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Zu den DZHK Papers of the Month


Periprocedural Changes of Nt-Probnp Are Associated with Survival after Transcatheter Aortic Valve Implantation. Seoudy, H., Frank, J., Neu, M., Gussefeld, N., Klaus, Y., Freitag-Wolf, S., Lambers, M., Lutter, G., Dempfle, A., Rangrez, A. Y., Kuhn, C., Frey, N. & Frank, D. Journal of the American Heart Association 8, e010876, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30686097  

Somatic and Sociodemographic Predictors of Depression Outcome among Depressed Patients with Coronary Artery Disease - a Secondary Analysis of the Spirr-Cad Study. Vitinius, F., Escherich, S., Deter, H.-C., Hellmich, M., Junger, J., Petrowski, K., Ladwig, K.-H., Lambertus, F., Michal, M., Weber, C., de Zwaan, M., Herrmann-Lingen, C., Ronel, J. & Albus, C. BMC Psychiatry 19, (2019). https://bmcpsychiatry.biomedcentral.com/articles/10.1186/s12888-019-2026-6

Preserved Cardiovascular Homeostasis Despite Blunted Acetylcholine-Induced Dilation in Mice with Endothelial Muscarinic M3 Receptor Deletion. Rhoden, A., Speiser, J., Geertz, B., Uebeler, J., Kjestine, S., de Wit, C. & Eschenhagen, T. Acta physiologica, e13262, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30716211  

Atypical Chemokine Receptors in Cardiovascular Disease. Gencer, S., van der Vorst, E. P. C., Aslani, M., Weber, C., Doring, Y. & Duchene, J. Thrombosis and haemostasis, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30716778  

Towards Better Definition, Quantification and Treatment of Fibrosis in Heart Failure. A Scientific Roadmap by the Committee of Translational Research of the Heart Failure Association (Hfa) of the European Society of Cardiology. de Boer, R. A., De Keulenaer, G., Bauersachs, J., Brutsaert, D., Cleland, J. G., Diez, J., Du, X. J., Ford, P., Heinzel, F. R., Lipson, K. E., McDonagh, T., Lopez-Andres, N., Lunde, I. G., Lyon, A. R., Pollesello, P., Prasad, S. K., Tocchetti, C. G., Mayr, M., Sluijter, J. P. G., Thum, T. et al. European journal of heart failure, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30714667  

Altered Laryngeal Morphology in Period1 Deficient Mice. Bahlmann, O., Schurmann, C. & Marond, E. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30716467   

Novel Features of Monocytes and Macrophages in Cardiovascular Biology and Disease. van der Vorst, E. P. C. & Weber, C. Arteriosclerosis, thrombosis, and vascular biology 39, e30-e37, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30673349  

Plasmid-Mediated Transmission of Kpc-2 Carbapenemase in Enterobacteriaceae in Critically Ill Patients. Schweizer, C., Bischoff, P., Bender, J. K., Kola, A., Gastmeier, P., Hummel, M., Klefisch, F.-R., Schoenrath, F., Fruhauf, A. & Pfeifer, Y. Front. Microbiol., (2019). https://www.frontiersin.org/articles/10.3389/fmicb.2019.00276/abstract  

Response To: Soluble Regulators of Interleukin-1 Signaling: Novel Biomarkers for Early Acute Myocardial Infarction Diagnosis and to Predict Ischemia/Reperfusion Injury? Schofer, N. & Zeller, T. International journal of cardiology 279, 32, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30704648  

Cholesterol-Lowering Agents. Rosenson, R. S., Hegele, R. A. & Koenig, W. Circulation research 124, 364-385, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30702994  

Impact of Chronic Obstructive Pulmonary Disease on the Outcomes of Patients with Peripheral Artery Disease. Keller, K., Hobohm, L., Munzel, T., Ostad, M. A. & Espinola-Klein, C. Respiratory medicine 147, 1-6, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30704692



Sgk1-Dependent Stimulation of Vascular Smooth Muscle Cell Osteo-/Chondrogenic Transdifferentiation by Interleukin-18. Schelski, N., Luong, T. T. D., Lang, F., Pieske, B., Voelkl, J. & Alesutan, I. Pflugers Archiv : European journal of physiology, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30706178  

Gender-Based Comparison of Takotsubo Syndrome Versus Patients with Myocardial Infarction. Giannakopoulos, K., El-Battrawy, I., Gietzen, T., Ansari, U., Borggrefe, M. & Akin, I. QJM : monthly journal of the Association of Physicians, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30715499  

Myocardial Injury in Transient Global Amnesia: A Case-Control Study. Erdur, H., Siegerink, B., Ganeshan, R., Audebert, H. J., Endres, M., Nolte, C. H. & Scheitz, J. F. European journal of neurology, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30706590  

Assessing Planning Ability across the Adult Life Span in a Large Population-Representative Sample: Reliability Estimates and Normative Data for the Tower of London (Tol-F) Task. Unterrainer, J. M., Rahm, B., Kaller, C. P., Wild, P. S., Munzel, T., Blettner, M., Lackner, K., Pfeiffer, N. & Beutel, M. E. Journal of the International Neuropsychological Society : JINS, 1-10, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30696511  

