Takotsubo syndrome. El-Battrawy, I., Borggrefe, M. & Akin, I. Future cardiology (2021).

Left Ventricular Pathology in Ebstein's Anomaly-Myocardium in Motion: CMR Insights Into Left Ventricular Fibrosis, Deformation, and Exercise Capacity. Steinmetz, M. & Schuster, A. Circulation. Cardiovascular imaging, Circimaging121012285 (2021).

Noninvasive peripheral vascular function, incident cardiovascular disease, and mortality in the general population. Schnabel, R. B., Magnussen, C., Schulz, A., Ojeda, F. M., Schmitt, V. H., Arnold, N., Sinning, C. R., Beutel, M. E., Schmidtmann, I., Pfeiffer, N., Leuschner, A., Lackner, K. J., Gori, T., Benjamin, E. J., Binder, H., Wild, P. S., Blankenberg, S. & Münzel, T. Cardiovascular research (2021).

Targeting angiotensin type 2 receptors located on pressor neurons in the nucleus of the solitary tract to relieve hypertension in mice. Mohammed, M., Johnson, D. N., Wang, L. A., Harden, S. W., Sheng, W., Spector, E. A., Elsaafien, K., Bader, M., Steckelings, U. M., Scott, K. A., Frazier, C. J., Sumners, C., Krause, E. G. & de Kloet, A. D. Cardiovascular research (2021).

Do β-Blockers Cause Depression?: Systematic Review and Meta-Analysis of Psychiatric Adverse Events During β-Blocker Therapy. Riemer, T. G., Villagomez Fuentes, L. E., Algharably, E. A. E., Schäfer, M. S., Mangelsen, E., Fürtig, M. A., Bittner, N., Bär, A., Zaidi Touis, L., Wachtell, K., Majic, T., Dinges, M. J. & Kreutz, R. Hypertension, Hypertensionaha12016590 (2021).



Prognostic impact of acute pulmonary triggers in patients with takotsubo syndrome: new insights from the International Takotsubo Registry. Kato, K., Cammann, V. L., Napp, L. C., Szawan, K. A., Micek, J., Dreiding, S., Levinson, R. A., Petkova, V., Wurdinger, M., Patrascu, A., Sumalinog, R., Gili, S., Clarenbach, C. F., Kohler, M., Wischnewsky, M., Citro, R., Vecchione, C., Bossone, E., Neuhaus, M., Franke, J. et al. ESC heart failure (2021).  

Glycosylation-dependent cleavage of the human beta1-adrenoceptor. Ahles, A. & Engelhardt, S. Journal of molecular and cellular cardiology (2021).  

Antithrombotic treatment in primary percutaneous coronary intervention. Voll, F., Kuna, C., Ndrepepa, G., Kastrati, A. & Cassese, S. Expert Rev Cardiovasc Ther (2021).  

Prosaposin mediates inflammation in atherosclerosis. van Leent, M. M. T., Beldman, T. J., Toner, Y. C., Lameijer, M. A., Rother, N., Bekkering, S., Teunissen, A. J. P., Zhou, X., van der Meel, R., Malkus, J., Nauta, S. A., Klein, E. D., Fay, F., Sanchez-Gaytan, B. L., Perez-Medina, C., Kluza, E., Ye, Y. X., Wojtkiewicz, G., Fisher, E. A., Swirski, F. K. et al. Sci Transl Med 13 (2021).  

Case Report: Early Transplant Rejection of a Methanol-Intoxicated Donor Heart in a Young Female Patient. A Diagnostic Approach With CMR, Cardiac Biopsy, and Genetic Risk Assessment. Stoiber, L., Schoenrath, F., Knosalla, C., Milting, H., Klingel, K., Tschope, C., Tanacli, R., Gebker, R., Berger, A., Pieske, B. & Kelle, S. Frontiers in immunology 11, 575635 (2020).   

Network-driven discovery yields new insight into Shox2-dependent cardiac rhythm control. Hoffmann, S., Schmitteckert, S., Raedecke, K., Rheinert, D., Diebold, S., Roeth, R., Weiss, B., Granzow, M., Niesler, B., Griesbeck, A., Eckstein, V., Zimmermann, W. H., Just, S. & Rappold, G. A. Biochimica et biophysica acta. Gene regulatory mechanisms, 194702 (2021).  

Change of the Physical Activity Scale for the Elderly (PASE) score after COVID-19 outbreak. Huber, B. C., Schlichtiger, J., Drey, M., Steffen, J. & Brunner, S. J Sports Med Phys Fitness (2021).  

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The "TIDE"-Algorithm for the Weaning of Patients With Cardiogenic Shock and Temporarily Mechanical Left Ventricular Support With Impella Devices. A Cardiovascular Physiology-Based Approach. Tschope, C., Spillmann, F., Potapov, E., Faragli, A., Rapis, K., Nelki, V., Post, H., Schmidt, G. & Alogna, A. Frontiers in cardiovascular medicine 8, 563484 (2021).  

Hepatic steatosis and hepatic iron overload modify the association of iron markers with glucose metabolism disorders and metabolic syndrome. Pitchika, A., Kuhn, J. P., Schipf, S., Nauck, M., Dorr, M., Lerch, M. M., Kromrey, M. L., Felix, S. B., Markus, M. R. P., Rathmann, W., Volzke, H. & Ittermann, T. Liver Int (2021).  

The CAD risk locus 9p21 increases the risk of vascular calcification in an iPSC-derived VSMC model. Trillhaase, A., Schmidt, B., Martens, M., Haferkamp, U., Erdmann, J. & Aherrahrou, Z. Stem Cell Res Ther 12, 166 (2021).  

Regulation of basal and norepinephrine-induced cAMP and ICa in hiPSC-cardiomyocytes: Effects of culture conditions and comparison to adult human atrial cardiomyocytes. Iqbal, Z., Ismaili, D., Dolce, B., Petersen, J., Reichenspurner, H., Hansen, A., Kirchhof, P., Eschenhagen, T., Nikolaev, V. O., Molina, C. E. & Christ, T. Cellular signalling, 109970 (2021).  

Genome-wide association analysis in dilated cardiomyopathy reveals two new players in systolic heart failure on chromosomes 3p25.1 and 22q11.23. Garnier, S., Harakalova, M., Weiss, S., Mokry, M., Regitz-Zagrosek, V., Hengstenberg, C., Cappola, T. P., Isnard, R., Arbustini, E., Cook, S. A., van Setten, J., Calis, J. J. A., Hakonarson, H., Morley, M. P., Stark, K., Prasad, S. K., Li, J., O'Regan, D. P., Grasso, M., Muller-Nurasyid, M. et al. European heart journal (2021).  

Speckle Tracking Analysis Reveals Altered Left Atrial and Ventricular Myocardial Deformation in Patients with End-Stage Liver Disease. von Kockritz, F., Braun, A., Schmuck, R. B., Dobrindt, E. M., Eurich, D., Heinzel, F. R., Pieske, B., Escher, F. & Zhang, K. Journal of clinical medicine 10 (2021).  

Deciphering the Role of Wnt and Rho Signaling Pathway in iPSC-Derived ARVC Cardiomyocytes by In Silico Mathematical Modeling. Parrotta, E. I., Procopio, A., Scalise, S., Esposito, C., Nicoletta, G., Santamaria, G., De Angelis, M. T., Dorn, T., Moretti, A., Laugwitz, K. L., Montefusco, F., Cosentino, C. & Cuda, G. International journal of molecular sciences 22 (2021).   

MicroRNAs and Long Non-Coding RNAs as Potential Candidates to Target Specific Motifs of SARS-CoV-2. Natarelli, L., Parca, L., Mazza, T., Weber, C., Virgili, F. & Fratantonio, D. Non-coding RNA 7 (2021).  

"Empowering" Cardiac Cells via Stem Cell Derived Mitochondrial Transplantation- Does Age Matter? Mietsch, M. & Hinkel, R. International journal of molecular sciences 22 (2021).  

Inflammation-Related Risk Loci in Genome-Wide Association Studies of Coronary Artery Disease. Mauersberger, C., Schunkert, H. & Sager, H. B. Cells 10 (2021).   

The lack of evidence-based therapeutic strategies for left ventricular unloading during venoarterial extracorporeal membrane oxygenation therapy calls for randomized trials. Lusebrink, E., Massberg, S. & Orban, M. European heart journal (2021).  

Accelerated Aging and Age-Related Diseases (CVD and Neurological) Due to Air Pollution and Traffic Noise Exposure. Hahad, O., Frenis, K., Kuntic, M., Daiber, A. & Munzel, T. International journal of molecular sciences 22 (2021).  

Energy Metabolites as Biomarkers in Ischemic and Dilated Cardiomyopathy. Haas, J., Frese, K. S., Sedaghat-Hamedani, F., Kayvanpour, E., Tappu, R., Nietsch, R., Tugrul, O. F., Wisdom, M., Dietrich, C., Amr, A., Weis, T., Niederdrank, T., Murphy, M. P., Krieg, T., Dorr, M., Volker, U., Fielitz, J., Frey, N., Felix, S. B., Keller, A. et al. International journal of molecular sciences 22 (2021).  

The ElonginB/C-Cullin5-SOCS-Box-Complex Is a Potential Biomarker for Growth Hormone Disorders. Gossing, W., Radke, L., Biering, H., Diederich, S., Mai, K. & Frohme, M. Biomedicines 9 (2021).  

Physical Activity Improves Mental Health in Children and Adolescents Irrespective of the Diagnosis of Attention Deficit Hyperactivity Disorder (ADHD)-A Multi-Wave Analysis Using Data from the KiGGS Study. Ganjeh, P., Meyer, T., Hagmayer, Y., Kuhnert, R., Ravens-Sieberer, U., von Steinbuechel, N., Rothenberger, A. & Becker, A. Int J Environ Res Public Health 18 (2021).  

Generation and Breeding of EGFP-Transgenic Marmoset Monkeys: Cell Chimerism and Implications for Disease Modeling. Drummer, C., Vogt, E. J., Heistermann, M., Roshani, B., Becker, T., Matz-Rensing, K., Kues, W. A., Kugler, S. & Behr, R. Cells 10 (2021).  

Clinical Factors Associated with Atrial Fibrillation Detection on Single-Time Point Screening Using a Hand-Held Single-Lead ECG Device. Boriani, G., Palmisano, P., Malavasi, V. L., Fantecchi, E., Vitolo, M., Bonini, N., Imberti, J. F., Valenti, A. C., Schnabel, R. B. & Freedman, B. Journal of clinical medicine 10 (2021).  

Regulation of Mitochondrial Homeostasis by sAC-Derived cAMP Pool: Basic and Translational Aspects. Aslam, M. & Ladilov, Y. Cells 10 (2021).   

Pooled Patient-Level Analysis of Inclisiran Trials in Patients With Familial Hypercholesterolemia or Atherosclerosis. Wright, R. S., Ray, K. K., Raal, F. J., Kallend, D. G., Jaros, M., Koenig, W., Leiter, L. A., Landmesser, U., Schwartz, G. G., Friedman, A., Wijngaard, P. L. J., Garcia Conde, L., Kastelein, J. J. P. & Investigators, O. P. I. Journal of the American College of Cardiology 77, 1182-1193 (2021).   

Risk factors, physical and mental health burden of male and female pathological gamblers in the German general population aged 40-80. Wejbera, M., Wolfling, K., Dreier, M., Michal, M., Brahler, E., Wiltink, J., Schulz, A., Wild, P. S., Munzel, T., Konig, J., Lackner, K., Pfeiffer, N. & Beutel, M. E. BMC Psychiatry 21, 123 (2021).

Is there a Future for Remote Ischemic Conditioning in Acute Myocardial Infarction? Stiermaier, T., Birnbaum, Y. & Eitel, I. Cardiovascular drugs and therapy (2021).   

Cardiometabolic disease: Mechanisms to therapies. Schiattarella, G. G., Wang, Y., Tian, R. & Hill, J. A. Journal of molecular and cellular cardiology (2021).  

A universal protocol for isolating retinal ON bipolar cells across species via fluorescence-activated cell sorting. Murenu, E., Pavlou, M., Richter, L., Rapti, K., Just, S., Cehajic-Kapetanovic, J., Tafrishi, N., Hayes, A., Scholey, R., Lucas, R., Buning, H., Grimm, D. & Michalakis, S. Mol Ther Methods Clin Dev 20, 587-600 (2021).  

MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm. Gao, P., Gao, P., Zhao, J., Shan, S., Luo, W., Slivano, O. J., Zhang, W., Tabuchi, A., LeMaire, S. A., Maegdefessel, L., Shen, Y. H., Miano, J. M., Singer, H. A. & Long, X. Redox biology 41, 101903 (2021).  

Developmental regulation of barrier- and non-barrier blood vessels in the CNS. Ben-Zvi, A. & Liebner, S. Journal of internal medicine (2021).  

Local cyclic adenosine monophosphate signalling cascades-Roles and targets in chronic kidney disease. Sholokh, A. & Klussmann, E. Acta physiologica, e13641 (2021).  

Impact of effective regurgitant orifice area on outcome of secondary mitral regurgitation transcatheter repair. Karam, N., Orban, M., Kalbacher, D., Butter, C., Praz, F., Lubos, E., Bannehr, M., Kassar, M., Petrescu, A., Iliadis, C., Unterhuber, M., Asselin, A., Thiele, H., Pfister, R., Windecker, S., Lurz, P., von Bardeleben, S., Hausleiter, J. & Euro, S. M. R. i. Clinical research in cardiology : official journal of the German Cardiac Society (2021).  

Is Continuous Eruption Related to Periodontal Changes? A 16-Year Follow-up. Wiedemann, C., Pink, C., Daboul, A., Samietz, S., Volzke, H., Schulz-Kornas, E., Krey, K. F., Holtfreter, B. & Kocher, T. J Dent Res, 22034521999363 (2021).  

Improvement of renal function after transcatheter aortic valve replacement and its impact on survival. Kylies, D., Freitag-Wolf, S., Fulisch, F., Seoudy, H., Kuhn, C., Kihm, L. P., Puhler, T., Lutter, G., Dempfle, A., Frey, N., Feldkamp, T. & Frank, D. BMC Nephrol 22, 77 (2021).  

