Vascular Regeneration/Remodelling


Förderkennzeichen

81Z1600211

Projektnummer

432

Institution
Klinikum der Universität München
Projektleiter
Ulrich Pohl
Standort
München
Kurzbeschreibung

In this project we study the role of vascular connexins in remodelling processes. Using genetic connexin mutations their effect on of vascular on cell growth and migration and … 

In this project we study the role of vascular connexins in remodelling processes. Using genetic connexin mutations their effect on of vascular on cell growth and migration and heterocellular communication are analyzed. We further study the role endothelial mitochondrial impairment, cytoskeletal reorganization and altered smooth muscle calcium homeostasis on cellular migration in isolated cultured microvessels and a model of arteriogenesis. One of the targets is the AMP-activated kinase (AMPK) which establishes a close link to metabolic and inflammatory diseases and microvascular remodelling

Projektart
Standortprojekt
Stichwörter
smooth muscle, AMPK, connexins, cell migration, cytoskelton, podosomes, mitochnodrial impairment
Topic
vascular remodelling/altering
Fördersumme
€ 722.556,00
Beginn
15.10.2011
Ende
31.12.2018