Impact of Different Pharmacotherapies on Long-Term Outcomes in Patients with Electrical Storm. Schupp, T., Behnes, M., Ellguth, D., Muller, J., Reiser, L., Bollow, A., Taton, G., Reichelt, T., Engelke, N., Kim, S. H., Nienaber, C., Akin, M., Mashayekhi, K., Bertsch, T., Borggrefe, M. & Akin, I. Pharmacology 103, 179-188, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30695778

Pcsk9: A Link between Air Pollution and Cardiovascular Disease? Prochaska, J. H., Trobs, S. O. & Wild, P. S. European journal of preventive cardiology, 2047487319827726, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30696261  

Avoidance of Outflow Graft Extrinsic Compression in Polytetrafluoroethylene Reinforcements of the Bend Relief Component. Potapov, E., Kaufmann, F., Mueller, M., Mulzer, J., Starck, C. & Falk, V. The Journal of Heart and Lung Transplantation, (2019). https://www.jhltonline.org/article/S1053-2498(19)31341-5/abstract  

Biglycan Evokes Autophagy in Macrophages Via a Novel Cd44/Toll-Like Receptor 4 Signaling Axis in Ischemia/Reperfusion Injury. Poluzzi, C., Nastase, M. V., Zeng-Brouwers, J., Roedig, H., Hsieh, L. T., Michaelis, J. B., Buhl, E. M., Rezende, F., Manavski, Y., Bleich, A., Boor, P., Brandes, R. P., Pfeilschifter, J., Stelzer, E. H. K., Munch, C., Dikic, I., Brandts, C., Iozzo, R. V., Wygrecka, M. & Schaefer, L. Kidney international, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30712922  

Biam Switch Assay Coupled to Mass Spectrometry Identifies Novel Redox Targets of Nadph Oxidase 4. Lowe, O., Rezende, F., Heidler, J., Wittig, I., Helfinger, V., Brandes, R. P. & Schroder, K. Redox biology 21, 101125, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30716538  

Endothelial Calcineurin Signaling Restrains Metastatic Outgrowth by Regulating Bmp2. Hendrikx, S., Coso, S., Prat-Luri, B., Wetterwald, L., Sabine, A., Franco, C. A., Nassiri, S., Zangger, N., Gerhardt, H., Delorenzi, M. & Petrova, T. V. Cell reports 26, 1227-1241 e1226, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30699351  

Diurnal Variability of on-Treatment Platelet Reactivity in Clopidogrel Versus Prasugrel Treated Acute Coronary Syndrome Patients: A Pre-Specified Tropical-Acs Sub-Study. Freynhofer, M. K., Hein-Rothweiler, R., Haller, P. M., Aradi, D., Dezsi, D. A., Gross, L., Orban, M., Trenk, D., Geisler, T., Huczek, Z., Toth-Gayor, G. G., Massberg, S., Huber, K. & Sibbing, D. Thrombosis and haemostasis, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30695790  

Apoe Attenuates Unresolvable Inflammation by Complex Formation with Activated C1q. Yin, C., Ackermann, S., Ma, Z., Mohanta, S. K., Zhang, C., Li, Y., Nietzsche, S., Westermann, M., Peng, L., Hu, D., Bontha, S. V., Srikakulapu, P., Beer, M., Megens, R. T. A., Steffens, S., Hildner, M., Halder, L. D., Eckstein, H. H., Pelisek, J., Herms, J. et al. Nature medicine, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30692699   

Depression and Coronary Heart Disease: 2018 Esc Position Paper of the Working Group of Coronary Pathophysiology and Microcirculation Developed under the Auspices of the Esc Committee for Practice Guidelines. Vaccarino, V., Badimon, L., Bremner, J. D., Cenko, E., Cubedo, J., Dorobantu, M., Duncker, D. J., Koller, A., Manfrini, O., Milicic, D., Padro, T., Pries, A. R., Quyyumi, A. A., Tousoulis, D., Trifunovic, D., Vasiljevic, Z., de Wit, C., Bugiardini, R. & Reviewers, E. S. C. S. D. G. European heart journal, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30698764  

Physical Activity Tracking in Correlation to Conventional Heart Failure Monitoring Assessing Improvements after Transcatheter Mitral and Tricuspid Valve Repair. Stocker, T. J., Scheck, F., Orban, M., Braun, D., Hertell, H., Lackermair, K., Deseive, S., Mehr, M., Orban, M., Karam, N., Nabauer, M., Massberg, S. & Hausleiter, J. European journal of heart failure, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30690826  

Optimizing Platelet Gpvi Inhibition Versus Haemostatic Impairment by the Btk Inhibitors Ibrutinib, Acalabrutinib, Ono/Gs-4059, Bgb-3111 and Evobrutinib. Denzinger, V., Busygina, K., Jamasbi, J., Pekrul, I., Spannagl, M., Weber, C., Lorenz, R. & Siess, W. Thrombosis and haemostasis, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30685871  