Effect of intravenous alteplase on post-stroke depression in the WAKE UP trial. Konigsberg, A., Sehner, S., Arlt, S., Cheng, B., Simonsen, C. Z., Boutitie, F., Serena, J., Thijs, V., Ebinger, M., Endres, M., Fiebach, J. B., Lemmens, R., Muir, K. W., Nighoghossian, N., Pedraza, S., Gerloff, C., Thomalla, G. & investigators, W.-U. European journal of neurology (2021).  

Periodontitis Is Related to Exercise Capacity: Two Cross-sectional Studies. Holtfreter, B., Stubbe, B., Glaser, S., Trabandt, J., Volzke, H., Ewert, R., Kocher, T., Ittermann, T. & Schaper, C. J Dent Res, 22034521995428 (2021).  

Machine learning based on biomarker profiles identifies distinct subgroups of heart failure with preserved ejection fraction. Woolley, R. J., Ceelen, D., Ouwerkerk, W., Tromp, J., Figarska, S. M., Anker, S. D., Dickstein, K., Filippatos, G., Zannad, F., Marco, M., Ng, L., Samani, N., van Veldhuisen, D., Lang, C., Lam, C. S. & Voors, A. European journal of heart failure (2021).  

Human Engineered Heart Tissue Patches Remuscularize the Injured Heart in a Dose-Dependent Manner. Querdel, E., Reinsch, M., Castro, L., Kose, D., Bahr, A., Reich, S., Geertz, B., Ulmer, B., Schulze, M., Lemoine, M. D., Krause, T., Lemme, M., Sani, J., Shibamiya, A., Studemann, T., Kohne, M., von Bibra, C. V., Hornaschewitz, N., Pecha, S., Nejahsie, Y. et al. Circulation (2021).  

Feasibility and diagnostic reliability of quantitative flow ratio in the assessment of non-culprit lesions in acute coronary syndrome. Erbay, A., Penzel, L., Abdelwahed, Y. S., Klotsche, J., Schatz, A. S., Steiner, J., Haghikia, A., Landmesser, U., Stahli, B. E. & Leistner, D. M. The international journal of cardiovascular imaging (2021).   

The dawn of radiofrequency catheter ablation for cardiac arrhythmias. Breithardt, G. & Borggrefe, M. Heart rhythm 18, 485-486 (2021).  

Nidogen-1 Mitigates Ischemia and Promotes Tissue Survival and Regeneration. Zbinden, A., Layland, S. L., Urbanczyk, M., Carvajal Berrio, D. A., Marzi, J., Zauner, M., Hammerschmidt, A., Brauchle, E. M., Sudrow, K., Fink, S., Templin, M., Liebscher, S., Klein, G., Deb, A., Duffy, G. P., Crooks, G. M., Eble, J. A., Mikkola, H. K. A., Nsair, A., Seifert, M. et al. Adv Sci (Weinh) 8, 2002500 (2021).  

Treatment of acute cardiac tamponade: A retrospective analysis of classical intermittent versus continuous pericardial drainage. Stremmel, C., Scherer, C., Lusebrink, E., Kupka, D., Schmid, T., Stocker, T., Kellnar, A., Kleeberger, J., Sinner, M. F., Petzold, T., Mehilli, J., Braun, D., Orban, M., Hausleiter, J., Massberg, S. & Orban, M. International journal of cardiology. Heart & vasculature 32, 100722 (2021).  

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice. Rotzer, R. D., Brox, V. F., Hennis, K., Thalhammer, S. B., Biel, M., Wahl-Schott, C. & Fenske, S. Journal of visualized experiments : JoVE (2021).   

Impact of Ventricular Stroke Work Indices on Mortality in Heart Failure Patients After Percutaneous Mitral Valve Repair. Osteresch, R., Diehl, K., Dierks, P., Schmucker, J., Ammar, A. B., Fach, A., Langer, H., Eitel, I., Hambrecht, R. & Wienbergen, H. The American journal of cardiology (2021).  

Circulatory efficiency in patients with severe aortic valve stenosis before and after aortic valve replacement. Nordmeyer, S., Lee, C. B., Goubergrits, L., Knosalla, C., Berger, F., Falk, V., Ghorbani, N., Hireche-Chikaoui, H., Zhu, M., Kelle, S., Kuehne, T. & Kelm, M. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 23, 15 (2021).  

Venoarterial extracorporeal membrane oxygenation as bridge to effective treatment in a 19-year-old woman with acute adrenal crisis: a case report. Lusebrink, E., Krieg, K., Massberg, S. & Orban, M. European heart journal. Case reports 5, ytab031 (2021).  

Mechanobiological Principles Influence the Immune Response in Regeneration: Implications for Bone Healing. Knecht, R. S., Bucher, C. H., Van Linthout, S., Tschope, C., Schmidt-Bleek, K. & Duda, G. N. Front Bioeng Biotechnol 9, 614508 (2021).  

Optical Coherence Tomography Assessment in Patients Treated With Rotational Atherectomy Versus Modified Balloons: PREPARE-CALC OCT. Hemetsberger, R., Gori, T., Toelg, R., Byrne, R., Allali, A., El-Mawardy, M., Rheude, T., Weissner, M., Sulimov, D. S., Robinson, D. R., Richardt, G. & Abdel-Wahab, M. Circulation. Cardiovascular interventions, CIRCINTERVENTIONS120009819 (2021).  

The novel cystatin C, lactate, interleukin-6, and N-terminal pro-B-type natriuretic peptide (CLIP)-based mortality risk score in cardiogenic shock after acute myocardial infarction. Ceglarek, U., Schellong, P., Rosolowski, M., Scholz, M., Willenberg, A., Kratzsch, J., Zeymer, U., Fuernau, G., de Waha-Thiele, S., Buttner, P., Jobs, A., Freund, A., Desch, S., Feistritzer, H. J., Isermann, B., Thiery, J., Poss, J. & Thiele, H. European heart journal (2021).  

Optimized High Quality DNA Extraction from Formalin-Fixed Paraffin-Embedded Human Atherosclerotic Lesions. Bauer, S., Pauli, J. & Pelisek, J. Journal of visualized experiments : JoVE (2021).  

A Genetic Mouse Model Recapitulates Immune Checkpoint Inhibitor-Associated Myocarditis and Supports a Mechanism-Based Therapeutic Intervention. Wei, S. C., Meijers, W. C., Axelrod, M. L., Anang, N. A. S., Screever, E. M., Wescott, E. C., Johnson, D. B., Whitley, E., Lehmann, L., Courand, P. Y., Mancuso, J. J., Himmel, L. E., Lebrun-Vignes, B., Wleklinski, M. J., Knollmann, B. C., Srinivasan, J., Li, Y., Atolagbe, O. T., Rao, X., Zhao, Y. et al. Cancer Discov 11, 614-625 (2021).  


Precisely Tuned Inhibition of HIF Prolyl Hydroxylases Is Key for Cardioprotection After Ischemia. Jatho, A., Zieseniss, A., Brechtel-Curth, K., Yamamoto, A., Coleman, M. L., Vergel Leon, A. M., Biggs, D., Davies, B., Pugh, C. W., Ratcliffe, P. J. & Katschinski, D. M. Circulation research 128, 1208-1210 (2021).  

The need for PCSK9 inhibitors and associated treatment costs according to the 2019 ESC dyslipidaemia guidelines vs. the risk-based allocation algorithm of the 2017 ESC consensus statement: a simulation study in a contemporary CAD cohort. Blaum, C., Seiffert, M., Goßling, A., Kröger, F., Bay, B., Lorenz, T., Braetz, J., Graef, A., Zeller, T., Schnabel, R., Clemmensen, P., Westermann, D., Blankenberg, S., Brunner, F. J. & Waldeyer, C. European journal of preventive cardiology 28, 47-56 (2021).

Patient factors associated with titration of medical therapy in patients with heart failure with reduced ejection fraction: data from the QUALIFY international registry. Cowie, M. R., Schöpe, J., Wagenpfeil, S., Tavazzi, L., Böhm, M., Ponikowski, P., Anker, S. D., Filippatos, G. S. & Komajda, M. ESC heart failure 8, 861-871 (2021).

MicroRNA-21-Dependent Macrophage-to-Fibroblast Signaling Determines the Cardiac Response to Pressure Overload. Ramanujam, D., Schon, A. P., Beck, C., Vaccarello, P., Felician, G., Dueck, A., Esfandyari, D., Meister, G., Meitinger, T., Schulz, C. & Engelhardt, S. Circulation 143, 1513-1525 (2021).

Single-Use Capture Purification of Adeno-Associated Viral Gene Transfer Vectors by Membrane-Based Steric Exclusion Chromatography. Marichal-Gallardo, P., Börner, K., Pieler, M. M., Sonntag-Buck, V., Obr, M., Bejarano, D., Wolff, M. W., Kräusslich, H. G., Reichl, U. & Grimm, D. Hum Gene Ther (2021).

Completion of neuronal remodeling prompts myelination along developing motor axon branches. Wang, M., Kleele, T., Xiao, Y., Plucinska, G., Avramopoulos, P., Engelhardt, S., Schwab, M. H., Kneussel, M., Czopka, T., Sherman, D. L., Brophy, P. J., Misgeld, T. & Brill, M. S. The Journal of cell biology 220 (2021).

Single versus double use of a suture-based closure device for transfemoral aortic valve implantation. Reifart, J., Liebetrau, C., Weferling, M., Dörr, O., Renker, M., Bhumimuang, K., Liakopoulos, O., Choi, Y. H., Nef, H., Hamm, C. W. & Kim, W. K. International journal of cardiology 331, 183-188 (2021).

Secreted modular calcium-binding protein 1 binds and activates thrombin to account for platelet hyperreactivity in diabetes. Delgado Lagos, F., Elgheznawy, A., Kyselova, A., Meyer Zu Heringdorf, D., Ratiu, C., Randriamboavonjy, V., Mann, A. W., Fisslthaler, B., Siragusa, M. & Fleming, I. Blood 137, 1641-1651 (2021).

Late-stage stitching enabled by manganese-catalyzed C horizontal line H activation: Peptide ligation and access to cyclopeptides. Kaplaneris, N., Kaltenhuser, F., Sirvinskaite, G., Fan, S., De Oliveira, T., Conradi, L. C. & Ackermann, L. Science advances 7 (2021).  

Correction to: Neurological update: use of cardiac troponin in patients with stroke. Scheitz, J. F., Stengl, H., Nolte, C. H., Landmesser, U. & Endres, M. Journal of neurology (2021).  

BDNF serum concentrations in 2053 participants of the Berlin Aging Study II. Kronenberg, G., Gertz, K., Schoner, J., Bertram, L., Liman, T., Steinhagen-Thiessen, E., Demuth, I., Endres, M. & Hellweg, R. Neurobiol Aging 101, 221-223 (2021).  

Modulating the Biomechanical Properties of Engineered Connective Tissues by Chitosan-Coated Multiwall Carbon Nanotubes. Kittana, N., Assali, M., Zimmermann, W. H., Liaw, N., Santos, G. L., Rehman, A. & Lutz, S. Int J Nanomedicine 16, 989-1000 (2021).  

Hemodynamic Modeling of Biological Aortic Valve Replacement Using Preoperative Data Only. Hellmeier, F., Bruning, J., Sundermann, S., Jarmatz, L., Schafstedde, M., Goubergrits, L., Kuhne, T. & Nordmeyer, S. Frontiers in cardiovascular medicine 7, 593709 (2020).  

Histopathological Findings Predict Renal Recovery in Severe ANCA-Associated Vasculitis Requiring Intensive Care Treatment. Hakroush, S., Tampe, D., Korsten, P., Strobel, P., Zeisberg, M. & Tampe, B. Frontiers in medicine 7, 622028 (2020).  

[Acute ischemic stroke and elevated troponin: Diagnostic work-up and therapeutic consequences]. Grassl, N., Baumann, S., Kruska, M., Fatar, M., Akin, I., Platten, M., Borggrefe, M., Alonso, A., Szabo, K. & Fastner, C. Deutsche medizinische Wochenschrift (2021).

Critical appraisal of the 2020 ESC guideline recommendations on diagnosis and risk assessment in patients with suspected non-ST-segment elevation acute coronary syndrome. Giannitsis, E., Blankenberg, S., Christenson, R. H., Frey, N., von Haehling, S., Hamm, C. W., Inoue, K., Katus, H. A., Lee, C. C., McCord, J., Mockel, M., Chieh, J. T. W., Tubaro, M., Wollert, K. C. & Huber, K. Clinical research in cardiology : official journal of the German Cardiac Society (2021).   

Association of lipid levels with motor and cognitive function and decline in advanced Parkinson's disease in the Mark-PD study. Choe, C. U., Petersen, E., Lezius, S., Cheng, B., Schulz, R., Buhmann, C., Potter-Nerger, M., Daum, G., Blankenberg, S., Gerloff, C., Schwedhelm, E. & Zeller, T. Parkinsonism Relat Disord 85, 5-10 (2021).  

Specific domain V reduction of beta-2-glycoprotein I induces protein flexibility and alters pathogenic antibody binding. Buchholz, I., McDonnell, T., Nestler, P., Tharad, S., Kulke, M., Radziszewska, A., Ripoll, V. M., Schmidt, F., Hammer, E., Toca-Herrera, J. L., Rahman, A. & Delcea, M. Scientific reports 11, 4542 (2021).    

Revealing the role of the human blood plasma proteome in obesity using genetic drivers. Zaghlool, S. B., Sharma, S., Molnar, M., Matias-Garcia, P. R., Elhadad, M. A., Waldenberger, M., Peters, A., Rathmann, W., Graumann, J., Gieger, C., Grallert, H. & Suhre, K. Nature communications 12, 1279 (2021).  

The Transcription Factor MAFF Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism. von Scheidt, M., Zhao, Y., de Aguiar Vallim, T. Q., Che, N., Wierer, M., Seldin, M. M., Franzen, O., Kurt, Z., Pang, S., Bongiovanni, D., Yamamoto, M., Edwards, P. A., Ruusalepp, A., Kovacic, J. C., Mann, M., Bjorkegren, J. L. M., Lusis, A. J., Yang, X. & Schunkert, H. Circulation (2021).   

