Identification and Validation of Novel Inotropy-Enhancing Molecular Targets


Förderkennzeichen

81Z2500205

Projektnummer

468

Institution
Ruprecht-Karls-Universität Heidelberg
Projektleiter
Thomas Wieland
Standort
Heidelberg/Mannheim
Kurzbeschreibung

In this project molecular targets in a novel positive inotropic pathway coupling M2 muscarinic receptors to RhoA/Rho-kinase in heart failure are characterized and validated. The so far … 

In this project molecular targets in a novel positive inotropic pathway coupling M2 muscarinic receptors to RhoA/Rho-kinase in heart failure are characterized and validated. The so far identified targets are the Regulator of G-protein signaling RGS3, the RhoGTPase-actvating protein p190RhoGAP and the guanine nucleotide exchange factor Tiam1. Depending on the expression level of RGS3 this proteins allow for a switch of the coupling of M2 muscarinic receptors to a Rho-kinase dependent positive inotropic response in cardiac myocytes. Therefore, all three proteins are putative molecular targets for novel therapies in heart failure.

Projektart
Standortprojekt
Stichwörter
cardiac contractiliy,muscarinic receptors, RhoGTPases, RhoGTPase-activating proteins, RhoGTPase guanine nucleotide exchange factors,
Topic
cardiomyocyte function
Fördersumme
€ 611.112,45
Beginn
01.01.2015
Ende
31.12.2018