Machine Learning Algorithms Estimating Prognosis and Guiding Therapy in Adult Congenital Heart Disease: Data from a Single Tertiary Centre Including 10 019 Patients. Diller, G. P., Kempny, A., Babu-Narayan, S. V., Henrichs, M., Brida, M., Uebing, A., Lammers, A. E., Baumgartner, H., Li, W., Wort, S. J., Dimopoulos, K. & Gatzoulis, M. A. European heart journal, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30689812  

Redox Regulation of Calpains: Consequences on Vascular Function. Randriamboavonjy, V., Kyselova, A. & Fleming, I. Antioxidants & redox signaling 30, 1011-1026, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30266074  

Relationship of Left Ventricular End-Diastolic Pressure with Extent of Myocardial Ischemia, Myocardial Salvage and Long-Term Outcome in Patients with St-Segment Elevation Myocardial Infarction. Ndrepepa, G., Cassese, S., Hashorva, D., Kufner, S., Xhepa, E., Hasimi, E., Fusaro, M., Laugwitz, K. L., Schunkert, H. & Kastrati, A. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30680881   

Transfemoral Implantation of the Acurate Neo Prosthesis Using a Low-Profile Expandable Introducer System: A Multicenter Registry. Kim, W. K., Brinkert, M., Mangner, N., Gatto, F., Husser, O., Renker, M., Liebetrau, C., Gasior, T., Doss, M., Walther, T., Hamm, C., Linke, A., Toggweiler, S. & Mollmann, H. International journal of cardiology, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30711266

Cardiovascular Magnetic Resonance Imaging Feature Tracking: Impact of Training on Observer Performance and Reproducibility. Backhaus, S. J., Metschies, G., Billing, M., Kowallick, J. T., Gertz, R. J., Lapinskas, T., Pieske, B., Lotz, J., Bigalke, B., Kutty, S., Hasenfuss, G., Beerbaum, P., Kelle, S. & Schuster, A. PloS one 14, e0210127, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30682045  

Genome-Wide Association Meta-Analysis of 30,000 Samples Identifies Seven Novel Loci for Quantitative Ecg Traits. van Setten, J., Verweij, N., Mbarek, H., Niemeijer, M. N., Trompet, S., Arking, D. E., Brody, J. A., Gandin, I., Grarup, N., Hall, L. M., Hemerich, D., Lyytikainen, L. P., Mei, H., Muller-Nurasyid, M., Prins, B. P., Robino, A., Smith, A. V., Warren, H. R., Asselbergs, F. W., Boomsma, D. I. et al. European journal of human genetics : EJHG, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30679814  

Body Weight Changes and Incidence of Cachexia after Stroke. Scherbakov, N., Pietrock, C., Sandek, A., Ebner, N., Valentova, M., Springer, J., Schefold, J. C., von Haehling, S., Anker, S. D., Norman, K., Haeusler, K. G. & Doehner, W. J Cachexia Sarcopenia Muscle, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30680953  

Physical Activity and Sex Hormone-Binding Globulin in Older Adults. Rothenbacher, D., Dallmeier, D., Denkinger, M. D., Boehm, B. O., Koenig, W., Klenk, J. & Acti, F. E. S. G. Journal of aging and physical activity, 1-13, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30676188  

High-Throughput Single-Cell Rheology in Complex Samples by Dynamic Real-Time Deformability Cytometry. Fregin, B., Czerwinski, F., Biedenweg, D., Girardo, S., Gross, S., Aurich, K. & Otto, O. Nature communications 10, 415, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30679420  

Synergy of Pulmonary Vein Isolation and Catheter Renal Denervation in Atrial Fibrillation Complicated with Uncontrolled Hypertension: Mapping the Renal Sympathetic Nerve and Pulmonary Vein (the Pulmonary Vein Isolation Plus Renal Denervation Strategy)? Chen, S., Kiuchi, M. G., Yin, Y., Liu, S., Schratter, A., Acou, W. J., Meyer, C., Purerfellner, H., Chun, K. R. J. & Schmidt, B. Journal of cardiovascular electrophysiology, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30680830  

Mutation-Induced Alterations of Intra-Filament Subunit Organization in Vimentin Filaments Revealed by Saxs. Brennich, M. E., Vainio, U., Wedig, T., Bauch, S., Herrmann, H. & Koster, S. The Royal Society of Chemistry, (2019). https://pubs.rsc.org/en/content/articlehtml/2019/sm/c8sm02281j  

An Integrative Systems Approach Identifies Novel Candidates in Marfan Syndrome-Related Pathophysiology. Bhushan, R., Altinbas, L., Jager, M., Zaradzki, M., Lehmann, D., Timmermann, B., Clayton, N. P., Zhu, Y., Kallenbach, K., Kararigas, G. & Robinson, P. N. Journal of cellular and molecular medicine, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30677223  