Generation and cardiac differentiation of an induced pluripotent stem cell line from a patient with arrhythmia-induced cardiomyopathy. Rebs, S., Beier, J., Argyriou, L., Schill, T., Hasenfuss, G., Vollmann, D., Sossalla, S. & Streckfuss-Bomeke, K. Stem Cell Res 53, 102263 (2021).  

Epigenetic regulation of cardiac electrophysiology in atrial fibrillation: HDAC2 determines action potential duration and suppresses NRSF in cardiomyocytes. Lugenbiel, P., Govorov, K., Syren, P., Rahm, A. K., Wieder, T., Wunsch, M., Weiberg, N., Manolova, E., Gramlich, D., Rivinius, R., Finke, D., Lehmann, L. H., Schweizer, P. A., Frank, D., El Tahry, F. A., Bruehl, C., Heimberger, T., Sandke, S., Weis, T., Most, P. et al. Basic research in cardiology 116, 13 (2021).   

Mapping genetic changes in the cAMP-signaling cascade in human atria. Garnier, A., Bork, N. I., Jacquet, E., Zipfel, S., Munoz-Guijosa, C., Baczko, I., Reichenspurner, H., Donzeau-Gouge, P., Maier, L. S., Dobrev, D., Girdauskas, E., Nikolaev, V. O., Fischmeister, R. & Molina, C. E. Journal of molecular and cellular cardiology 155, 10-20 (2021).  

Mitral valve surgery: current status and future prospects of the minimally invasive approach. Van Praet, K. M., Kempfert, J., Jacobs, S., Stamm, C., Akansel, S., Kofler, M., Sundermann, S. H., Nazari Shafti, T. Z., Jakobs, K., Holzendorf, S., Unbehaun, A. & Falk, V. Expert review of medical devices (2021).  

Screening for Atrial Fibrillation in the Older Population: A Randomized Clinical Trial. Gladstone, D. J., Wachter, R., Schmalstieg-Bahr, K., Quinn, F. R., Hummers, E., Ivers, N., Marsden, T., Thornton, A., Djuric, A., Suerbaum, J., von Grunhagen, D., McIntyre, W. F., Benz, A. P., Wong, J. A., Merali, F., Henein, S., Nichol, C., Connolly, S. J., Healey, J. S., Investigators, S.-A. et al. JAMA cardiology (2021).  

Impact of renal function on outcomes of patients with cardiac troponin elevation and non-obstructive coronary arteries. Steiner, J., Kerschl, M., Erbay, A., Abdelwahed, Y. S., Jakob, P., Landmesser, U., Leistner, D. M. & Stahli, B. E. International journal of cardiology (2021).  

Blunted beta-adrenoceptor-mediated inotropy in valvular cardiomyopathy: another piece of the puzzle in human aortic valve disease. Petersen, J., Kloth, B., Iqbal, S., Reichenspurner, H., Geelhoed, B., Schnabel, R., Eschenhagen, T., Christ, T. & Girdauskas, E. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021).  

Single Nuclei Sequencing Reveals Novel Insights into the Regulation of Cellular Signatures in Children with Dilated Cardiomyopathy. Nicin, L., Abplanalp, W. T., Schanzer, A., Sprengel, A., John, D., Mellentin, H., Tombor, L., Keuper, M., Ullrich, E., Klingel, K., Dettmeyer, R. B., Hoffmann, J., Akintuerk, H., Jux, C., Schranz, D., Zeiher, A. M., Rupp, S. & Dimmeler, S. Circulation (2021).  

The vasculature: a therapeutic target in heart failure? Luxan, G. & Dimmeler, S. Cardiovascular research (2021).  

Functional outcomes with Carillon device over 1 year in patients with functional mitral regurgitation of Grades 2+ to 4+: results from the REDUCE-FMR trial. Khan, M. S., Siddiqi, T. J., Butler, J., Friede, T., Levy, W. C., Witte, K. K., Lipiecki, J., Sievert, H. & Coats, A. J. S. ESC heart failure (2021).  

Preventing SARS-CoV-2 In-Hospital Infections in Cardiovascular Patients and Medical Staff: An Observational Study From the German Heart Center Berlin. Schoppenthau, D., Weiss, K. J., Estepa-Martinez, M., Hommel, M., Miera, O., Schoenrath, F., Hubler, S., Obermeier, M., Pieske, B. & Stawowy, P. Frontiers in medicine 7, 616648 (2020).  

Antiplatelet and direct oral anticoagulation management after coronary artery bypass graft surgery: the Cinderella of current cardiovascular trials, please show me (some) evidence. Schoenrath, F., Just, I. A., Falk, V. & Emmert, M. Y. European heart journal (2021).  

Similarities and Differences of Mental Health in Women and Men: A Systematic Review of Findings in Three Large German Cohorts. Otten, D., Tibubos, A. N., Schomerus, G., Brahler, E., Binder, H., Kruse, J., Ladwig, K. H., Wild, P. S., Grabe, H. J. & Beutel, M. E. Front Public Health 9, 553071 (2021).   

Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature. Hooglugt, A., van der Stoel, M. M., Boon, R. A. & Huveneers, S. Frontiers in oncology 10, 612802 (2020).

Blood Cholesterol and Outcome of Patients with Cancer under Regular Cardiological Surveillance. Hohneck, A. L., Rosenkaimer, S., Hofheinz, R. D., Akin, I., Borggrefe, M. & Gerhards, S. Curr Oncol 28, 863-872 (2021).  

Extent of FLAIR Hyperintense Vessels May Modify Treatment Effect of Thrombolysis: A Post hoc Analysis of the WAKE-UP Trial. Grosch, A. S., Kufner, A., Boutitie, F., Cheng, B., Ebinger, M., Endres, M., Fiebach, J. B., Fiehler, J., Konigsberg, A., Lemmens, R., Muir, K. W., Nighoghossian, N., Pedraza, S., Siemonsen, C. Z., Thijs, V., Wouters, A., Gerloff, C., Thomalla, G. & Galinovic, I. Front Neurol 11, 623881 (2020).   

Deficiency of endothelial CD40 induces a stable plaque phenotype and limits inflammatory cell recruitment to atherosclerotic lesions in mice. Gissler, M. C., Scherrer, P., Anto Michel, N., Pennig, J., Hoppe, N., Funer, L., Hardtner, C., Stachon, P., Li, X., Mitre, L. S., Marchini, T., Madl, J., Wadle, C., Hilgendorf, I., von Zur Muhlen, C., Bode, C., Weber, C., Lutgens, E., Wolf, D., Gerdes, N. et al. Thrombosis and haemostasis (2021).  

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat. Curini, L., Christopher, M. R., Grubitzsch, H., Landmesser, U., Amedei, A., Lauten, A. & Alushi, B. Journal of visualized experiments : JoVE (2021).  

Cardiac events associated with immune checkpoint inhibitor therapy: the devil is in the detail. Anker, M. S., Coats, A. J. S. & Anker, S. D. European heart journal (2021).  

Risk stratification and management of women with cardiomyopathy/heart failure planning pregnancy or presenting during/after pregnancy: a position statement from the Heart Failure Association of the European Society of Cardiology Study Group on Peripartum Cardiomyopathy. Sliwa, K., van der Meer, P., Petrie, M. C., Frogoudaki, A., Johnson, M. R., Hilfiker-Kleiner, D., Hamdan, R., Jackson, A. M., Ibrahim, B., Mbakwem, A., Tschope, C., Regitz-Zagrosek, V., Omerovic, E., Roos-Hesselink, J., Gatzoulis, M., Tutarel, O., Price, S., Heymans, S., Coats, A. J., Muller, C. et al. European journal of heart failure (2021).  

J-shaped association between circulating apoC-III and cardiovascular mortality. Silbernagel, G., Scharnagl, H., Kleber, M. E., Hoffmann, M. M., Delgado, G. E., Stojakovic, T., Gary, T., Zeng, L., Ritsch, A., Zewinger, S., Speer, T., Schunkert, H., Landmesser, U., Marz, W. & Grammer, T. B. European journal of preventive cardiology (2021).  

Differences in Biomarkers of Inflammation Between Novel Subgroups of Recent-Onset Diabetes. Herder, C., Maalmi, H., Strassburger, K., Zaharia, O. P., Ratter, J. M., Karusheva, Y., Elhadad, M. A., Bodis, K., Bongaerts, B. W. C., Rathmann, W., Trenkamp, S., Waldenberger, M., Burkart, V., Szendroedi, J., Roden, M. & Group, G. D. S. Diabetes (2021).  

Digital, risk-based screening for atrial fibrillation in the European community-the AFFECT-EU project funded by the European Union. Engler, D., Heidbuchel, H., Schnabel, R. B. & Investigators, A.-E. European heart journal (2021).  

Clinical results of fibroblast activation protein (FAP) specific PET for non-malignant indications: systematic review. Windisch, P., Zwahlen, D. R., Giesel, F. L., Scholz, E., Lugenbiel, P., Debus, J., Haberkorn, U. & Adeberg, S. EJNMMI research 11, 18 (2021).  

Ticagrelor Monotherapy After Coronary Stenting: Like a Twilight Through the Looking Glass. Sibbing, D. & Cassese, S. JACC. Cardiovascular interventions 14, 457-460 (2021).  

Temporal trends in incidence, causes, use of mechanical circulatory support and mortality in cardiogenic shock. Schrage, B., Becher, P. M., Gossling, A., Savarese, G., Dabboura, S., Yan, I., Beer, B., Soffker, G., Seiffert, M., Kluge, S., Kirchhof, P., Blankenberg, S. & Westermann, D. ESC heart failure (2021).  

Plasma microRNA signature associated with retinopathy in patients with type 2 diabetes. Santovito, D., Toto, L., De Nardis, V., Marcantonio, P., D'Aloisio, R., Mastropasqua, A., De Cesare, D., Bucci, M., Paganelli, C., Natarelli, L., Weber, C., Consoli, A., Mastropasqua, R. & Cipollone, F. Scientific reports 11, 4136 (2021).  

Dynamics of SARS-CoV-2 shedding in the respiratory tract depends on the severity of disease in COVID-19 patients. Munker, D., Osterman, A., Stubbe, H., Muenchhoff, M., Veit, T., Weinberger, T., Barnikel, M., Mumm, J. N., Milger, K., Khatamzas, E., Klauss, S., Scherer, C., Hellmuth, J. C., Giessen-Jung, C., Zoller, M., Herold, T., Stecher, S., de Toni, E. N., Schulz, C., Kneidinger, N. et al. The European respiratory journal (2021).  

Alpha 1-adrenoceptor signalling contributes to toxic effects of catecholamine on electrical properties in cardiomyocytes. Huang, M., Fan, X., Yang, Z., Cyganek, L., Li, X., Yuecel, G., Lan, H., Li, Y., Wendel, A., Lang, S., Bieback, K., El-Battrawy, I., Zhou, X., Akin, I. & Borggrefe, M. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2021).  

Prediction of the dose range for adverse neurological effects of amiodarone in patients from an in vitro toxicity test by in vitro-in vivo extrapolation. Algharably, E. A. E., Di Consiglio, E., Testai, E., Kreutz, R. & Gundert-Remy, U. Arch Toxicol (2021).  

Regenerative potential of epicardium-derived extracellular vesicles mediated by conserved miRNA transfer. Villa Del Campo, C., Liaw, N. Y., Gunadasa-Rohling, M., Matthaei, M., Braga, L., Kennedy, T., Salinas, G., Voigt, N., Giacca, M., Zimmermann, W. H. & Riley, P. R. Cardiovascular research (2021).   

Extracting Robust Biomarkers From Multichannel EEG Time Series Using Nonlinear Dimensionality Reduction Applied to Ordinal Pattern Statistics and Spectral Quantities. Kottlarz, I., Berg, S., Toscano-Tejeida, D., Steinmann, I., Bahr, M., Luther, S., Wilke, M., Parlitz, U. & Schlemmer, A. Frontiers in physiology 11, 614565 (2020).  

Reply to Pollari and Fischlein. Kofler, M., Unbehaun, A., Falk, V. & Kempfert, J. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021).  

Regulation of dual leucine zipper kinase activity through its interaction with calcineurin. Duque Escobar, J., Kutschenko, A., Schroder, S., Blume, R., Koster, K. A., Painer, C., Lemcke, T., Maison, W. & Oetjen, E. Cellular signalling 82, 109953 (2021).  

Use of sodium-glucose co-transporter 2 inhibitors in patients with heart failure and type 2 diabetes mellitus: data from the Swedish Heart Failure Registry. Becher, P. M., Schrage, B., Ferrannini, G., Benson, L., Butler, J., Carrero, J. J., Cosentino, F., Dahlstrom, U., Mellbin, L., Rosano, G. M. C., Sinagra, G., Stolfo, D., Lund, L. H. & Savarese, G. European journal of heart failure (2021).  

Multiple breath washout (MBW) testing using sulfur hexafluoride: reference values and influence of anthropometric parameters. Trinkmann, F., Maros, M., Roth, K., Hermanns, A., Schafer, J., Gawlitza, J., Saur, J., Akin, I., Borggrefe, M., Herth, F. J. F. & Ganslandt, T. Thorax (2021).  

Non-classical monocytes in cardiovascular physiology and disease. Tahir, S. & Steffens, S. Am J Physiol Cell Physiol (2021).   

A Brave New World: Toward Precision Phenotyping and Understanding of Coronary Artery Disease Using Radiomics Plaque Analysis. Schoepf, U. J. & Emrich, T. Radiology, 204456 (2021).  

Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years. Frangou, S., Modabbernia, A., Williams, S. C. R., Papachristou, E., Doucet, G. E., Agartz, I., Aghajani, M., Akudjedu, T. N., Albajes-Eizagirre, A., Alnaes, D., Alpert, K. I., Andersson, M., Andreasen, N. C., Andreassen, O. A., Asherson, P., Banaschewski, T., Bargallo, N., Baumeister, S., Baur-Streubel, R., Bertolino, A. et al. Hum Brain Mapp (2021).   

