Identification and Validation of Novel Inotropy-Enhancing Molecular Targets
- Förderkennzeichen
81Z2500205
- Projektnummer
468
- Institution
- Ruprecht-Karls-Universität Heidelberg
- Projektleiter
- Thomas Wieland
- Standort
- Heidelberg/Mannheim
- Kurzbeschreibung
-
In this project molecular targets in a novel positive inotropic pathway coupling M2 muscarinic receptors to RhoA/Rho-kinase in heart failure are characterized and validated. The so far …
In this project molecular targets in a novel positive inotropic pathway coupling M2 muscarinic receptors to RhoA/Rho-kinase in heart failure are characterized and validated. The so far identified targets are the Regulator of G-protein signaling RGS3, the RhoGTPase-actvating protein p190RhoGAP and the guanine nucleotide exchange factor Tiam1. Depending on the expression level of RGS3 this proteins allow for a switch of the coupling of M2 muscarinic receptors to a Rho-kinase dependent positive inotropic response in cardiac myocytes. Therefore, all three proteins are putative molecular targets for novel therapies in heart failure.
- Projektart
- Standortprojekt
- Stichwörter
- cardiac contractiliy,muscarinic receptors, RhoGTPases, RhoGTPase-activating proteins, RhoGTPase guanine nucleotide exchange factors,
- Topic
- cardiomyocyte function
- Fördersumme
- € 609.514,92
- Beginn
- 01.01.2015
- Ende
- 31.12.2018