Macrophage Migration Inhibitory Factor (Mif) Expression Increases During Myocardial Infarction and Supports Pro-Inflammatory Signaling in Cardiac Fibroblasts. Voss, S., Kruger, S., Scherschel, K., Warnke, S., Schwarzl, M., Schrage, B., Girdauskas, E., Meyer, C., Blankenberg, S., Westermann, D. & Lindner, D. Biomolecules 9, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30678084  

Methylation of the Fkbp5 Gene in Association with Fkbp5 Genotypes, Childhood Maltreatment and Depression. Klinger-Konig, J., Hertel, J., Van der Auwera, S., Frenzel, S., Pfeiffer, L., Waldenberger, M., Golchert, J., Teumer, A., Nauck, M., Homuth, G., Volzke, H. & Grabe, H. J. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, (2019). www.ncbi.nlm.nih.gov/pubmed/30700816

Predictors of New Remote Cerebral Microbleeds after Iv Thrombolysis for Ischemic Stroke. Braemswig, T. B., Villringer, K., Turc, G., Erdur, H., Fiebach, J. B., Audebert, H. J., Endres, M., Nolte, C. H. & Scheitz, J. F. Neurology, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30674591  

Cardiac Pet/Mri—an Update. Rischpler, C., Nekolla, S. G., Heusch, G., Umutlu, L., Rassaf, T., Heusch, P., Herrmann, K. & Nensa, F. European Journal of Hybrid Imaging, (2019). https://ejhi.springeropen.com/articles/10.1186/s41824-018-0050-2  

Therapeutic Hypothermia after Perinatal Asphyxia in Infants with Severe, Ductal-Dependent Congenital Heart Disease. Boos, V., Tietze, A., Berger, F. & Buhrer, C. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30676491  

Targeting Mannose Receptor Expression on Macrophages in Atherosclerotic Plaques of Apolipoprotein E-Knockout Mice Using (68)Ga-Nota-Anti-Mmr Nanobody: Non-Invasive Imaging of Atherosclerotic Plaques. Varasteh, Z., Mohanta, S., Li, Y., Lopez Armbruster, N., Braeuer, M., Nekolla, S. G., Habenicht, A., Sager, H. B., Raes, G., Weber, W., Hernot, S. & Schwaiger, M. EJNMMI research 9, 5, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30666513  

A Neutrophil Timer Coordinates Immune Defense and Vascular Protection. Adrover, J. M., Del Fresno, C., Crainiciuc, G., Cuartero, M. I., Casanova-Acebes, M., Weiss, L. A., Huerga-Encabo, H., Silvestre-Roig, C., Rossaint, J., Cossio, I., Lechuga-Vieco, A. V., Garcia-Prieto, J., Gomez-Parrizas, M., Quintana, J. A., Ballesteros, I., Martin-Salamanca, S., Aroca-Crevillen, A., Chong, S. Z., Evrard, M., Balabanian, K. et al. Immunity, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30709741  

Lipid-Independent Control of Endothelial and Neuronal Trpc3 Channels by Light Tiapko, O., Shrestha, N., Lindinger, S., Guedes de la Cruz, G., Graziani, A., Klec, C., Butorac, C., Graier, W. F., Kubista, H., Freichel, M., Birnbaumer, L., Romanin, C., Glasnov, T. & Groschner, K. Chem. Sci., (2019). https://pubs.rsc.org/en/content/articlelanding/2019/sc/c8sc05536j#!divAbstract  

Novel Approach for in Vivo Detection of Vulnerable Coronary Plaques Using Molecular 3-T Cmr Imaging with an Albumin-Binding Probe. Engel, L. C., Landmesser, U., Gigengack, K., Wurster, T., Manes, C., Girke, G., Jaguszewski, M., Skurk, C., Leistner, D. M., Lauten, A., Schuster, A., Hamm, B., Botnar, R. M., Makowski, M. R. & Bigalke, B. JACC. Cardiovascular imaging, (2018). http://www.ncbi.nlm.nih.gov/pubmed/29361487  

Control of Leukocyte Trafficking by Stress-Associated Hormones. Ince, L. M., Weber, J. & Scheiermann, C. Frontiers in immunology 9, 3143, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30687335  

Identification of Functional Protein Regions through Chimeric Protein Construction. Adrian-Segarra, J. M., Lorchner, H., Braun, T. & Poling, J. Journal of visualized experiments : JoVE, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30688304  

Impact of Atrial Fibrillation on in-Hospital Mortality of Ischemic Stroke Patients and Identification of Promoting Factors of Atrial Thrombi - Results from the German Nationwide Inpatient Sample and a Single-Center Retrospective Cohort. Keller, K., Geyer, M., Munzel, T., Ostad, M. A. & Gori, T. Medicine 98, e14086, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30681566  

Novel Features of Monocytes and Macrophages in Cardiovascular Biology and Disease. van der Vorst, E. P. C. & Weber, C. Arteriosclerosis, thrombosis, and vascular biology 39, e30-e37, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30673349  