Different genotypes of Brugada syndrome may present different clinical phenotypes: electrophysiology from bench to bedside. El-Battrawy, I., Lang, S., Zhou, X. & Akin, I. European heart journal (2021).  

Low-molecular-weight heparin administered by subcutaneous catheter is a safe and effective anti-coagulation regimen in selected inpatient infants and children with complex congenital heart disease. Pardun, N., Lemmer, J., Belker, K., Pringsheim, M., Ewert, P. & Wolf, C. M. Cardiology in the young, 1-6 (2021).  

[Nutrition and hypertension : What one should pay attention to in addition to the pharmaceutical treatment]. McParland, V. & Wilck, N. Der Internist 62, 269-276 (2021).  

TAMEP are brain tumor parenchymal cells controlling neoplastic angiogenesis and progression. Kalin, R. E., Cai, L., Li, Y., Zhao, D., Zhang, H., Cheng, J., Zhang, W., Wu, Y., Eisenhut, K., Janssen, P., Schmitt, L., Enard, W., Michels, F., Fluh, C., Hou, M., Kirchleitner, S. V., Siller, S., Schiemann, M., Andra, I., Montanez, E. et al. Cell Syst (2021).  

Exposure to perfluoroalkyl substances and blood pressure in pregnancy among 1436 women from the Odense Child Cohort. Birukov, A., Andersen, L. B., Andersen, M. S., Nielsen, J. H., Nielsen, F., Kyhl, H. B., Jorgensen, J. S., Grandjean, P., Dechend, R. & Jensen, T. K. Environ Int 151, 106442 (2021).  

Safety and efficacy of transvenous lead extraction in octogenarians using powered extraction sheaths. Burger, H., Hakmi, S., Petersen, J., Yildirim, Y., Choi, Y. H., Willems, S., Reichenspurner, H., Ziegelhoeffer, T. & Pecha, S. Pacing and clinical electrophysiology : PACE (2021).  

Monitoring mitochondrial translation in living cells. Yousefi, R., Fornasiero, E. F., Cyganek, L., Montoya, J., Jakobs, S., Rizzoli, S. O., Rehling, P. & Pacheu-Grau, D. EMBO reports, e51635 (2021).  

TTN Circular RNAs Create A Backsplice Motif Essential for SRSF10 Splicing. Tijsen, A. J., Cocera Ortega, L., Reckman, Y. J., Zhang, X., van der Made, I., Aufiero, S., Li, J., Kamps, S. C., van den Bout, A., Devalla, H. D., van Spaendonck-Zwarts, K., Engelhardt, S., Gepstein, L., Ware, J. S. & Pinto, Y. M. Circulation (2021).  

Influence of cardiometabolic comorbidities on myocardial function, infarction, and cardioprotection: Role of cardiac redox signaling. Andreadou, I., Daiber, A., Baxter, G. F., Brizzi, M. F., Di Lisa, F., Kaludercic, N., Lazou, A., Varga, Z. V., Zuurbier, C. J., Schulz, R. & Ferdinandy, P. Free radical biology & medicine 166, 33-52 (2021).  

Prospective validation of an acoustic-based system for the detection of obstructive coronary artery disease in a high-prevalence population. Renker, M., Kriechbaum, S. D., Schmidt, S. E., Larsen, B. S., Wolter, J. S., Dorr, O., Fischer-Rasokat, U., Kim, W. K., Liebetrau, C., Bottcher, M., Nef, H., Bauer, T. & Hamm, C. W. Heart and vessels (2021).  

Hypertrophic signaling compensates for contractile and metabolic consequences of DNA methyltransferase 3A loss in human cardiomyocytes. Madsen, A., Krause, J., Hoppner, G., Hirt, M. N., Tan, W. L. W., Lim, I., Hansen, A., Nikolaev, V. O., Foo, R. S. Y., Eschenhagen, T. & Stenzig, J. Journal of molecular and cellular cardiology 154, 115-123 (2021).

Determinants of paravalvular leakage following transcatheter aortic valve replacement in patients with bicuspid and tricuspid aortic stenosis. Kim, W. K., Bhumimuang, K., Renker, M., Fischer-Rasokat, U., Mollmann, H., Walther, T., Choi, Y. H., Nef, H. & Hamm, C. W. European heart journal cardiovascular Imaging (2021).  

Multicenter Consistency Assessment of Valvular Flow Quantification With Automated Valve Tracking in 4D Flow CMR. Juffermans, J. F., Minderhoud, S. C. S., Wittgren, J., Kilburg, A., Ese, A., Fidock, B., Zheng, Y. C., Zhang, J. M., Blanken, C. P. S., Lamb, H. J., Goeman, J. J., Carlsson, M., Zhao, S., Planken, R. N., van Ooij, P., Zhong, L., Chen, X., Garg, P., Emrich, T., Hirsch, A. et al. JACC. Cardiovascular imaging (2021).  

Transfemoral Transcatheter Tricuspid Valve Replacement With the EVOQUE System: A Multicenter, Observational, First-in-Human Experience. Fam, N. P., von Bardeleben, R. S., Hensey, M., Kodali, S. K., Smith, R. L., Hausleiter, J., Ong, G., Boone, R., Ruf, T., George, I., Szerlip, M., Nabauer, M., Ali, F. M., Moss, R., Bapat, V., Schnitzler, K., Kreidel, F., Ye, J., Deva, D. P., Mack, M. J. et al. JACC. Cardiovascular interventions 14, 501-511 (2021).  

Development and external validation of prediction models to predict implantable cardioverter-defibrillator efficacy in primary prevention of sudden cardiac death. Verstraelen, T. E., van Barreveld, M., van Dessel, P., Boersma, L. V. A., Delnoy, P., Tuinenburg, A. E., Theuns, D., van der Voort, P. H., Kimman, G. P., Buskens, E., Hulleman, M., Allaart, C. P., Strikwerda, S., Scholten, M. F., Meine, M., Abels, R., Maass, A. H., Firouzi, M., Widdershoven, J., Elders, J. et al. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology (2021).  

Development of an AAV9-RNAi-mediated silencing strategy to abrogate TRPM4 expression in the adult heart. Medert, R., Jungmann, A., Hildebrand, S., Busch, M., Grimm, D., Flockerzi, V., Muller, O. J., Most, P., Schumacher, D. & Freichel, M. Pflugers Archiv : European journal of physiology 473, 533-546 (2021).  

Rothia aeria and Rothia dentocariosa as biofilm builders in infective endocarditis. Greve, D., Moter, A., Kleinschmidt, M. C., Pfafflin, F., Stegemann, M. S., Kursawe, L., Grubitzsch, H., Falk, V. & Kikhney, J. Int J Med Microbiol 311, 151478 (2021).  

'Hit and run' therapy averts macular degeneration. Bubeck, F. & Grimm, D. Nat Biomed Eng 5, 132-133 (2021).  

Cross-sectional and prospective relationships of endogenous progestogens and estrogens with glucose metabolism in men and women: a KORA F4/FF4 Study. Lau, L. H. Y., Nano, J., Cecil, A., Schederecker, F., Rathmann, W., Prehn, C., Zeller, T., Lechner, A., Adamski, J., Peters, A. & Thorand, B. BMJ Open Diabetes Res Care 9 (2021).  

Deficiency of inactive rhomboid protein 2 (iRhom2) attenuates diet-induced hyperlipidemia and early atherogenesis. Hannemann, C., Schecker, J. H., Brettschneider, A., Grune, J., Rosener, N., Weller, A., Stangl, V., Fisher, E. A., Stangl, K., Ludwig, A. & Hewing, B. Cardiovascular research (2021).  

From heterogeneous healthcare data to disease-specific biomarker networks: A hierarchical Bayesian network approach. Becker, A. K., Dorr, M., Felix, S. B., Frost, F., Grabe, H. J., Lerch, M. M., Nauck, M., Volker, U., Volzke, H. & Kaderali, L. PLoS computational biology 17, e1008735 (2021).  

Creatine kinase and bleeding in patients with acute coronary syndromes. Ndrepepa, G., Holdenrieder, S., Cassese, S. & Kastrati, A. European journal of clinical investigation, e13514 (2021).  

Haemodynamic documentation of epicardial coronary spasm. Gori, T. & Ahoopai, M. European heart journal. Case reports 5, ytab008 (2021).  

Non-immune risk predictors of cardiac allograft vasculopathy: Results from the U.S. organ procurement and transplantation network. Fluschnik, N., Geelhoed, B., Becher, P. M., Schrage, B., Brunner, F. J., Knappe, D., Bernhardt, A. M., Blankenberg, S., Kobashigawa, J., Reichenspurner, H., Schnabel, R. B. & Magnussen, C. International journal of cardiology (2021).   

Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years. Dima, D., Modabbernia, A., Papachristou, E., Doucet, G. E., Agartz, I., Aghajani, M., Akudjedu, T. N., Albajes-Eizagirre, A., Alnaes, D., Alpert, K. I., Andersson, M., Andreasen, N. C., Andreassen, O. A., Asherson, P., Banaschewski, T., Bargallo, N., Baumeister, S., Baur-Streubel, R., Bertolino, A., Bonvino, A. et al. Hum Brain Mapp (2021).  

Patient factors associated with titration of medical therapy in patients with heart failure with reduced ejection fraction: data from the QUALIFY international registry. Cowie, M. R., Schope, J., Wagenpfeil, S., Tavazzi, L., Bohm, M., Ponikowski, P., Anker, S. D., Filippatos, G. S., Komajda, M. & Investigators, Q. ESC heart failure (2021).  

TAVR in nonagenarians: An analysis investigating safety, efficacy, symptomatic improvement, and long-term survival. Zadrozny, M., Hainzer, N., Mehilli, J., Jochheim, D., Gschwendtner, S., Steffen, J., Theiss, H., Braun, D., Hagl, C., Sadoni, S., Massberg, S., Hausleiter, J. & Deseive, S. J Cardiol (2021).  

The diagnostic and prognostic value of galectin-3 in patients at risk for heart failure with preserved ejection fraction: results from the DIAST-CHF study. Trippel, T. D., Mende, M., Dungen, H. D., Hashemi, D., Petutschnigg, J., Nolte, K., Herrmann-Lingen, C., Binder, L., Hasenfuss, G., Pieske, B., Wachter, R. & Edelmann, F. ESC heart failure (2021).  

Macrophage migration inhibitory factor inhibits neutrophil apoptosis by inducing cytokine release from mononuclear cells. Schindler, L., Zwissler, L., Krammer, C., Hendgen-Cotta, U., Rassaf, T., Hampton, M. B., Dickerhof, N. & Bernhagen, J. J Leukoc Biol (2021).  

Starting Antihypertensive Drug Treatment With Combination Therapy: Controversies in Hypertension - Pro Side of the Argument. Persu, A., Lopez-Sublet, M., Algharably, E. A. E. & Kreutz, R. Hypertension 77, 800-805 (2021).  

Anticoagulation therapy in non-valvular atrial fibrillation in the COVID-19 era: is it time to reconsider our therapeutic strategy? Papakonstantinou, P. E., Borovac, J. A., Gasecka, A., Bongiovanni, D., Ehrlinder, H., Giustozzi, M., Parker, W. A. E. & Guerreiro, R. A. European journal of preventive cardiology (2021).  

Impact of sinus rhythm versus atrial fibrillation on left ventricular remodeling after transcatheter aortic valve replacement. Ledwoch, J., Frohlich, C., Olbrich, I., Poch, F., Thalmann, R., Fellner, C., Bradaric, C., Laugwitz, K. L., Kupatt, C. & Hoppmann, P. Clinical research in cardiology : official journal of the German Cardiac Society (2021).  

Measurement accuracy of prototype non-contrast, compressed sensing-based, respiratory motion-resolved whole heart cardiovascular magnetic resonance angiography for the assessment of thoracic aortic dilatation: comparison with computed tomography angiography. Yacoub, B., Stroud, R. E., Piccini, D., Schoepf, U. J., Heerfordt, J., Yerly, J., Di Sopra, L., Rollins, J. D., Turner, D. A., Emrich, T., Xiong, F., Suranyi, P. & Varga-Szemes, A. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 23, 7 (2021).  

Impella versus extracorporal life support in cardiogenic shock: a propensity score adjusted analysis. Wernly, B., Karami, M., Engstrom, A. E., Windecker, S., Hunziker, L., Luscher, T. F., Henriques, J. P., Ferrari, M. W., Binnebossel, S., Masyuk, M., Niederseer, D., Abel, P., Fuernau, G., Franz, M., Kelm, M., Busch, M. C., Felix, S. B., Thiele, H., Lauten, A. & Jung, C. ESC heart failure (2021).  

Lifestyle Intervention in Chronic Ischaemic Heart Disease and Type 2 Diabetes (the LeIKD study): study protocol of a prospective, multicentre, randomised, controlled trial. von Korn, P., Sydow, H., Neubauer, S., Duvinage, A., Mocek, A., Dinges, S., Hackenberg, B., Weichenberger, M., Schoenfeld, J., Amelung, V., Mueller, S. & Halle, M. BMJ open 11, e042818 (2021).  

Correlation of cardiac function and cerebral perfusion in a murine model of subarachnoid hemorrhage. Neulen, A., Molitor, M., Kosterhon, M., Pantel, T., Holzbach, E., Rudi, W. S., Karbach, S. H., Wenzel, P., Ringel, F. & Thal, S. C. Scientific reports 11, 3317 (2021).  

Effect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity Advice on Peak Oxygen Consumption in Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial. Mueller, S., Winzer, E. B., Duvinage, A., Gevaert, A. B., Edelmann, F., Haller, B., Pieske-Kraigher, E., Beckers, P., Bobenko, A., Hommel, J., Van de Heyning, C. M., Esefeld, K., von Korn, P., Christle, J. W., Haykowsky, M. J., Linke, A., Wisloff, U., Adams, V., Pieske, B., van Craenenbroeck, E. M. et al. JAMA : the journal of the American Medical Association 325, 542-551 (2021).  

Unfolding and disentangling coronary vascular disease through genome-wide association studies. Erdmann, J. & van der Laan, S. W. European heart journal 42, 934-937 (2021).  

