Platform Reprogramming


Förderkennzeichen

81Z7600671

Projektnummer

534

Institution
Klinikum rechts der Isar der Technischen Universität München
Projektleiter
Laugwitz/Moretti
Standort
München
Kurzbeschreibung

The focus of this project is the generation of patient-specific models of monogenic and complex cardiovascular diseases using induced pluripotent stem cells (iPSCs) in order to study the … 

The focus of this project is the generation of patient-specific models of monogenic and complex cardiovascular diseases using induced pluripotent stem cells (iPSCs) in order to study the molecular pathways that drive the disease and screen for both genes and drugs that can block the disease onset or progression at a cellular level. We work on optimization of reprogramming methods and differentiation protocols into the cardiovascular lineages as well as the development of high-throughput functional assays and CRISPR/Cas9-based genome editing in iPSCs.

Projektart
Standortprojekt
Stichwörter
induced pluripotent stem cells, disease modelling, drug/intervention testing
Topic
iPSC
Fördersumme
€ 725.269,93
Beginn
15.10.2011
Ende
31.12.2018