Assessment of the Relationship between Genetic Determinants of Thyroid Function and Atrial Fibrillation: A Mendelian Randomization Study. Ellervik, C., Roselli, C., Christophersen, I. E., Alonso, A., Pietzner, M., Sitlani, C. M., Trompet, S., Arking, D. E., Geelhoed, B., Guo, X., Kleber, M. E., Lin, H. J., Lin, H., MacFarlane, P., Selvin, E., Shaffer, C., Smith, A. V., Verweij, N., Weiss, S., Cappola, A. R. et al. JAMA cardiology, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30673084

U-Shaped Association of Central Pulse Pressure with Long-Term Prognosis after St-Segment Elevation Myocardial Infarction. Ndrepepa, G., Cassese, S., Kufner, S., Xhepa, E., Fusaro, M., Laugwitz, K. L., Schunkert, H. & Kastrati, A. Heart and vessels, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30671640

Multi-Ancestry Study of Blood Lipid Levels Identifies Four Loci Interacting with Physical Activity. Kilpelainen, T. O., Bentley, A. R., Noordam, R., Sung, Y. J., Schwander, K., Winkler, T. W., Jakupovic, H., Chasman, D. I., Manning, A., Ntalla, I., Aschard, H., Brown, M. R., de Las Fuentes, L., Franceschini, N., Guo, X., Vojinovic, D., Aslibekyan, S., Feitosa, M. F., Kho, M., Musani, S. K. et al. Nature communications 10, 376, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30670697  

Coronary Chronic Total Occlusions Represent an Independent Predictor of Mortality in Ventricular Tachyarrhythmias. Behnes, M., Akin, I., Kuche, P., Schupp, T., Reiser, L., Bollow, A., Taton, G., Reichelt, T., Ellguth, D., Engelke, N., El-Battrawy, I., Lang, S., Brilakis, E. S., Azzalini, L., Galassi, A. R., Boukhris, M., Neuser, H., Neumann, F. J., Nienaber, C., Weiss, C. et al. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30666964  

The Dedicate Trial: An Independent All-Comers Trial of Transcatheter Aortic Valve Implantation Vs. Surgical Aortic Valve Replacement in Patients at Low to Intermediate Operative Risk Is Recruiting Patients. Seiffert, M., Walther, T., Hamm, C., Falk, V., Frey, N., Thiele, H., Hagl, C., Landmesser, U., Borger, M., Massberg, S., Reichenspurner, H., Baumgartner, H., Blankenberg, S. & Cremer, J. European heart journal 40, 331-333, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30668699  

Atrial Fibrosis in Non-Atrial Fibrillation Individuals and Prediction of Atrial Fibrillation by Use of Late Gadolinium Enhancement (Lge) Mri. Siebermair, J., Suksaranjit, P., McGann, C. J., Peterson, K. A., Kheirkhahan, M., Baher, A. A., Damal, K., Wakili, R., Marrouche, N. F. & Wilson, B. D. Journal of cardiovascular electrophysiology, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30661270  

Protein Kinase a-Mediated Novel Serine 584 Phosphorylation of Hdac4. Doddi, S. K., Kummari, G., M, V. J. & Kalle, A. M. Biochemistry and cell biology = Biochimie et biologie cellulaire, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30661366  

Transcatheter Valve-in-Valve and Valve-in-Ring Interventions for Failing Bioprostheses and Annuloplasty Rings. Kofler, M., Unbehaun, A., Klein, C., Meyer, A., Buz, S., Hommel, M., Falk, V. & Kempfert, J. Surgical technology international 34, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30664224

E47 Modulates Hepatic Glucocorticoid Action. Hemmer, M. C., Wierer, M., Schachtrup, K., Downes, M., Hubner, N., Evans, R. M. & Uhlenhaut, N. H. Nature communications 10, 306, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30659202  

Amino Acids and Their Metabolism in Atherosclerosis. Nitz, K., Lacy, M. & Atzler, D. Arteriosclerosis, thrombosis, and vascular biology, ATVBAHA118311572, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30650999  

Esc Working Group on Cellular Biology of the Heart: Tissue Engineering and Cell-Based Therapies for Cardiac Repair in Ischemic Heart Disease and Heart Failure. Madonna, R., Van Laake, L. W., Botker, H. E., Davidson, S. M., De Caterina, R., Engel, F. B., Eschenhagen, T., Fernandez-Aviles, F., Hausenloy, D. J., Hulot, J. S., Lecour, S., Leor, J., Menasche, P., Pesce, M., Perrino, C., Prunier, F., Van Linthout, S., Ytrehus, K., Zimmermann, W. H., Ferdinandy, P. et al. Cardiovascular research, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30657875  

Dynamic Changes of Cardiac Repolarization Instability During Exercise Testing. Hamm, W., von Stulpnagel, L., Rizas, K. D., Vdovin, N., Klemm, M., Bauer, A. & Brunner, S. Medicine and science in sports and exercise, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30664030  