Venous lactate improves the prediction of in-hospital adverse outcomes in normotensive pulmonary embolism. Ebner, M., Pagel, C. F., Sentler, C., Harjola, V. P., Bueno, H., Lerchbaumer, M. H., Stangl, K., Pieske, B., Hasenfuss, G., Konstantinides, S. V. & Lankeit, M. European journal of internal medicine (2021).  

Pharmacogenomics of the Efficacy and Safety of Colchicine in COLCOT. Dube, M. P., Legault, M. A., Lemacon, A., Lemieux Perreault, L. P., Fouodjio, R., Waters, D. D., Kouz, S., Pinto, F. J., Maggioni, A. P., Diaz, R., Berry, C., Koenig, W., Lopez-Sendon, J., Gamra, H., Kiwan, G. S., Asselin, G., Provost, S., Barhdadi, A., Sun, M., Cossette, M. et al. Circulation. Genomic and precision medicine (2021).   

The interpretation of CHA2DS2-VASc score components in clinical practice: a joint survey by the European Heart Rhythm Association (EHRA) Scientific Initiatives Committee, the EHRA Young Electrophysiologists, the Association of Cardiovascular Nursing and Allied Professionals, and the European Society of Cardiology Council on Stroke. Zhang, J., Lenarczyk, R., Marin, F., Malaczynska-Rajpold, K., Kosiuk, J., Doehner, W., Van Gelder, I. C., Lee, G., Hendriks, J. M., Lip, G. Y. H. & Potpara, T. S. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 23, 314-322 (2021).  

Xenotransplantation in the era of a zoonotic pandemic. Schoenrath, F., Falk, V. & Emmert, M. Y. European heart journal (2021).  

One-year results of the first-in-man study investigating the Atrial Flow Regulator for left atrial shunting in symptomatic heart failure patients: the PRELIEVE study. Paitazoglou, C., Bergmann, M. W., Ozdemir, R., Pfister, R., Bartunek, J., Kilic, T., Lauten, A., Schmeisser, A., Zoghi, M., Anker, S. D., Sievert, H., Mahfoud, F. & Investigators, A.-P. European journal of heart failure (2021).  

MiR-21-Dependent Macrophage-to-Fibroblast Signaling Determines the Cardiac Response to Pressure Overload. Ramanujam, D., Schon, A. P., Beck, C., Vaccarello, P., Felician, G., Dueck, A., Esfandyari, D., Meister, G., Meitinger, T., Schulz, C. & Engelhardt, S. Circulation (2021).  

Low-fat hypocaloric diet reduces neprilysin in overweight and obese human subjects. Henke, C., Haufe, S., Ziehl, D., Bornstein, S. R., Schulz-Menger, J., Heni, M., Engeli, S., Jordan, J. & Birkenfeld, A. L. ESC heart failure (2021).  

Quality of Life Three and Twelve Months after Acute Pulmonary Embolism: Analysis from a Prospective Multicenter Cohort Study. Valerio, L., Barco, S., Jankowski, M., Rosenkranz, S., Lankeit, M., Held, M., Gerhardt, F., Bruch, L., Ewert, R., Faehling, M., Freise, J., Ghofrani, H. A., Grunig, E., Halank, M., Hoeper, M. M., Klok, F. A., Leuchte, H. H., Mayer, E., Meyer, F. J., Neurohr, C. et al. Chest (2021).  

Impact of a surgical approach for implantation of durable left ventricular assist devices in patients on extracorporeal life support. Potapov, E., Loforte, A., Pappalardo, F., Morshuis, M., Schibilsky, D., Zimpfer, D., Lewin, D., Riebandt, J., Von Aspern, K., Stein, J., Attisani, M., Haneya, A., Ramjankhan, F., Donker, D. W., Jorde, U. P., Wieloch, R., Ayala, R., Cremer, J., Rinaldi, M., Montisci, A. et al. J Card Surg 36, 1344-1351 (2021).  

Synthesis and evaluation of novel cyclopentane urea FPR2 agonists and their potential application in the treatment of cardiovascular inflammation. Maciuszek, M., Ortega-Gomez, A., Maas, S. L., Perretti, M., Merritt, A., Soehnlein, O. & Chapman, T. M. Eur J Med Chem 214, 113194 (2021).  

Thyroid function, sex hormones and sexual function: a Mendelian randomization study. Kjaergaard, A. D., Marouli, E., Papadopoulou, A., Deloukas, P., Kus, A., Sterenborg, R., Teumer, A., Burgess, S., Asvold, B. O., Chasman, D. I., Medici, M. & Ellervik, C. European journal of epidemiology (2021).  

Vasohibin 1 selectively regulates secondary sprouting and lymphangiogenesis in the zebrafish trunk. de Oliveira, M. B., Meier, K., Jung, S., Bartels-Klein, E., Coxam, B., Geudens, I., Szymborska, A., Skoczylas, R., Fechner, I., Koltowska, K. & Gerhardt, H. Development 148 (2021).  

Safety and Effectiveness of Edoxaban in Atrial Fibrillation Patients in Routine Clinical Practice: One-Year Follow-Up from the Global Noninterventional ETNA-AF Program. De Caterina, R., Kim, Y. H., Koretsune, Y., Wang, C. C., Yamashita, T., Chen, C., Reimitz, P. E., Unverdorben, M. & Kirchhof, P. Journal of clinical medicine 10 (2021).  

Correction to: Impact of a 2year trial of nutritional ketosis on indices of cardiovascular disease risk in patients with type 2 diabetes. Athinarayanan, S. J., Hallberg, S. J., McKenzie, A. L., Lechner, K., King, S., McCarter, J. P., Volek, J. S., Phinney, S. D. & Krauss, R. M. Cardiovascular diabetology 20, 37 (2021).  

Cardiomyocyte Injury Following Acute Ischemic Stroke: Protocol for a Prospective Observational Cohort Study. Stengl, H., Ganeshan, R., Hellwig, S., Blaszczyk, E., Fiebach, J. B., Nolte, C. H., Bauer, A., Schulz-Menger, J., Endres, M. & Scheitz, J. F. JMIR Res Protoc 10, e24186 (2021).  

Effects of sarcopenia and malnutrition on morbidity and mortality in gynecologic cancer surgery: results of a prospective study. Sehouli, J., Mueller, K., Richter, R., Anker, M., Woopen, H., Rasch, J., Grabowski, J. P., Prinz-Theissing, E. & Inci, M. G. J Cachexia Sarcopenia Muscle (2021).  

Experience with the novel unifemoral parallel sheath technique in percutaneous intervention of chronic total coronary occlusions. Reifart, J., Schilling, K., Hamm, C. W. & Reifart, N. Egypt Heart J 73, 14 (2021).  

The effect of spironolactone on diastolic function in haemodialysis patients. Hauser, T., Dornberger, V., Malzahn, U., Grebe, S. J., Liu, D., Stork, S., Nauck, M., Friedrich, N., Dorr, M., Wanner, C., Krane, V., Hammer, F., Mi, R. S. G. & Collaborating, i. The international journal of cardiovascular imaging (2021).  

Transcatheter pulmonary valve replacement: a new polycarbonate urethane valve. Lutter, G., Topal, A., Hansen, J. H., Haneya, A., Santhanthan, J., Freitag-Wolf, S., Frank, D. & Puehler, T. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021).  

Repeated Measurements of Cardiac Troponin T and N-Terminal Pro-B-Type Natriuretic Peptide to Assess Long-Term Mortality Risk in Subjects with Osteoarthritis. Rehm, M., Buchele, G., Brenner, R. E., Gunther, K. P., Brenner, H., Koenig, W. & Rothenbacher, D. Biomolecules 11 (2021).  

KLF5 Is Induced by FOXO1 and Causes Oxidative Stress and Diabetic Cardiomyopathy. Kyriazis, I. D., Hoffman, M., Gaignebet, L., Lucchese, A. M., Markopoulou, E., Palioura, D., Wang, C., Bannister, T. D., Christofidou-Solomidou, M., Oka, S. I., Sadoshima, J., Koch, W. J., Goldberg, I. J., Yang, V. W., Bialkowska, A. B., Kararigas, G. & Drosatos, K. Circulation research 128, 335-357 (2021).  

Low muscle strength and increased arterial stiffness go hand in hand. Konig, M., Buchmann, N., Seeland, U., Spira, D., Steinhagen-Thiessen, E. & Demuth, I. Scientific reports 11, 2906 (2021).  

[Strategy for Chronic Coronary Syndrome - PCI or optimal medical therapy]. Kim, S. H., Behnes, M. & Akin, I. Ther Umsch 78, 2-10 (2021).  

Myocardial deformation assessed among heart failure entities by cardiovascular magnetic resonance imaging. Hashemi, D., Motzkus, L., Blum, M., Kraft, R., Tanacli, R., Tahirovic, E., Doeblin, P., Zieschang, V., Zamani, S. M., Kelm, M., Kuehne, T., Pieske, B., Alogna, A., Edelmann, F., Duengen, H. D. & Kelle, S. ESC heart failure (2021).  

Hemoptysis due to a primary aortobronchial fistula of the ascending aorta. Eulert-Grehn, J. J., Veit, J., Falk, V. & Dusterhoft, V. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2021).   

On the preservation of vessel bifurcations during flow-mediated angiogenic remodelling. Edgar, L. T., Franco, C. A., Gerhardt, H. & Bernabeu, M. O. PLoS computational biology 17, e1007715 (2021).  

Association of Global Longitudinal Strain With Clinical Status and Mortality in Patients With Chronic Heart Failure. Trobs, S. O., Prochaska, J. H., Schwuchow-Thonke, S., Schulz, A., Muller, F., Heidorn, M. W., Gobel, S., Diestelmeier, S., Lerma Monteverde, J., Lackner, K. J., Gori, T., Munzel, T. & Wild, P. S. JAMA cardiology (2021).  

Increased C reactive protein, cardiac troponin I and GLS are associated with myocardial inflammation in patients with non-ischemic heart failure. Schwuchow-Thonke, S., Gobel, S., Emrich, T., Schmitt, V. H., Fueting, F., Klank, C., Escher, F., Schultheiss, H. P., Munzel, T., Keller, K. & Wenzel, P. Scientific reports 11, 3008 (2021).  

Mapping strategies and ablation of premature atrial complexes. Riesinger, L., Siebermair, J. & Wakili, R. Herzschrittmachertherapie & Elektrophysiologie 32, 9-13 (2021).  

Genome editing for Duchenne muscular dystrophy: a glimpse of the future? Kupatt, C., Windisch, A., Moretti, A., Wolf, E., Wurst, W. & Walter, M. C. Gene therapy (2021).  

Quantification of fibroblast growth factor 23 and N-terminal pro-B-type natriuretic peptide to identify patients with atrial fibrillation using a high-throughput platform: A validation study. Chua, W., Law, J. P., Cardoso, V. R., Purmah, Y., Neculau, G., Jawad-Ul-Qamar, M., Russell, K., Turner, A., Tull, S. P., Nehaj, F., Brady, P., Kastner, P., Ziegler, A., Gkoutos, G. V., Pavlovic, D., Ferro, C. J., Kirchhof, P. & Fabritz, L. PLoS medicine 18, e1003405 (2021).  

Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice. Zhang, H., Hanson, A., de Almeida, T. S., Emfinger, C., McClenaghan, C., Harter, T., Yan, Z., Cooper, P. E., Brown, G. S., Arakel, E. C., Mecham, R. P., Kovacs, A., Halabi, C. M., Schwappach, B., Remedi, M. S. & Nichols, C. G. JCI insight 6 (2021).  

Association Between Dispatch of Mobile Stroke Units and Functional Outcomes Among Patients With Acute Ischemic Stroke in Berlin. Ebinger, M., Siegerink, B., Kunz, A., Wendt, M., Weber, J. E., Schwabauer, E., Geisler, F., Freitag, E., Lange, J., Behrens, J., Erdur, H., Ganeshan, R., Liman, T., Scheitz, J. F., Schlemm, L., Harmel, P., Zieschang, K., Lorenz-Meyer, I., Napierkowski, I., Waldschmidt, C. et al. JAMA : the journal of the American Medical Association 325, 454-466 (2021).  

Impact of Statins on Hematoma, Edema, Seizures, Vascular Events, and Functional Recovery After Intracerebral Hemorrhage. Sprugel, M. I., Kuramatsu, J. B., Volbers, B., Saam, J. I., Sembill, J. A., Gerner, S. T., Balk, S., Hamer, H. M., Lucking, H., Holter, P., Nolte, C. H., Scheitz, J. F., Rocco, A., Endres, M. & Huttner, H. B. Stroke 52, 975-984 (2021).  

Clonal Hematopoiesis and Premature Menopause: Unexpected Liaison. Mas-Peiro, S., Cremer, S. & Zeiher, A. M. Circulation 143, 424-426 (2021).  

Residual inflammatory risk at 12 months after acute coronary syndromes is frequent and associated with combined adverse events. Klingenberg, R., Aghlmandi, S., Gencer, B., Nanchen, D., Raber, L., Carballo, D., Carballo, S., Stahli, B. E., Landmesser, U., Rodondi, N., Mach, F., Windecker, S., Bucher, H. C., von Eckardstein, A., Luscher, T. F. & Matter, C. M. Atherosclerosis 320, 31-37 (2021).  

Mitigated viral myocarditis in A/J mice by the immunoproteasome inhibitor ONX 0914 depends on inhibition of systemic inflammatory responses in CoxsackievirusB3 infection. Goetzke, C. C., Althof, N., Neumaier, H. L., Heuser, A., Kaya, Z., Kespohl, M., Klingel, K. & Beling, A. Basic research in cardiology 116, 7 (2021).





Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes. Peper, J., Kownatzki-Danger, D., Weninger, G., Seibertz, F., Pronto, J. R. D., Sutanto, H., Pacheu-Grau, D., Hindmarsh, R., Brandenburg, S., Kohl, T., Hasenfuss, G., Gotthardt, M., Rog-Zielinska, E. A., Wollnik, B., Rehling, P., Urlaub, H., Wegener, J., Heijman, J., Voigt, N., Cyganek, L. et al. Circulation research 128, e102-e120 (2021).

