Risk factor patterns associated with systolic and diastolic left ventricular dysfunction


Förderkennzeichen

81Z3400131

Projektnummer

492

Institution
Universitätsmedizin Greifswald
Projektleiter
Marcus Dörr
Standort
Greifswald
Kurzbeschreibung

The aim of this project is to identify risk profiles which are associated with the development of systolic and diastolic left ventricular dysfunction (HFrEF/ HFpEF). Based on … 

The aim of this project is to identify risk profiles which are associated with the development of systolic and diastolic left ventricular dysfunction (HFrEF/ HFpEF). Based on populations-based data new knowledge should be generated regarding the general population. Furthermore patient cohorts (GANI_MED) in an early asymptomatic disease stage shall be investigated to identify factors and mechanisms which indicate or lead to the transition to symptomatic heart failure. Generated hypotheses will be validated and further investigated by cell and animal model based experimental approaches. The major aim is to identify new targets and mechanisms that can be tackled in new prevention and therapeutic approaches in early stages of heart failure to inhibit disease progression.

Projektart
Standortprojekt
Stichwörter
heart failure, HFrEF, HFpEF, risk profiles biomarker, animal models, TAC, cell culture
Topic
cardiomyocyte function
Fördersumme
€ 1.476.780,81
Beginn
01.01.2012
Ende
31.12.2018