Flawed Methods and Inappropriate Conclusions for Health Policy on Overweight and Obesity: The Global Bmi Mortality Collaboration Meta-Analysis. Flegal, K. M., Ioannidis, J. P. A. & Doehner, W. J Cachexia Sarcopenia Muscle, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30656860  

Cardiovascular Risk Factors Associated with Venous Thromboembolism. Gregson, J., Kaptoge, S., Bolton, T., Pennells, L., Willeit, P., Burgess, S., Bell, S., Sweeting, M., Rimm, E. B., Kabrhel, C., Zoller, B., Assmann, G., Gudnason, V., Folsom, A. R., Arndt, V., Fletcher, A., Norman, P. E., Nordestgaard, B. G., Kitamura, A., Mahmoodi, B. K. et al. JAMA cardiology, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30649175  

Cardiac Contractility Modulation Improves Long-Term Survival and Hospitalizations in Heart Failure with Reduced Ejection Fraction. Anker, S. D., Borggrefe, M., Neuser, H., Ohlow, M. A., Roger, S., Goette, A., Remppis, B. A., Kuck, K. H., Najarian, K. B., Gutterman, D. D., Rousso, B., Burkhoff, D. & Hasenfuss, G. European journal of heart failure, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30652394

Midkine Drives Cardiac Inflammation by Promoting Neutrophil Trafficking and Netosis in Myocarditis. Weckbach, L. T., Grabmaier, U., Uhl, A., Gess, S., Boehm, F., Zehrer, A., Pick, R., Salvermoser, M., Czermak, T., Pircher, J., Sorrelle, N., Migliorini, M., Strickland, D. K., Klingel, K., Brinkmann, V., Abu Abed, U., Eriksson, U., Massberg, S., Brunner, S. & Walzog, B. The Journal of experimental medicine, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30647120  

Sodium in the Microenvironment Regulates Immune Responses and Tissue Homeostasis. Muller, D. N., Wilck, N., Haase, S., Kleinewietfeld, M. & Linker, R. A. Nature reviews. Immunology, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30644452   

En-Bloc Aspiration of a Giant Lung Embolism. Gori, T. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30636677  

Procedural Predictors for Bioresorbable Vascular Scaffold Thrombosis: Analysis of the Individual Components of the "Psp" Technique. Dimitriadis, Z., Polimeni, A., Anadol, R., Geyer, M., Weissner, M., Ullrich, H., Munzel, T. & Gori, T. Journal of clinical medicine 8, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30650586  

Exercise Training for Patients with Type 2 Diabetes and Cardiovascular Disease: What to Pursue and How to Do It. A Position Paper of the European Association of Preventive Cardiology (Eapc). Kemps, H., Krankel, N., Dorr, M., Moholdt, T., Wilhelm, M., Paneni, F., Serratosa, L., Ekker Solberg, E., Hansen, D., Halle, M., Guazzi, M. & European Association of Preventive, C. European journal of preventive cardiology, 2047487318820420, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30642190  

Reply: Impact of Diabetes on Coronary Artery Plaque Volume by Coronary Ct Angiography and Subsequent Adverse Cardiac Events. Deseive, S. & Hausleiter, J. Journal of cardiovascular computed tomography, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30665878  

Cachexia as a Common Characteristic in Multiple Chronic Disease. Scherbakov, N. & Doehner, W. Journal of Cachexia, Sarcopenia and Muscle, (2019). https://onlinelibrary.wiley.com/doi/full/10.1002/jcsm.12388  

Angiotensin-(1-7) Receptor Mas in Hemodynamic and Thermoregulatory Dysfunction after High-Level Spinal Cord Injury in Mice: A Pilot Study. Jarve, A., Todiras, M., Kny, M., Fischer, F. I., Kraemer, J. F., Wessel, N., Plehm, R., Fielitz, J., Alenina, N. & Bader, M. Front. Physiol., (2019). https://www.frontiersin.org/articles/10.3389/fphys.2018.01930/full  

Non-Enzymatic Cleavage of Hsp90 by Oxidative Stress Leads to Actin Aggregate Formation: A Novel Gain-of-Function Mechanism. Castro, J. P., Fernando, R., Reeg, S., Meinl, W., Almeida, H. & Grune, T. Redox biology 21, 101108, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30660959  

Atrial Mechanics and Their Prognostic Impact in Takotsubo Syndrome: A Cardiovascular Magnetic Resonance Imaging Study. Backhaus, S. J., Stiermaier, T., Lange, T., Chiribiri, A., Uhlig, J., Freund, A., Kowallick, J. T., Gertz, R. J., Bigalke, B., Villa, A., Lotz, J., Hasenfuss, G., Thiele, H., Eitel, I. & Schuster, A. European heart journal cardiovascular Imaging, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30649241  

Methylglyoxal Evokes Acute Ca(2+) Transients in Distinct Cell Types and Increases Agonist-Evoked Ca(2+) Entry in Endothelial Cells Via Crac Channels. Sachdeva, R., Fleming, T., Schumacher, D., Homberg, S., Stilz, K., Mohr, F., Wagner, A. H., Tsvilovskyy, V., Mathar, I. & Freichel, M. Cell calcium 78, 66-75, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30658323  