Exercise Stress Real-Time Cardiac Magnetic Resonance Imaging for Noninvasive Characterization of Heart Failure With Preserved Ejection Fraction: The HFpEF-Stress Trial. Backhaus, S. J., Lange, T., George, E. F., Hellenkamp, K., Gertz, R. J., Billing, M., Wachter, R., Steinmetz, M., Kutty, S., Raaz, U., Lotz, J., Friede, T., Uecker, M., Hasenfuss, G., Seidler, T. & Schuster, A. Circulation 143, 1484-1498 (2021).  

Impaired complex I repair causes recessive Leber's hereditary optic neuropathy. Stenton, S. L., Sheremet, N. L., Catarino, C. B., Andreeva, N. A., Assouline, Z., Barboni, P., Barel, O., Berutti, R., Bychkov, I., Caporali, L., Capristo, M., Carbonelli, M., Cascavilla, M. L., Charbel Issa, P., Freisinger, P., Gerber, S., Ghezzi, D., Graf, E., Heidler, J., Hempel, M. et al. The Journal of clinical investigation 131 (2021).

Apixaban or Vitamin K Antagonists and Aspirin or Placebo According to Kidney Function in Patients With Atrial Fibrillation After Acute Coronary Syndrome or Percutaneous Coronary Intervention: Insights From the AUGUSTUS Trial. Hijazi, Z., Alexander, J. H., Li, Z., Wojdyla, D. M., Mehran, R., Granger, C. B., Parkhomenko, A., Bahit, M. C., Windecker, S., Aronson, R., Berwanger, O., Halvorsen, S., de Waha-Thiele, S., Sinnaeve, P., Darius, H., Storey, R. F. & Lopes, R. D. Circulation 143, 1215-1223 (2021).

Impact of chronic kidney disease in 29 893 patients undergoing transcatheter or surgical aortic valve replacement from the German Aortic Valve Registry. Mas-Peiro, S., Faerber, G., Bon, D., Herrmann, E., Bauer, T., Bleiziffer, S., Bekeredjian, R., Boning, A., Frerker, C., Beckmann, A., Mollmann, H., Vasa-Nicotera, M., Ensminger, S., Hamm, C. W., Beyersdorf, F., Fichtlscherer, S., Walther, T. & Board, G. A.-E. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 59, 532-544 (2021).  

Telomerase therapy attenuates cardiotoxic effects of doxorubicin. Chatterjee, S., Hofer, T., Costa, A., Lu, D., Batkai, S., Gupta, S. K., Bolesani, E., Zweigerdt, R., Megias, D., Streckfuss-Bomeke, K., Brandenberger, C., Thum, T. & Bar, C. Molecular therapy : the journal of the American Society of Gene Therapy 29, 1395-1410 (2021).  

A Panel of 6 Biomarkers Significantly Improves the Prediction of Type 2 Diabetes in the MONICA/KORA Study Population. Thorand, B., Zierer, A., Büyüközkan, M., Krumsiek, J., Bauer, A., Schederecker, F., Sudduth-Klinger, J., Meisinger, C., Grallert, H., Rathmann, W., Roden, M., Peters, A., Koenig, W., Herder, C. & Huth, C. The Journal of clinical endocrinology and metabolism 106, e1647-e1659 (2021).


Shared genetic pathways contribute to risk of hypertrophic and dilated cardiomyopathies with opposite directions of effect. Tadros, R., Francis, C., Xu, X., Vermeer, A. M. C., Harper, A. R., Huurman, R., Kelu Bisabu, K., Walsh, R., Hoorntje, E. T., Te Rijdt, W. P., Buchan, R. J., van Velzen, H. G., van Slegtenhorst, M. A., Vermeulen, J. M., Offerhaus, J. A., Bai, W., de Marvao, A., Lahrouchi, N., Beekman, L., Karper, J. C. et al. Nature genetics 53, 128-134 (2021).  

Valvular atrial fibrillation and a CHA2DS2-VASc score of 1-a statement of the ESC working group on cardiovascular pharmacotherapy and ESC council on stroke. Sulzgruber, P., Doehner, W. & Niessner, A. European heart journal 42, 541-543 (2021).  

Low serum vitamin D level associated with incident advanced liver disease in the general population - a prospective study. Mannisto, V., Jaaskelainen, T., Farkkila, M., Jula, A., Mannisto, S., Lundqvist, A., Zeller, T., Blankenberg, S., Salomaa, V., Perola, M. & Aberg, F. Scand J Gastroenterol 56, 299-303 (2021).  

Acid sphingomyelinase promotes SGK1-dependent vascular calcification. Luong, T. T. D., Tuffaha, R., Schuchardt, M., Moser, B., Schelski, N., Boehme, B., Gollmann-Tepekoylu, C., Schramm, C., Holfeld, J., Pieske, B., Gulbins, E., Tolle, M., van der Giet, M., Lang, F., Eckardt, K. U., Voelkl, J. & Alesutan, I. Clin Sci (Lond) 135, 515-534 (2021).  

miR-375- and miR-1-Regulated Coxsackievirus B3 Has No Pancreas and Heart Toxicity But Strong Antitumor Efficiency in Colorectal Carcinomas. Hazini, A., Dieringer, B., Pryshliak, M., Knoch, K. P., Heimann, L., Tolksdorf, B., Pappritz, K., El-Shafeey, M., Solimena, M., Beling, A., Kurreck, J., Klingel, K. & Fechner, H. Hum Gene Ther 32, 216-230 (2021).  

Detection of aberrant gene expression events in RNA sequencing data. Yepez, V. A., Mertes, C., Muller, M. F., Klaproth-Andrade, D., Wachutka, L., Fresard, L., Gusic, M., Scheller, I. F., Goldberg, P. F., Prokisch, H. & Gagneur, J. Nat Protoc 16, 1276-1296 (2021).  

Association of proton pump inhibitor use with endothelial function and metabolites of the nitric oxide pathway: A cross-sectional study. Nolde, M., Bahls, M., Friedrich, N., Dorr, M., Dreischulte, T., Felix, S. B., Ruckert-Eheberg, I. M., Ahn, N., Amann, U., Schwedhelm, E., Volzke, H., Lerch, M. M., Linseisen, J., Meisinger, C. & Baumeister, S. E. Pharmacotherapy 41, 198-204 (2021).  

Ablation of Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy: Treatment Strategy, Characteristics of Consecutive Atrial Tachycardia and Long-Term Outcome. Dinshaw, L., Munkler, P., Schaffer, B., Klatt, N., Jungen, C., Dickow, J., Tamenang, A., Schleberger, R., Pecha, S., Pinnschmidt, H., Patten, M., Reichenspurner, H., Willems, S. & Meyer, C. Journal of the American Heart Association 10, e017451 (2021).   

Vascular biotransformation of organic nitrates is independent of cytochrome P450 monooxygenases. Lopez, M., Malacarne, P. F., Gajos-Draus, A., Ding, X., Daiber, A., Lundberg, J. O., Offermanns, S., Brandes, R. P. & Rezende, F. British journal of pharmacology 178, 1495-1506 (2021).  

Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: The New Working Horse in Cardiovascular Pharmacology? Lemoine, M. D. & Christ, T. Journal of cardiovascular pharmacology 77, 265-266 (2021).  

[Personalized treatment concepts for arterial hypertension]. Lechner, K. & Schunkert, H. Herz 46, 91-104 (2021).  

Ythdf is a N6-methyladenosine reader that modulates Fmr1 target mRNA selection and restricts axonal growth in Drosophila. Worpenberg, L., Paolantoni, C., Longhi, S., Mulorz, M. M., Lence, T., Wessels, H. H., Dassi, E., Aiello, G., Sutandy, F. X. R., Scheibe, M., Edupuganti, R. R., Busch, A., Mockel, M. M., Vermeulen, M., Butter, F., Konig, J., Notarangelo, M., Ohler, U., Dieterich, C., Quattrone, A. et al. The EMBO journal 40, e104975 (2021).  

Health-related quality of life, anxiety and depression up to 12 months post-stroke: Influence of sex, age, stroke severity and atrial fibrillation - A longitudinal subanalysis of the Find-AFRANDOMISED trial. Sadlonova, M., Wasser, K., Nagel, J., Weber-Kruger, M., Groschel, S., Uphaus, T., Liman, J., Hamann, G. F., Kermer, P., Groschel, K., Herrmann-Lingen, C. & Wachter, R. Journal of psychosomatic research 142, 110353 (2021).  

Quantitative analysis of three-dimensional left ventricular global strain using coronary computed tomography angiography in patients with heart failure: Comparison with 3T cardiac MR. Wang, R., Fang, Z., Wang, H., Schoepf, U. J., Emrich, T., Giovagnoli, D., Biles, E., Zhou, Z., Du, Z., Liu, T. & Xu, L. European journal of radiology 135, 109485 (2021).  

Risk markers of incident atrial fibrillation in patients with coronary heart disease. Tomasdottir, M. M., Held C Md, P., Hadziosmanovic, N., Westerbergh, J., Lindback, J., Aylward, P. E., Budaj, A., Cannon, C. P., Engdahl, J., Granger, C. B., Koenig, W., Manolis, A. J., Oldgren, J., Stewart, R. A. H., Svennberg, E., Vinereanu, D., White, H. D., Siegbahn, A., Wallentin, L. & Hijazi, Z. American heart journal 233, 92-101 (2021).  

Delayed onset hypophysitis after therapy with daclizumab for multiple sclerosis - A report of two cases. Stascheit, F., Li, L., Mai, K., Baum, K., Siebert, E. & Ruprecht, K. J Neuroimmunol 351, 577469 (2021).  

Major Depression and Anxiety Among Patients Hospitalized With Heart Failure. Sreenivasan, J., Khan, M. S., Ochani, R. K., Bhinder, J., Usman, M. S., Anker, S. D., Fonarow, G. C. & Butler, J. The American journal of cardiology 142, 153-155 (2021).  

Nutrition in the spotlight in cachexia, sarcopenia and muscle: avoiding the wildfire. Prado, C. M., Anker, S. D., Coats, A. J. S., Laviano, A. & von Haehling, S. J Cachexia Sarcopenia Muscle 12, 3-8 (2021).  

Weight loss, malnutrition, and cachexia in COVID-19: facts and numbers. Anker, M. S., Landmesser, U., von Haehling, S., Butler, J., Coats, A. J. S. & Anker, S. D. J Cachexia Sarcopenia Muscle 12, 9-13 (2021).  

Clonal Hematopoiesis-Driver Dnmt3a Mutations Alter Immune Cells in Heart Failure. Abplanalp, W. T., Cremer, S., John, D., Hoffmann, J., Schuhmacher, B., Merten, M., Rieger, M. A., Vasa-Nicotera, M., Zeiher, A. M. & Dimmeler, S. Circ Res. 128, 216-28, (2021)

Single-Cell Rna-Sequencing Reveals Profound Changes in Circulating Immune Cells in Patients with Heart Failure. Abplanalp, W. T., John, D., Cremer, S., Assmus, B., Dorsheimer, L., Hoffmann, J., Becker-Pergola, G., Rieger, M. A., Zeiher, A. M., Vasa-Nicotera, M. & Dimmeler, S. Cardiovasc Res. 117, 484-94, (2021)

Genome-Wide Association Study of Circulating Interleukin 6 Levels Identifies Novel Loci. Ahluwalia, T. S., Prins, B. P., Abdollahi, M., Armstrong, N. J., Aslibekyan, S., Bain, L., Jefferis, B., Baumert, J., Beekman, M., Ben-Shlomo, Y., Bis, J. C., Mitchell, B. D., de Geus, E., Delgado, G. E., Marek, D., Eriksson, J., Kajantie, E., Kanoni, S., Kemp, J. P., Lu, C., Marioni, R. E., McLachlan, S., Milaneschi, Y., Nolte, I. M., Petrelis, A. M., Porcu, E., Sabater-Lleal, M., Naderi, E., Seppälä, I., Shah, T., Singhal, G., Standl, M., Teumer, A., Thalamuthu, A., Thiering, E., Trompet, S., Ballantyne, C. M., Benjamin, E. J., Casas, J. P., Toben, C., Dedoussis, G., Deelen, J., Durda, P., Engmann, J., Feitosa, M. F., Grallert, H., Hammarstedt, A., Harris, S. E., Homuth, G., Hottenga, J. J., Jalkanen, S., Jamshidi, Y., Jawahar, M. C., Jess, T., Kivimaki, M., Kleber, M. E., Lahti, J., Liu, Y., Marques-Vidal, P., Mellström, D., Mooijaart, S. P., Müller-Nurasyid, M., Penninx, B., Revez, J. A., Rossing, P., Räikkönen, K., Sattar, N., Scharnagl, H., Sennblad, B., Silveira, A., Pourcain, B. S., Timpson, N. J., Trollor, J., van Dongen, J., Van Heemst, D., Visvikis-Siest, S., Vollenweider, P., Völker, U., Waldenberger, M., Willemsen, G., Zabaneh, D., Morris, R. W., Arnett, D. K., Baune, B. T., Boomsma, D. I., Chang, Y. C., Deary, I. J., Deloukas, P., Eriksson, J. G., Evans, D. M., Ferreira, M. A., Gaunt, T., Gudnason, V., Hamsten, A., Heinrich, J., Hingorani, A., Humphries, S. E., Jukema, J. W., Koeing, W., Kumari, M., Kutalik, Z., Lawlor, D. A., Lehtimäki, T., März, W., Mather, K., Naitza, S., Nauck, M., Ohlsson, C., Price, J. F., Raitakari, O., Rice, K., Sachdev, P. S., Slagboom, E., Sørensen, T. I. A., Spector, T., Stacey, D., Stathopoulou, M. G., Tanaka, T., Wannamethee, S. G., Whincup, P., Rotter, J. I., Dehghan, A., Boerwinkle, E., Psaty, B. M., Snieder, H. & Alizadeh, B. Z. Hum Mol Genet. (2021)

Measuring Myocardial Extracellular Volume of the Right Ventricle in Patients with Congenital Heart Disease. Al-Wakeel-Marquard, N., Ferreira da Silva, T., Jeuthe, S., Rastin, S., Muench, F., D, O. H. I., Yilmaz, S., Berger, F., Kuehne, T. & Messroghli, D. R. Sci Rep. 11, 2679, (2021)

