Oxidative post-translational modifications in cardiovascular disease


Förderkennzeichen

81Z2710106

Projektnummer

483

Institution
Universitätsklinikum Hamburg-Eppendorf
Projektleiter
Friederike Cuello
Standort
Hamburg/Kiel/Lübeck
Kurzbeschreibung

The group‘s research aims to increase the understanding of the molecular mechanisms of heart failure. In particular, we study how signals from the sympathetic nervous system are … 

The group‘s research aims to increase the understanding of the molecular mechanisms of heart failure. In particular, we study how signals from the sympathetic nervous system are transduced into the cardiac myocyte, which processes are subsequently triggered and what molecular alterations occur during heart failure development. Over the past years, we have concentrated our attention on the redox-regulation of protein kinase signalling and the effect on posttranslational regulation of kinases and their substrates. Through this, we have recently established disease-specific posttranslational fingerprints of the myofilament proteome in human heart failure tissue by combining interdisciplinary techniques such as molecular biology and redox-proteomics analyses.

Projektart
Standortprojekt
Stichwörter
Signalling pathways in cardiovascular disease, Protein kinase, Redox regulation
Topic
cardiomyocyte function
Fördersumme
€ 378.759,90
Beginn
29.10.2014
Ende
31.12.2018