[Arena-Project Atrial Fibrillation in the Rhein-Neckar Region]. Baumann, S., Grau, A., Senges, J., Schneider, S., Alonso, A., Katus, H. A., Thomas, D., Waldecker, B., Haass, M., Zahn, R., Zeymer, U., Akin, I., Kruska, M., Fischer, C. & Borggrefe, M. Herz, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30643922

OneYear Clinical Outcome of Angiography, Fractional Flow Reserve and Instantaneous WaveFree Ratio Guided Percutaneous Coronary Intervention: A PrismaCompliant MetaAnalysis. Baumann, S., Mueller, K. S. E., Hetjens, S., Eder, F., Schaefer, A. C., Becher, T., Borggrefe, M., Akin, I. & Lossnitzer, D. Experimental and Therapeutic Therapy, (2019). https://www.spandidos-publications.com/10.3892/etm.2019.7156

Endothelial Metabolism—More Complex (Iii) Than Previously Thought. Andrade, J. & Potente, M. Nature Metabolism, (2019). https://www.nature.com/articles/s42255-018-0019-2

Dpp10 Is a New Regulator of Nav1.5 Channels in Human Heart. Belau, F., Metzner, K., Christ, T., Ravens, U., Schaefer, M., Kunzel, S., Li, W., Wettwer, E., Dobrev, D., El-Armouche, A. & Kammerer, S. International journal of cardiology, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30638748

Association of Mutations Contributing to Clonal Hematopoiesis with Prognosis in Chronic Ischemic Heart Failure. Dorsheimer, L., Assmus, B., Rasper, T., Ortmann, C. A., Ecke, A., Abou-El-Ardat, K., Schmid, T., Brune, B., Wagner, S., Serve, H., Hoffmann, J., Seeger, F., Dimmeler, S., Zeiher, A. M. & Rieger, M. A. JAMA cardiology 4, 25-33, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30566180

Genetic Assessment of Potential Long-Term on-Target Side Effects of Pcsk9 (Proprotein Convertase Subtilisin/Kexin Type 9) Inhibitors. Nelson, C. P., Lai, F. Y., Nath, M., Ye, S., Webb, T. R., Schunkert, H. & Samani, N. J. Circulation. Genomic and precision medicine 12, e002196, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30645167

Antihypertensive Decapeptide from Cyanobacterium Spirulina Platensis. Munzel, T. & Daiber, A. Hypertension 73, 291-293, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30595126  

Posterior Reversible Encephalopathy Syndrome. Liman, T. G., Siebert, E. & Endres, M. Current opinion in neurology 32, 25-35, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30531559  

Mri-Based Assessment and Characterization of Epicardial and Paracardial Fat Depots in the Context of Impaired Glucose Metabolism and Subclinical Left-Ventricular Alterations. Rado, S. D., Lorbeer, R., Gatidis, S., Machann, J., Storz, C., Nikolaou, K., Rathmann, W., Hoffmann, U., Peters, A., Bamberg, F. & Schlett, C. L. The British journal of radiology, 20180562, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30633543  

Cardiovascular Comorbidities in Chronic Obstructive Pulmonary Disease (Copd)-Current Considerations for Clinical Practice. Trinkmann, F., Saur, J., Borggrefe, M. & Akin, I. Journal of clinical medicine 8, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30634565  

Utility of Machine Learning Algorithms in Assessing Patients with a Systemic Right Ventricle. Diller, G. P., Babu-Narayan, S., Li, W., Radojevic, J., Kempny, A., Uebing, A., Dimopoulos, K., Baumgartner, H., Gatzoulis, M. A. & Orwat, S. European heart journal cardiovascular Imaging, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30629127  

Amiodarone Treatment in the Early Phase of Acute Myocardial Infarction Protects against Ventricular Fibrillation in a Porcine Model. Sattler, S. M., Lubberding, A. F., Skibsbye, L., Jabbari, R., Wakili, R., Jespersen, T. & Tfelt-Hansen, J. Journal of cardiovascular translational research, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30617762  

The Homozygous K280n Troponin T Mutation Alters Cross-Bridge Kinetics and Energetics in Human Hcm. Piroddi, N., Witjas-Paalberends, E. R., Ferrara, C., Ferrantini, C., Vitale, G., Scellini, B., Wijnker, P. J. M., Sequiera, V., Dooijes, D., Dos Remedios, C., Schlossarek, S., Leung, M. C., Messer, A., Ward, D. G., Biggeri, A., Tesi, C., Carrier, L., Redwood, C. S., Marston, S. B., van der Velden, J. et al. The Journal of general physiology 151, 18-29, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30578328  

Proactive Multipurpose Health Risk Screening in Health Care Settings: Methods, Design, and Reach. Guertler, D., Moehring, A., Krause, K., Eck, S., Batra, A., Chenot, J. F., Freyer-Adam, J., Ulbricht, S., Rumpf, H. J., Bischof, G., John, U. & Meyer, C. International journal of methods in psychiatric research, e1760, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30614134  