Feasibility of a Culturally Adapted Dietary Weight-Loss Intervention among Ghanaian Migrants in Berlin, Germany: The Adapt Study. Amoah, S., Ennin, R., Sagoe, K., Steinbrecher, A., Pischon, T., Mockenhaupt, F. P. & Danquah, I. Int J Environ Res Public Health. 18, (2021)

Exercise-Stress Real-Time Cardiac Magnetic Resonance Imaging for Non-Invasive Characterisation of Heart Failure with Preserved Ejection Fraction: The Hfpef Stress Trial. Backhaus, S. J., Lange, T., George, E. F., Hellenkamp, K., Gertz, R. J., Billing, M., Wachter, R., Steinmetz, M., Kutty, S., Raaz, U., Lotz, J., Friede, T., Uecker, M., Hasenfuß, G., Seidler, T. & Schuster, A. Circulation. (2021)

Effects of a Brief Alcohol Intervention Addressing the Full Spectrum of Drinking in an Adult General Population Sample: A Randomized Controlled Trial. Baumann, S., Staudt, A., Freyer-Adam, J., Bischof, G., Meyer, C. & John, U. Addiction. (2021)

Plasminogen Activator Inhibitor-1 Reduces Cardiac Fibrosis and Promotes M2 Macrophage Polarization in Inflammatory Cardiomyopathy. Baumeier, C., Escher, F., Aleshcheva, G., Pietsch, H. & Schultheiss, H. P. Basic Res Cardiol. 116, 1, (2021)

Brown Adipose Tissue Is Associated with Cardiometabolic Health. Becher, T., Palanisamy, S., Kramer, D. J., Eljalby, M., Marx, S. J., Wibmer, A. G., Butler, S. D., Jiang, C. S., Vaughan, R., Schöder, H., Mark, A. & Cohen, P. Nat Med. 27, 58-65, (2021)

Research Priorities in Atrial Fibrillation Screening: A Report from a National Heart, Lung, and Blood Institute Virtual Workshop. Benjamin, E. J., Go, A. S., Desvigne-Nickens, P., Anderson, C. D., Casadei, B., Chen, L. Y., Crijns, H., Freedman, B., Hills, M. T., Healey, J. S., Kamel, H., Kim, D. Y., Link, M. S., Lopes, R. D., Lubitz, S. A., McManus, D. D., Noseworthy, P. A., Perez, M. V., Piccini, J. P., Schnabel, R. B., Singer, D. E., Tieleman, R. G., Turakhia, M. P., Van Gelder, I. C., Cooper, L. S. & Al-Khatib, S. M. Circulation. 143, 372-88, (2021)

Left and Right Ventricular Dysfunction in Patients with Covid-19-Associated Myocardial Injury. Bieber, S., Kraechan, A., Hellmuth, J. C., Muenchhoff, M., Scherer, C., Schroeder, I., Irlbeck, M., Kaeaeb, S., Massberg, S., Hausleiter, J., Grabmaier, U., Orban, M. & Weckbach, L. T. Infection. (2021)

Interdisciplinary Clinical Target Volume Generation for Cardiac Radioablation: Multi-Center Benchmarking for the Radiosurgery for Ventricular Tachycardia (Raventa) Trial. Boda-Heggemann, J., Blanck, O., Mehrhof, F., Ernst, F., Buergy, D., Fleckenstein, J., Tülümen, E., Krug, D., Siebert, F. A., Zaman, A., Kluge, A. K., Parwani, A. S., Andratschke, N., Mayinger, M. C., Ehrbar, S., Saguner, A. M., Celik, E., Baus, W. W., Stauber, A., Vogel, L., Schweikard, A., Budach, V., Dunst, J., Boldt, L. H., Bonnemeier, H. & Rudic, B. Int J Radiat Oncol Biol Phys. (2021)

Dual Sglt-1 and Sglt-2 Inhibition Improves Left Atrial Dysfunction in Hfpef. Bode, D., Semmler, L., Wakula, P., Hegemann, N., Primessnig, U., Beindorff, N., Powell, D., Dahmen, R., Ruetten, H., Oeing, C., Alogna, A., Messroghli, D., Pieske, B. M., Heinzel, F. R. & Hohendanner, F. Cardiovasc Diabetol. 20, 7, (2021)

Coxsackievirus B3 Infection of Human Ipsc Lines and Derived Primary Germ-Layer Cells Regarding Receptor Expression. Böhnke, J., Pinkert, S., Schmidt, M., Binder, H., Bilz, N. C., Jung, M., Reibetanz, U., Beling, A., Rujescu, D. & Claus, C. Int J Mol Sci. 22, (2021)

Sars-Cov-2 Infection Is Associated with a Pro-Thrombotic Platelet Phenotype. Bongiovanni, D., Klug, M., Lazareva, O., Weidlich, S., Biasi, M., Ursu, S., Warth, S., Buske, C., Lukas, M., Spinner, C. D., Scheidt, M. V., Condorelli, G., Baumbach, J., Laugwitz, K. L., List, M. & Bernlochner, I. Cell Death Dis. 12, 50, (2021)

Risk Prediction of Atrial Fibrillation in the Community Combining Biomarkers and Genetics. Börschel, C. S., Ohlrogge, A. H., Geelhoed, B., Niiranen, T., Havulinna, A. S., Palosaari, T., Jousilahti, P., Rienstra, M., van der Harst, P., Blankenberg, S., Zeller, T., Salomaa, V. & Schnabel, R. B. Europace. (2021)

Dgk and Dzhk Position Paper on Genome Editing: Basic Science Applications and Future Perspective. Brandes, R. P., Dueck, A., Engelhardt, S., Kaulich, M., Kupatt, C., De Angelis, M. T., Leisegang, M. S., le Noble, F., Moretti, A., Müller, O. J., Skryabin, B. V., Thum, T. & Wurst, W. Basic Res Cardiol. 116, 2, (2021)

Empagliflozin and Health-Related Quality of Life Outcomes in Patients with Heart Failure with Reduced Ejection Fraction: The Emperor-Reduced Trial. Butler, J., Anker, S. D., Filippatos, G., Khan, M. S., Ferreira, J. P., Pocock, S. J., Giannetti, N., Januzzi, J. L., Piña, I. L., Lam, C. S. P., Ponikowski, P., Sattar, N., Verma, S., Brueckmann, M., Jamal, W., Vedin, O., Peil, B., Zeller, C., Zannad, F. & Packer, M. Eur Heart J. (2021)

Adult with Congenital Heart Disease We Need More Europe for a Better Care. Chessa, M. & Tutarel, O. Eur J Heart Fail. (2021)

Variation in the Serpina6/Serpina1 Locus Alters Morning Plasma Cortisol, Hepatic Corticosteroid Binding Globulin Expression, Gene Expression in Peripheral Tissues, and Risk of Cardiovascular Disease. Crawford, A. A., Bankier, S., Altmaier, E., Barnes, C. L. K., Clark, D. W., Ermel, R., Friedrich, N., van der Harst, P., Joshi, P. K., Karhunen, V., Lahti, J., Mahajan, A., Mangino, M., Nethander, M., Neumann, A., Pietzner, M., Sukhavasi, K., Wang, C. A., Bakker, S. J. L., Bjorkegren, J. L. M., Campbell, H., Eriksson, J., Gieger, C., Hayward, C., Jarvelin, M. R., McLachlan, S., Morris, A. P., Ohlsson, C., Pennell, C. E., Price, J., Rudan, I., Ruusalepp, A., Spector, T., Tiemeier, H., Völzke, H., Wilson, J. F., Michoel, T., Timpson, N. J., Smith, G. D. & Walker, B. R. J Hum Genet. (2021)

Alcohol Consumption, Cardiac Biomarkers, and Risk of Atrial Fibrillation and Adverse Outcomes. Csengeri, D., Sprünker, N. A., Di Castelnuovo, A., Niiranen, T., Vishram-Nielsen, J. K., Costanzo, S., Söderberg, S., Jensen, S. M., Vartiainen, E., Donati, M. B., Magnussen, C., Camen, S., Gianfagna, F., Løchen, M. L., Kee, F., Kontto, J., Mathiesen, E. B., Koenig, W., Stefan, B., de Gaetano, G., Jørgensen, T., Kuulasmaa, K., Zeller, T., Salomaa, V., Iacoviello, L. & Schnabel, R. B. Eur Heart J. (2021)

Phosphoproteomics Identify Arachidonic-Acid-Regulated Signal Transduction Pathways Modulating Macrophage Functions with Implications for Ovarian Cancer. Dietze, R., Hammoud, M. K., Gómez-Serrano, M., Unger, A., Bieringer, T., Finkernagel, F., Sokol, A. M., Nist, A., Stiewe, T., Reinartz, S., Ponath, V., Preußer, C., von Strandmann, E. P., Müller-Brüsselbach, S., Graumann, J. & Müller, R. Theranostics. 11, 1377-95, (2021)

Ablation of Atrial Fibrillation in Patients with Hypertrophic Cardiomyopathy: Treatment Strategy, Characteristics of Consecutive Atrial Tachycardia and Long-Term Outcome. Dinshaw, L., Münkler, P., Schäffer, B., Klatt, N., Jungen, C., Dickow, J., Tamenang, A., Schleberger, R., Pecha, S., Pinnschmidt, H., Patten, M., Reichenspurner, H., Willems, S. & Meyer, C. J Am Heart Assoc. e017451, (2021)

Cost Saving Analysis of Specialized, Ehealth-Based Management of Patients Receiving Oral Anticoagulation Therapy: Results from the Thrombeval Study. Eggebrecht, L., Ludolph, P., Göbel, S., Panova-Noeva, M., Arnold, N., Nagler, M., Bickel, C., Lauterbach, M., Hardt, R., Cate, H. T., Lackner, K. J., Espinola-Klein, C., Münzel, T., Prochaska, J. H. & Wild, P. S. Sci Rep. 11, 2577, (2021)

Rationale and Design of the Cardiovascular Status in Patients with Endogenous Cortisol Excess Study (Cv-Cort-Ex): A Prospective Non-Interventional Follow-up Study. Ehrlich, K., Morbach, C., Reiter, T., Heuschmann, P. U., Hannemann, A., Fassnacht, M., Störk, S., Hahner, S. & Deutschbein, T. BMC Endocr Disord. 21, 11, (2021)

Inflammation Predicts New Onset of Depression in Men, but Not in Women within a Prospective, Representative Community Cohort. Ernst, M., Brähler, E., Otten, D., Werner, A. M., Tibubos, A. N., Reiner, I., Wicke, F., Wiltink, J., Michal, M., Nagler, M., Münzel, T., Wild, P. S., König, J., Pfeiffer, N., Borta, A., Lackner, K. J. & Beutel, M. E. Sci Rep. 11, 2271, (2021)

Uncertainty Resolved? Falk, V. Innovations (Phila). 1556984520988796, (2021)

An Overview of Anamorelin as a Treatment Option for Cancer-Associated Anorexia and Cachexia. Fonseca, G. & von Haehling, S. Expert Opin Pharmacother. 1-8, (2021)

Impact of Oral Anticoagulation on Clinical Outcomes of Covid-19: A Nationwide Cohort Study of Hospitalized Patients in Germany. Fröhlich, G. M., Jeschke, E., Eichler, U., Thiele, H., Alhariri, L., Reinthaler, M., Kastrati, A., Leistner, D. M., Skurk, C., Landmesser, U. & Günster, C. Clin Res Cardiol. 1-10, (2021)

Corrigendum to "Interaction between Cieds and Modern Radiotherapy Techniques: Flattening Filter Free-Vmat, Dose-Rate Effects, Scatter Radiation, and Neutron-Generating Energies" [Radiother Oncol 152 (2020) 196-202]. Gauter-Fleckenstein, B., Nguyen, J., Jahnke, L., Gaiser, T., Rudic, B., Büttner, S., Wenz, F., Borggrefe, M. & Tülümen, E. Radiother Oncol. 154, 291, (2021)

Inflammatory Chemokines in Atherosclerosis. Gencer, S., Evans, B. R., van der Vorst, E. P. C., Döring, Y. & Weber, C. Cells. 10, (2021)

Concomitant Tricuspid Regurgitation Severity and Its Secondary Reduction Determine Long-Term Prognosis after Transcatheter Mitral Valve Edge-to-Edge Repair. Geyer, M., Keller, K., Bachmann, K., Born, S., Tamm, A. R., Ruf, T. F., Kreidel, F., Hahad, O., Petrescu, A., Hell, M., Beiras-Fernandez, A., Kornberger, A., Schulz, E., Münzel, T. & von Bardeleben, R. S. Clin Res Cardiol. (2021)

Cardiomyocytes Stimulate Angiogenesis after Ischemic Injury in a Zeb2-Dependent Manner. Gladka, M. M., Kohela, A., Molenaar, B., Versteeg, D., Kooijman, L., Monshouwer-Kloots, J., Kremer, V., Vos, H. R., Huibers, M. M. H., Haigh, J. J., Huylebroeck, D., Boon, R. A., Giacca, M. & van Rooij, E. Nat Commun. 12, 84, (2021)

DNA Methylation and Lipid Metabolism: An Ewas of 226 Metabolic Measures. Gomez-Alonso, M. D. C., Kretschmer, A., Wilson, R., Pfeiffer, L., Karhunen, V., Seppälä, I., Zhang, W., Mittelstraß, K., Wahl, S., Matias-Garcia, P. R., Prokisch, H., Horn, S., Meitinger, T., Serrano-Garcia, L. R., Sebert, S., Raitakari, O., Loh, M., Rathmann, W., Müller-Nurasyid, M., Herder, C., Roden, M., Hurme, M., Jarvelin, M. R., Ala-Korpela, M., Kooner, J. S., Peters, A., Lehtimäki, T., Chambers, J. C., Gieger, C., Kettunen, J. & Waldenberger, M. Clin Epigenetics. 13, 7, (2021)

