Individualized Tools for Life style Intervention in Patients with Chronic Heart Failure [Secondary Prevention]


Förderkennzeichen

81Z5400153

Projektnummer

502

Institution
Universitätsmedizin Greifswald
Projektleiter
Marcus Dörr
Standort
Greifswald
Kurzbeschreibung

This projects aims to develop new life-style intervention approaches for secondary prevention of heart failure (HFrEF/HFpEF) and coronary heart disease. Pilotstudies will investigate the … 

This projects aims to develop new life-style intervention approaches for secondary prevention of heart failure (HFrEF/HFpEF) and coronary heart disease. Pilotstudies will investigate the effects of life-style changes mainly exercise training on cardiovascular surrogate parameters and disease progression. Additionally, intervention-related biomarkers shall be investigated using transcriptomics, proteomics and metabolomics (urine, plasma, whole blood) which can be used as monitoring factors during intervention or as predictive factors for disease progression. The major aim is to find suitable surrogate paramters which can be easily implemented into large prevention RCTs and can be used to amplify the positive effects of life-style changes by increasing motivation and therapy complience and adherence. A W2 professorship for molecular cardiology will be established to support the investigation of prevention approaches and to interact with and support the other partner site projects.

Projektart
Standortprojekt
Stichwörter
exercise training, secondary prevention, biomarker profiles, heart failure, molecular cardiology
Topic
Inflammatory heart diseases
Fördersumme
€ 1.319.066,03
Beginn
01.01.2012
Ende
31.12.2018