A Randomized Trial of Everolimus-Based Quadruple Therapy Versus Standard Triple Therapy Early after Lung Transplantation. Gottlieb, J., Neurohr, C., Muller-Quernheim, J., Wirtz, H., Sill, B., Wilkens, H., Bessa, V., Knosalla, C., Porstner, M., Capusan, C. & Struber, M. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30615259  

Meta-Analysis of up to 622,409 Individuals Identifies 40 Novel Smoking Behaviour Associated Genetic Loci. Erzurumluoglu, A. M., Liu, M., Jackson, V. E., Barnes, D. R., Datta, G., Melbourne, C. A., Young, R., Batini, C., Surendran, P., Jiang, T., Adnan, S. D., Afaq, S., Agrawal, A., Altmaier, E., Antoniou, A. C., Asselbergs, F. W., Baumbach, C., Bierut, L., Bertelsen, S., Boehnke, M. et al. Molecular psychiatry, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30617275  

New Therapeutic Implications of Endothelial Nitric Oxide Synthase (Enos) Function/Dysfunction in Cardiovascular Disease. Daiber, A., Xia, N., Steven, S., Oelze, M., Hanf, A., Kroller-Schon, S., Munzel, T. & Li, H. International journal of molecular sciences 20, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30621010  

Prognostic Significance of Changes in Heart Rate Following Uptitration of Beta-Blockers in Patients with Sub-Optimally Treated Heart Failure with Reduced Ejection Fraction in Sinus Rhythm Versus Atrial Fibrillation. Mordi, I. R., Santema, B. T., Kloosterman, M., Choy, A. M., Rienstra, M., van Gelder, I., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., van der Harst, P., Hillege, H. L., Metra, M., Ng, L. L., Ouwerkerk, W., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zwinderman, A. H., Zannad, F. et al. Clinical research in cardiology : official journal of the German Cardiac Society, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30610382  

Crosstalk between the Endoplasmic Reticulum and Mtor Signaling. Malovrh, E. & Volkers, M. Circulation research 124, 9-11, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30605413  

Deficiency of Monoacylglycerol Lipase Enhances Igm Plasma Levels and Limits Atherogenesis in a Cb2-Dependent Manner. Guillamat Prats, R., Rami, M., Ring, L., Rinne, P., Lauer, E., Lenglet, S., Thomas, A., Pagano, S., Vuilleumier, N., Cravatt, B. F., Weber, C., Faussner, A. & Steffens, S. Thrombosis and haemostasis, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30609444  

Linking Ventricular Tachyarrhythmias Following an Acute Coronary Syndrome to Trajectories of Depression and Anxiety. Sadlonova, M. & Meyer, T. Journal of psychosomatic research, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30635123  

S100b and Its Relation to Cerebral Oxygenation in Neonates and Infants Undergoing Surgery for Congenital Heart Disease. Hansen, J. H., Kissner, L., Logoteta, J., Jung, O., Dutschke, P., Attmann, T., Scheewe, J. & Kramer, H. H. Congenital heart disease, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30604917  

The Year in Cardiology 2018: Prevention. Reiner, Z., Laufs, U., Cosentino, F. & Landmesser, U. European heart journal, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30601998  

Direct Oral Anticoagulants and Vitamin K Antagonists Are Linked to Differential Profiles of Cardiac Function and Lipid Metabolism. Eggebrecht, L., Prochaska, J. H., Trobs, S. O., Schwuchow-Thonke, S., Gobel, S., Diestelmeier, S., Schulz, A., Arnold, N., Panova-Noeva, M., Koeck, T., Rapp, S., Gori, T., Lackner, K. J., Ten Cate, H., Munzel, T. & Wild, P. S. Clinical research in cardiology : official journal of the German Cardiac Society, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30604046  

Maintaining Cardiovascular Health in the Digital Era. Leistner, D. M. & Landmesser, U. European heart journal 40, 9-12, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30602010  

Identification of Methylated Transcripts Using the Tribe Approach. Worpenberg, L., Jakobi, T., Dieterich, C. & Roignant, J. Y. Methods in molecular biology 1870, 89-106, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30539549  

Clinical Chemistry's Special Issue on Men's Health. Park, J. Y., Deutsch, M. B., Koenig, W., Lilja, H. & Platz, E. A. Clinical chemistry 65, 1-3, (2019). http://www.ncbi.nlm.nih.gov/pubmed/30602467  

Extravascular Compared to Intravascular Femoral Closure Is Associated with Less Bleeding and Similar Mace after Percutaneous Coronary Intervention. Kim, S. H., Behnes, M., Baron, S., Shchetynska-Marinova, T., Uensal, M., Mashayekhi, K., Hoffmann, U., Borggrefe, M. & Akin, I. Int J Med Sci 16, 43-50, (2018). http://www.medsci.org/v16p0043