Associated Factors of White Matter Hyperintensity Volume: A Machine-Learning Approach. Grosu, S., Rospleszcz, S., Hartmann, F., Habes, M., Bamberg, F., Schlett, C. L., Galie, F., Lorbeer, R., Auweter, S., Selder, S., Buelow, R., Heier, M., Rathmann, W., Mueller-Peltzer, K., Ladwig, K. H., Grabe, H. J., Peters, A., Ertl-Wagner, B. B. & Stoecklein, S. Sci Rep. 11, 2325, (2021)

Role of Cardiac Biomarkers in Epidemiology and Risk Outcomes. Haller, P. M., Beer, B. N., Tonkin, A. M., Blankenberg, S. & Neumann, J. T. Clin Chem. 67, 96-106, (2021)

Mir-375- and Mir-1-Regulated Coxsackievirus B3 Has No Pancreas and Heart Toxicity but Strong Antitumor Efficiency in Colorectal Carcinomas. Hazini, A., Dieringer, B., Pryshliak, M., Knoch, K. P., Heimann, L., Tolksdorf, B., Pappritz, K., El-Shafeey, M., Solimena, M., Beling, A., Kurreck, J., Klingel, K. & Fechner, H. Hum Gene Ther. (2021)

Impaired in Vitro Growth Response of Plasma-Treated Cardiomyocytes Predicts Poor Outcome in Patients with Transthyretin Amyloidosis. Hein, S., Furkel, J., Knoll, M., Aus dem Siepen, F., Schönland, S., Hegenbart, U., Katus, H. A., Kristen, A. V. & Konstandin, M. H. Clin Res Cardiol. (2021)

Apixaban or Vitamin K Antagonists and Aspirin or Placebo According to Kidney Function in Patients with Atrial Fibrillation after Acute Coronary Syndrome or Pci: Insights from the Augustus Trial. Hijazi, Z., Alexander, J. H., Li, Z., Wojdyla, D. M., Mehran, R., Granger, C. B., Parkhomenko, A., Bahit, M. C., Windecker, S., Aronson, R., Berwanger, O., Halvorsen, S., de Waha-Thiele, S., Sinnaeve, P., Darius, H., Storey, R. F. & Lopes, R. D. Circulation. (2021)

Randomized Study Defining the Optimum Target Interlesion Distance in Ablation Index-Guided Atrial Fibrillation Ablation: Authors' Reply. Hoffmann, P. & Althoff, T. F. Europace. (2021)

Prognostic Impact of Pretherapeutic Hemoglobin Levels on All-Cause Mortality in Cardiooncology. Hohneck, A., Rosenkaimer, S., Sieburg, T., Holzwarth, J., Hofheinz, R. D., Akin, I., Borggrefe, M. & Gerhards, S. Anticancer Res. 41, 369-78, (2021)

Epigenetic Gene Expression Links Heart Failure to Memory Impairment. Islam, M. R., Lbik, D., Sakib, M. S., Maximilian Hofmann, R., Berulava, T., Jiménez Mausbach, M., Cha, J., Goldberg, M., Vakhtang, E., Schiffmann, C., Zieseniss, A., Katschinski, D. M., Sananbenesi, F., Toischer, K. & Fischer, A. EMBO Mol Med. e11900, (2021)

Prognostic Impact of Percutaneous Coronary Intervention of Chronic Total Occlusion in Acute and Periprocedural Myocardial Infarction. Kim, S. H., Behnes, M., Mashayekhi, K., Bufe, A., Meyer-Gessner, M., El-Battrawy, I. & Akin, I. J Clin Med. 10, (2021)

Proteomics in Kidney and Cardiovascular Clinical Research. Klein, O. Proteomics Clin Appl. 15, e1900132, (2021)

Empagliflozin Improves Endothelial and Cardiomyocyte Function in Human Heart Failure with Preserved Ejection Fraction Via Reduced Pro-Inflammatory-Oxidative Pathways and Protein Kinase Gα Oxidation. Kolijn, D., Pabel, S., Tian, Y., Lódi, M., Herwig, M., Carrizzo, A., Zhazykbayeva, S., Kovács, Á., Fülöp, G., Falcão-Pires, I., Reusch, P. H., Linthout, S. V., Papp, Z., van Heerebeek, L., Vecchione, C., Maier, L. S., Ciccarelli, M., Tschöpe, C., Mügge, A., Bagi, Z., Sossalla, S. & Hamdani, N. Cardiovasc Res. 117, 495-507, (2021)

Fast Strain-Encoded Cardiac Magnetic Resonance for Diagnostic Classification and Risk Stratification of Heart Failure Patients. Korosoglou, G., Giusca, S., Montenbruck, M., Patel, A. R., Lapinskas, T., Götze, C., Zieschang, V., Al-Tabatabaee, S., Pieske, B., Florian, A., Erley, J., Katus, H. A., Kelle, S. & Steen, H. JACC Cardiovasc Imaging. (2021)

A Guide to Understanding Endoplasmic Reticulum Stress in Metabolic Disorders. Lemmer, I. L., Willemsen, N., Hilal, N. & Bartelt, A. Mol Metab. 101169, (2021)

Human Induced Pluripotent Stem Cell Derived Cardiomyocytes: The New Working Horse in Cardiovascular Pharmacology? Lemoine, M. D. & Christ, T. J Cardiovasc Pharmacol. Publish Ahead of Print, (2021)

Association of Antecedent Cardiovascular Risk Factor Levels and Trajectories with Cardiovascular Magnetic Resonance-Derived Cardiac Function and Structure. Lorbeer, R., Rospleszcz, S., Schlett, C. L., Rado, S. D., Thorand, B., Meisinger, C., Rathmann, W., Heier, M., Vasan, R. S., Bamberg, F., Peters, A. & Lieb, W. J Cardiovasc Magn Reson. 23, 2, (2021)

The Multiple Options of Left Atrial and Ventricular Venting During Veno-Arterial Extra-Corporeal Membrane Oxygenation: Practical Considerations. Lüsebrink, E., Massberg, S. & Orban, M. Eur Heart J. (2021)

Cognitive Impairment in Patients with Atrial Fibrillation: Implications for Outcome in a Cohort Study. Malavasi, V. L., Zoccali, C., Brandi, M. C., Micali, G., Vitolo, M., Imberti, J. F., Mussi, C., Schnabel, R. B., Freedman, B. & Boriani, G. Int J Cardiol. 323, 83-89, (2021)

Low Serum Vitamin D Level Associated with Incident Advanced Liver Disease in the General Population - a Prospective Study. Männistö, V., Jääskeläinen, T., Färkkilä, M., Jula, A., Männistö, S., Lundqvist, A., Zeller, T., Blankenberg, S., Salomaa, V., Perola, M. & Åberg, F. Scand J Gastroenterol. 1-5, (2021)

Trend-Db-a Transcriptome-Wide Atlas of the Dynamic Landscape of Alternative Polyadenylation. Marini, F., Scherzinger, D. & Danckwardt, S. Nucleic Acids Res. 49, D243-d53, (2021)

Impact of Chronic Kidney Disease in 29 893 Patients Undergoing Transcatheter or Surgical Aortic Valve Replacement from the German Aortic Valve Registry. Mas-Peiro, S., Faerber, G., Bon, D., Herrmann, E., Bauer, T., Bleiziffer, S., Bekeredjian, R., Böning, A., Frerker, C., Beckmann, A., Möllmann, H., Vasa-Nicotera, M., Ensminger, S., Hamm, C. W., Beyersdorf, F., Fichtlscherer, S. & Walther, T. Eur J Cardiothorac Surg. (2021)

Mental Disorders and Cardiovascular Disease: What Should We Be Looking out For? Michal, M. & Beutel, M. Heart. (2021)

Current Use of Cardiac Magnetic Resonance in Tertiary Referral Centres for the Diagnosis of Cardiomyopathy: The Esc Eorp Cardiomyopathy/Myocarditis Registry. Mizia-Stec, K., Charron, P., Gimeno Blanes, J. R., Elliott, P., Kaski, J. P., Maggioni, A. P., Tavazzi, L., Tendera, M., Felix, S. B., Dominguez, F., Ojrzynska, N., Losi, M. A., Limongelli, G., Barriales-Villa, R., Seferovic, P. M., Biagini, E., Wybraniec, M., Laroche, C. & Caforio, A. L. P. Eur Heart J Cardiovasc Imaging. (2021)

Effects of Statins on Mitochondrial Pathways. Mollazadeh, H., Tavana, E., Fanni, G., Bo, S., Banach, M., Pirro, M., von Haehling, S., Jamialahmadi, T. & Sahebkar, A. J Cachexia Sarcopenia Muscle. (2021)

Hybrid Arch Repair for Acute Type a Aortic Dissection: A New Concept and Step-by-Step Procedure. Montagner, M., Kofler, M., Buz, S. & Kempfert, J. Interact Cardiovasc Thorac Surg. (2021)

Interdisciplinary Management of Acute Ischaemic Stroke: Current Evidence Training Requirements for Endovascular Stroke Treatment: Position Paper from the Esc Council on Stroke and the European Association for Percutaneous Cardiovascular Interventions with the Support of the European Board of Neurointervention. Nardai, S., Lanzer, P., Abelson, M., Baumbach, A., Doehner, W., Hopkins, L. N., Kovac, J., Meuwissen, M., Roffi, M., Sievert, H., Skrypnik, D., Sulzenko, J., van Zwam, W., Gruber, A., Ribo, M., Cognard, C., Szikora, I., Flodmark, O. & Widimsky, P. Eur Heart J. 42, 298-307, (2021)

Gender Score Development in the Berlin Aging Study Ii: A Retrospective Approach. Nauman, A. T., Behlouli, H., Alexander, N., Kendel, F., Drewelies, J., Mantantzis, K., Berger, N., Wagner, G. G., Gerstorf, D., Demuth, I., Pilote, L. & Regitz-Zagrosek, V. Biol Sex Differ. 12, 15, (2021)

Surgical Implantation Techniques of Modern Continuous Flow Ventricular Assist Devices. Nersesian, G., Potapov, E., Starck, C. T., Nazari-Shafti, T. Z., Kofler, M., Kempfert, J., Falk, V. & Van Praet, K. M. Surg Technol Int. 38, (2021)

Endothelial Barrier Function after Stenting: Science-Fiction or Relevant Endpoint? Nicol, P. & Joner, M. Cardiovasc Revasc Med. (2021)

Association of Proton Pump Inhibitor Use with Endothelial Function and Metabolites of the Nitric Oxide Pathway: A Cross-Sectional Study. Nolde, M., Bahls, M., Friedrich, N., Dörr, M., Dreischulte, T., Felix, S. B., Rückert-Eheberg, I. M., Ahn, N., Amann, U., Schwedhelm, E., Völzke, H., Lerch, M. M., Linseisen, J., Meisinger, C. & Baumeister, S. E. Pharmacotherapy. (2021)

Molecular Mechanism of Autosomal Recessive Long Qt-Syndrome 1 without Deafness. Oertli, A., Rinné, S., Moss, R., Kääb, S., Seemann, G., Beckmann, B. M. & Decher, N. Int J Mol Sci. 22, (2021)

Improving Translational Research in Sex-Specific Effects of Comorbidities and Risk Factors in Ischaemic Heart Disease and Cardioprotection: Position Paper and Recommendations of the Esc Working Group on Cellular Biology of the Heart. Perrino, C., Ferdinandy, P., Bøtker, H. E., Brundel, B., Collins, P., Davidson, S. M., den Ruijter, H. M., Engel, F. B., Gerdts, E., Girao, H., Gyöngyösi, M., Hausenloy, D. J., Lecour, S., Madonna, R., Marber, M., Murphy, E., Pesce, M., Regitz-Zagrosek, V., Sluijter, J. P. G., Steffens, S., Gollmann-Tepeköylü, C., Van Laake, L. W., Van Linthout, S., Schulz, R. & Ytrehus, K. Cardiovasc Res. 117, 367-85, (2021)

History of Acute Coronary Syndrome: A Common, Maybe Underestimated, Risk Factor for Heart Failure with Preserved Ejection Fraction. Pieske, B. & Morris, D. A. Rev Esp Cardiol (Engl Ed). (2021)

Sex-Related Differences in D-Dimer Levels for Venous Thromboembolism Screening. Reagh, J. J., Zheng, H., Stolz, U., Parry, B. A., Chang, A. M., House, S. L., Giordano, N. J., Cohen, J., Singer, A. J., Francis, S., Prochaska, J. H., Zeserson, E., Wild, P. S., Limkakeng, A. T., Jr., Walters, E. L., LoVecchio, F., Theodoro, D., Hollander, J. E., Kabrhel, C. & Fermann, G. J. Acad Emerg Med. (2021)

Age- and Gender-Related Reference Values of Cardiac Morphology and Function in Cardiovascular Magnetic Resonance. Riffel, J. H., Mayo, R., Mueller-Hennessen, M., Giannitsis, E., Katus, H. A. & Andre, F. Int J Cardiovasc Imaging. (2021)

Health-Related Quality of Life, Anxiety and Depression up to 12 months Post-Stroke: Influence of Sex, Age, Stroke Severity and Atrial Fibrillation - a Longitudinal Subanalysis of the Find-Af(Randomised) Trial. Sadlonova, M., Wasser, K., Nagel, J., Weber-Krüger, M., Gröschel, S., Uphaus, T., Liman, J., Hamann, G. F., Kermer, P., Gröschel, K., Herrmann-Lingen, C. & Wachter, R. J Psychosom Res. 142, 110353, (2021)

Immune Cell-Based Cardiovascular Risk Assessment: Spotlight on the Neutrophil-Lymphocyte Ratio. Sager, H. B. & Koenig, W. Eur Heart J. (2021)

When Big Eaters Stop Feasting: Loss of Metabolic Control in Macrophages Exacerbates Hypertension in Obesity. Schäfer, K. & Wenzel, P. Cardiovasc Res. 117, 351-53, (2021)

Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution. Schlein, C., Fischer, A. W., Sass, F., Worthmann, A., Tödter, K., Jaeckstein, M. Y., Behrens, J., Lynes, M. D., Kiebish, M. A., Narain, N. R., Bussberg, V., Darkwah, A., Jespersen, N. Z., Nielsen, S., Scheele, C., Schweizer, M., Braren, I., Bartelt, A., Tseng, Y. H., Heeren, J. & Scheja, L. Cell Rep. 34, 108624, (2021)

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